Astrazeneca

This study tested new combinations of experimental drugs for people with advanced cancers that had stopped responding to standard treatments. It first aimed to find safe doses in patients with various solid tumors. It then focused on people with advanced head and neck cancer to s…

This early-stage study tested the safety of an experimental oral drug called AZD4144 in people with both heart and kidney disease. Twenty-nine participants took either the drug or a placebo pill daily for 28 days. The main goal was to see if the drug was safe and to measure its e…

This study tested a new daily inhaler called AZD8630 for adults whose asthma is not well-controlled despite using standard inhalers. Over 500 participants used the inhaler or a placebo for 12 weeks to see if it could reduce the risk of asthma attacks and improve lung function. Th…

This study followed 92 adults with severe asthma who were prescribed tezepelumab to see how well it controls asthma and reduces cough in real-world settings. Researchers measured asthma control and cough-related quality of life over 52 weeks to understand the drug's effectiveness…

This early-stage study tested a new drug called sabestomig (AZD7789) in adults and young adults whose Hodgkin lymphoma had returned or did not respond to at least two prior treatments. The main goals were to find a safe dose and see how the body processes the drug. The drug is de…

This study tested if adding a second medicine (formoterol) to a common asthma steroid (budesonide) in one inhaler works better than the steroid alone for people whose asthma isn't well controlled. About 374 adults and teens used either the two-drug or one-drug inhaler twice daily…

This study tested whether a new daily pill called AZD0780 could lower 'bad' cholesterol (LDL-C) in people who already take statins. Over 400 adults with high cholesterol took different doses of the drug or a placebo for 12 weeks. Researchers measured cholesterol levels and checke…

This completed Phase 3 trial compared a daily oral medication called olaparib against standard chemotherapy chosen by doctors. It involved 302 patients with metastatic breast cancer who have specific inherited BRCA gene mutations. The study aimed to see if the targeted pill could…

This study aimed to monitor the long-term safety and effectiveness of the asthma medication FASENRA in real-world patients. It involved 653 people with severe asthma that was hard to control with other treatments. The main goal was to track any side effects and see how well the d…

This study tested whether a combination of two drugs (zibotentan and dapagliflozin) is safe for people with liver cirrhosis. Researchers compared the combination against each drug alone and against a placebo in 73 patients across multiple countries. The main goal was to monitor s…

This study monitored the safety and effectiveness of FASENRA, a medication for severe asthma and a related condition called EGPA, in real-world Korean patients. Doctors observed 51 adults who were starting FASENRA treatment for the first time, following them for up to 48 weeks. T…

This study tested whether a new weekly injection called AZD6234 helps people with obesity or overweight lose weight. About 262 adults received either the drug or a placebo (dummy injection) for 36 weeks. The main goal was to see if the drug led to better weight loss results compa…

This study followed 250 Italian adults with moderate-to-severe COPD for up to one year after they started using the Trixeo triple-therapy inhaler in routine care. Researchers tracked changes in breathing symptoms, quality of life, and healthcare visits to understand how the treat…

This early-stage study tested a new experimental drug called AZD7798 in healthy volunteers and people with Crohn's disease. Researchers wanted to understand the drug's safety, side effects, and how the body processes it. The study involved 112 participants who received either the…

This study tested whether a drug called anifrolumab could better control active systemic lupus erythematosus (lupus) in Asian adults compared to a placebo. All 277 participants continued their standard lupus medications and received either the new drug or a placebo via IV every 4…

This study observed 212 adults in Greece with moderate to severe COPD who were newly prescribed a triple-combination inhaler (Trixeo Aerosphere™) as part of their regular care. The goal was to see how patients felt and functioned over one year after switching to this stronger med…

This study tested if a single pill combining two common diabetes medications (dapagliflozin and metformin) works as well as taking the two pills separately. It involved over 600 Chinese adults newly diagnosed with type 2 diabetes and lasted 24 weeks. The main goal was to see if t…

This study tested whether a new daily pill called AZD5004 helps people lose weight compared to a placebo (dummy pill). It involved about 310 adults who were living with obesity or were overweight and had at least one related health condition, like high blood pressure. Participant…

This study monitored the safety of two already-approved drugs, IMJUDO and IMFINZI, in real-world patients with advanced liver cancer that cannot be removed by surgery. It involved 1200 patients in Japan to collect safety information after the drugs were made available to doctors.…

This study tested a new combination inhaler for asthma against a standard inhaler and an existing treatment. It involved 645 adults and teenagers whose asthma symptoms were not well controlled despite using daily medication. The goal was to see if the new inhaler improved lung fu…

This study monitored 923 Korean patients with a specific type of lung cancer who were already prescribed the drug Tagrisso (osimertinib) by their doctors. The goal was to see how safe and effective the drug is in everyday, real-world use, not in a controlled trial. Researchers tr…

This study tested whether continuing a potassium-lowering medication called SZC after hospital discharge helps people with chronic kidney disease better maintain safe potassium levels compared to standard care. It involved about 186 adults who were hospitalized for high potassium…

This study monitored the safety of LYNPARZA, a medication given after surgery to help prevent breast cancer from returning in high-risk patients. Researchers tracked 61 patients with specific genetic mutations to see how often they experienced bone marrow suppression, a known sid…

This large, completed study tested a new drug called AZD9291 (osimertinib) against standard first-line treatments for adults with advanced non-small cell lung cancer that has a specific genetic mutation (EGFR). The goal was to see if the new drug could better control the cancer a…

This study tested a new daily pill called AZD5462 for people with stable chronic heart failure. Researchers wanted to see if different doses could improve how well the heart pumps and reduce symptoms, compared to a placebo. About 375 participants took the pill or a dummy pill for…

This study tested a new inhaled medication called AZD4604 for adults whose moderate-to-severe asthma was not well controlled by their usual high-dose inhalers. Over 300 participants used the drug or a placebo twice daily for 12 weeks. The main goal was to see if the new treatment…

This study compared two different inhaler treatments for adults with mild asthma over 12 weeks. Researchers tested whether a combination inhaler (AIRSUPRA) worked better than the standard albuterol inhaler at reducing airway inflammation and asthma symptoms. The study involved 10…

This study tested if a new combination inhaler (PT027) works as well or better than a standard rescue inhaler (PT007) for adults with asthma. Researchers compared how quickly and effectively each inhaler opened airways after a breathing test that triggered asthma symptoms. The go…

This study tested whether an experimental drug called baxdrostat affects the body's ability to produce cortisol, a key stress hormone, in people whose high blood pressure isn't well controlled by current medications. Forty-eight participants took either baxdrostat or a placebo pi…

This was a small, early-stage study to check if a new oral drug called AZD4144 is safe for people with obesity. Twenty-eight healthy adults with obesity took the drug or a placebo daily for up to 28 days. Researchers primarily looked for side effects and measured changes in blood…

This study tested whether a daily oral medication called atuliflapon could help control asthma and prevent worsening episodes in adults whose asthma was not well-managed with standard inhaler treatments. About 670 participants took either the study drug or a placebo pill for 12 w…

This study tested whether a drug called cotadutide is safe and can help people with a type of fatty liver disease called NASH, which causes liver scarring. Fifty-four adults with confirmed liver scarring received either the drug or a placebo for about six months. The main goals w…

This early-stage study tested the safety and how the body processes a new oral drug called AZD2014 when given alongside an existing breast cancer treatment, fulvestrant. It involved 99 adults with advanced, hormone-sensitive breast cancer that had spread. The main goal was to fin…

This study tested whether a new oral medicine called AZD4604 could reduce inflammation in the airways of adults with moderate-to-severe asthma. For 4 weeks, 36 participants took either the drug or a placebo pill, and researchers measured changes in cells and genes from lung sampl…

This study tested an experimental drug called AZD5004 in adults with type 2 diabetes. It aimed to see if the drug could help lower long-term blood sugar levels and reduce body weight compared to a placebo. The trial involved 406 participants and was designed to check the medicine…

This study tested whether a new drug called baxdrostat could help lower blood pressure in people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Over 200 participants were randomly assigned to receive either baxdrostat or …

This study compared the safety of a new inhaler device (HFO) to a standard one (HFA) for delivering the same triple-combination COPD medication. It involved 559 adults with moderate to very severe COPD over 12 weeks, with some continuing for a year. The main goal was to see if th…

This study tested whether a new injectable drug, AZD3427, could reduce high blood pressure in the lungs of people who also have heart failure. About 260 participants received either the drug or a placebo injection every two weeks for 24 weeks. The main goal was to see if the drug…

This study tested an experimental drug called AZD9291 for people in Asia Pacific with advanced non-small cell lung cancer. The participants had a specific genetic change (T790M mutation) and their cancer had gotten worse despite previous treatment with a common type of targeted t…

This large, completed Phase 3 trial tested whether a new injectable medication called tezepelumab could help adults with severe, long-term sinusitis and large nasal polyps. Over 400 participants received either tezepelumab or a placebo shot every four weeks for a year, while cont…

This study looked at how well and how safely the injectable medication tezepelumab works for people with severe asthma in real-world settings. It included 287 adults and adolescents whose asthma was not well controlled despite using standard high-dose inhalers and other controlle…

This study looked back at the medical records of 718 people in Spain with chronic obstructive pulmonary disease (COPD) who started using a triple-combination inhaler called Trixeo Aerosphere. Researchers wanted to see what kinds of patients used this inhaler and how often they ex…

This early-stage study aimed to find a safe dose for a new two-drug combination (adavosertib and durvalumab) for patients with advanced solid tumors that had stopped responding to standard treatments. It involved 56 adult patients and tested different dosing schedules to see how …

This study tested whether a new drug called baxdrostat could help lower blood pressure in people whose high blood pressure wasn't controlled despite taking two or more medications. About 800 adults took either baxdrostat or a placebo pill daily for 12 weeks while continuing their…

This study tested an investigational drug called CIN-107 for adults with primary aldosteronism, a condition where the adrenal glands produce too much of a hormone, causing hard-to-control high blood pressure. The main goals were to see if the drug was safe and if it could effecti…

This study followed asthma patients for 28 weeks to check the long-term safety of roflumilast, a daily pill. It continued from a previous 24-week study, tracking 150 adults who had already completed that trial. The main goal was to see if the medication remained safe and effectiv…

This study looked back at medical records to see how well the drug benralizumab worked for 197 adults with severe asthma in Israel. Researchers tracked patients for up to five years to measure how many asthma flare-ups they experienced before and after starting treatment. The goa…

This early-stage study tested the safety and how the body processes a new inhaled drug called AZD8630 in adults with moderate-to-severe asthma. Twenty-four participants who were already using standard asthma inhalers took either the new drug or a placebo once daily for two weeks.…

This study tested a medicine called D961H in Japanese children. It aimed to see if the medicine could keep acid reflux from coming back after initial treatment, and prevent stomach or intestinal ulcers from returning in kids who need to take long-term painkillers like aspirin. Ab…

This study tested whether an experimental drug called AZD0780 could lower blood pressure in people with heart disease or high risk for it. Researchers measured blood pressure changes over 24 hours in 202 adults who already had high cholesterol. Participants took either the drug o…

This early-stage study tested a new experimental drug called AZD0780 when added to existing cholesterol-lowering medications. Researchers enrolled 81 healthy adults with high 'bad' LDL cholesterol to check how the body processes the drug, its safety, and its effect on cholesterol…

This study monitored the safety of Evusheld, a drug used to treat and prevent COVID-19 symptoms, after it was approved for use in Japan. It followed 366 Japanese patients who received the drug in real-world medical settings to track any side effects. The goal was to understand th…

This study monitored the safety of Calquence (acalabrutinib) in real-world patients with previously untreated chronic lymphocytic leukemia. It tracked how often side effects like infections and low blood counts occurred after the drug was approved for this use. The goal was to un…

This study followed 291 patients with severe asthma who were prescribed benralizumab in real-world clinics across multiple countries. Researchers tracked how patients felt and reported their symptoms over 56 weeks to understand the treatment's real-world effectiveness. The goal w…

This study tested whether a daily pill called roflumilast could improve lung function and control symptoms in adults with asthma. About 450 non-smoking adults with moderate asthma took either the medication or a placebo pill for 24 weeks. Researchers measured breathing ability, a…

This study observed patients with moderate-to-severe COPD who were newly prescribed the inhaled medication BREZTRI in routine Russian clinics. Researchers tracked their symptoms, breathing ability, and treatment satisfaction over 24 weeks to see how they fared in real-world use. …

This study tested whether a training program for lung doctors and nurses could improve how asthma is managed in real-world clinics. About 1,500 asthma patients across China were followed for a year to see if their doctors, after receiving updated guideline training, prescribed be…

This study monitored the safety of the drug Calquence (acalabrutinib) in a real-world setting after it was approved for use. It involved 104 patients whose chronic lymphocytic leukemia had returned or did not respond to prior treatment. The main goal was to track the frequency an…

This study followed 513 people with severe, hard-to-control asthma for one year after they started taking tezepelumab, a prescription medication. The goal was to see how well the drug worked in everyday life, outside of a controlled clinical trial, by tracking asthma symptoms, br…

This study tested an investigational injection called AZD2693 to see if it could treat NASH, a type of fatty liver disease that causes scarring. It specifically enrolled 220 adults with NASH and liver scarring who carry a certain gene (PNPLA3 148M) that increases their risk. The …

This large, global study aimed to understand the safety and effectiveness of the drug acalabrutinib for adults with chronic lymphocytic leukemia (CLL). It included over 550 people, including those newly diagnosed, those whose cancer returned, and those who had taken a similar dru…

This study monitored the safety of LYNPARZA, a maintenance drug, in 130 patients with a specific type of advanced pancreatic cancer (BRCA-mutated) who had already finished platinum-based chemotherapy. The goal was to track and understand the side effects that occurred in real-wor…

This study tested whether a new propellant (HFO) in asthma inhalers causes breathing problems compared to the current propellant (HFA). Researchers enrolled 52 adults with well-controlled asthma who tried both propellants in a single dose. They measured lung function immediately …

This study monitored how well the cancer drug durvalumab (Imfinzi) worked and how safe it was for patients in everyday medical practice in Korea. It included 712 people with lung cancer or biliary tract cancer who were eligible to receive the drug as per its approved label. The m…

This study monitored the safety of a drug called IMFINZI when used with standard chemotherapy in 236 patients with advanced bile duct cancer that cannot be removed by surgery. It was conducted in Japan after the treatment was approved, to better understand the real-world side eff…

This completed Phase 3 trial compared two hormone treatments for postmenopausal women with advanced breast cancer that responds to hormones. The study involved 462 women who hadn't received prior hormone therapy, randomly assigning them to receive either fulvestrant or anastrozol…

This study tested whether a drug called tezepelumab, given as a shot, could help adults with severe asthma safely reduce or stop their daily oral steroid pills. It involved 305 participants who were already taking high doses of inhaled medicine plus daily steroid pills. The main …

This study tested whether a targeted drug called olaparib works better than standard hormone treatments for Chinese men with advanced prostate cancer that has spread and stopped responding to other hormone therapies. The men in the study all had specific genetic changes (BRCA1/2 …

This study aimed to find a specific level on a simple breath test (FeNO) that could predict whether adults with a chronic dry cough would respond to a standard asthma inhaler treatment. About 1000 participants in China with a cough lasting at least 8 weeks used the inhaler for 8 …

This study observed how patients with moderate to severe COPD felt after starting a standard triple-inhaler medication (BGF MDI) in real Romanian clinics. It tracked changes in their self-reported breathing symptoms and treatment satisfaction over 6 months. The goal was to unders…

This study tested a new experimental inhaler called PT007 to see how well it opens the airways in adults with asthma. It compared a single dose of PT007 to a dummy inhaler (placebo) and to a standard rescue inhaler (Ventolin) over a short period. The main goal was to measure the …

This completed Phase 3 study tested two combination inhalers against a placebo inhaler in 171 people with moderate-to-severe COPD who get short of breath during exercise. The goal was to see if the inhalers could help patients breathe better and exercise longer by reducing lung i…

This study observed how patients with advanced HER2-positive or HER2-low breast cancer used the drug trastuzumab deruxtecan (T-DXd) in routine Canadian clinics. Researchers tracked 22 patients to see how often treatment was stopped early or doses were changed, and how long patien…

This study aimed to figure out the best practical methods for collecting, shipping, and testing stool and blood samples from adults with active C. difficile (C. diff) infections. It observed participants to see how well they could complete sample collection and questionnaires, an…

This study looked back at the medical records of 74 adults in Portugal with severe asthma who were treated with the drug benralizumab. The goal was to understand what types of patients received the drug, how it was used in real hospitals, and what happened to their asthma symptom…

This is a very early-stage study to check if a new drug called AZD5148 is safe for people and to see how the body processes it. It involved 84 healthy adult volunteers who received a single injection of either the drug or a placebo. The main goal was to monitor for any side effec…

This was the first study in humans for a potential new drug called AZD4076, which is being developed for a serious liver disease called NASH. The main goal was to check if single, increasing doses were safe and to see how the body processes the drug. It involved 40 healthy male v…

This was an early-stage study to check if a new inhaled drug called AZD4604 is safe and how the body processes it. It involved 56 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The main goal was to see if the drug caused any side effects and to…

This study aimed to monitor the safety of the drug Forxiga (dapagliflozin) when used by over 1,000 patients with chronic kidney disease in real-world medical settings. It specifically looked to identify any unexpected side effects and understand what factors might influence safet…

This study looked back at the medical records of 730 patients in Japan with advanced bile duct cancer who received standard drug treatment. Researchers wanted to understand if serious bile duct complications that required hospital stays affected how long patients could continue t…

This study monitored 1,001 adults with type 2 diabetes in Vietnam who were newly prescribed Forxiga (dapagliflozin). Researchers followed patients for 24 weeks to track any side effects that occurred during routine medical care. The goal was to understand the real-world safety pr…

This early-stage study tested how the experimental drug AZD4144 behaves in people with different levels of kidney function compared to healthy volunteers. Researchers gave a single dose to 41 participants, including people with mild to severe kidney impairment and those on dialys…

This study observed how Chinese patients with ovarian or prostate cancer tolerated the cancer drug olaparib during regular medical care. Researchers followed 1,018 patients for 6-12 months to track side effects and treatment patterns. The goal was to understand the drug's safety …

This early-stage study tested how an experimental breast cancer drug called camizestrant interacts with two common medications: midazolam (a sedative) and carbamazepine (an anti-seizure drug). Researchers enrolled 40 healthy postmenopausal women to measure how these drugs affect …

This study aimed to understand the challenges and unmet needs in caring for people with systemic lupus erythematosus (SLE). Researchers analyzed existing health data and gathered opinions from specialist doctors to identify gaps in diagnosis, treatment, and patient support. The g…

This study looked back at the medical records of 342 women in Europe with advanced ovarian cancer linked to a BRCA gene mutation. The goal was to see how well the drug olaparib worked and how it was used in real-world settings after initial chemotherapy. Researchers collected dat…

This early-stage study tested how a single dose of an experimental drug, AZD6234, is processed by the body in people with different levels of kidney problems. Researchers compared 24 people with mild to severe kidney impairment, including some on dialysis, to healthy volunteers. …

This study aimed to understand how adults with severe, hard-to-control asthma are treated and how they fare in everyday life. Researchers followed over 1,500 patients across the US for at least three years, collecting data through regular online surveys and medical records. The g…

This early-stage study tested how a new drug called AZD5004 is processed by people with different levels of liver damage compared to people with healthy livers. Researchers gave a single dose to 33 adults with mild, moderate, or severe liver impairment, plus a matched healthy gro…

This study aimed to understand how lung nodules are identified, diagnosed, and treated across Latin America. Researchers observed the care journey of over 500 adults with lung nodules to see how long diagnosis takes, what resources are used, and what treatments are decided. The g…

This study looked back at medical records to see how 33 patients with severe, hard-to-control asthma responded to the drug tezepelumab in real Spanish clinics. The goal was to gather the first information on how the drug worked outside of formal clinical trials, specifically for …

This study looked at how a new drug called AZD2389 is processed by the body in people with different levels of liver problems compared to people with normal liver function. It involved 35 participants who received a single dose of the drug. The main goal was to understand how liv…

This study looked back at the medical records of 217 patients in the Netherlands who were hospitalized for severe bleeding while taking certain blood thinners. All patients received a specific drug (andexanet alfa) designed to reverse the blood thinner's effect. The goal was to u…

This was the first study in people for a new drug called AZD2389. Its main goal was to check if the drug is safe and to see how the body absorbs and processes it. The study involved 120 healthy volunteers, including people of Japanese and Chinese descent, who received either the …

This study looked back at the medical records of 420 patients in Spain with severe, hard-to-control asthma who were treated with the biologic drug tezepelumab. The goal was to understand the real-world characteristics of these patients and see how the treatment affected their ast…

This study tested how an experimental cancer drug called capivasertib might change the way the body processes a common cholesterol-lowering drug, rosuvastatin. Twenty healthy volunteers took both drugs separately and together so researchers could measure the levels in their blood…

This study observed 257 patients in Greece who were newly prescribed dapagliflozin for heart failure. The goal was to understand how patients use the medication in real life and how it affects their quality of life. Researchers tracked whether patients continued taking the drug a…

This study looked back at medical records to understand how common a specific subtype of breast cancer called 'HER2-low' is in the Gulf region. Researchers reviewed records of 517 women with advanced breast cancer to count cases and describe patient experiences. The goal is to ga…

This study observed 11 adult patients in Korea who were already taking or starting Soliris for a rare autoimmune disorder called Neuromyelitis Optica Spectrum Disorder (NMOSD). Its main purpose was to collect real-world information on the drug's safety and how well it prevents di…

This study looked back at the medical records of over 91,000 Spanish adults with chronic kidney disease to understand how doctors manage this condition in everyday practice. Researchers analyzed what treatments patients received, how often they started or stopped medications, and…

This study tested whether two different injection devices—a prefilled syringe and an autoinjector pen—deliver the same amount of an experimental drug called tozorakimab into the body. Researchers gave a single injection to 254 healthy volunteers and tracked the drug levels in the…

This study aimed to understand how a common antifungal drug (itraconazole) affects the blood levels of a lung cancer drug (AZD9291, now known as osimertinib). It involved 39 adults with a specific type of advanced lung cancer that had worsened after previous treatment. The main g…

This early-stage study aimed to understand how the experimental drug zibotentan is absorbed, distributed, and eliminated by the body in healthy volunteers. It involved 30 healthy Japanese and non-Asian participants who each received four different single doses of the drug over se…

This study tested how a new drug, AZD2693, is processed in people with different levels of liver problems compared to people with normal liver function. It involved 35 people who received a single injection. The main goal was to understand if liver impairment changes how the drug…

This study tested a wearable heart monitor patch to see if it could reliably track recovery in patients recently hospitalized for sudden, severe heart failure. About 54 participants wore the patch at home for a few days right after leaving the hospital and again 6-8 weeks later. …

This study looked back at the medical records of over 1,100 patients with advanced breast cancer in Asia and Latin America. The goal was to understand how many patients actually have a specific subtype called 'HER2-low' by re-checking old tissue samples. Researchers also wanted t…

This study aimed to understand how doctors in Greece actually use a medication called sodium zirconium cyclosilicate to treat high potassium levels in patients with chronic kidney disease or heart failure. Researchers observed the treatment patterns and patient characteristics of…

This study aimed to understand how common hidden heart failure is in people with type 2 diabetes who are at high risk for heart problems. Researchers followed 245 patients in Greece for two years to see who developed symptoms and to identify factors that might predict this risk. …

This was an early-stage study to check the safety and see how the body processes a new oral drug called AZD6793. It involved 39 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The main goal was to understand the drug's side effects and how it mo…

This study aimed to understand why a common first-line lung cancer drug (osimertinib) stops working for some patients. Researchers analyzed genetic material from 182 patients with advanced lung cancer after their disease progressed on this drug. By comparing tissue and blood samp…

This study looked back at the medical records of 352 UK patients with severe asthma who were treated with the biologic drug tezepelumab. The goal was to understand the types of patients who receive this treatment and how it affects their asthma attacks, symptoms, and quality of l…

This study tested how an experimental heart medication called AZD0780 affects the way the body processes metformin, a common diabetes drug. Researchers gave both drugs to 14 healthy volunteers to measure how they interact in the body. The goal was to understand if taking these me…

This study looked back at the health records of over 361,000 adults hospitalized with COVID-19 in Brazil between 2021 and 2023. Researchers used a national public health database to describe who was hospitalized, their outcomes, and the impact of vaccination. The goal was to unde…

This early study tested a new potential rheumatoid arthritis drug called AZD6912 in 40 healthy volunteers. Researchers gave single injections at increasing doses to check for side effects and see how the body processes the drug. The main goal was to determine if the drug is safe …

This study aimed to better understand what happens to patients who experience a major bleeding event while taking a common type of blood thinner (Factor Xa inhibitor). Researchers observed over 2,200 hospitalized patients to learn about their characteristics, the medical care the…

This early-stage study tested a single dose of an experimental drug called AZD5148, which is being developed to treat Clostridioides difficile (C. diff) infections. The main goal was to check if the drug was safe and to see how the body processes it in 16 healthy Japanese adults.…

This study aimed to learn directly from patients about their experiences taking a specific drug combination (capivasertib + fulvestrant) for advanced breast cancer. Researchers interviewed 48 people who had taken the treatment to understand their attitudes, dosing experiences, an…

This study looked back at the medical records of 350 Australian patients with advanced lung cancer who had a specific genetic change (EGFR mutation). Researchers analyzed how long patients stayed on a targeted drug called osimertinib, and how it affected their survival, when it w…

This study aimed to find out how many adults in Brazil with risk factors like diabetes or high blood pressure might have undiagnosed chronic kidney disease. Researchers used a quick finger-prick test at local clinics to screen over 8,400 people across the country. People with abn…

This study looked back at the medical records of 405 Egyptian patients with advanced breast cancer. Its main goal was to find out how many of these patients had a specific subtype called 'HER2-low,' which is a newer way to classify the disease. The results will help doctors under…

This was the first study in humans for a new drug called AZD8965. Its main goal was to check if the drug is safe and to see how the body absorbs and processes it. The study involved 147 healthy volunteers, including specific groups of Japanese and Chinese participants. Researcher…

This study aimed to better understand a rare and serious blood disease called Paroxysmal Nocturnal Hemoglobinuria (PNH) in China. Researchers observed 724 patients with PNH to learn about their disease characteristics, symptoms, and how different treatments, including a newer dru…

This study looked back at the medical records of 1,669 Russian patients with advanced breast cancer that was classified as HER2-negative. The main goal was to see how many of these patients actually had a specific subtype called 'HER2-low' when their tests were re-checked. Resear…

This study aimed to better understand Chronic Obstructive Pulmonary Disease (COPD) by closely tracking patients over 12 weeks. Researchers observed how daily symptoms, lung function, and markers of inflammation in the body changed and related to each other. The information gather…

This study tested whether a new, more environmentally friendly inhaler propellant (HFO) works as well as the current standard (HFA) at helping clear mucus from healthy lungs. Thirty-five healthy, non-smoking adults used both types of inhalers for one week each. Researchers used a…

This study looked back at the medical records of 300 liver cancer patients treated in Brazilian hospitals between 2017 and 2022. The goal was to understand how liver cancer is typically managed in Brazil, what treatments patients receive, and how they fare over time. By analyzing…

This early study aimed to understand how a single dose of an experimental drug, AZD5462, is processed by the body in people with moderate to severe kidney problems. It compared 16 participants with reduced kidney function to healthy volunteers to check for safety and see if the d…

This study looked back at the medical records of 123 adults who were hospitalized with a brain bleed while taking a common type of blood thinner (called a Factor Xa inhibitor). The goal was to understand what these patients were like, how they were treated, and what happened to t…

This study created a patient registry to observe how newer, targeted cancer drugs work in everyday practice for people with mantle cell lymphoma. It followed 227 patients who had recently started one of these newer treatments to track their treatment patterns, how well the drugs …

This study aimed to gather information, not test a treatment. Researchers surveyed 201 adults with severe asthma across Egypt to find out how many rely on oral steroid pills to manage their condition. They also collected data on patients' specific disease features and how well th…

This study observed how doctors use the medication dapagliflozin to treat chronic kidney disease in everyday practice. It followed over 1,000 patients across seven Eastern European countries for up to a year after they started the drug. The goal was to understand which patients r…

This study aimed to gather real-world information about patients in Russia living with moderate to severe systemic lupus erythematosus (SLE), a complex autoimmune disease. Researchers collected existing medical records and followed about 600 patients for over a year to understand…

This was the first study in people to test the safety of an experimental drug called AZD1163. It involved 108 healthy volunteers who received either the drug or a placebo via injection. The main goal was to see how well the drug was tolerated, how it moved through the body, and i…

This study tested how a new lung cancer drug (AZD9291) affects the body's processing of a common cholesterol medication (simvastatin). Researchers enrolled 52 patients with advanced lung cancer that had stopped responding to standard treatments. The goal was to understand potenti…

This early-stage study tested how a new drug called AZD5004 interacts with other medications in healthy volunteers. In one part, researchers checked if a common antifungal drug (itraconazole) changed how AZD5004 works in the body. In another part, they tested if AZD5004 changed h…

This early-stage study tested how a new drug, AZD5004, interacts with several common medications, including cholesterol drugs (like atorvastatin) and a diabetes drug (repaglinide). It also checked how an antibiotic (erythromycin) affects AZD5004. The goal was to see if taking AZD…

This early-stage study aimed to check the safety and see how the body processes a new drug called AZD6793. It involved healthy volunteers and a small group of people with moderate-to-severe COPD, a chronic lung disease. The main goal was to understand side effects and how the dru…

This study tested a single dose of a new inhaled asthma medicine called AZD8630 in 10 teenagers with asthma. The main goal was to see how the drug moves through the body and to check for any side effects. Researchers also tested the inhaler device used to deliver the medicine.

This study looked back at medical records to understand how doctors in Brazil treat advanced breast cancer that has spread or cannot be surgically removed. Researchers analyzed data from 204 adult patients who had already received a specific type of targeted therapy. The goal was…

This study looked back at existing health records to understand what happens to people with COPD after they have a severe flare-up requiring hospitalization. Researchers analyzed data from over 3,500 patients who started a specific inhaler medication (BGF) to see if starting it p…