Astrazeneca

This early-stage trial tested a new drug called AZD0022 in 17 people with advanced solid tumors (like lung, pancreatic, or colorectal cancer) that have a specific KRASG12D mutation. The study was stopped early, but researchers were checking if the drug is safe and shrinks tumors …

This study tested a drug called sodium zirconium cyclosilicate (SZC) to see if it could slow the worsening of chronic kidney disease (CKD) in people who also have high potassium levels or are at risk for it. Over 1,100 adults with moderate-to-severe CKD took SZC or a placebo alon…

This study tested whether adding a new drug called AZD5462 to standard treatment (dapagliflozin) could help people with both heart failure and moderate kidney disease. The goal was to see how the combination affected sodium excretion and other health markers. Only 8 participants …

This study tested a drug called benralizumab in 295 adults with severe nasal polyps and chronic sinusitis. The goal was to see if it could shrink polyps and improve breathing and smell better than a placebo. The trial was stopped early, so the full results are not available, but …

This study tested a combination of the targeted drug osimertinib and chemotherapy as a first treatment for people with advanced non-small cell lung cancer that has uncommon EGFR mutations. The goal was to see if the combo could shrink tumors and delay cancer growth. However, the …

This study looked at the long-term safety of the drug brazikumab for people with moderate to severe Crohn's disease. It was designed for patients who had already completed or left an earlier study of the same drug. The study was terminated early and only enrolled 18 participants,…

This study was designed to collect information about Chinese patients with nonalcoholic steatohepatitis (NASH) and liver scarring. Researchers aimed to describe patient characteristics, how they are diagnosed and treated in real life, and their knowledge about the disease. Over 1…

This study aimed to see how a drug called ceralasertib affects the way the body processes three other drugs (Drug X, Y, and Z) in people with advanced solid tumours. Only one person took part before the study was stopped early. The main goal was to measure drug levels in the bloo…

This study looked at adults with severe uncontrolled asthma in Germany to see how well their asthma was controlled over 12 months. Participants used a simple questionnaire called AIRQ® to track symptoms, medication use, and risk of flare-ups. The goal was to gather real-world inf…

This early-phase study tested the safety and how the body processes a new drug called AZD0233 in healthy adults aged 18 to 50. The trial was stopped early and did not involve people with the heart condition it was being developed for. The main goal was to check for side effects a…

This early-stage study aimed to see if the experimental drug AZD3427 could improve blood flow to the kidneys in people with heart failure and reduced kidney function. Only 10 participants were planned, and the study was terminated early. The main goal was to measure changes in ki…

This study aimed to find out how often a rare heart condition called transthyretin amyloidosis cardiomyopathy (ATTR-CM) occurs in Russian patients with a common type of heart failure. Researchers planned to review medical records of 1,770 patients and then examine those with high…

This study followed 83 adults with advanced lung cancer who were starting standard treatments. The goal was to collect data to help develop a digital tool that can better predict when patients might develop a serious lung inflammation called pneumonitis. The study did not test an…