Antifungal pill may change how lung cancer drug works

NCT ID NCT02157883

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at how itraconazole, an antifungal medication, affects the levels of the lung cancer drug AZD9291 in the body. It involved 39 adults with advanced EGFR-mutant non-small cell lung cancer whose disease had worsened after previous treatments. The goal was to understand drug interactions, not to test a cure, and results help guide safe dosing.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    San Diego, California, 92123, United States

  • Research Site

    Cleveland, Ohio, 44106, United States

  • Research Site

    Edegem, 2650, Belgium

  • Research Site

    Ghent, 9000, Belgium

  • Research Site

    Amsterdam, 1066 CX, Netherlands

  • Research Site

    Maastricht, 6229 HX, Netherlands

  • Research Site

    Rotterdam, 3015 GD, Netherlands

  • Research Site

    lJongno-gu, 03080, South Korea

  • Research Site

    Seongnam-si, 13620, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 05505, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Taipei, 10002, Taiwan

  • Research Site

    Taipei, 11217, Taiwan

  • Research Site

    London, SE1 9RT, United Kingdom

  • Research Site

    Manchester, M20 4BX, United Kingdom