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New safety data on LYNPARZA for pancreatic cancer patients with BRCA mutation

NCT ID NCT04889404

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the safety of LYNPARZA (olaparib) when used as a maintenance treatment after platinum-based chemotherapy in 130 patients with BRCA-mutated pancreatic cancer that could not be surgically removed. Researchers tracked side effects like bone marrow problems, lung inflammation, new cancers, and harm to unborn babies. The goal was to understand real-world risks in this specific patient group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Olaparib (LYNPARZA)

What this could lead to

If successful, this study could confirm that LYNPARZA is a safe maintenance option for people with BRCA-mutated pancreatic cancer after chemotherapy.

What could go wrong

This is an observational safety study, not a test of effectiveness. It may not show clear benefits, and side effects like bone marrow depression or lung issues remain possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

exocrine pancreatic carcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC NEOPLASMS

Contacts and locations

Locations

  • Research Site

    Osaka, Lyn010001, D081FC00004, Japan

  • Research Site

    Kanagawa, Lyn010003, D081FC00004, Japan

  • Research Site

    Okayama, Lyn010004, D081FC00004, Japan

  • Research Site

    Akita, Lyn010005, D081FC00004, Japan

  • Research Site

    Niigata, Lyn010006, D081FC00004, Japan

  • Research Site

    Shizuoka, Lyn010007, D081FC00004, Japan

  • Research Site

    Niigata, Lyn010008, D081FC00004, Japan

  • Research Site

    Tokyo, Lyn010009, D081FC00004, Japan

  • Research Site

    Saitama, Lyn010010, D081FC00004, Japan

  • Research Site

    Aichi, Lyn010011, D081FC00004, Japan

  • Research Site

    Osaka, Lyn010012, D081FC00004, Japan

  • Research Site

    Tokyo, Lyn010013, D081FC00004, Japan

  • Research Site

    Nara, Lyn010014, D081FC00004, Japan

  • Research Site

    Wakayama, Lyn010015, D081FC00004, Japan

  • Research Site

    Miyagi, Lyn010016, D081FC00004, Japan

  • Research Site

    Tokyo, Lyn010017, D081FC00004, Japan

  • Research Site

    Osaka, Lyn010018, D081FC00004, Japan

  • Research Site

    Gunma, Lyn010019, D081FC00004, Japan

  • Research Site

    Hiroshima, Lyn010020, Japan

  • Research Site

    Tochigi, Lyn010021, D081FC00004, Japan

  • Research Site

    Numakunai, Lyn010022, D081FC00004, Japan

  • Research Site

    Osaka, Lyn010025, D081FC00004, Japan

  • Research Site

    Shizuoka, Lyn010026, D081FC00004, Japan

  • Research Site

    Nagasaki, Lyn010027, D081FC00004, Japan

  • Research Site

    Kumamoto, Lyn010028, D081FC00004, Japan

  • Research Site

    Saitama, Lyn010029, D081FC00004, Japan

  • Research Site

    Nagano, Lyn010031, D081FC00004, Japan

  • Research Site

    Hyōgo, Lyn010032, D081FC00004, Japan

  • Research Site

    Shimane, Lyn010033, D081FC00004, Japan

  • Research Site

    Hyōgo, Lyn010034, D081FC00004, Japan

  • Research Site

    Shizuoka, Lyn010035, D081FC00004, Japan

  • Research Site

    Hyōgo, Lyn010036, D081FC00004, Japan

  • Research Site

    Okayama, Lyn010038, D081FC00004, Japan

  • Research Site

    Fukuoka, Lyn010041, Japan

  • Research Site

    Hokkaido, Lyn010042, Japan

  • Research Site

    Ehime, Lyn010044, Japan

  • Research Site

    Osaka, Lyn010045, Japan

  • Research Site

    Shizuoka, Lyn010047, Japan

  • Research Site

    Tokyo, Lyn010050, Japan

  • Research Site

    Aichi, Japan

  • Research Site

    Chiba, Japan

  • Research Site

    Fukuoka, Japan

  • Research Site

    Gunma, Japan

  • Research Site

    Hiroshima, Japan

  • Research Site

    Hokkaido, Japan

  • Research Site

    Hyōgo, Japan

  • Research Site

    Ibaraki, Japan

  • Research Site

    Kagawa, Japan

  • Research Site

    Kanagawa, Japan

  • Research Site

    Kyoto, Japan

  • Research Site

    Nagano, Japan

  • Research Site

    Nagasaki, Japan

  • Research Site

    Nara, Japan

  • Research Site

    Okayama, Japan

  • Research Site

    Osaka, Japan

  • Research Site

    Shizuoka, Japan

  • Research Site

    Tokyo, Japan

  • Research Site

    Tottori, Japan

  • Research Site

    Toyama, Japan

  • Research Site

    Yamagata, Japan