Astrazeneca

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed prostate cancer. The goal is to see how these drugs affect cancer cells and check for side effects. About 120 men with localized, higher-ris…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two standard two-drug inhalers for people with asthma that is not well controlled. Adults and adolescents aged 12 to 80 with moderate-to-severe asthma will use the tripl…

This study tests a new drug, AZD9829, in people with blood cancers that have come back or not responded to other treatments. The drug targets a protein called CD123 found on cancer cells. The main goals are to find a safe dose and check for side effects. About 56 adults will take…

This study tests a drug called acalabrutinib in Japanese adults with advanced B-cell blood cancers (like leukemia and lymphoma). The goal is to see if it is safe and helps control the cancer. Participants take the drug daily, and researchers monitor side effects and how well the …

This study tested whether adding balcinrenone to the standard drug dapagliflozin helps people with chronic kidney disease more than dapagliflozin alone. 324 adults with kidney disease and protein in their urine took either a combination pill or dapagliflozin alone for 12 weeks. R…

This completed study followed 152 COPD patients who started using a triple-combination inhaler (BGF) as part of their routine care. Researchers measured changes in symptoms and quality of life after 12 and 24 weeks. The goal was to see if the inhaler helps patients feel better an…

This study tested a drug called tozorakimab in over 1,700 people with COPD who had a history of flare-ups. The goal was to see if it could safely reduce severe breathing attacks over the long term. Participants who completed earlier trials were given either tozorakimab or a place…

This study looked at the long-term safety of the drug roflumilast in adults with asthma. Participants had already finished a 24-week study and took the drug once daily for another 28 weeks. The goal was to see if the drug remained safe over a longer period.

This study tested a daily pill called roflumilast (APTA-2217) to see if it improves lung function in adults with asthma. About 450 participants took either the drug or a placebo for 24 weeks. Researchers measured breathing tests, asthma symptoms, and side effects to evaluate safe…

This study looked at over 4,000 people with asthma to see if Airsupra works better than albuterol at preventing severe asthma attacks in everyday life. Researchers reviewed medical records to compare how often attacks happened and how long it took for the first attack to occur. T…

This study looked at 152 adults with systemic lupus erythematosus (SLE) who started taking anifrolumab during its first year on the market in Spain. Researchers tracked their disease activity, flare-ups, and remission rates using standard medical records. The goal was to see how …

This study looked at the safety of two drugs, IMJUDO and IMFINZI, given together or alone to 1,200 people with advanced liver cancer that cannot be removed by surgery. The main goal was to track any side effects that happen in everyday medical use. The study is now complete and h…

This study tested whether two experimental drugs, AZD9550 and AZD6234, given together as weekly shots, help people with obesity or overweight lose more weight than a placebo or either drug alone. 377 adults aged 18-75 with a BMI of 27 or higher and at least one weight-related hea…

This early-stage trial tested a new drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researcher…

This study tested a drug called anifrolumab in 277 Asian adults with active lupus. The goal was to see if it could better control the disease compared to a placebo, when added to standard treatments. Participants received the drug or placebo through an IV, and researchers measure…

This completed study looked at the safety of Calquence (acalabrutinib) capsules in 67 people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. Researchers tracked side effects like infections and bone marrow problems during everyday use. …

This study looked at 200 people with moderate to severe COPD who started taking the triple-combination inhaler BREZTRI. Researchers tracked changes in symptoms and lung function over 24 weeks in routine doctor visits. The goal was to see how the medicine performs outside of stric…

This study tested a new targeted therapy, AZD9291 (osimertinib), against the usual targeted drugs for people with a specific genetic mutation (EGFR) in advanced non-small cell lung cancer. Over 600 participants received either the new drug or standard care. The main goal was to s…

This study looked at whether the drug anifrolumab, when added to standard lupus treatments, can reduce long-term organ damage compared to standard care alone. Researchers analyzed data from 561 adults with active lupus, comparing those who took anifrolumab in earlier trials to si…

This study tested a new drug called baxdrostat in 326 adults whose high blood pressure was not controlled even with two or more medications. Participants took either 1 mg, 2 mg of baxdrostat, or a placebo daily for 12 weeks. The main goal was to see if baxdrostat could lower syst…

This study tested a new drug called AZD9291 in 603 people with advanced non-small cell lung cancer whose tumors had started growing again after previous targeted therapy. The main goals were to find the safest and most effective dose, measure how the drug moves through the body, …

This study followed 152 adults in Greece with severe eosinophilic asthma who were starting benralizumab, a medication that helps control severe asthma. Researchers measured not only standard asthma control but also quality of life, sleep, mood, and physical activity using wearabl…

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants received either the drug or a placebo as a shot, while continuing their usual inhalers. The main goal was to see if the drug could reduce the number of…

This study tested a new medicine called tozorakimab in over 1,100 adults with COPD who had frequent or severe flare-ups. Participants received either a low or high dose of the drug or a placebo as a shot under the skin, while continuing their usual inhalers. The main goal was to …

This study tracked 296 patients with advanced or recurrent non-small cell lung cancer who received a combination of IMJUDO, IMFINZI, and platinum-based chemotherapy. The goal was to see how safe the treatment is in everyday medical practice. Researchers recorded any side effects …

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study tested the drug durvalumab in 446 people with advanced non-small cell lung cancer who had already tried at least two prior treatments. The goal was to see if the drug could shrink tumors or slow the disease. Participants received infusions every two weeks for up to 12 …

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and d…

This study looked at 43 adults in Taiwan with severe eosinophilic asthma who were already prescribed benralizumab. Researchers tracked changes in asthma control using a standard questionnaire over time. The goal was to see how well the drug works in everyday medical practice, not…

This study followed 212 adults with moderate to severe COPD in Greece who were prescribed a triple-combination inhaler (Trixeo Aerosphere). Researchers tracked why patients switched from dual therapy and how their symptoms and quality of life changed over 52 weeks. The goal was t…

This study followed 250 adults with COPD who were starting a new triple-combination inhaler (budesonide/glycopyrronium/formoterol, or BGF) in routine Italian clinics. Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see re…

This study looked at how well the drug tezepelumab works for people with severe asthma when used in real-world settings, not just in controlled trials. Over 500 participants aged 12 and older were followed after starting tezepelumab. The main goal was to see if their asthma sympt…

This study looked at how often bone marrow suppression occurs in patients with BRCA-mutated, HER2-negative high-risk breast cancer who took LYNPARZA after surgery. It involved 61 participants in Japan. The goal was to monitor side effects in real-world use, not to measure how wel…

This study looked at how well benralizumab (Fasenra) works for people with severe eosinophilic asthma in real-world clinics across the Gulf, Latin America, and India. Researchers tracked 291 patients to see if their asthma control improved over time using a standard questionnaire…

This completed Phase 3 study tested the drug D961H (esomeprazole) in 50 Japanese children to see if it can prevent reflux esophagitis from coming back and stop stomach or duodenal ulcers from recurring in kids taking NSAIDs or low-dose aspirin. Children took the drug for up to 52…

This early-phase study tested the safety of combining two drugs—AZD1775 (a pill) and durvalumab (an IV infusion)—in 56 adults with advanced solid tumours that had stopped responding to standard treatments. The goal was to find safe doses and watch for side effects. While not a cu…

This study tested an experimental inhaled drug called AZD8630 in 537 adults whose asthma is not well controlled despite using standard inhalers. Participants took the drug or a placebo once daily for 12 weeks. The goal was to see if the drug could reduce asthma flare-ups and impr…

This study tested a new drug called CIN-107 in 15 adults with primary aldosteronism, a condition where the body makes too much of a hormone that raises blood pressure. Participants took the drug once daily for up to 12 weeks to see if it safely lowered blood pressure. The goal wa…

This Phase 3 trial tested two hormone therapies, fulvestrant (Faslodex) and anastrozole (Arimidex), in 462 postmenopausal women with advanced hormone receptor-positive breast cancer who had not received prior hormone treatment. The study compared how long each drug kept the cance…

This completed Phase 4 trial tested whether a combination inhaler (AIRSUPRA, containing albuterol and budesonide) works better than albuterol alone for adults with mild asthma. Over 12 weeks, researchers measured airway inflammation, daily symptoms, and how often participants nee…

This early-phase trial tested a new experimental drug called AZD2014 combined with the standard hormone therapy fulvestrant in 99 people with advanced ER+ breast cancer. The main goals were to check the safety of the combination and find the right dose. Researchers also looked fo…

This study tested a new medicine called AZD5462 in 375 adults with stable chronic heart failure. The goal was to see if the drug could improve how well the heart pumps blood. Participants continued their usual heart failure medications while receiving either AZD5462 or a placebo.…

This study tested a new drug called AZD0780 in 202 people with heart disease or related risks and high LDL cholesterol. Participants took either the drug or a placebo for 4 weeks, and researchers measured changes in blood pressure using a 24-hour monitor. The goal was to see if A…

This study tested combinations of the immunotherapy drug durvalumab with other drugs (danvatirsen, AZD5069, or tremelimumab) in 340 adults with advanced solid tumors or head and neck cancer. The goal was to find safe doses and see if the combinations shrink tumors. The trial has …

This Phase 3 trial compared the pill olaparib to standard chemotherapy in 302 people with metastatic breast cancer who have inherited BRCA1 or BRCA2 mutations. The goal was to see if olaparib could slow cancer growth better than chemo. Participants took olaparib twice daily or re…

This Phase 3 trial tested a once-daily pill called baxdrostat in 218 adults with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Participants received either baxdrostat or a placebo for 12 weeks. The main goal was to see if bax…

This completed study looked at the safety and effectiveness of FASENRA (benralizumab) in 51 Korean adults with severe eosinophilic asthma or eosinophilic granulomatosis with polyangiitis (EGPA). Researchers tracked side effects and how well the drug controlled symptoms during rou…

This study tested a new inhaler containing two medicines (budesonide and formoterol) in 645 people aged 12 to 80 with asthma that was not well controlled. The trial compared the new inhaler to a standard budesonide-only inhaler and an existing combination inhaler over 24 weeks. T…

This phase 3 trial tested tezepelumab, a biologic drug given as a shot, in 416 adults with severe chronic sinusitis and nasal polyps. Participants received either tezepelumab or a placebo, plus a standard nasal steroid spray. The study measured changes in polyp size and nasal con…

This completed Phase 3 trial tested whether a combination inhaler containing albuterol and budesonide (PT027) works better than albuterol alone (PT007) for treating sudden asthma attacks. 190 adults with asthma who only used rescue inhalers as needed took part. Researchers measur…

This study tested whether a combination inhaler containing both an anti-inflammatory steroid (budesonide) and a fast-acting bronchodilator (formoterol) works better than the steroid alone for people whose asthma is not well controlled. 374 adults and adolescents took part over 12…

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with cirrhosis, a serious liver condition. 73 adults with cirrhosis took part, receiving either the drug combo, zibotentan alone, or a placebo. The main goal was to check for si…

This study tested a daily pill called atuliflapon in 670 adults with moderate to severe asthma that is not well controlled by current treatments. The goal was to see if the drug could reduce asthma flare-ups over 12 weeks compared to a placebo. The trial is now complete, and resu…

This study looked at the safety of LYNPARZA (olaparib) when used as a maintenance treatment after platinum-based chemotherapy in 130 patients with BRCA-mutated pancreatic cancer that could not be surgically removed. Researchers tracked side effects like bone marrow problems, lung…

This study tracked side effects in 236 people with advanced biliary tract cancer who received IMFINZI (durvalumab) together with standard chemotherapy (gemcitabine and cisplatin). The goal was to see how often adverse reactions happen in everyday medical practice, outside of a co…

This study tested a new medicine called AZD5004 in 406 adults with type 2 diabetes. The goal was to see if it helps lower blood sugar better than a placebo or an existing diabetes drug. Participants had to have had diabetes for at least 6 months and be on diet, exercise, or stabl…

This study tested a daily pill called AZD9291 in 171 people from Asia Pacific with advanced lung cancer that has a specific genetic change (T790M mutation). The goal was to see if the drug could shrink tumors and control the disease after other treatments stopped working. Researc…

This study tested a new daily pill called AZD5004 for weight loss in 310 adults with obesity or overweight who also had a weight-related health problem like high blood pressure. Participants took either the drug or a placebo for 36 weeks. The main goal was to see if the drug help…

This study tested a new medicine called AZD6234, given as a weekly shot, to help people with obesity or overweight lose weight. About 262 adults took part for 36 weeks. The goal was to see if the drug leads to greater weight loss compared to a placebo, especially for those with w…

This study tested a drug called tezepelumab in 305 adults with severe asthma who were already taking daily steroid pills. The goal was to see if tezepelumab could help them safely reduce or stop their oral steroids without losing asthma control. Participants received tezepelumab …

This early-stage study tested a new biologic drug called AZD7798 in 112 people, including healthy volunteers and patients with Crohn's disease. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or repeated doses and monitored fo…

This early-stage trial tested a single dose of the experimental drug AZD6912 in 40 healthy adults to see if it is safe and how the body processes it. The study is a first step toward possibly treating rheumatoid arthritis, but it does not involve people with the disease. Results …

This study tested a daily medication called acalabrutinib in 552 adults with chronic lymphocytic leukemia (CLL), a type of blood cancer. Participants included those newly diagnosed, those whose cancer returned, and those who had previously taken a similar drug. The goal was to se…

This study looked at whether continuing a drug called sodium zirconium cyclosilicate (Lokelma) after hospital discharge helps people with chronic kidney disease maintain normal potassium levels. 186 hospitalized patients were randomly assigned to either continue the drug or recei…

This early-stage trial tested a new drug called AZD4144 in 29 people who have both heart disease and chronic kidney disease. The main goal was to see if the drug is safe and if it lowers certain markers of inflammation in the blood. The study compared the drug against a placebo o…

This study tested a new daily medication called AZD0780 in 428 adults with dyslipidemia (abnormal cholesterol levels). Participants took one of several doses of AZD0780 or a placebo for 12 weeks. The main goal was to see how much the drug lowered LDL (bad) cholesterol compared to…

This study tested an experimental inhaled drug called AZD4604 in 339 adults with moderate-to-severe asthma that remains uncontrolled despite standard treatment. Participants took the drug or a placebo twice daily for 12 weeks. The main goal was to see if the drug could reduce ast…

This early-stage study tested a new drug called AZD0780 in 81 healthy adults with high cholesterol. Participants received AZD0780 alongside other cholesterol-lowering medicines like ezetimibe, rosuvastatin, or bempedoic acid. The goal was to see how well the combination lowers LD…

This Phase 3 trial tested a daily pill called baxdrostat in about 800 adults whose blood pressure stays high even when taking two or more other medications. Participants received either 1 mg, 2 mg, or a placebo for 12 weeks. The main goal was to see if baxdrostat could safely low…

This study tested whether a single pill containing two diabetes drugs (dapagliflozin and metformin) works as well as taking them separately in Chinese adults with type 2 diabetes. Over 24 weeks, 633 participants were randomly assigned to either the combo pill or the separate pill…

This study tested a monthly injection called AZD2693 in 220 adults with non-alcoholic steatohepatitis (NASH) and liver scarring, who carry a specific genetic risk factor. The goal was to see if the drug could reverse liver inflammation and scarring without making it worse. The tr…

This study tested a new drug called AZD4604 in 36 adults with moderate-to-severe asthma. The goal was to see if it reduces airway inflammation and affects certain genes over a 4-week treatment period. Participants took either the drug or a placebo, and researchers measured change…

This study looked at how well the drug Tagrisso (osimertinib) works and how safe it is for people with a certain type of lung cancer (non-small cell lung cancer with EGFR mutations) in everyday medical practice. Over 900 patients in Korea were observed while taking Tagrisso as th…

This study tested a drug called tezepelumab in 287 adults and teens with severe asthma, including groups often left out of research. The goal was to see if the drug reduces asthma attacks and is safe over 52 weeks. Results showed fewer flare-ups compared to the year before starti…

This early-stage study tested a new drug called AZD4144 in 28 adults with obesity to see if it is safe and how it affects inflammation markers in the blood. Participants took either the drug or a placebo daily for a short time. The goal was to check for side effects and measure c…

This study tested a new drug called AZD7789 in 45 people with classical Hodgkin lymphoma that had returned or not responded to at least two prior treatments. The drug is a special antibody designed to help the immune system fight cancer cells. The main goals were to check safety …

This study looked at how well tezepelumab works for people with severe asthma when used in everyday medical practice, outside of a clinical trial. Researchers tracked 33 patients in Spain who received the drug through a special access program. The goal was to see how the drug aff…

This study tested the drug tezepelumab in 92 adults with severe asthma to see if it improves asthma control and reduces chronic cough. Participants took the drug as prescribed by their doctor, and researchers tracked their symptoms and quality of life for a year. The goal was to …

This study tested an experimental drug called AZD3427 in 260 adults with heart failure and a type of high blood pressure in the lungs (pulmonary hypertension). The goal was to see if the drug could lower pressure in the lung's blood vessels after 24 weeks of treatment. Participan…

This study tested a new inhaler (BGF MDI HFO) delivering a triple-drug combination (budesonide, glycopyrronium, formoterol fumarate) against the current inhaler (BGF MDI HFA) in 559 people with moderate to very severe COPD. The main goal was to compare safety over 12 weeks, with …

This study tested a drug called cotadutide in 54 adults with a type of fatty liver disease that includes liver scarring but not cirrhosis. Participants received either the drug or a placebo as a daily injection. The main goal was to check safety and tolerability, with results hel…

This completed study looked at the safety of the drug Calquence (acalabrutinib) in 104 patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. Researchers tracked side effects like bleeding, infections, and heart issues in a real-wor…

This study looked at the long-term safety and effectiveness of Fasenra (benralizumab) in 653 people with severe asthma that wasn't controlled by other treatments. Researchers tracked side effects and asthma control over time. The goal was to confirm that Fasenra works well and is…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part across multiple hospitals. Researchers measured how well the questionnaire predicted kidney prob…

This study tested an experimental antibody called AZD3152 to see if it can safely prevent COVID-19 in people with weakened immune systems. About 3,882 adults received either the antibody or a placebo/comparator. The goal was to measure how well the antibody neutralizes the virus …

This study tested a single dose of nirsevimab, a lab-made antibody, in 800 healthy preterm and term infants in China to see if it could prevent serious lung infections caused by RSV. The goal was to reduce doctor visits and hospital stays during the RSV season. Results showed the…

This study tested a triple-combination inhaler (BGF) in 171 adults with moderate-to-severe COPD. Participants received BGF, a dual-combination inhaler (BFF), or placebo in random order. The goal was to see if BGF improves breathing capacity and exercise endurance compared to the …

This study tested whether a new propellant (HFO) in asthma inhalers causes airway narrowing (bronchospasm) compared to the standard propellant (HFA). It involved 52 adults with well-controlled or partially controlled asthma. Researchers measured lung function right after use and …

This study followed 10 people with moderate to severe COPD in Romania who started taking the inhaler TRIXEO AEROSPHERE. Researchers measured changes in their health status and treatment satisfaction over 3 and 6 months. The goal was to see how the medication works in everyday lif…

This early-stage study tested a single inhaled dose of a new drug called AZD8630 in 10 teenagers with asthma. The main goal was to see how the drug moves through the body and to check for any safety issues. Participants used a dry powder inhaler and were monitored for side effect…

This early-stage study tested an experimental inhaler called AZD8630 in 24 adults with asthma who already use medium-to-high dose steroid inhalers and long-acting bronchodilators. Participants took the drug once daily for 2 weeks to check its safety, how the body processes it, an…

This study tested a single dose of a new albuterol inhaler called PT007 in 118 adults with asthma. Researchers compared how well it opened airways and its safety against a placebo inhaler and the standard Ventolin inhaler. The goal is to see if PT007 works as a quick-relief treat…

This completed study looked at how the drug opemalirsen (AZD2373) is processed in people with different levels of kidney function. Researchers gave a single injection to 35 adults, some with kidney impairment and some with healthy kidneys. The goal was to compare drug levels and …

This study looked at medical records of 204 Brazilian adults with a specific type of advanced breast cancer (HR+/HER2-). The goal was to see which treatments doctors actually use and how patients fare. No new treatments were tested; instead, researchers collected information to u…

This study looks at how healthy men absorb, break down, and get rid of a test medicine called AZD4144. Eight men aged 30 to 65 will receive a single dose either by mouth or through a vein. A tiny radioactive tag lets researchers follow the drug's path in the body.

This completed Phase 1 study tested whether a single tablet combining laroprovstat and rosuvastatin works as well as taking the two drugs separately. 44 healthy adults aged 18 to 55 took part in a crossover design, receiving different formulations. The goal was to measure how muc…

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This completed study in Russia checked how many people with carpal tunnel syndrome also have a rare inherited nerve condition called hereditary transthyretin amyloidosis. Researchers reviewed medical records of 721 patients and will test some for the genetic mutation. The goal is…

This study reviewed medical records of 350 Australian patients with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). Researchers looked at how long patients stayed on the drug osimertinib when it was given as their first or second treatment, and h…

This study looked at how doctors in Russia treat a specific type of ovarian cancer called HRD-positive. Researchers collected information from 414 patients to understand what treatments they received and how they fared. The goal was to describe real-world practice, not to test a …

This completed observational study analyzed electronic health records of nearly 13,000 adults with chronic kidney disease in Spain to see how the drug dapagliflozin is used in everyday practice. Researchers looked at patient characteristics, lab results, and healthcare costs over…

This study looked at how doctors in 20 Spanish hospitals use the drug Lokelma to treat patients with high potassium levels (hyperkalemia). Researchers collected information from 232 patients' medical records to understand how the drug is prescribed and how patients respond in rea…

This study looked at how a single dose of the drug AZD2693 moves through the body in people with liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood to understand safety and processing differences. A total of 35 adults took part. The goa…

This study tested whether a new, more environmentally friendly propellant (HFO) in a budesonide/albuterol inhaler delivers the same amount of medicine into the bloodstream as the current version (HFA). Sixty-six healthy adults received single doses of both inhalers in a random or…

This study looked at medical records of 729 people in Japan with biliary tract cancer that could not be removed by surgery. Researchers wanted to see if bile duct problems during first treatment affected how long patients could stay on that treatment. The study did not test any n…

This study looked at 217 Dutch patients who were hospitalized with serious bleeding while taking a type of blood thinner called a factor Xa inhibitor. All patients received a drug called andexanet alfa to reverse the bleeding. Researchers wanted to learn more about the patients' …

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This small, early-stage study tested whether a new drug called AZD7798 changes how a special imaging tracer binds to the gut in people with Crohn's disease. Nine adults with active Crohn's disease involving the small intestine received multiple doses of AZD7798 and underwent PET …

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of healthy people. Twenty-six adults took a single dose of the combined pill once after eating and once on an empty stomach. The goal was to see if f…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested a wearable heart monitoring patch in people recovering from a severe heart failure episode. The goal was to see if the patch could collect useful health data at home, making future drug research easier. About 54 adults wore the patch for a few days after leaving…

This study looked back at medical records of over 1,600 adults in Russia with HER2-low breast cancer that had spread or could not be removed by surgery. Researchers wanted to understand how common this type is, what patient characteristics are, and how doctors actually diagnose a…

This study looked back at the medical records of 833 people with advanced non-small cell lung cancer to understand how they were treated and how long they lived. Researchers collected information from doctors' surveys across multiple countries. The goal was to learn about real-wo…

This completed Phase 1 study looked at how the cancer drug capivasertib changes the way the body processes rosuvastatin, a common cholesterol-lowering medicine. Twenty healthy adults took rosuvastatin alone and then with capivasertib to compare drug levels in their blood. The res…

This study tested a new propellant (HFO) for metered dose inhalers to see if it affects how the lungs clear mucus, compared to the standard propellant (HFA). Thirty-five healthy volunteers inhaled both types and had their lung clearance measured using a radioactive tracer and a s…

This study interviewed 48 adults with HR+/HER2- metastatic breast cancer who had taken capivasertib + fulvestrant for at least one week. The goal was to learn about their attitudes, experiences, and any side effects related to the treatment schedule. No new drugs were given; it w…

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were later treated with the medication BGF. Researchers tracked how many additional flare-ups and heart-related events occurred over time. The goal was to understand real-world outco…

This completed Phase 1 study tested how a new drug called AZD5004 interacts with the antifungal itraconazole and with birth control pills in 51 healthy volunteers. The goal was to measure how these drugs affect each other's levels in the body, not to treat any disease. Results wi…

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This early-stage trial tested the safety and tolerability of an experimental drug called AZD1163 in 108 healthy volunteers. Participants received either the drug or a placebo by IV or injection, and researchers monitored side effects and how the drug moved through the body. Since…

This study looked back at medical records of 352 adults with severe asthma who started taking tezepelumab in UK hospitals between January 2023 and March 2024. Researchers wanted to see how often patients had asthma attacks and whether they needed oral steroids during the year aft…

This study looked back at medical records of 420 people with severe asthma in Spain who were given tezepelumab after it was approved. The goal was to see how well the drug works in real life, not just in controlled trials. Researchers tracked things like asthma attacks, symptoms,…

This study checked how safe Evusheld is for treating and preventing COVID-19 in Japanese patients. It included 366 people who got the drug in real-world settings. The main goal was to track side effects like allergic reactions and heart problems. The study is now complete and hel…

This study looked at how an experimental drug called AZD0780 affects the way the body processes metformin, a common diabetes medicine. Fourteen healthy volunteers took both drugs, and researchers measured drug levels in the blood. The goal was purely to gather information on drug…

This study tested whether a program that educates doctors on the latest asthma guidelines can improve how they treat patients. About 1500 people with asthma in China took part. The program included training sessions and reminders to help doctors follow best practices. The main go…

This completed study in Greece observed 125 patients with chronic kidney disease (on or off dialysis) or heart failure who were taking sodium zirconium cyclosilicate for high potassium levels. Researchers collected data on patient characteristics and treatment patterns over six m…

This completed study followed 724 people in China with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Researchers aimed to better understand how the disease progresses and how patients respond to different treatments, including the newly available drug eculizum…

This study looked at how well stool and blood samples could be collected from 7 adults with an active C. diff infection. Researchers wanted to see if the collection, shipping, and testing methods worked smoothly. Participants also filled out questionnaires about their symptoms. T…

This study looked at how safe and effective the drug Soliris is for Korean patients with a rare disease called NMOSD. It involved 11 people who were already taking the drug as part of their normal medical care. The goal was to track side effects and see if the drug helped prevent…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This study tested whether baxdrostat, an experimental drug for high blood pressure, affects the body's stress hormone cortisol. 48 adults with uncontrolled hypertension took baxdrostat or a placebo for 8 weeks. Researchers measured cortisol levels before and after a stimulation t…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This completed study looked at 621 people with moderate to severe systemic lupus erythematosus (SLE) in Russia. Researchers collected information about their disease activity and background to better understand the condition. The study did not test any new treatment, but aimed to…

This completed Phase 1 study looked at how the drug AZD5462 behaves in people with reduced kidney function compared to healthy volunteers. Sixteen participants received a single oral dose, and researchers measured drug levels in the blood and monitored for side effects. The goal …

This study tested whether the drug tozorakimab enters the body the same way when given by two different injection devices: an autoinjector and a prefilled syringe. 254 healthy adults each received one injection. The goal was to see if the devices deliver the drug consistently, wh…

This study looked at how the drug zibotentan is absorbed and cleared by the body in 30 healthy adults, including both non-Asian and Japanese participants. It was a phase 1 trial, meaning it was an early step to gather safety and drug-level information. The study did not aim to tr…

This study looked back at the medical records of 718 adults with COPD in Spain who started taking the triple-combination inhaler Trixeo. Researchers wanted to see how many lung flare-ups (exacerbations) patients had in the year after starting the drug. The goal was to understand …

This completed study in Greece observed 257 adults with heart failure who were prescribed dapagliflozin as part of their routine care. Researchers tracked how long patients stayed on the drug, any changes in their other heart medications, and how their quality of life changed ove…

This study followed 245 people with type 2 diabetes and high heart risk for two years to see how many develop heart failure. Researchers collected data from doctor visits and phone calls to track heart health over time. The goal was to better understand who is at risk and how the…

This study looked at how the lung cancer drug AZD9291 (osimertinib) affects the breakdown of simvastatin, a common cholesterol medicine, in 52 adults with a specific type of advanced lung cancer (EGFR mutation-positive NSCLC) that had stopped responding to earlier treatments. The…

This study tracked over 700 people in Korea who were already receiving the cancer drug Imfinzi (durvalumab) for lung or biliary tract cancer. The goal was to see how safe and effective the drug is in everyday medical practice, not just in strict clinical trials. Researchers monit…

This study looked at how itraconazole, an antifungal medication, affects the levels of the lung cancer drug AZD9291 in the body. It involved 39 adults with advanced EGFR-mutant non-small cell lung cancer whose disease had worsened after previous treatments. The goal was to unders…

This study tested a new drug called AZD4076 in 40 healthy men to see if it is safe and how the body processes it. The drug is being developed for non-alcoholic steatohepatitis (NASH), a serious liver condition. This is an early, first-in-human trial, so it focused only on safety …

This early-stage study tested the safety and how the body handles an inhaled drug called AZD4604 in 56 healthy Japanese and Chinese adults. Participants received either the drug or a placebo as a dry powder inhaler. The goal was only to check for side effects and measure drug lev…

This study created a registry of 227 adults with mantle cell lymphoma who had recently started a new type of therapy. Researchers tracked which treatments were used, how long patients stayed on them, and how patients rated their own quality of life. The goal was to gather real-wo…

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or a vein, or a placebo. The study did not aim to treat any disease, only to …

This completed Phase 1 study looked at how different levels of kidney function affect the way the body processes a single dose of the drug AZD6234. Researchers compared 24 adults with various degrees of kidney impairment to healthy volunteers. The goal was to understand how the d…

This completed study looked at over 2,200 patients who had a major bleeding event while taking a Factor Xa inhibitor (a type of blood thinner). Researchers collected information on patient characteristics, how the bleeding was treated in the hospital, and what happened to patient…

This study looked back at medical records of 123 adults hospitalized with a brain bleed while taking a type of blood thinner called a factor Xa inhibitor. The goal was to understand what happens to these patients and how they are treated in countries where a specific reversal dru…

This early-stage study tested a new drug called AZD6793 in 93 people to see if it is safe and how the body processes it. The study included healthy volunteers and people with moderate to severe COPD. The main goal was to check for side effects and measure drug levels in the blood…

This study looked at how doctors in seven Central Eastern European countries prescribe dapagliflozin for chronic kidney disease in routine care. Researchers reviewed medical records of about 1,090 adults to understand who gets the drug and what happens over the next year. The goa…

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The study was comple…

This completed study looked back at medical records of 74 adults in Portugal with severe eosinophilic asthma who were treated with benralizumab. Researchers wanted to describe patient characteristics, treatment patterns, and outcomes in real-world settings. The study did not test…

This completed study observed 22 adults with HER2-positive or HER2-low metastatic breast cancer who were taking trastuzumab deruxtecan (Enhertu) as part of routine care. Researchers tracked how many patients stopped treatment early or needed dose changes, and why. The goal is to …

This completed Phase 1 study looked at how a single dose of the drug AZD5004 moves through the body in people with mild, moderate, or severe liver impairment compared to healthy volunteers. The goal was to measure drug levels and check safety. 33 adults aged 18-80 took part. The …

This study looked at how a new drug called AZD5004 affects the way the body processes several common medicines, including statins (for cholesterol) and repaglinide (for diabetes), in healthy adults aged 18 to 55. It also checked how another drug, erythromycin, affects AZD5004. Th…

This completed study tracked over 1,000 chronic kidney disease patients taking Forxiga in everyday medical practice. The main goal was to see how often side effects occur and what factors might increase risks. The study did not test whether the drug works, but rather gathered saf…

This study reviewed medical records from over 91,000 adults in Spain to understand how chronic kidney disease (CKD) is diagnosed and treated in routine practice. Researchers looked at lab results, medications, and heart/kidney events over time. The goal was to see how often kidne…

This study tracked over 1,000 adults with type 2 diabetes in Vietnam who were prescribed dapagliflozin (Forxiga) as part of routine care. Researchers monitored side effects and serious events over 24 weeks to confirm the drug's safety in real-world use. The goal was to support th…

This study observed over 1,000 Chinese patients with ovarian or prostate cancer who were already taking or starting the drug olaparib. Researchers tracked side effects and how doctors managed them in everyday practice. The goal was to better understand the drug's safety in this s…

This completed study screened over 8,400 Brazilian adults with known risk factors for chronic kidney disease (CKD) using a portable creatinine test. Participants were randomly selected from five regions. Those with abnormal results were referred for lab confirmation and follow-up…

This study followed 31 adults with COPD for 12 weeks to track how their inflammation levels, lung function, and symptoms change over time. Researchers measured daily lung function and symptoms, along with weekly or biweekly blood and sputum tests. The goal was to better understan…

This study reviewed medical records of 300 liver cancer patients treated in Brazil between 2017 and 2022. Researchers aimed to understand patient characteristics, how the cancer was managed, and survival outcomes. No new treatments were tested; instead, the goal was to gather rea…

This completed study looked at how lung nodules are found and managed in hospitals across Latin America. Researchers tracked 562 adults to see how long it takes from finding a nodule to getting a diagnosis and treatment. The goal is to understand current practices and find ways t…

This study looked at how the drug AZD2389 behaves in people with liver impairment compared to healthy volunteers. 35 adults took a single dose, and researchers measured drug levels in the blood to check safety and processing. The goal is to understand if liver problems change how…

This study measured how often people with severe asthma in Egypt use oral corticosteroids (OCS), a common but strong medication. Researchers looked at 201 patients across multiple clinics to understand treatment patterns and asthma types. The goal was to gather information, not t…

This completed study followed 18 adults with severe asthma in the United States for at least 3 years. Researchers collected data on treatments, symptoms, hospital visits, and quality of life from medical records and monthly patient surveys. The goal was to understand how severe a…

This study looked back at medical records of 517 women in Gulf countries with advanced breast cancer that was previously labeled HER2-negative. Researchers re-tested old tumor samples to find out how many actually have HER2-low breast cancer, a newer subtype. The goal is to bette…

This study looked back at medical records of 342 women in Europe with advanced ovarian cancer and a BRCA gene mutation. All had taken the drug olaparib (Lynparza) as their first maintenance treatment after initial chemotherapy. Researchers tracked how long patients lived without …

This study reviewed medical records of over 1,100 people with a type of breast cancer called HER2-negative that had spread and stopped responding to treatment. Researchers wanted to find out how many of these patients actually have a subtype called HER2-low, and to understand the…

This study reviewed medical records of 405 people in Egypt with advanced HER2-negative breast cancer to find out how many actually have a subtype called HER2-low. Researchers looked at past test results to estimate the prevalence. The goal is to better understand who might be eli…

This completed study looked back at data from over 361,000 people hospitalized with COVID-19 in Brazil. Researchers used a public health database to describe patient characteristics and outcomes, such as death rates. They also compared the impact of vaccination on immunocompromis…

This study looked at 1000 adults with chronic dry or nighttime cough to find a cutoff value for a breath test called FeNO that can predict whether they will respond to the asthma medication budesonide-formoterol. Participants took the drug twice daily for 8 weeks, and their cough…

This completed study looked at gene changes in 182 people with advanced lung cancer whose disease got worse after first-line treatment with Osimertinib. Researchers collected tissue and blood samples to understand why the drug stopped working. The goal is to use this information …

This early-stage trial tested the safety and tolerability of an experimental drug called AZD2389 in 120 healthy volunteers. Participants received either the drug or a placebo as single or multiple doses. The study focused on monitoring side effects and how the drug moves through …

This completed phase 1 study looked at how the experimental cancer drug camizestrant affects the breakdown of midazolam (a sedative) and how carbamazepine (a seizure drug) affects camizestrant levels. Forty healthy postmenopausal women took part. The goal was to gather safety and…