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Lung cancer drug interaction study seeks safer dosing

NCT ID NCT02197234

Completed Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how the lung cancer drug AZD9291 (osimertinib) affects the breakdown of simvastatin, a common cholesterol medicine, in 52 adults with a specific type of advanced lung cancer (EGFR mutation-positive NSCLC) that had stopped responding to earlier treatments. The goal was to understand if AZD9291 changes simvastatin levels in the blood, which could affect safety and dosing. Participants took both drugs and had blood tests to measure drug levels, with no direct treatment benefit intended from this part of the study.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • Research Site

    Atlanta, Georgia, 30322, United States

  • Research Site

    Leuven, 3000, Belgium

  • Research Site

    Angers, 49055, France

  • Research Site

    Dijon, 21079, France

  • Research Site

    Marseille, 13385, France

  • Research Site

    Rennes, 35033, France

  • Research Site

    Saint-Herblain, 44805, France

  • Research Site

    Seongnam-si, 13620, South Korea

  • Research Site

    Seoul, 03080, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 05505, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Badalona, 08916, Spain

  • Research Site

    Barcelona, 08041, Spain

  • Research Site

    Madrid, 28046, Spain

  • Research Site

    Seville, 41013, Spain

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