Astrazeneca

This early-stage study aimed to see if a single dose of an experimental drug, AZD3427, could improve blood flow to the kidneys in people who have both heart failure and reduced kidney function. Researchers used special PET scans to measure blood flow in the kidneys before and aft…

This early-stage study tested a new oral drug, AZD0022, alone and combined with another cancer drug, in people with advanced solid tumors driven by a specific genetic change called KRASG12D. The main goals were to find a safe dose and see if the treatment caused any side effects.…

This large international study aimed to see if a drug called sodium zirconium cyclosilicate (SZC), which lowers blood potassium, could help slow the worsening of chronic kidney disease (CKD). It involved over 1,100 adults with CKD who either had high potassium or were at risk for…

This early-stage study aimed to test the safety and effects of an experimental drug called AZD5462 when added to a standard heart failure medication (dapagliflozin). It involved a small group of people who had both heart failure and moderate kidney impairment. The study was termi…

This study tested whether regular injections of benralizumab could reduce nasal polyps and improve breathing in adults with severe nasal polyps and asthma. About 295 participants received either the drug or a placebo injection every few weeks for a year. The trial was terminated …

This study aimed to test the effectiveness and safety of a combination treatment for adults with advanced non-small cell lung cancer (NSCLC) who have specific, less common genetic mutations. The treatment combined a targeted pill (osimertinib) with standard chemotherapy drugs. Th…

This study aims to find out how common a specific heart muscle disease (transthyretin amyloidosis cardiomyopathy, or ATTR-CM) is among Russian patients with a certain type of heart failure. Researchers will look back at medical records and also follow some patients forward in tim…

This was an early safety study for a new drug called AZD0233, which is being developed for a serious heart condition called dilated cardiomyopathy. The trial tested single and multiple doses in 84 healthy volunteers to check for side effects and see how the body processes the dru…

This early-stage study aimed to understand how a cancer drug called ceralasertib changes the way the body processes three other cancer drugs. It was designed for a small group of adults with advanced solid tumors. The study was terminated after enrolling only one participant.

This study aimed to create a detailed picture of how non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease, is diagnosed and managed in China. Researchers planned to observe over 1,100 patients to collect real-world information on their symptoms, treatments,…

This study aimed to better understand the real-world situation of adults in Germany with severe, uncontrolled asthma. It observed 19 patients for 12 months to track their symptoms, medication use (especially steroid pills), and quality of life using questionnaires and health reco…