Could a daily shot tame fatty liver scarring?

NCT ID NCT05364931

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a drug called cotadutide in 54 adults with a type of fatty liver disease that includes liver scarring but not cirrhosis. Participants received either the drug or a placebo as a daily injection. The main goal was to check safety and tolerability, with results helping to decide if larger studies are worthwhile.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Cotadutide (a daily injection)

What this could lead to

If it works, this could point toward a treatment for NASH-related liver scarring, potentially slowing or stopping disease progression.

What could go wrong

This is a small, early-phase study focused on safety, not proof of effectiveness. The drug may not improve liver health or could cause side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-CIRRHOTIC NON-ALCOHOLIC STEATOHEPATITIS WITH FIBROSIS

Contacts and locations

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Locations

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Tucson, Arizona, 85712, United States
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Canoga Park, California, 91303, United States
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Gilroy, California, 95020, United States
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Sacramento, California, 95821, United States
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Englewood, Colorado, 80113, United States
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Bradenton, Florida, 34208, United States
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Homestead, Florida, 33032, United States
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Jacksonville, Florida, 32216, United States
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Miami, Florida, 33175, United States
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Miami, Florida, 33176, United States
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Winter Park, Florida, 32789, United States
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Munster, Indiana, 46321, United States
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Houma, Louisiana, 70363, United States
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Marrero, Louisiana, 70006, United States
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Marrero, Louisiana, 70072, United States
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Shreveport, Louisiana, 71105, United States
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Ann Arbor, Michigan, 48109, United States
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Las Vegas, Nevada, 89104, United States
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Las Vegas, Nevada, 89109, United States
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Lawrence, New Jersey, 08648, United States
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Warren Township, New Jersey, 07059, United States
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Morehead City, North Carolina, 28557, United States
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Chattanooga, Tennessee, 37421, United States
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Arlington, Texas, 76012, United States
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Austin, Texas, 78745, United States
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Dallas, Texas, 75230, United States
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Lewisville, Texas, 75057, United States
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San Antonio, Texas, 78215, United States
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Ogden, Utah, 84403, United States
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CABA, C1056ABJ, Argentina
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Heidelberg, 3084, Australia
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Kogarah, 2217, Australia
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Meadowbrook, 4131, Australia
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Melbourne, 3004, Australia
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Westmead, 2145, Australia
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Vienna, 1030, Austria
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Vienna, 1130, Austria
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London, Ontario, N6A 5A5, Canada
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Terrebonne, Quebec, J6X 4P7, Canada
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Montpellier, 34090, France
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Paris, 75651, France
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Dresden, 01307, Germany
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Konstanz, 78464, Germany
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Athens, 12462, Greece
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Ioannina, 45500, Greece
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Haifa, 34362, Israel
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Jerusalem, 91031, Israel
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Nahariya, 22100, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 64239, Israel
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Tel Litwinsky, 52621, Israel
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Catania, 95100, Italy
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Foggia, 71100, Italy
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Milan, 20127, Italy
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Roma, 00100, Italy
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Roma, 00161, Italy
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Rozzano, 20089, Italy
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San Giovanni Rotondo, 71013, Italy
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Chiba, 260-8677, Japan
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Fukui-shi, 918-8503, Japan
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Gifu, 500-8513, Japan
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Hiroshima, 734-8551, Japan
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Kawasaki-shi, 215-0026, Japan
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Kawasaki-shi, 216-8511, Japan
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Kure-shi, 737-0023, Japan
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Osaka, 637086, Japan
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Saga, 849-8501, Japan
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Sapporo, 062-0921, Japan
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Sendai, 980-0873, Japan
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Shinjuku-ku, 160-0023, Japan
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Suita-shi, 564-0013, Japan
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Takasaki-shi, 370-0829, Japan
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Toon-shi, 791-0281, Japan
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Yokohama, 236-0004, Japan
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Yokohama, 245-8575, Japan
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Kuala Lumpur, 56000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Malacca, 75400, Malaysia
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Seremban, 70300, Malaysia
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Auckland, 2025, New Zealand
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Christchurch, 8011, New Zealand
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Grafton, 1023, New Zealand
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Plumstead, 7800, South Africa
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Busan, 49241, South Korea
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Gangwon-do, 26426, South Korea
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Junggu, 41944, South Korea
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Seoul, 03080, South Korea
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Seoul, 04763, South Korea
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Seoul, 06351, South Korea
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A Coruña, 15006, Spain
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Almería, 04009, Spain
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Lleida, 25198, Spain
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Madrid, 28046, Spain
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Málaga, 29010, Spain
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Seville, 41013, Spain
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Kaohsiung City, 80756, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 110, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 114, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06800, Turkey (Türkiye)
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Istanbul, 34093, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Glasgow, G51 4LB, United Kingdom
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Ipswich, IP4 5PD, United Kingdom
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Liverpool, L1 9ED, United Kingdom
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London, EN1 1LJ, United Kingdom
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Preston, PR2 9QB, United Kingdom
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Rochdale, OL11 4AU, United Kingdom
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Sheffield, S2 5FX, United Kingdom