New study tracks how gene mutations affect lung cancer treatment success

NCT ID NCT06494540

Recruiting now Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is following 600 people in Germany with a type of advanced lung cancer (non-squamous non-small cell) who are starting a three-drug treatment: tremelimumab, durvalumab, and platinum chemotherapy. Researchers want to see how well the treatment works in real life, especially for patients with certain genetic mutations (like KRAS, STK11, KEAP1, or TP53). The goal is to learn which patients might benefit most from this combination, helping doctors make better treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tremelimumab, durvalumab, and platinum chemotherapy
What this could lead to: If successful, this could help doctors identify which lung cancer patients benefit most from this combination therapy based on their genetic profile.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by patient selection and real-world variability. It does not test a new treatment, only gathers data on existing use.

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Conditions

The condition(s) this trial relates to.

hereditary sensory and autonomic neuropathy non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SQUAMOUS METASTATIC NON-SMALL-CELL LUNG CARCINOMA

Contacts and locations

Locations

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Bad Homburg, Germany
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Berlin, Germany
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Bremen, Germany
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Celle, Germany
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Chemnitz, Germany
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Cologne, Germany
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Deggendorf, Germany
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Frankfurt, Germany
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Georgsmarienhütte, Germany
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Gera, Germany
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Goslar, Germany
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Greifswald, Germany
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Halle-Dolau, Germany
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Hanover, Germany
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Herne, Germany
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Hösbach, Germany
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Koln-Mehrheim, Germany
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Mainz, Germany
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Marburg, Germany
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Münnerstadt, Germany
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Neuss, Germany
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Offenbach, Germany
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Querfurt, Germany
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Ravensburg, Germany
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Rüsselsheim am Main, Germany
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Treuenbrietzen, Germany
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Ulm, Germany
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Wiesbaden, Germany
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Zwickau, Germany