Targeted pill slows BRCA breast cancer better than chemo

NCT ID NCT02000622

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Feb 20, 2026 · Last updated May 15, 2026 · Updated 11 times

Summary

This study tested a daily pill (olaparib) against standard chemotherapy in 302 people with metastatic breast cancer who have inherited BRCA1/2 mutations. The goal was to see if olaparib could delay cancer growth longer than chemo. Participants were randomly assigned to olaparib or one of three chemo drugs. The results help guide treatment choices for this specific genetic form of breast cancer.

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Contacts and locations

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Locations

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San Diego, California, 92123, United States
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Santa Rosa, California, 95403, United States
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Whittier, California, 90602, United States
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Denver, Colorado, 80204, United States
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New Haven, Connecticut, 06510, United States
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Washington D.C., District of Columbia, 20007, United States
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Jacksonville, Florida, 32224, United States
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Orlando, Florida, 32804, United States
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Plantation, Florida, 33324, United States
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Columbus, Georgia, 31904, United States
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Marietta, Georgia, 30060, United States
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Chicago, Illinois, 60612, United States
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Niles, Illinois, 60714, United States
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Wichita, Kansas, 67214, United States
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Lafayette, Louisiana, 70506, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02118, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48201, United States
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Grand Rapids, Michigan, 49503, United States
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Rochester, Minnesota, 55905-0001, United States
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Saint Louis Park, Minnesota, 55416, United States
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Jackson, Mississippi, 39202, United States
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Columbia, Missouri, 65212, United States
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St Louis, Missouri, 63131, United States
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Lebanon, New Hampshire, 03756, United States
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Commack, New York, 11725, United States
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Harrison, New York, 10604, United States
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New York, New York, 10021, United States
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New York, New York, 10065, United States
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Rockville Centre, New York, 11570, United States
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Syracuse, New York, 13210, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44106, United States
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Cleveland, Ohio, 44195, United States
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Portland, Oregon, 97213, United States
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Philadelphia, Pennsylvania, 19104, United States
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Sayre, Pennsylvania, 18840, United States
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Germantown, Tennessee, 38138, United States
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Houston, Texas, 77030, United States
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Tyler, Texas, 75701, United States
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Burlington, Vermont, 05401, United States
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4004, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1303, Bulgaria
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Sofia, 1330, Bulgaria
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Sofia, 1504, Bulgaria
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Varna, 9010, Bulgaria
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Vratsa, 3000, Bulgaria
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Beijing, 100006, China
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Beijing, 100021, China
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Beijing, 100142, China
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Changchun, 130061, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Dalian, 116011, China
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Guangzhou, 510060, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Nanjing, 210009, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shenyang, 110016, China
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Tianjin, 300060, China
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Brno, 656 53, Czechia
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Olomouc, 775 20, Czechia
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Prague, 128 08, Czechia
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Caen, 14076, France
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Montpellier, 34298, France
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Rouen, 76038, France
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Strasbourg, 67065, France
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Villejuif, 94800, France
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Budapest, 1032, Hungary
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Budapest, 1083, Hungary
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Budapest, 1115, Hungary
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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Nyíregyháza, 4400, Hungary
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Veszprém, 8200, Hungary
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Bologna, 40138, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Roma, 00144, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-0045, Japan
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Chūōku, 104-8560, Japan
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Fukuoka, 811-1395, Japan
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Kagoshima, 892-0833, Japan
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Nagoya, 464-8681, Japan
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Osaka, 540-0006, Japan
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Sapporo, 003-0804, Japan
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Shinagawa-ku, 142-8666, Japan
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Suita, 565-0871, Japan
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Estado de México, 50080, Mexico
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Mérida, 97000, Mexico
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Mérida, 97070, Mexico
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Mérida, 97133, Mexico
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México, 6760, Mexico
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San Juan del Río, 76800, Mexico
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Cusco, CUSCO 01, Peru
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Lima, LIMA 01, Peru
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Lima, Lima 18, Peru
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Lima, LIMA 27, Peru
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Lima, LIMA 34, Peru
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Lima, LIMA 41, Peru
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San Borja, LIMA 41, Peru
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Elblag, 82-300, Poland
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Gdansk, 80-952, Poland
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Grzepnica, 72-003, Poland
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Lodz, 93-513, Poland
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Tarnobrzeg, 39-400, Poland
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Warsaw, 01-748, Poland
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Warsaw, 03-291, Poland
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Bucharest, 011171, Romania
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Bucharest, 013811, Romania
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Bucharest, 030171, Romania
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Cluj-Napoca, 400015, Romania
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Arkhangelsk, 163045, Russia
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Ivanovo, 153040, Russia
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Moscow, 115478, Russia
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Omsk, 644013, Russia
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Saint Petersburg, 191014, Russia
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Saint Petersburg, 195257, Russia
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Saint Petersburg, 195271, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 197758, Russia
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Saransk, 430005, Russia
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Yaroslavl, 150054, Russia
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Cheongju-si, 28644, South Korea
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Daegu, 41404, South Korea
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Incheon, 21565, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 158-710, South Korea
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Seoul, 6351, South Korea
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Barcelona, 08003, Spain
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Córdoba, 14004, Spain
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Granada, 18014, Spain
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Madrid, 28034, Spain
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Majadahonda, 28222, Spain
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Oviedo, 33011, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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Zaragoza, 50009, Spain
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Bern, CH-3010, Switzerland
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Lausanne, CH-1011, Switzerland
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Zurich, 8063, Switzerland
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Kaohsiung City, 80756, Taiwan
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Taichung, 407, Taiwan
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Taipei, 10048, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 333, Taiwan
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Adana, 1260, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Gaziantep, 27310, Turkey (Türkiye)
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Istanbul, 34390, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Mersin, 33110, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Colchester, CO4 5JL, United Kingdom
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Coventry, CV2 2DX, United Kingdom
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London, W6 8RF, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Plymouth, PL6 8DH., United Kingdom

Conditions

Explore the condition pages connected to this study.

BRCA 1 GENE MUTATION BRCA 2 GENE MUTATION BREAST CANCER METASTATIC