Astrazeneca

This study is testing a weekly injection called anifrolumab, added to standard lupus medication, in people who have not yet tried strong immunosuppressant drugs. The main goal is to see if the treatment can help patients achieve a state of very low disease activity or remission. …

This study aims to see how well a medication called anifrolumab, given as an injection under the skin, works for controlling lupus in everyday medical practice. It will follow 125 adult lupus patients for two years after they start this treatment, tracking their disease activity,…

This study is testing whether a combination of two targeted drugs (acalabrutinib and venetoclax) can effectively treat patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) when their cancer returns after successful first-line treatment. The trial w…

This study is testing a treatment plan for adults with a specific type of advanced, inoperable lung cancer who are not candidates for or refuse chemotherapy. The plan involves taking a targeted pill called osimertinib for about 12 weeks, followed by radiation therapy, and then co…

This study aims to monitor the safety and effectiveness of the asthma drug Tezspire (tezepelumab) in real-world medical practice in South Korea. It will follow 210 patients with severe asthma for 24 weeks to track any side effects and see if their asthma control improves. The goa…

This study will observe how well the medication ravulizumab works for Polish patients with atypical hemolytic uremic syndrome (aHUS), a rare and serious blood disorder that can damage the kidneys. Researchers will follow about 80 patients already receiving this drug as part of th…

This study provides continued access to the medication benralizumab (Fasenra) for people with asthma, EGPA, or HES who completed a previous clinical trial and are still benefiting from the treatment. It aims to monitor the long-term safety of the drug while allowing participants …

This early-stage trial is testing a new oral drug called AZD4956, both alone and combined with other cancer treatments, for people with advanced solid tumors that have stopped responding to standard therapies. The study aims to find safe doses and see if the drug can help control…

This study is testing a combination of two experimental drugs, camizestrant and atirmociclib, for people with a specific type of advanced breast cancer that has worsened after prior treatment. The main goals are to see if the drug combination is safe and to look for early signs t…

This study aims to monitor the safety and effectiveness of Danicopan, a medication for a rare blood disease called PNH, in real-world Korean medical settings. It will follow 8 patients already receiving Danicopan alongside their standard treatment to check for side effects and se…

This early-stage study is testing a new way to give the cancer drug durvalumab as an injection under the skin instead of through an IV. Researchers want to find a dose that works as well as the IV version and check if it's safe. The study will enroll 40 adults with certain advanc…

This study tests whether adding chemotherapy to the drug osimertinib helps control lung cancer that has spread to other parts of the body after initial treatment. The trial will enroll about 100 patients in China whose lung cancer returned despite previous surgery and medication.…

This early-stage clinical trial is testing a new drug called AZD9750 in men with metastatic prostate cancer that has spread. Researchers will study the drug's safety, how it moves through the body, and early signs of effectiveness when given alone or combined with another cancer …

This study aims to monitor the safety and side effects of the Breztri inhaler when used as a long-term treatment for moderate-to-severe COPD. It will follow 150 Indian patients for about 6 months to see how well they tolerate the medication. The inhaler is already approved and av…

This study aims to see if training doctors on a standard process helps find more cases of ATTR amyloidosis, a serious heart disease, earlier. It will enroll about 4,000 older adults in China who have heart failure and are at high risk for this condition. The main goal is to measu…

This study is testing if a steroid mouthwash can prevent painful mouth sores, a common side effect of the cancer drug Dato-DXd. It will enroll about 100 adults with advanced breast or lung cancer who are starting treatment with Dato-DXd. The main goal is to see how many patients …

This early-stage study aims to understand how different injected formulations of an experimental drug called AZD6234 are absorbed into the body. It will involve 21 healthy volunteers who will each try four different versions of the injection. Researchers will measure the drug lev…

This study looks back at existing medical records to understand how high blood pressure is treated in Brazil's public healthcare system. Researchers will analyze data from 15,000 patients to see if treatment follows guidelines and identify delays in care. The goal is to learn abo…

This study aims to observe and describe what happens to patients in China after they have surgery for chronic sinusitis with nasal polyps. It will follow about 200 patients for one year to track their symptoms, quality of life, and what treatments they use after the operation. Th…

This early-stage study aims to understand how a new investigational drug, AZD5004, affects how the body processes two existing diabetes medications (mitiglinide and pioglitazone). It will involve 32 healthy volunteers to measure drug levels and check for safety. The goal is to ga…

This study aims to understand how common a specific protein called HER2 is in five types of gynecological cancers. Researchers will analyze stored tumor tissue samples from 350 adult patients in Brazil to measure HER2 levels. The goal is to gather information that could help guid…

This early-stage study aims to see how the body processes a new single pill containing two medications (laroprovstat and rosuvastatin) compared to taking the two medications as separate pills. It will involve 44 healthy adults who will take different versions of the medication in…

This study aims to understand how young women of childbearing age use the lupus drug Saphnelo (anifrolumab) in real-world settings. It will track treatment patterns and gather safety information, particularly regarding pregnancy, by reviewing existing health records from millions…

This study will review medical records of 3,000 Chinese patients with early-stage non-small cell lung cancer. Researchers want to understand what treatments doctors are currently using and how well those treatments work in real-world settings. The study will not test new treatmen…

This study aims to understand the real-world results of lung cancer screening in Brazil. Researchers will observe about 477 high-risk smokers to see how often scans incorrectly suggest cancer, leading to unnecessary follow-up tests. The goal is to learn if screening works as well…

This study aims to understand how a cancer drug called capivasertib affects the way the body processes a common cough medicine, dextromethorphan. It will involve 35 healthy volunteers who will take both drugs in a specific order. The main goal is to measure drug levels in the blo…

This study aims to see if different labs and pathologists get the same results when testing cancer tissue for the HER2 protein. Researchers will look back at tissue samples from about 2,100 Chinese patients with lung, gynecologic, bile duct, or bladder cancer. The goal is to unde…

This study aims to understand how common high potassium levels are and what factors contribute to them in Brazilian patients with heart failure, kidney disease, diabetes, or high blood pressure. Researchers will analyze anonymous medical records from over 6,000 patients who visit…