Astrazeneca

This study looked at side effects of the drug IMFINZI when given together with standard chemotherapy (gemcitabine and cisplatin) to people with advanced bile duct cancer that cannot be removed by surgery. A total of 236 patients took part. The main goal was to track any unwanted …

This study tested a new medicine called AZD5462 in 375 adults with stable chronic heart failure. The goal was to see if the drug could improve how well the heart pumps blood. Participants took either the study drug or a placebo, and doctors measured heart function using ultrasoun…

This study tested a medicine called nirsevimab in 33 Japanese infants under 1 year old who have health problems like heart or lung disease, weak immune systems, Down syndrome, or were born early. The goal was to see if two doses given 5-6 months apart are safe and help protect ag…

This study tested a new drug called AZD4604 in 36 adults with moderate-to-severe asthma. The goal was to see if it reduces airway inflammation better than a placebo over 4 weeks. Participants took the drug or a placebo and had their airway cells checked for signs of inflammation.…

This study followed 104 people with relapsed or refractory chronic lymphocytic leukemia (CLL) who were taking the drug Calquence (acalabrutinib). The goal was to track any side effects that happened in everyday medical use. The study did not test if the drug worked, but rather ho…

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with liver cirrhosis. 73 adults with cirrhosis took either the combination, zibotentan alone, or a placebo. The main goal was to see if the drugs caused fluid retention, a commo…

This study tested whether a combination inhaler containing two medicines (budesonide and formoterol) works better than an inhaler with just one medicine (budesonide) for people whose asthma is not well controlled. 374 adults and teens aged 12–80 took part over 12 weeks. The goal …

This early-phase study tested a new oral drug (AZD2014) combined with a standard hormone therapy (fulvestrant) in 99 people with advanced, ER+ breast cancer. The main goal was to check safety and how the body processes the drugs, not to cure the disease. Participants had to have …

This study looked at the safety and effectiveness of the drug FASENRA in 51 Korean adults with severe eosinophilic asthma or a related condition called EGPA. Researchers tracked side effects and how well the drug controlled symptoms during routine medical care. The goal was to co…

This study checked how safe and effective the cancer drug durvalumab (Imfinzi) is when used in real-world clinics, not just in strict research settings. It included 712 people in Korea with lung or biliary tract cancer who were already eligible for the drug. Researchers tracked s…

This study tested a daily pill called roflumilast to see if it improves lung function in adults with asthma. About 450 participants took either the drug or a placebo for 24 weeks. Researchers measured breathing tests, asthma symptoms, and side effects to determine if the drug is …

This study tested a new drug called AZD9291 in 603 people with advanced non-small cell lung cancer whose tumors had started growing again after previous targeted therapy. The main goals were to find the safest and most effective dose, measure how the drug moves through the body, …

This study tested an experimental oral tablet called AZD5004, taken once daily for 36 weeks, to see if it helps people with obesity or overweight lose weight. About 310 adults aged 18 and older with a body mass index of 27 or higher and at least one weight-related health problem …

This study tested a drug called cotadutide in 54 adults with a type of fatty liver disease (NASH) that includes liver scarring but not cirrhosis. The main goal was to see if the drug is safe and helps the liver. Participants received either the drug or a placebo, and researchers …

This study tested a new daily medication called AZD0780 in 428 adults with high cholesterol. Participants took either a low or high dose of the drug or a placebo for 12 weeks. The main goal was to see how much the drug lowered 'bad' LDL cholesterol compared to the placebo. The st…

This study tested an investigational drug called AZD3427 in 260 adults with heart failure and a related lung condition called pulmonary hypertension (Group 2). The goal was to see if the drug could lower blood pressure in the lungs' arteries after 24 weeks of treatment. Participa…

This study tested how well tezepelumab works for adults with severe asthma that is not controlled by other treatments. It focused on improving asthma control and reducing cough. 92 participants were followed for a year to see real-world effects.

This study tested two doses of a drug called tozorakimab in over 1100 adults with COPD who had frequent or severe flare-ups in the past year. Participants continued their usual inhaled treatments and received either the study drug or a placebo as a shot. The main goal was to see …

This study tested whether a triple-combination inhaler (BGF MDI) helps people with moderate to severe COPD breathe better and exercise longer compared to a placebo or a dual-combination inhaler. 171 adults aged 40-80 took part. The main focus was on how well the lungs work during…

This early-stage study tested a new drug called AZD0780 in 81 adults with high LDL ("bad") cholesterol. Participants took AZD0780 or a placebo on top of their usual cholesterol medicines like ezetimibe or statins. The goal was to see if AZD0780 safely lowers LDL more than placebo…

This early-stage trial tested a new drug called AZD7789 in 45 people whose Hodgkin lymphoma had returned or stopped responding to at least two prior treatments. The drug is a special antibody designed to help the immune system attack cancer cells. The main goals were to check saf…

This study looked at how well the drug tezepelumab works for people with severe asthma in real-world settings, outside of a controlled lab. Over 500 participants tracked their symptoms and quality of life for months. The goal was to see if the drug helps control asthma day-to-day…

This study tested a daily pill (olaparib) against standard chemotherapy in 302 people with metastatic breast cancer who have inherited BRCA1/2 mutations. The goal was to see if olaparib could delay cancer growth longer than chemo. Participants were randomly assigned to olaparib o…

This study looked at the long-term safety of the drug roflumilast in adults with asthma. It included 150 people who had already completed a 24-week study of the same drug. They took roflumilast once daily for another 28 weeks, for a total of 52 weeks. The goal was to see if the d…

This study tested whether a combination inhaler (AIRSUPRA, which contains albuterol and budesonide) works better than albuterol alone for adults with mild asthma. Over 12 weeks, researchers measured airway inflammation, asthma symptoms, and how often participants needed rescue me…

This study tested two hormone-blocking drugs, fulvestrant and anastrozole, in 462 postmenopausal women with advanced breast cancer that is fueled by hormones. The goal was to see which drug better delays cancer growth. Participants had not received hormone therapy before. The res…

This early-phase study tested a new combination of two drugs, AZD1775 (a pill) and durvalumab (given by IV), in 56 adults with advanced solid tumours that had stopped responding to standard treatments. The main goal was to check the safety and side effects of the combination, and…

This study tested a new drug called baxdrostat in 218 adults whose high blood pressure remained high despite taking three or more medications. Participants received either baxdrostat or a placebo daily for 12 weeks. The main goal was to see if baxdrostat could lower average blood…

This study tested a drug called acalabrutinib in 552 adults with chronic lymphocytic leukemia (CLL), a type of blood cancer. Participants took the drug twice daily for up to 48 cycles (about 4 years). The main goal was to check safety and side effects, and researchers also looked…

This study looked at 33 people with severe asthma who received tezepelumab before it was widely available in Spain. Researchers checked how well the drug controlled asthma symptoms and tracked side effects. The goal was to see how the drug works outside of a clinical trial settin…

This study looked at how safe and effective the drug Tagrisso (osimertinib) is for people with a certain type of advanced lung cancer in everyday medical practice. Over 900 patients in Korea took part, and researchers tracked side effects and how well the drug controlled the canc…

This study looked at the safety of the drug LYNPARZA when used as ongoing treatment after chemotherapy for people with a specific type of pancreatic cancer linked to BRCA gene changes. About 130 patients took part. The main goal was to track side effects like bone marrow problems…

This study followed 43 adults in Taiwan with severe uncontrolled asthma who were prescribed benralizumab. Researchers tracked changes in asthma control using a standard questionnaire over time. The goal was to see how well the drug works in everyday life, not just in a lab.

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants were former or current smokers already on standard inhalers. The goal was to see if the drug could safely reduce the number of moderate to severe COPD …

This study looked at 291 adults with severe eosinophilic asthma who were starting benralizumab (Fasenra). Researchers tracked how well the drug controlled their asthma symptoms over time using patient questionnaires. The goal was to see if benralizumab improves asthma control in …

This study tested a new drug called AZD0780 to see if it can lower blood pressure in people with heart disease or related risks who also have high cholesterol. About 202 adults took part, and they received either the drug or a placebo for 4 weeks. The main goal was to measure cha…

This study looked at whether tezepelumab, an approved asthma medication, is safe and effective for people with severe asthma, especially those often left out of research. About 287 adults and teens took the drug for a year. The main goal was to see if it reduced the number of ser…

This study tested a new medicine called AZD6234, given as a weekly shot, to help people with obesity or overweight lose weight. 262 adults took part, receiving either the drug or a placebo for 36 weeks. The main goal was to see if the drug led to greater weight loss than placebo,…

This study looked at whether the drug anifrolumab, when added to standard treatment, can prevent long-term organ damage in adults with active lupus. Researchers compared data from 561 patients who took anifrolumab in earlier trials to similar patients receiving only standard care…

This study tested combinations of the immunotherapy durvalumab with two other experimental drugs (danvatirsen or AZD5069) in 340 adults with advanced solid tumors or head & neck cancer that had spread or come back. The goal was to find safe doses and see if the combinations could…

This study looked at the safety of two drugs, IMJUDO and IMFINZI, given together or alone to 1,200 people with advanced liver cancer that cannot be removed by surgery. The goal was to track any side effects that happen in real-world use. The study is now complete, and the results…

This study tested a drug called anifrolumab in 277 Asian adults with active lupus. Participants received either the drug or a placebo by IV, along with their usual treatments. The goal was to see if anifrolumab could better control lupus activity and reduce flare-ups. Results hel…

This study looked at the safety of combining two immunotherapy drugs (IMJUDO and IMFINZI) with standard chemotherapy for people with advanced or recurrent non-small cell lung cancer that cannot be removed by surgery. Researchers tracked side effects in 296 patients treated in eve…

This study tested whether a new version of a common COPD inhaler (BGF) is as safe as the current one. 559 adults with moderate to very severe COPD took the medicine twice a day for 12 weeks, with some continuing for a year. Researchers tracked serious and common side effects to c…

This study tracked side effects of the drug Calquence (acalabrutinib) in 67 people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal was to see how often side effects like infections or low blood counts happen in real-world…

This early-stage study tested a new drug called AZD4144 in 29 adults with both heart disease and chronic kidney disease. The goal was to check if the drug is safe and if it lowers certain markers of inflammation in the blood. Participants took either the drug or a placebo for 4 w…

This study tested a medicine called D961H in 50 Japanese children. The goal was to see if it could stop reflux esophagitis (heartburn damage) from coming back and prevent stomach or duodenal ulcers in kids who need long-term pain relievers or low-dose aspirin. Children took the m…

This study looked at 186 adults with chronic kidney disease who had high potassium levels while in the hospital. It compared a drug called SZC to usual care to see if continuing SZC after discharge helps keep potassium in a healthy range and reduces hospital visits. The goal is t…

This study followed 152 adults in Greece with severe eosinophilic asthma who were starting benralizumab, a medication that helps control the condition. Over 48 weeks, researchers measured not only standard asthma control but also quality of life, sleep, mood, and physical activit…

This early-stage study tested a new daily pill, AZD4144, in 28 adults with obesity to see if it is safe and how it affects body inflammation. Participants took either the drug or a placebo for a short time. The main goals were to check for side effects and measure changes in bloo…

This study tested a new drug called baxdrostat in about 800 adults with high blood pressure that remains high despite taking two or more medications. Participants took either 1 mg, 2 mg, or a placebo pill daily for 12 weeks. The goal was to see if baxdrostat could safely lower bl…

This study tested a new drug called CIN-107 in 15 adults with primary aldosteronism, a condition where the body makes too much of a hormone that raises blood pressure. The goal was to see if the drug could safely lower blood pressure over 12 weeks, with a longer follow-up for saf…

This study tested a drug called AZD9291 (osimertinib) in 171 people from Asia Pacific with advanced non-small cell lung cancer that had a specific gene mutation (T790M) and had stopped responding to earlier treatments. The main goal was to see how many patients had their tumors s…

This study tested a new targeted drug, AZD9291 (osimertinib), against the usual targeted therapy for people with a specific type of advanced lung cancer (EGFR mutation-positive non-small cell lung cancer). 674 adults with incurable, advanced or spreading lung cancer took part. Th…

This study tested a drug called AZD2693 in 220 adults with a type of fatty liver disease (NASH) that includes liver scarring, but not cirrhosis. Participants had a specific genetic risk factor. The goal was to see if the drug could improve or reverse liver damage over 52 weeks co…

This study tested an experimental inhaled medication called AZD8630 in 537 adults whose asthma is not well controlled despite using standard inhalers. Participants took the drug or a placebo once daily for 12 weeks. The goal was to see if the drug could prevent asthma attacks and…

This study looked at 61 patients with BRCA-mutated, HER2-negative breast cancer at high risk of recurrence. They took LYNPARZA tablets after surgery to see how often bone marrow suppression occurred. The goal was to monitor safety in real-world use.

This study followed 200 adults with moderate to severe COPD who were prescribed BREZTRI as part of their normal care. Researchers measured changes in symptoms and lung function over 24 weeks. The goal was to see how well the medication works in everyday settings.

This study tested a monthly injection called tezepelumab in 305 adults with severe asthma who needed daily steroid pills. The goal was to see if the drug could help them safely reduce or stop their steroid use. Results showed many participants could lower their steroid dose witho…

This study tested whether a single pill containing two diabetes drugs (dapagliflozin and metformin) works as well as taking them separately in Chinese adults with type 2 diabetes. Over 600 participants took either the combo pill or the two separate pills for 24 weeks. The main go…

This study tested a new inhaler medicine called AZD4604 in 339 adults with moderate-to-severe asthma that is not well controlled by their current treatments. Participants took the medicine or a placebo twice a day for 12 weeks. The goal was to see if the new medicine could reduce…

This early-stage study tested a single dose of the experimental drug AZD6912 in 40 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed before testing the drug in people with rheumatoid arthritis. No treatment benefit was exp…

This study tested a new medicine called AZD5004 in 406 adults with type 2 diabetes. The goal was to see if it lowers blood sugar better than a placebo or an existing drug. Participants had diabetes for at least 6 months and were on diet, exercise, or stable doses of metformin or …

This study tested a new inhaler that combines two asthma medicines (budesonide and formoterol) in one device. It involved 645 adults and teens aged 12-80 whose asthma was not well controlled. The goal was to see if this combination inhaler works better than using just one medicin…

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if repeated doses are safe and tolerable compared to a placebo. Researchers also measured how the drug moves through the body. This is a first step…

This study tested an experimental daily pill called atuliflapon in 670 adults with moderate to severe asthma that is not well controlled by current treatments. The goal was to see if the drug could reduce asthma worsening episodes over 12 weeks compared to a placebo. The study is…

This study tested a new drug called baxdrostat in 326 adults whose high blood pressure was not controlled by two or more medications. Participants took either 1 mg, 2 mg of baxdrostat, or a placebo daily. The main goal was to see if baxdrostat could lower sitting systolic blood p…

This study monitored the long-term safety and effectiveness of FASENRA injections in people with severe asthma. It involved 653 patients who were already prescribed this medication for asthma that wasn't controlled by standard treatments. Researchers tracked side effects and how …

This study tested whether a medication called tezepelumab, given as an injection, could reduce nasal polyps and improve symptoms in people with severe chronic sinusitis. Over 400 participants with severe symptoms who needed surgery received either the drug or a placebo for 52 wee…

This study tested an immunotherapy drug called durvalumab for people with advanced non-small cell lung cancer that had worsened despite previous chemotherapy treatments. Researchers enrolled 446 patients to see if the drug could shrink tumors and extend survival. The treatment wa…

This study tested a single injection of nirsevimab, a lab-made antibody, to prevent severe RSV lung infections in healthy babies born at 29 weeks or later in China. About 800 infants received either the antibody or a placebo and were monitored for 150 days during RSV season. The …

This study followed 10 adults with moderate to severe COPD in Romania who were newly prescribed the inhaler TRIXEO AEROSPHERE. Researchers wanted to see how patients' health status and treatment satisfaction changed over 3 and 6 months in everyday life. The goal was to understand…

This study tested a new asthma inhaler called PT007 in 118 adults with asthma. Participants received a single dose of PT007, a placebo, or the standard inhaler Ventolin on different days to compare how well each opens the airways. The main goal was to measure lung function improv…

This early-stage study tested a single inhaled dose of a new drug called AZD8630 in 10 teenagers with asthma. The goal was to see how the drug moves through the body and to check for any safety issues. Participants used a dry powder inhaler and were monitored for side effects and…

This study tested whether a new inhaler (PT027) that combines a fast-acting reliever (albuterol) with an anti-inflammatory (budesonide) works better than albuterol alone for sudden asthma attacks. 190 adults with mild asthma who only used rescue inhalers as needed took part. Rese…

This study tested whether a new propellant (HFO) used in asthma inhalers causes sudden airway narrowing (bronchospasm) compared to the standard propellant (HFA). 52 adults with well-controlled or partially controlled asthma took part. Researchers measured lung function right afte…

This early-stage study tested a new inhaled medicine called AZD8630 in 24 adults with asthma who already use medium-to-high dose steroid inhalers plus long-acting bronchodilators. Participants took the drug once daily for 2 weeks to check for side effects, how the body processes …

This study looked at how a new experimental drug, AZD5004, affects the way the body processes several common medicines, including statins (for cholesterol) and repaglinide (for diabetes). It also checked how another drug, erythromycin (an antibiotic), affects AZD5004. The study i…

This study tested over 8,400 Brazilian adults who have risk factors for chronic kidney disease (CKD) using a simple finger-prick test at local clinics. The goal was to find out how many people might have undiagnosed CKD. Those with abnormal results were referred for confirmatory …

This study looked back at medical records of 74 adults with severe asthma in Portugal who received benralizumab, a biologic drug. Researchers wanted to understand patient characteristics, how the drug was used, and what happened after treatment started. The goal is to provide rea…

This study looked at how the drug zibotentan moves through the bodies of healthy non-Asian and Japanese volunteers. Thirty people took a single dose, and researchers measured drug levels and checked for side effects. The goal was to gather information, not to treat any disease.

This study looked at over 2,200 patients who had serious bleeding while taking a type of blood thinner called a Factor Xa inhibitor. Researchers collected information on patient characteristics, treatments given, and health outcomes to better understand how to manage these emerge…

This study tested a wearable heart monitoring patch in 54 adults recently hospitalized for sudden, severe heart failure. Participants wore the patch at home for up to a week after discharge and again 6-8 weeks later. The goal was to see if the patch could reliably measure heart h…

This study looked back at medical records of over 500 women in Gulf countries with advanced breast cancer that was previously labeled as HER2-negative. Researchers re-tested old tumor samples to find out how many actually had a newer subtype called HER2-low. The goal was to bette…

This study looked at how a lung cancer drug (AZD9291) affects the way the body processes simvastatin, a common cholesterol medicine. It involved 52 adults with a specific type of advanced lung cancer (EGFR mutation-positive NSCLC) whose disease had worsened after previous treatme…

This study interviewed 48 adults with HR+/HER2- metastatic breast cancer who had taken capivasertib plus fulvestrant for at least one week. Researchers wanted to learn about patients' attitudes toward the dosing schedule and any side effects that affected their ability to stay on…

This study tracked the safety of the drug olaparib in over 1,000 Chinese patients with ovarian or prostate cancer. Researchers recorded side effects and how doctors managed them in everyday practice. The goal was to better understand the drug's real-world safety profile in this p…

This study created a registry of 227 adults with mantle cell lymphoma who had recently started a newer type of treatment. Researchers collected information on which drugs were used, how long people stayed on them, and how patients reported their quality of life. The goal was to u…

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used existing data from earlier trials and real-world medical records to compare outcomes.…

This study checked if a new propellant (HFO) in a combined budesonide and albuterol inhaler delivers the same amount of medicine into the body as the current version (HFA). 66 healthy adults received single doses of each inhaler type. The goal was to compare drug levels in the bl…

This study reviewed medical records of 420 people with severe asthma who received tezepelumab after it was approved in Spain. The goal was to see how patients fared in real life, including asthma attacks and symptom control. It did not test a new treatment but gathered informatio…

This study reviewed medical records of 405 adults in Egypt with advanced HER2-negative breast cancer to find out how many actually have a subtype called HER2-low. Researchers looked at past test results to count cases and describe patient characteristics. The goal was to better u…

This study looked at how the drug camizestrant affects another drug (midazolam) and how carbamazepine affects camizestrant in 40 healthy postmenopausal women. The goal was to measure drug levels in the blood, not to treat any disease. Results help guide future dosing for patients…

This study tested a single dose of a new drug called AZD5148 in 16 healthy Japanese adults to see if it is safe and how the body processes it. The drug is being developed for Clostridioides difficile infection. Participants received either the drug or a placebo by injection. The …

This study reviewed medical records of 350 Australian adults with advanced EGFR-mutant non-small cell lung cancer to see how they responded to the drug osimertinib, either as their first or second treatment. Researchers tracked how long patients stayed on the drug and their overa…

This early-stage study tested the safety and how the body handles an inhaled drug called AZD4604. It involved 56 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to …

This study reviewed medical records of 729 people in Japan with biliary tract cancer who received standard cancer therapy. Researchers wanted to see if bile duct complications (like blockages or infections) that required hospital care affected how long patients could stay on trea…

This study looked at how capivasertib, a cancer drug, changes the way the body handles rosuvastatin, a cholesterol-lowering statin. Twenty healthy adults took rosuvastatin alone and then with capivasertib to measure differences in drug levels. The goal was to understand potential…

This study looked at 11 Korean adults with a rare nerve disease called NMOSD who were already taking or starting the drug Soliris. Researchers tracked side effects and how well the drug prevented relapses in normal medical practice. The goal was to confirm the drug's safety and e…

This study tested a new drug called AZD4076 in 40 healthy men to see if it is safe and how the body processes it. The drug is being developed for non-alcoholic steatohepatitis (NASH), a serious liver condition. Since this was the first time the drug was given to humans, the main …

This study looked at how the antifungal drug itraconazole changes the levels of the lung cancer drug AZD9291 in the body. It involved 39 adults with advanced EGFR-mutant non-small cell lung cancer whose disease had worsened after previous treatments. The goal was to understand th…

This study looked at how doctors in Central Eastern Europe prescribe dapagliflozin for chronic kidney disease (CKD) in routine care. Researchers collected data from medical records of over 1,000 adults to understand who gets the drug and what happens to their health over a year. …

This study followed 724 people with paroxysmal nocturnal hemoglobinuria (PNH) in China to learn more about the disease and how patients respond to treatments. PNH is a rare blood disorder that can cause red blood cell breakdown, blood clots, and other serious problems. The study …

This study tested whether a medicine called tozorakimab enters the body the same way when given by two different injectors (a prefilled syringe or an autoinjector). It involved 254 healthy adults and did not aim to treat any disease. The goal was simply to compare how the drug mo…

This study looked at how the drug AZD2389 behaves in people with stable liver disease compared to healthy adults. Researchers gave a single dose to 35 participants and measured drug levels in the blood. The goal was to understand safety and how the liver affects drug processing, …

This study looked at 201 adults with severe asthma across Egypt to find out how many use oral corticosteroids (steroid pills). The researchers also checked for different asthma types, like eosinophilic asthma, and how well patients' asthma was controlled. The goal was to better u…

This study tested a program to train doctors on the latest asthma guidelines and help them put that knowledge into practice. About 1500 people with asthma from 30 hospitals in China took part. The goal was to see if the program led to better use of inhaled steroids and improved a…

This study looked back at the medical records of 352 adults with severe asthma who received tezepelumab in UK clinics. Researchers tracked asthma attacks, steroid use, and other outcomes for one year after starting treatment. The goal was to see how well the drug works in real-wo…

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or through a vein. The study did not aim to treat any disease, but to gather …

This study reviewed medical records of 342 women with advanced ovarian cancer and BRCA gene mutations who took olaparib as a first maintenance treatment after chemotherapy. Researchers tracked how long the cancer stayed under control and overall survival over 36 months. The goal …

This study looked at how different levels of kidney function affect the way the body processes a single dose of the drug AZD6234. Researchers compared people with various stages of kidney disease to healthy volunteers. The goal was to understand safety and drug levels, not to tre…

This study monitored over 1,000 people with chronic kidney disease (but not on dialysis) who were taking the drug Forxiga. Researchers tracked side effects and factors that might affect safety. The goal was to gather real-world safety information, not to test if the drug works.

This study looked at how the experimental drug AZD0780 changes the way the body processes metformin, a standard diabetes medication. Fourteen healthy adults took both drugs in a fixed order, and researchers measured drug levels and side effects. The goal was purely to gather info…

This early-stage study tested a new drug called AZD1163 in 108 healthy volunteers to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or IV. The goal was to check for side effects and measure drug levels in the blood…

This study looked at 22 adults with advanced HER2-positive or HER2-low breast cancer who were taking the drug trastuzumab deruxtecan (T-DXd). Researchers wanted to see how often patients stopped treatment early or needed dose changes in everyday medical practice. The goal was to …

This study followed 18 adults with severe asthma for at least 3 years to understand how their condition is managed in real life. Researchers collected data on treatments, hospital visits, symptoms, and quality of life through surveys and medical records. No new drugs or treatment…

This study tested a single dose of the drug AZD5004 in 33 adults with different levels of liver function (from normal to severe impairment). The goal was to see how the liver affects the drug levels in the blood and how safe it is. Results will help doctors decide the right dose …

This study tracked 366 people in Japan who received Evusheld to treat or prevent COVID-19. Researchers monitored for side effects like allergic reactions and heart problems. The goal was to confirm the drug's safety in real-world use.

This study followed 257 adults with heart failure who were prescribed dapagliflozin. Researchers wanted to see how patients used the medication in everyday life and how their quality of life changed. The goal was to gather real-world information, not to test a new treatment.

This study followed 31 adults with COPD for 12 weeks to track how their symptoms, lung function, and markers of inflammation change over time. Researchers measured things like breathing tests, daily symptoms, and blood or sputum markers. The goal was to better understand COPD and…

This study tested whether a short questionnaire called SCORED can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Researchers enrolled 1,426 participants and checked how well the questionnaire predicted kidney problems compared to standard tes…

This study involved 7 adults with an active C. diff infection to see how well stool and blood samples could be collected, shipped, and tested. Researchers also tracked if diarrhea came back and asked participants to complete questionnaires. The goal was to improve methods for fut…

This study looked at gene changes in 182 people with advanced lung cancer whose first treatment with the drug Osimertinib stopped working. Researchers collected tumor tissue and blood samples to find out why the drug failed and what other treatments might work next. The goal is t…

This study looked back at the medical records of 123 adults hospitalized for a brain bleed while taking a type of blood thinner called a Factor Xa inhibitor. The goal was to understand the patients' health, how the bleed was treated, and what happened to them, especially in count…

This study looked at how doctors in Latin America find and follow up on lung nodules (small spots in the lungs) to catch lung cancer early. Researchers tracked 562 adults with lung nodules to see how long it took to get a diagnosis and start treatment. The goal was to find gaps i…

This study looked at the safety of the diabetes drug Forxiga (dapagliflozin) in over 1,000 adults with type 2 diabetes across eight hospitals in Vietnam. Researchers tracked side effects for 24 weeks as part of a routine safety check required by local health authorities. The goal…

This study reviewed medical records of about 1,669 adults with HER2-low advanced breast cancer in Russia to understand how doctors diagnose and treat this type of cancer in everyday practice. Researchers looked at patient characteristics, treatment choices, and outcomes from 2021…

This study reviewed medical records of 300 liver cancer patients in Brazil to understand their health history, treatments, and outcomes. It did not test any new drug or therapy. The goal was to gather real-world information to help doctors better manage the disease.

This study reviewed medical records of 217 Dutch adults hospitalized with severe bleeding while taking a factor Xa inhibitor blood thinner. All patients received andexanet alfa to reverse the bleeding. Researchers wanted to understand patient characteristics and outcomes, includi…

This study looked at 621 adults with moderate to severe lupus to track how active their disease is over time. Researchers collected medical records and checked disease activity using a standard scoring tool. The goal was to better understand lupus patterns, not to test a new trea…

This study followed 250 adults with COPD in Italy who started a new triple-combination inhaler (budesonide/glycopyrronium/formoterol). Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see how well the treatment works in re…

This study looked at how doctors in Greece treat high potassium levels in patients with chronic kidney disease or heart failure using a drug called sodium zirconium cyclosilicate. About 125 adults were followed for 6 months to see what treatments they received and how their condi…

This study followed 212 adults with moderate to severe COPD in Greece who were prescribed a triple-combination inhaler (Trixeo Aerosphere). Researchers recorded why doctors switched from dual therapy to triple therapy and measured changes in patients' breathing symptoms and quali…

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were later treated with a medication called BGF. Researchers tracked how many additional flare-ups and heart-related events occurred over time. The goal was to better understand real…

This early-stage study tested the safety of a new drug, AZD8965, in 147 healthy adults, including Japanese and Chinese participants. Researchers gave single or multiple doses to see how the body processes the drug and whether food affects it. The goal was to gather safety informa…

This study looked at medical records of 721 Russian patients who had surgery for carpal tunnel syndrome to see how many also have a rare inherited nerve disease called hereditary transthyretin amyloidosis. The goal was to measure how common this disease is in that group. No treat…

This early-stage study tested an experimental drug called AZD2389 in 120 healthy volunteers to see if it is safe and how the body handles it. Participants received either the drug or a placebo, and researchers monitored for side effects and measured drug levels in blood and urine…

This study tested a new drug called AZD7798 in 112 healthy volunteers and people with Crohn's disease. The main goal was to check if the drug is safe and how the body processes it. No treatment effects were measured, so this is an early safety-only study.

This study tested a single dose of the drug AZD4144 in 41 adults to see how their bodies processed it. Some had severe kidney disease or end-stage kidney disease, while others were healthy. The goal was to understand safety and drug levels, not to treat the disease.

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of 26 healthy adults. Participants took the drugs once with food and once without, and researchers measured drug levels and side effects. The goal wa…

This study looked back at medical records of 833 people with advanced non-small cell lung cancer to understand what treatments they received and how they fared. Researchers collected data from doctor surveys across multiple countries. The goal was to learn about real-world treatm…

This early-stage study tested a new drug called AZD6793 in 39 healthy Japanese and Chinese adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a liquid by mouth. The goal was to check for side effects and measure drug l…

This study tested a new drug (AZD7798) in 9 adults with Crohn's disease to see how it changes inflammation in the small intestine. Researchers used special PET scans to measure these changes. The goal was to understand how the drug works in the body, not to treat the disease dire…

This study looked at how baxdrostat, a potential new blood pressure medicine, affects the body's stress hormone cortisol in people with uncontrolled high blood pressure. 48 adults took either baxdrostat or a placebo for 8 weeks. Researchers measured cortisol levels before and aft…

This study reviewed medical records of over 1,100 adults with advanced breast cancer that was previously labeled HER2-negative. Researchers re-tested old tumor samples to find out how many actually have HER2-low cancer, a subtype that may respond to newer targeted therapies. The …

This study analyzed health records from over 2 million people with type 2 diabetes to see if those taking the drug dapagliflozin had a different risk of developing breast or bladder cancer compared to those on other diabetes medications. Researchers followed participants for up t…

This study tested whether a new inhaler propellant (HFO) affects the lungs' natural cleaning process differently than the current standard (HFA). Thirty-five healthy, non-smoking adults inhaled a harmless radioactive tracer and had their lung clearance measured with a special cam…

This study looked at how the body handles a single dose of the experimental drug AZD2693 in people with liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood to understand safety and processing differences. The study involved 35 adults and…

This completed study looked at information from 1,000 people with lupus to understand the challenges they face. Researchers reviewed existing data, talked with doctors, and built agreement among experts on how to improve patient care. The goal was to identify gaps in diagnosis an…

This study looked at 718 adults with COPD in Spain who started taking Trixeo Aerosphere, a triple-combination inhaler. Researchers tracked their health records for up to 12 months to see how many lung flare-ups (exacerbations) they had. The goal was to understand the patients' ch…

This study looked at how the drug AZD5462 behaves in people with kidney problems compared to healthy volunteers. Sixteen adults took a single dose, and researchers measured drug levels in the blood and checked for side effects. The goal was to understand if kidney function change…

This study looked back at data from over 361,000 people hospitalized with COVID-19 in Brazil. Researchers used a large public health database to describe patient characteristics and outcomes, and to see how vaccination affected immunocompromised patients. The goal was to better u…

This study looked at 1000 adults with a long-term dry cough that might be cough-variant asthma. Researchers measured a breath marker called FeNO to see if it could predict who would feel better after 8 weeks of treatment with a common asthma inhaler (budesonide-formoterol). The g…

This study reviewed health records from over 91,000 adults with chronic kidney disease in Spain to understand how the condition is diagnosed and treated in routine practice. Researchers looked at lab results, medications, and heart/kidney events over time. The goal was to describ…

This study followed 245 people with type 2 diabetes who are at high risk for heart problems. Researchers wanted to find out how many already have heart failure and what factors might predict it getting worse over two years. The goal is to better understand the link between diabet…

This study observed 204 Brazilian adults with a common type of advanced breast cancer (HR-positive/HER2-negative) that has spread or cannot be removed by surgery. Researchers looked at which treatments patients actually received and their outcomes, without testing any new drugs. …

This study reviewed medical records of 197 adults in Israel with severe asthma who started taking benralizumab between 2019 and 2024. Researchers looked at how many asthma attacks patients had before and during treatment. The goal was to understand real-world benefits and patient…

This early-stage study tested a new drug called AZD6793 in 93 people to see if it is safe and how the body processes it. The study included healthy volunteers and people with moderate to severe COPD, a lung disease. The main goal was to check for side effects and measure drug lev…

This study looked at how a new drug called AZD5004 interacts with two other medications in healthy volunteers. In one part, participants took AZD5004 with itraconazole (an antifungal) to see if it changed drug levels. In another part, healthy women took AZD5004 with birth control…