New drug brazikumab aims to tame ulcerative colitis Flare-Ups

NCT ID NCT03616821

Terminated Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested brazikumab in 242 adults with moderate-to-severe ulcerative colitis. Participants received either brazikumab or a placebo intravenously and then as injections over 54 weeks. The goal was to see if the drug could improve symptoms and heal the colon lining. The study was terminated early, so final conclusions are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

brazikumab

What this could lead to

If successful, brazikumab could offer a new treatment option to control moderate-to-severe ulcerative colitis and improve symptoms and colon healing.

What could go wrong

This is an early-phase trial that was terminated, so results are limited. The drug may not work better than placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IBD ULCERATIVE COLITIS

Contacts and locations

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Locations

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Phoenix, Arizona, 85037, United States
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Tucson, Arizona, 85712, United States
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Little Rock, Arkansas, 72212, United States
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Chula Vista, California, 91911, United States
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Lancaster, California, 93534, United States
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Lincoln, California, 95648, United States
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Mission Hills, California, 91345, United States
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Poway, California, 92064, United States
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Colorado Springs, Colorado, 80907, United States
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Clearwater, Florida, 33756, United States
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Inverness, Florida, 34452, United States
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Kissimmee, Florida, 34741, United States
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Lakeland, Florida, 33813, United States
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Miami, Florida, 33157, United States
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Miami, Florida, 33165, United States
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Miami Lakes, Florida, 33016, United States
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Naples, Florida, 34102, United States
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New Port Richey, Florida, 34653, United States
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Tampa, Florida, 33614, United States
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Tampa, Florida, 33626, United States
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Atlanta, Georgia, 30328, United States
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Gurnee, Illinois, 60031, United States
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Oak Lawn, Illinois, 60453, United States
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Brownsburg, Indiana, 46112, United States
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Evansville, Indiana, 47715, United States
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Shawnee Mission, Kansas, 66226, United States
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Topeka, Kansas, 66606, United States
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Baton Rouge, Louisiana, 70809, United States
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Marrero, Louisiana, 70072, United States
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Shreveport, Louisiana, 71105, United States
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Wyoming, Michigan, 49519, United States
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Biloxi, Mississippi, 39531, United States
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Las Vegas, Nevada, 89106, United States
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Las Vegas, Nevada, 89123, United States
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New York, New York, 10016, United States
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Sunnyside, New York, 11104, United States
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Morehead City, North Carolina, 28557, United States
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Beachwood, Ohio, 44122, United States
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Springfield, Ohio, 45503, United States
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Oklahoma City, Oklahoma, 73112, United States
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Uniontown, Pennsylvania, 15401, United States
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Amarillo, Texas, 79109, United States
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Carrollton, Texas, 75007, United States
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Houston, Texas, 77017, United States
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Houston, Texas, 77058, United States
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Houston, Texas, 77598, United States
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Humble, Texas, 77346, United States
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Pflugerville, Texas, 78660, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78258, United States
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North Chesterfield, Virginia, 23236, United States
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Chicoutimi, Quebec, G7H 5H6, Canada
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Brno, 636 00, Czechia
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České Budějovice, 370 01, Czechia
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Hradec Králové, 500 12, Czechia
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Ostrava, 702 00, Czechia
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Hamburg, 20251, Germany
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Kiel, 24105, Germany
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Ulm, 89081, Germany
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Debrecen, 4032, Hungary
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Bangalore, 560054, India
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Hyderabad, 500032, India
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Jaipur, 302001, India
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New Delhi, 110075, India
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Rajkot, 360004, India
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Surat, 395002, India
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Haifa, 31096, Israel
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Jerusalem, 9103102, Israel
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Petah Tikva, 4941492, Israel
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Milan, 20132, Italy
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Negrar, 37024, Italy
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Rho, 20017, Italy
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Roma, 00168, Italy
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Asahikawa-shi, 070-8610, Japan
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Chiba, 260-8677, Japan
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Fukuoka, 810-8563, Japan
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Fukuyama-shi, Japan
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Hakodate-shi, 040-8585, Japan
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Kasama-shi, 309-1793, Japan
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Kashiwa-shi, 277-0871, Japan
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Koshigaya-shi, 343-8555, Japan
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Kure-shi, 737-0023, Japan
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Minatoku, 108-8642, Japan
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Nagaoka-shi, 940-2085, Japan
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Onga-gun, 807-0051, Japan
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Sapporo, 064-0919, Japan
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Takarazuka-shi, 665-0827, Japan
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Bydgoszcz, 85-079, Poland
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Chojnice, 89-600, Poland
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Częstochowa, 42-202, Poland
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Gdansk, 80-382, Poland
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Krakow, 31-513, Poland
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Ksawerów, 95-054, Poland
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Piaseczno, 05-500, Poland
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Poznan, 60-702, Poland
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Rzeszów, 35-302, Poland
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Sopot, 81-756, Poland
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Torun, 87-100, Poland
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Warsaw, 00-189, Poland
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Warsaw, 03-580, Poland
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Wroclaw, 52-210, Poland
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San Juan, 00927, Puerto Rico
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Aramil, 624002, Russia
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Izhevsk, 426035, Russia
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Moscow, 115419, Russia
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Novosibirsk, 630007, Russia
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Perm, 614000, Russia
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Tomsk, 634050, Russia
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Košice, 04013, Slovakia
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Bloemfontein, 9301, South Africa
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Cape Town, 7500, South Africa
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Cape Town, 7708, South Africa
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Plumstead, 7800, South Africa
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Busan, 48108, South Korea
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Daegu, 42415, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 06973, South Korea
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Wŏnju, 26426, South Korea
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Valencia, 46010, Spain
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Taichung, 40447, Taiwan
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Taipei, 100, Taiwan
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Kyiv, 03680, Ukraine
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Vinnytsia, 21009, Ukraine
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West Bromwich, B71 4HJ, United Kingdom