New drug combo tested for ovarian cancer: will it work?
NCT ID NCT07402915
First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times
Summary
This early-phase trial is testing how the antifungal drug itraconazole affects the levels of a new cancer drug, AZD5335, in the body. The study involves 24 people with ovarian, peritoneal, or fallopian tube cancer that has stopped responding to platinum chemotherapy. The goal is to understand drug interactions, not to treat the cancer directly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AZD5335 (antibody drug conjugate) and itraconazole
- What this could lead to
- If successful, this could help determine the right dose of AZD5335 when given with other drugs, potentially improving treatment for ovarian cancer.
- What could go wrong
- This is a very early Phase 1 study with only 24 people. It focuses on drug levels, not on curing cancer, and may not lead to a new treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
NOT_YET_RECRUITINGBatumi, 6010, Georgia
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Research Site
NOT_YET_RECRUITINGTbilisi, 0114, Georgia
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Research Site
NOT_YET_RECRUITINGTbilisi, 112, Georgia
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Research Site
RECRUITINGDublin, D07 R2WY, Ireland
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Research Site
RECRUITINGLisbon, 1250-068, Portugal
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Research Site
RECRUITINGBarcelona, 08023, Spain
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Research Site
RECRUITINGLogroño, 26006, Spain
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Research Site
RECRUITINGMadrid, 28040, Spain
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Research Site
RECRUITINGMadrid, 28050, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new PET tracer light up hidden cancers?
- A Two-for-One surgery: could tube removal during Weight-Loss surgery slash ovarian cancer risk?
- Can AI spot ovarian cancer on CT scans before It's too late?
- Can Lab-Grown tumors unlock the secrets of ovarian cancer resistance?
- Can a smart drug home in on Hard-to-Treat cancers?