New hope for tough lymphoma: experimental drug AZD4512 enters human trials

NCT ID NCT07123454

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests a new drug called AZD4512, alone or with other cancer medicines, in adults with relapsed or refractory B-cell Non-Hodgkin lymphoma (a type of blood cancer). The goal is to find safe doses and check if the drug shrinks tumors. About 91 participants will take part across multiple centers worldwide.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement mantle cell lymphoma non-Hodgkin lymphoma primary mediastinal large B-cell lymphoma Recurrence T-cell/histiocyte rich large B cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

Research Site
RECRUITING

Irvine, California, 92618, United States
Research Site
RECRUITING

Jacksonville, Florida, 32224, United States
Research Site
RECRUITING

Rochester, Minnesota, 55905, United States
Research Site
RECRUITING

New York, New York, 10016, United States
Research Site
RECRUITING

New York, New York, 10021, United States
Research Site
WITHDRAWN

Cleveland, Ohio, 44195, United States
Research Site
WITHDRAWN

Myrtle Beach, South Carolina, 29572, United States
Research Site
RECRUITING

Franklin, Tennessee, 37067, United States
Research Site
RECRUITING

Melbourne, 3000, Australia
Research Site
NOT_YET_RECRUITING

Chengdu, 610041, China
Research Site
NOT_YET_RECRUITING

Guangzhou, 510060, China
Research Site
RECRUITING

Bologna, 40138, Italy
Research Site
RECRUITING

Milan, 20133, Italy
Research Site
RECRUITING

Milan, 20141, Italy
Research Site
RECRUITING

Bunkyō City, 113-8677, Japan
Research Site
RECRUITING

Kōtoku, 135-8550, Japan
Research Site
RECRUITING

Seoul, 03080, South Korea
Research Site
RECRUITING

Seoul, 5505, South Korea
Research Site
RECRUITING

Taichung, 40705, Taiwan
Research Site
RECRUITING

Taipei, 106, Taiwan
Research Site
RECRUITING

London, W1T 7HA, United Kingdom
Research Site
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

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