Targeted pill challenges chemo for inherited breast cancer

NCT ID NCT02000622

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This completed Phase 3 trial compared a daily oral medication called olaparib against standard chemotherapy chosen by doctors. It involved 302 patients with metastatic breast cancer who have specific inherited BRCA gene mutations. The study aimed to see if the targeted pill could better control cancer growth and improve survival compared to traditional chemotherapy.

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Contacts and locations

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Locations

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San Diego, California, 92123, United States
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Santa Rosa, California, 95403, United States
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Whittier, California, 90602, United States
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Denver, Colorado, 80204, United States
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New Haven, Connecticut, 06510, United States
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Washington D.C., District of Columbia, 20007, United States
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Jacksonville, Florida, 32224, United States
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Orlando, Florida, 32804, United States
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Plantation, Florida, 33324, United States
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Columbus, Georgia, 31904, United States
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Marietta, Georgia, 30060, United States
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Chicago, Illinois, 60612, United States
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Niles, Illinois, 60714, United States
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Wichita, Kansas, 67214, United States
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Lafayette, Louisiana, 70506, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02118, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48201, United States
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Grand Rapids, Michigan, 49503, United States
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Rochester, Minnesota, 55905-0001, United States
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Saint Louis Park, Minnesota, 55416, United States
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Jackson, Mississippi, 39202, United States
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Columbia, Missouri, 65212, United States
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St Louis, Missouri, 63131, United States
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Lebanon, New Hampshire, 03756, United States
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Commack, New York, 11725, United States
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Harrison, New York, 10604, United States
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New York, New York, 10021, United States
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New York, New York, 10065, United States
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Rockville Centre, New York, 11570, United States
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Syracuse, New York, 13210, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44106, United States
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Cleveland, Ohio, 44195, United States
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Portland, Oregon, 97213, United States
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Philadelphia, Pennsylvania, 19104, United States
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Sayre, Pennsylvania, 18840, United States
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Germantown, Tennessee, 38138, United States
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Houston, Texas, 77030, United States
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Tyler, Texas, 75701, United States
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Burlington, Vermont, 05401, United States
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4004, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1303, Bulgaria
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Sofia, 1330, Bulgaria
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Sofia, 1504, Bulgaria
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Varna, 9010, Bulgaria
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Vratsa, 3000, Bulgaria
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Beijing, 100006, China
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Beijing, 100021, China
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Beijing, 100142, China
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Changchun, 130061, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Dalian, 116011, China
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Guangzhou, 510060, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Nanjing, 210009, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shenyang, 110016, China
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Tianjin, 300060, China
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Brno, 656 53, Czechia
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Olomouc, 775 20, Czechia
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Prague, 128 08, Czechia
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Caen, 14076, France
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Montpellier, 34298, France
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Rouen, 76038, France
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Strasbourg, 67065, France
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Villejuif, 94800, France
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Budapest, 1032, Hungary
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Budapest, 1083, Hungary
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Budapest, 1115, Hungary
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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Nyíregyháza, 4400, Hungary
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Veszprém, 8200, Hungary
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Bologna, 40138, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Roma, 00144, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-0045, Japan
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Chūōku, 104-8560, Japan
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Fukuoka, 811-1395, Japan
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Kagoshima, 892-0833, Japan
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Nagoya, 464-8681, Japan
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Osaka, 540-0006, Japan
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Sapporo, 003-0804, Japan
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Shinagawa-ku, 142-8666, Japan
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Suita, 565-0871, Japan
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Estado de México, 50080, Mexico
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Mérida, 97000, Mexico
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Mérida, 97070, Mexico
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Mérida, 97133, Mexico
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México, 6760, Mexico
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San Juan del Río, 76800, Mexico
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Cusco, CUSCO 01, Peru
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Lima, LIMA 01, Peru
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Lima, Lima 18, Peru
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Lima, LIMA 27, Peru
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Lima, LIMA 34, Peru
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Lima, LIMA 41, Peru
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San Borja, LIMA 41, Peru
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Elblag, 82-300, Poland
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Gdansk, 80-952, Poland
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Grzepnica, 72-003, Poland
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Lodz, 93-513, Poland
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Tarnobrzeg, 39-400, Poland
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Warsaw, 01-748, Poland
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Warsaw, 03-291, Poland
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Bucharest, 011171, Romania
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Bucharest, 013811, Romania
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Bucharest, 030171, Romania
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Cluj-Napoca, 400015, Romania
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Arkhangelsk, 163045, Russia
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Ivanovo, 153040, Russia
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Moscow, 115478, Russia
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Omsk, 644013, Russia
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Saint Petersburg, 191014, Russia
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Saint Petersburg, 195257, Russia
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Saint Petersburg, 195271, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 197758, Russia
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Saransk, 430005, Russia
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Yaroslavl, 150054, Russia
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Cheongju-si, 28644, South Korea
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Daegu, 41404, South Korea
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Incheon, 21565, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 158-710, South Korea
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Seoul, 6351, South Korea
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Barcelona, 08003, Spain
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Córdoba, 14004, Spain
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Granada, 18014, Spain
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Madrid, 28034, Spain
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Majadahonda, 28222, Spain
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Oviedo, 33011, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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Zaragoza, 50009, Spain
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Bern, CH-3010, Switzerland
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Lausanne, CH-1011, Switzerland
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Zurich, 8063, Switzerland
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Kaohsiung City, 80756, Taiwan
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Taichung, 407, Taiwan
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Taipei, 10048, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan District, 333, Taiwan
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Adana, 1260, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Gaziantep, 27310, Turkey (Türkiye)
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Istanbul, 34390, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Mersin, 33110, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Colchester, CO4 5JL, United Kingdom
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Coventry, CV2 2DX, United Kingdom
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London, W6 8RF, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Plymouth, PL6 8DH., United Kingdom

Conditions

Explore the condition pages connected to this study.

BRCA 1 GENE MUTATION BRCA 2 GENE MUTATION BREAST CANCER METASTATIC