Cure My Disease

Don't miss your cure!

 Log in / Sign up

New biologic drug brazikumab tested for Crohn's – trial cut short

NCT ID NCT03759288

Terminated Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested brazikumab, an experimental biologic drug, in 89 adults with moderate-to-severe Crohn's disease. Participants received either brazikumab, a placebo, or an active comparator (Humira) to see if the drug could improve symptoms and heal the gut lining. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Brazikumab (a biologic drug given by IV and then injection)

What this could lead to

If successful, brazikumab could offer a new treatment option to reduce symptoms and gut inflammation in people with moderate-to-severe Crohn's disease.

What could go wrong

This trial was terminated early, so results are limited. As a phase 2b/3 study, it is still experimental, and the drug may not prove effective or safe enough for approval.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CROHN'S DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Crohn disease inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE IBD

Contacts and locations

Locations

  • Research Site

    Phoenix, Arizona, 85037, United States

  • Research Site

    Little Rock, Arkansas, 72212, United States

  • Research Site

    Lancaster, California, 93534, United States

  • Research Site

    Lincoln, California, 95648, United States

  • Research Site

    Poway, California, 92064, United States

  • Research Site

    San Diego, California, 92103, United States

  • Research Site

    Colorado Springs, Colorado, 80907, United States

  • Research Site

    Boca Raton, Florida, 33487, United States

  • Research Site

    Clearwater, Florida, 33756, United States

  • Research Site

    Kissimmee, Florida, 34741, United States

  • Research Site

    Lakeland, Florida, 33813, United States

  • Research Site

    Miami, Florida, 33157, United States

  • Research Site

    Miami, Florida, 33165, United States

  • Research Site

    Miami, Florida, 33189, United States

  • Research Site

    Miami Lakes, Florida, 33016, United States

  • Research Site

    Naples, Florida, 34102, United States

  • Research Site

    St. Petersburg, Florida, 33710, United States

  • Research Site

    Tampa, Florida, 33626, United States

  • Research Site

    Atlanta, Georgia, 30328, United States

  • Research Site

    Atlanta, Georgia, 30342, United States

  • Research Site

    Decatur, Georgia, 30033, United States

  • Research Site

    Oak Lawn, Illinois, 60453, United States

  • Research Site

    Brownsburg, Indiana, 46112, United States

  • Research Site

    Chesterfield, Michigan, 48047, United States

  • Research Site

    Las Vegas, Nevada, 89123, United States

  • Research Site

    Albuquerque, New Mexico, 87108, United States

  • Research Site

    Morehead City, North Carolina, 28557, United States

  • Research Site

    Beachwood, Ohio, 44122, United States

  • Research Site

    Oklahoma City, Oklahoma, 73102, United States

  • Research Site

    Uniontown, Pennsylvania, 15401, United States

  • Research Site

    Carrollton, Texas, 75007, United States

  • Research Site

    Houston, Texas, 77017, United States

  • Research Site

    Houston, Texas, 77058, United States

  • Research Site

    McAllen, Texas, 78503, United States

  • Research Site

    Pflugerville, Texas, 78660, United States

  • Research Site

    Stafford, Texas, 77477, United States

  • Research Site

    North Chesterfield, Virginia, 23236, United States

  • Research Site

    Spokane, Washington, 99204, United States

  • Research Site

    New Westminster, British Columbia, V3L 3W4, Canada

  • Research Site

    Chicoutimi, Quebec, G7H 5H6, Canada

  • Research Site

    České Budějovice, 370 01, Czechia

  • Research Site

    Hořovice, 268 31, Czechia

  • Research Site

    Hradec Králové, 500 12, Czechia

  • Research Site

    Olomouc, 772 00, Czechia

  • Research Site

    Augsburg, 86156, Germany

  • Research Site

    Berlin, 10825, Germany

  • Research Site

    Hamburg, 20251, Germany

  • Research Site

    Kiel, 24105, Germany

  • Research Site

    Minden, 32423, Germany

  • Research Site

    Remscheid, 42859, Germany

  • Research Site

    Ulm, 89081, Germany

  • Research Site

    Budapest, 1082, Hungary

  • Research Site

    Bangalore, 560054, India

  • Research Site

    Hyderabad, 500032, India

  • Research Site

    Jaipur, 302001, India

  • Research Site

    Surat, 395002, India

  • Research Site

    Haifa, 3109601, Israel

  • Research Site

    Jerusalem, 9103102, Israel

  • Research Site

    Petah Tikva, 4941492, Israel

  • Research Site

    Milan, 20132, Italy

  • Research Site

    Milan, 20154, Italy

  • Research Site

    Padova, 35128, Italy

  • Research Site

    Rozzano, 20089, Italy

  • Research Site

    Bydgoszcz, 85 168, Poland

  • Research Site

    Chojnice, 89-600, Poland

  • Research Site

    Krakow, 31-513, Poland

  • Research Site

    Poznan, 61-731, Poland

  • Research Site

    Rzeszów, 35-302, Poland

  • Research Site

    Sopot, 81-756, Poland

  • Research Site

    Torun, 87-100, Poland

  • Research Site

    Warsaw, 00-189, Poland

  • Research Site

    Warsaw, 00-728, Poland

  • Research Site

    Warsaw, 03-580, Poland

  • Research Site

    Wroclaw, 52-210, Poland

  • Research Site

    Zamość, 22-400, Poland

  • Research Site

    Aramil, 624002, Russia

  • Research Site

    Moscow, 115419, Russia

  • Research Site

    Perm, 614000, Russia

  • Research Site

    Banská Bystrica, 97401, Slovakia

  • Research Site

    Košice, 04013, Slovakia

  • Research Site

    Nitra, 94901, Slovakia

  • Research Site

    Cape Town, 7500, South Africa

  • Research Site

    Cape Town, 7708, South Africa

  • Research Site

    Johannesburg, 1827, South Africa

  • Research Site

    Plumstead, 7800, South Africa

  • Research Site

    Busan, 48108, South Korea

  • Research Site

    Daegu, 42415, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Seoul, 156-755, South Korea

  • Research Site

    Madrid, 28046, Spain

  • Research Site

    Pontevedra, 36071, Spain

  • Research Site

    Valencia, 46010, Spain

  • Research Site

    Kaohsiung City, 80756, Taiwan

  • Research Site

    Taichung, 40447, Taiwan

  • Research Site

    Taipei, 100, Taiwan

  • Research Site

    Taipei, 114, Taiwan

  • Research Site

    Kharkiv, 61037, Ukraine

  • Research Site

    Kyiv, 03680, Ukraine

  • Research Site

    Kyiv, 04050, Ukraine

  • Research Site

    Kyiv, 04078, Ukraine

  • Research Site

    Coventry, CV2 2DX, United Kingdom

  • Research Site

    West Bromwich, B71 4HJ, United Kingdom