Lung cancer breakthrough? new drug cocktail trial aims to boost surgery success

NCT ID NCT05061550

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This study tests several drug combinations given before and after surgery for early-stage non-small cell lung cancer. About 630 participants will receive immunotherapy drugs like durvalumab along with chemotherapy or other targeted agents. The goal is to see if these combos can eliminate more cancer cells and improve long-term outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Durvalumab, Oleclumab, Monalizumab, Dato-DXd, AZD0171, Volrustomig, Rilvegostomig, plus chemotherapy
What this could lead to: If successful, this could lead to better treatment options for early-stage lung cancer, potentially improving survival and reducing recurrence after surgery.
What could go wrong: This is an early Phase 2 trial, so results are not yet proven. The drug combinations may cause serious side effects, and not all participants may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Research Site
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Little Rock, Arkansas, 72205, United States
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Los Angeles, California, 90095, United States
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WITHDRAWN

Oakland, California, 94611, United States
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New Haven, Connecticut, 06510, United States
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COMPLETED

Stuart, Florida, 34994, United States
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COMPLETED

Gainesville, Georgia, 30501, United States
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Chicago, Illinois, 60637, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21231, United States
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Boston, Massachusetts, 02215, United States
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Saint Louis Park, Minnesota, 55426, United States
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Omaha, Nebraska, 68124, United States
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Buffalo, New York, 14263, United States
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Cleveland, Ohio, 44195, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Chattanooga, Tennessee, 37404, United States
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Memphis, Tennessee, 38120, United States
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WITHDRAWN

Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Fairfax, Virginia, 22031, United States
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Edmonds, Washington, 98026, United States
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Seattle, Washington, 98104, United States
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Ghent, 9000, Belgium
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Ghent, 9000, Belgium
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Roeselare, 8800, Belgium
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Edmonton, Alberta, T6G 1Z2, Canada
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Winnipeg, Manitoba, R3E 0V9, Canada
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Montreal, Quebec, H2W 1S6, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Avignon, 84902, France
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Bobigny, 93009, France
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Bordeaux, 33076, France
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Limoges, 83000, France
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Rennes, 35000, France
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Rouen, 76031, France
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Suresnes, 92150, France
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Toulon, 83000, France
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Kecskemét, 6000, Hungary
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Székesfehérvár, 8000, Hungary
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COMPLETED

Tatabánya, 2800, Hungary
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Törökbálint, 2045, Hungary
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Dublin, D07 R2WY, Ireland
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Dublin, D08 NHY1, Ireland
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Dublin, D09 V2N0, Ireland
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Galway, H91 YR71, Ireland
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Aviano, 33081, Italy
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Brescia, 25123, Italy
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Catanzaro, 88100, Italy
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Florence, 50134, Italy
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Genova, 16100, Italy
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Meldola, 47014, Italy
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Milan, 20162, Italy
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Monza, 20900, Italy
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Padova, 35128, Italy
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Perugia, 06156, Italy
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Pisa, 56124, Italy
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Roma, 00144, Italy
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Rozzano, 20089, Italy
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Lisbon, 1099-023, Portugal
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Lisbon, 1169-050, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1500-650, Portugal
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WITHDRAWN

Porto, 4099-001, Portugal
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COMPLETED

Porto, 4100-180, Portugal
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Porto, 4200-072, Portugal
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COMPLETED

Busan, 48108, South Korea
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WITHDRAWN

Chungcheongbuk-do, 28644, South Korea
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Seongnam-si, 13496, South Korea
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Seoul, 03080, South Korea
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Seoul, 05505, South Korea
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Suwon, 16247, South Korea
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Suwon, 440-746, South Korea
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A Coruña, 15006, Spain
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Alicante, 03010, Spain
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Barcelona, 08036, Spain
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Barcelona, 8035, Spain
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Córdoba, 14004, Spain
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Madrid, 28040, Spain
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Majadahonda, 28250, Spain
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Málaga, 29010, Spain
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Reus, 43204, Spain
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Seville, 41009, Spain
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Terrassa, 08221, Spain
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Valencia, 46010, Spain
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Liuying, 736, Taiwan
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New Taipei City, 235, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06500, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35575, Turkey (Türkiye)

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