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Real-World check: Calquence's side effects under the microscope

NCT ID NCT04872621

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study looked at the safety of the drug Calquence (acalabrutinib) in 104 patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. Researchers tracked side effects like bleeding, infections, and heart issues in a real-world setting after the drug was already on the market. The goal was to better understand how often these side effects occur outside of controlled clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Calquence (acalabrutinib)

What this could lead to

If successful, this study could confirm that Calquence is safe enough for routine use in patients with relapsed or refractory CLL.

What could go wrong

This is an observational study, not a controlled trial, so it cannot prove effectiveness. Side effects like bleeding, infection, and heart issues were tracked and may still occur.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED OR REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (INCLUDING SMALL LYMPHOCYTIC LYMPHOMA)

Contacts and locations

Locations

  • Research Site

    Aichi, D8224C00001, Japan

  • Research Site

    Aichi, Japan

  • Research Site

    Akita, Japan

  • Research Site

    Aomori, D8224C00001, Japan

  • Research Site

    Chiba, D8224C00001, Japan

  • Research Site

    Chiba, Japan

  • Research Site

    Fukui, Japan

  • Research Site

    Fukuoka, D8224C00001, Japan

  • Research Site

    Fukuoka, Japan

  • Research Site

    Gifu, Japan

  • Research Site

    Gunma, D8224C00001, Japan

  • Research Site

    Gunma, Japan

  • Research Site

    Hiroshima, D8224C00001, Japan

  • Research Site

    Hiroshima, Japan

  • Research Site

    Hokkaido, D8224C00001, Japan

  • Research Site

    Hokkaido, Japan

  • Research Site

    Hyōgo, D8224C00001, Japan

  • Research Site

    Hyōgo, Japan

  • Research Site

    Ibaraki, D8224C00001, Japan

  • Research Site

    Ibaraki, Japan

  • Research Site

    Ishikawa, Japan

  • Research Site

    Kagoshima, D8224C00001, Japan

  • Research Site

    Kagoshima, Japan

  • Research Site

    Kanagawa, D8224C00001, Japan

  • Research Site

    Kanagawa, Japan

  • Research Site

    Kochi, Japan

  • Research Site

    Kumamoto, Japan

  • Research Site

    Kyoto, D8224C00001, Japan

  • Research Site

    Kyoto, Japan

  • Research Site

    Mie, Japan

  • Research Site

    Miyagi, D8224C00001, Japan

  • Research Site

    Miyagi, Japan

  • Research Site

    Miyazaki, Japan

  • Research Site

    Nagano, Japan

  • Research Site

    Nagasaki, D8224C00001, Japan

  • Research Site

    Nagasaki, Japan

  • Research Site

    Nara, Japan

  • Research Site

    Niigata, Japan

  • Research Site

    Numakunai, Japan

  • Research Site

    Okayama, Japan

  • Research Site

    Okinawa, Japan

  • Research Site

    Osaka, D8224C00001, Japan

  • Research Site

    Osaka, Japan

  • Research Site

    Ōita, Japan

  • Research Site

    Saitama, D8224C00001, Japan

  • Research Site

    Saitama, Japan

  • Research Site

    Shiga, D8224C00001, Japan

  • Research Site

    Shiga, Japan

  • Research Site

    Shimane, Japan

  • Research Site

    Shizuoka, D8224C00001, Japan

  • Research Site

    Shizuoka, Japan

  • Research Site

    Tokyo, D8224C00001, Japan

  • Research Site

    Tokyo, Japan

  • Research Site

    Tottori, Japan

  • Research Site

    Toyama, Japan

  • Research Site

    Wakayama, D8224C00001, Japan

  • Research Site

    Wakayama, Japan

  • Research Site

    Yamagata, Japan

  • Research Site

    Yamaguchi, Japan