New hope for lung cancer patients: experimental drug takes on standard therapy
NCT ID NCT06627647
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 5 times
Summary
This study tests a new drug called rilvegostomig against the standard drug pembrolizumab, both given with chemotherapy, as a first treatment for people with advanced non-squamous lung cancer that has spread. About 878 adults whose tumors have a specific protein (PD-L1) will take part. The goal is to see which combination helps people live longer and keeps the cancer from growing.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 1,160 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Nov 2030
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Histologically or cytologically documented non-squamous NSCLC. * Stage III B/C or IV NSCLC (based on the American Joint Committee on Cancer Edition 8) not amenable to curative treatment. * Absence of sensitizing EGFR mutations (including, but not limited to, exon 19 deletion and exon 21 L858R, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations) and ALK and ROS1 rearrangements. * Absence of documented tumor genomic mutation results from tests conducted as part of standard local practice in any other actionable driver oncogenes for which there are locally approved and available targeted 1L therapies. * Provision of acceptable tumor sample, to confirm tumor PD-L1 expression TC ≥ 1%. * At least one lesion not previously irradiated that qualifies as a RECIST 1.1 TL at baseline and can be accurately measured at baseline as ≥ 10 mm in the longest diameter (except lymph nodes, which must have short axis ≥ 15 mm) with CT or MRI and is suitable for accurate repeated measurements. * Adequate organ and bone marrow function Exclusion Criteria: * Presence of small cell and neuroendocrine histology components. * Brain metastases unless asymptomatic, stable, and not requiring steroids or anticonvulsants for at least 7 days prior to randomization. A minimum of 2 weeks must have elapsed between the end of local therapy (brain radiotherapy or surgery) and randomization. Participants must have recovered from the acute toxic effect of radiotherapy (eg, dizziness and signs of increased intracranial pressure) or surgery prior to randomization. * Any prior systemic therapy received for NSCLC except in the neoadjuvant or adjuvant setting or definitive chemoradiotherapy with the intent to cure, provided that progression has occurred \> 12 months after the end of systemic therapy treatment. * Any prior exposure to an anti-TIGIT therapy or any other anticancer therapy targeting immune-regulatory receptors or mechanisms. * Any prior treatment with an anti-PD-1 or anti-PD-L1 agent. * History of another primary malignancy except for malignancy treated with curative intent with no known active disease ≥ 2 years before the first dose of study intervention and of low potential risk for recurrence. * Active or prior documented autoimmune or inflammatory disorders requiring chronic systemic treatment with the use of disease-modifying agents, corticosteroids, or immunosuppressive drugs. * Active primary immunodeficiency/active infectious disease(s). * Active tuberculosis infection.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
262 sites in 24 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Research Site
RECRUITINGMobile, Alabama, 36608, United States
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WITHDRAWNChandler, Arizona, 85224, United States
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RECRUITINGPhoenix, Arizona, 85054, United States
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RECRUITINGAnaheim, California, 92801, United States
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RECRUITINGBeverly Hills, California, 90211, United States
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RECRUITINGLoma Linda, California, 92350, United States
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RECRUITINGRedlands, California, 92373, United States
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RECRUITINGSan Diego, California, 92123, United States
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RECRUITINGSan Francisco, California, 94121, United States
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RECRUITINGSanta Rosa, California, 95403, United States
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RECRUITINGWalnut Creek, California, 94598, United States
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RECRUITINGLone Tree, Colorado, 80124, United States
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RECRUITINGStamford, Connecticut, 06902, United States
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RECRUITINGWest Haven, Connecticut, 06516, United States
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RECRUITINGNewark, Delaware, 19713, United States
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RECRUITINGBay Pines, Florida, 33744, United States
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RECRUITINGFort Lauderdale, Florida, 33308, United States
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WITHDRAWNGainesville, Florida, 32610, United States
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RECRUITINGJacksonville, Florida, 32224, United States
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RECRUITINGMiami, Florida, 33125, United States
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RECRUITINGOcala, Florida, 34474, United States
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RECRUITINGSt. Petersburg, Florida, 33709, United States
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WITHDRAWNAtlanta, Georgia, 30342, United States
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RECRUITINGBoise, Idaho, 83712, United States
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RECRUITINGChicago, Illinois, 60637, United States
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RECRUITINGDecatur, Illinois, 62526, United States
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RECRUITINGHinsdale, Illinois, 60521, United States
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RECRUITINGQuincy, Illinois, 62305, United States
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WITHDRAWNRockford, Illinois, 61114, United States
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RECRUITINGWaterloo, Iowa, 50702, United States
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RECRUITINGLexington, Kentucky, 40509, United States
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WITHDRAWNLexington, Kentucky, 40536, United States
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RECRUITINGLouisville, Kentucky, 40207, United States
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WITHDRAWNAlexandria, Louisiana, 71301, United States
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RECRUITINGBaton Rouge, Louisiana, 70808, United States
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RECRUITINGShreveport, Louisiana, 71103, United States
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RECRUITINGShreveport, Louisiana, 71105, United States
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RECRUITINGSouth Portland, Maine, 04106, United States
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RECRUITINGBaltimore, Maryland, 21202, United States
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RECRUITINGGrand Rapids, Michigan, 49503, United States
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WITHDRAWNDuluth, Minnesota, 55805, United States
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RECRUITINGRochester, Minnesota, 55905, United States
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RECRUITINGSaint Paul, Minnesota, 55102, United States
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RECRUITINGBridgeton, Missouri, 63044, United States
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WITHDRAWNColumbia, Missouri, 65212, United States
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RECRUITINGLincoln, Nebraska, 68506, United States
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RECRUITINGCamden, New Jersey, 08103, United States
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RECRUITINGBuffalo, New York, 14221, United States
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RECRUITINGWestbury, New York, 11590, United States
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RECRUITINGCanton, Ohio, 44710, United States
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RECRUITINGMedford, Oregon, 97504, United States
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WITHDRAWNPortland, Oregon, 97239, United States
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RECRUITINGSalem, Oregon, 97301, United States
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WITHDRAWNPittsburgh, Pennsylvania, 15212, United States
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RECRUITINGYork, Pennsylvania, 17403, United States
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WITHDRAWNProvidence, Rhode Island, 02903, United States
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RECRUITINGPierre, South Dakota, 57501, United States
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RECRUITINGSioux Falls, South Dakota, 57105, United States
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RECRUITINGChattanooga, Tennessee, 37404, United States
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RECRUITINGNashville, Tennessee, 37203, United States
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RECRUITINGFort Worth, Texas, 76104, United States
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WITHDRAWNHouston, Texas, 77090, United States
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RECRUITINGIrving, Texas, 75063, United States
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RECRUITINGKingwood, Texas, 77339, United States
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WITHDRAWNLubbock, Texas, 79410, United States
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RECRUITINGPalestine, Texas, 75801, United States
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RECRUITINGRound Rock, Texas, 78665, United States
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RECRUITINGFairfax, Virginia, 22031, United States
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RECRUITINGNorfolk, Virginia, 23502, United States
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RECRUITINGRoanoke, Virginia, 24014, United States
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RECRUITINGSeattle, Washington, 98101, United States
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WITHDRAWNSeattle, Washington, 98104, United States
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RECRUITINGSilverdale, Washington, 98383, United States
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RECRUITINGSpokane, Washington, 99208, United States
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RECRUITINGTacoma, Washington, 98405, United States
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WITHDRAWNWenatchee, Washington, 98801, United States
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WITHDRAWNLa Crosse, Wisconsin, 54601, United States
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RECRUITINGBuenos Aires, C1431FWO, Argentina
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RECRUITINGCABA, 1425, Argentina
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WITHDRAWNLa Plata, 1900, Argentina
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RECRUITINGPilar, B1629ODT, Argentina
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RECRUITINGRosario, S2000DEJ, Argentina
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RECRUITINGDarlinghurst, 2010, Australia
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RECRUITINGHyde Park, 4812, Australia
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RECRUITINGSouthport, 4215, Australia
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RECRUITINGWollongong, 2500, Australia
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RECRUITINGBrussels, 1160, Belgium
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RECRUITINGCharleroi, 6060, Belgium
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RECRUITINGKortrijk, 8500, Belgium
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RECRUITINGOttignies, 1340, Belgium
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WITHDRAWNSint-Niklaas, 9100, Belgium
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RECRUITINGIjuí, 98700-000, Brazil
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RECRUITINGLondrina, 86015-520, Brazil
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RECRUITINGPasso Fundo, 99010-260, Brazil
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RECRUITINGPorto Alegre, 91350-200, Brazil
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RECRUITINGSalvador, 40050 410, Brazil
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WITHDRAWNSão Paulo, 01246-000, Brazil
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RECRUITINGSão Paulo, 01327-001, Brazil
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RECRUITINGSão Paulo, 05652000, Brazil
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WITHDRAWNTaubaté, 12030-200, Brazil
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RECRUITINGVitória, 29043-260, Brazil
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RECRUITINGSaint John, New Brunswick, E2L 4L2, Canada
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NOT_YET_RECRUITINGSydney, Nova Scotia, B1P 1P3, Canada
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NOT_YET_RECRUITINGGreater Sudbury, Ontario, P3E 5J1, Canada
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RECRUITINGHamilton, Ontario, L8V 1C3, Canada
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RECRUITINGKingston, Ontario, K7L 2V7, Canada
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RECRUITINGSault Ste. Marie, Ontario, P6A 0A8, Canada
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RECRUITINGMontreal, Quebec, H2X 0A9, Canada
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RECRUITINGMontreal, Quebec, H4A 3J1, Canada
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RECRUITINGSaint-Jérôme, Quebec, J7Z 2V4, Canada
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RECRUITINGBeijing, 100021, China
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RECRUITINGBeijing, 100029, China
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RECRUITINGBeijing, CN-100730, China
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RECRUITINGChangchun, 130012, China
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RECRUITINGChangsha, 410013, China
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RECRUITINGChengdu, 610041, China
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RECRUITINGChongqing, 400030, China
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RECRUITINGFuzhou, 350007, China
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RECRUITINGGuangzhou, 510062, China
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RECRUITINGGuangzhou, 510180, China
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RECRUITINGHangzhou, 310003, China
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RECRUITINGHangzhou, 310016, China
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RECRUITINGHangzhou, 310022, China
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RECRUITINGHarbin, 150081, China
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RECRUITINGHefei, 230601, China
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RECRUITINGJinan, 250117, China
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RECRUITINGJingzhou, 434000, China
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RECRUITINGKunming, 650118, China
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RECRUITINGLinhai, 317000, China
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RECRUITINGNanchang, 330008, China
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RECRUITINGNingbo, 315010, China
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RECRUITINGShanghai, 200030, China
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RECRUITINGShanghai, 200433, China
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RECRUITINGWenzhou, CN-325000, China
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RECRUITINGWuhan, 430000, China
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RECRUITINGXi'an, 710061, China
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RECRUITINGXiangyang, 441000, China
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RECRUITINGZhengzhou, 450008, China
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RECRUITINGZhengzhou, 450052, China
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RECRUITINGAvignon, 84902, France
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RECRUITINGLa Rochelle, 17019, France
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RECRUITINGLyon, 69373, France
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RECRUITINGNîmes, 30029, France
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RECRUITINGRennes, 35033, France
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RECRUITINGStrasbourg, 67091, France
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RECRUITINGSuresnes, 92150, France
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RECRUITINGToulon, 83800, France
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RECRUITINGBad Berka, 99437, Germany
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WITHDRAWNBerlin, 13585, Germany
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NOT_YET_RECRUITINGBielefeld, 33611, Germany
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NOT_YET_RECRUITINGBochum, 44791, Germany
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NOT_YET_RECRUITINGChemnitz, 09116, Germany
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RECRUITINGCologne, 51109, Germany
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RECRUITINGEsslingen am Neckar, 73730, Germany
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RECRUITINGFrankfurt, 60488, Germany
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NOT_YET_RECRUITINGFrankfurt am Main, 60431, Germany
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RECRUITINGGauting, 82131, Germany
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RECRUITINGGiessen, 35392, Germany
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RECRUITINGGroßhansdorf, 22927, Germany
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NOT_YET_RECRUITINGHalle, 06120, Germany
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RECRUITINGHamburg, 20251, Germany
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RECRUITINGHanover, 30459, Germany
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RECRUITINGHanover, 30625, Germany
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RECRUITINGHemer, 58675, Germany
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RECRUITINGHomburg, 66424, Germany
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RECRUITINGKassel, 34125, Germany
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RECRUITINGKiel, 24105, Germany
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RECRUITINGKrefeld, 47805, Germany
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NOT_YET_RECRUITINGMagdeburg, 39130, Germany
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RECRUITINGMinden, 32429, Germany
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RECRUITINGMoers, 47441, Germany
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NOT_YET_RECRUITINGMünchen, 81925, Germany
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RECRUITINGRegensburg, 93053, Germany
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NOT_YET_RECRUITINGSchwerin, 19049, Germany
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NOT_YET_RECRUITINGVelbert, 42551, Germany
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RECRUITINGWürzburg, 97067, Germany
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RECRUITINGBudapest, 1083, Hungary
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RECRUITINGBudapest, 1121, Hungary
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RECRUITINGBudapest, 1122, Hungary
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RECRUITINGDebrecen, 4032, Hungary
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WITHDRAWNGyöngyös, 3200, Hungary
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RECRUITINGGyöngyös - Mátraháza, 3200, Hungary
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RECRUITINGGyőr, 9024, Hungary
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RECRUITINGPécs, 7624, Hungary
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WITHDRAWNSzékesfehérvár, 8000, Hungary
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RECRUITINGTörökbálint, 2045, Hungary
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RECRUITINGCalicut, 673601, India
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RECRUITINGDelhi, 110029, India
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NOT_YET_RECRUITINGGurgaon, 122001, India
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WITHDRAWNKolkata, 700054, India
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RECRUITINGMadurai, 625107, India
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RECRUITINGMumbai, 400012, India
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RECRUITINGNashik, 422002, India
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WITHDRAWNNew Delhi, 110075, India
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RECRUITINGVaranasi, 221005, India
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RECRUITINGFlorence, 50134, Italy
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NOT_YET_RECRUITINGLegnano, 20025, Italy
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NOT_YET_RECRUITINGLivorno, 57126, Italy
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RECRUITINGMonza, 20052, Italy
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RECRUITINGPeschiera del Garda, 37019, Italy
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RECRUITINGRome, 00168, Italy
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RECRUITINGAmagasaki-shi, 660-8550, Japan
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RECRUITINGBunkyō City, 113-8603, Japan
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RECRUITINGChūōku, 104-0045, Japan
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RECRUITINGFukuoka, 812-8582, Japan
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RECRUITINGFukuoka, 814-0180, Japan
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RECRUITINGHiroshima, 734-8551, Japan
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RECRUITINGKawagoe-shi, 350-8550, Japan
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RECRUITINGKawasaki-shi, 216-8511, Japan
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RECRUITINGKitaadachi-gun, 362-0806, Japan
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RECRUITINGKitakyushu-shi, 807-8555, Japan
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RECRUITINGKobe, 650-0017, Japan
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RECRUITINGKōtoku, 135-8550, Japan
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RECRUITINGKumamoto, 860-8556, Japan
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RECRUITINGKumamoto, 861-4193, Japan
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RECRUITINGKyoto, 612-8555, Japan
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RECRUITINGMatsusaka-shi, 515-8544, Japan
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RECRUITINGOsaka, 541-8567, Japan
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RECRUITINGOta-shi, 373-8550, Japan
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RECRUITINGSaitama-shi, 338-0001, Japan
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RECRUITINGShinjuku-ku, 160-0023, Japan
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RECRUITINGSunto-gun, 411-8777, Japan
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RECRUITINGTakaoka-shi, 933-8555, Japan
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RECRUITINGYokohama, 232-0024, Japan
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RECRUITINGYokohama, 241-8515, Japan
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RECRUITINGKuala Lumpur, 59100, Malaysia
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RECRUITINGKuching, 93586, Malaysia
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RECRUITINGPetaling Jaya, 47500, Malaysia
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RECRUITINGAlkmaar, 1815 JD, Netherlands
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RECRUITINGEde, 6716 RP, Netherlands
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WITHDRAWNGroningen, 9713 GZ, Netherlands
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RECRUITINGLeidschendam, 2262 BA, Netherlands
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RECRUITINGVeldhoven, 5504 DB, Netherlands
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WITHDRAWNLima, 15036, Peru
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WITHDRAWNLima, 15102, Peru
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WITHDRAWNLima, LIMA 29, Peru
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WITHDRAWNLima, Lima 34, Peru
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WITHDRAWNBialystok, 15-027, Poland
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SUSPENDEDBiała Podlaska, 21-500, Poland
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SUSPENDEDBydgoszcz, 85-796, Poland
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RECRUITINGBystra, 43-360, Poland
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RECRUITINGLodz, 93-338, Poland
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NOT_YET_RECRUITINGLublin, 20-090, Poland
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RECRUITINGPoznan, 60-569, Poland
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NOT_YET_RECRUITINGWarsaw, 04-141, Poland
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NOT_YET_RECRUITINGWroclaw, 53-413, Poland
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NOT_YET_RECRUITINGSan Juan, 00918, Puerto Rico
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RECRUITINGSan Juan, 00935, Puerto Rico
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RECRUITINGGyeonggi-do, 13620, South Korea
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RECRUITINGSeoul, 03080, South Korea
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RECRUITINGSeoul, 03722, South Korea
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RECRUITINGSeoul, 06351, South Korea
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RECRUITINGSeoul, 06591, South Korea
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RECRUITINGSeoul, 07061, South Korea
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RECRUITINGSongpa-gu, 05505, South Korea
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RECRUITINGBarcelona, 8035, Spain
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RECRUITINGCastellon, 12002, Spain
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RECRUITINGLas Palmas de Gran Canaria, 35016, Spain
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RECRUITINGMadrid, 28034, Spain
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RECRUITINGMadrid, 28046, Spain
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RECRUITINGMajadahonda, 28222, Spain
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RECRUITINGSeville, 41013, Spain
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RECRUITINGKaohsiung City, 80756, Taiwan
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RECRUITINGKaohsiung City, 824, Taiwan
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RECRUITINGNew Taipei City, 220, Taiwan
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RECRUITINGNew Taipei City, 23561, Taiwan
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RECRUITINGTaichung, 40201, Taiwan
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RECRUITINGTaichung, 40705, Taiwan
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WITHDRAWNTainan, 736, Taiwan
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RECRUITINGTaoyuan, 333423, Taiwan
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RECRUITINGBangkok, 10700, Thailand
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RECRUITINGChiang Mai, 50200, Thailand
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RECRUITINGDusit, 10300, Thailand
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RECRUITINGNakhon Ratchasima, 30000, Thailand
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RECRUITINGSongkhla, 90110, Thailand
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RECRUITINGAnkara, 06010, Turkey (Türkiye)
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RECRUITINGAntalya, 07070, Turkey (Türkiye)
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RECRUITINGAntalya, 07100, Turkey (Türkiye)
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RECRUITINGEdirne, 22030, Turkey (Türkiye)
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RECRUITINGIzmir, 35965, Turkey (Türkiye)
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RECRUITINGSeyhan, 1060, Turkey (Türkiye)
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RECRUITINGAberdeen, AB25 2ZN, United Kingdom
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Research Site
RECRUITINGCambridge, CB2 0QQ, United Kingdom
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RECRUITINGEdinburgh, EH4 2XU, United Kingdom
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WITHDRAWNExeter, EX2 5DW, United Kingdom
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RECRUITINGGreater London, SW3 6JJ, United Kingdom
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RECRUITINGLondon, EC1A 7BE, United Kingdom
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RECRUITINGLondon, SE1 9RT, United Kingdom
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RECRUITINGManchester, M20 4BX, United Kingdom
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RECRUITINGNewcastle upon Tyne, NE7 7AF, United Kingdom
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RECRUITINGTorquay, TQ2 7AA, United Kingdom
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RECRUITINGCan Tho, 900000, Vietnam
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RECRUITINGHanoi, 100000, Vietnam
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RECRUITINGHo Chi Minh City, 700000, Vietnam
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RECRUITINGVinh, 460000, Vietnam
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