Lung cancer drug interaction study seeks safer dosing
NCT ID NCT02197234
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how the lung cancer drug AZD9291 (osimertinib) affects the breakdown of simvastatin, a common cholesterol medicine, in 52 adults with a specific type of advanced lung cancer (EGFR mutation-positive NSCLC) that had stopped responding to earlier treatments. The goal was to understand if AZD9291 changes simvastatin levels in the blood, which could affect safety and dosing. Participants took both drugs and had blood tests to measure drug levels, with no direct treatment benefit intended from this part of the study.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Site
Atlanta, Georgia, 30322, United States
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Research Site
Leuven, 3000, Belgium
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Research Site
Angers, 49055, France
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Research Site
Dijon, 21079, France
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Research Site
Marseille, 13385, France
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Research Site
Rennes, 35033, France
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Research Site
Saint-Herblain, 44805, France
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Research Site
Seongnam-si, 13620, South Korea
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Research Site
Seoul, 03080, South Korea
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Research Site
Seoul, 03722, South Korea
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Research Site
Seoul, 05505, South Korea
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Research Site
Seoul, 06351, South Korea
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Research Site
Badalona, 08916, Spain
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Research Site
Barcelona, 08041, Spain
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Research Site
Madrid, 28046, Spain
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Research Site
Seville, 41013, Spain