New lupus drug aims to cut steroid use in italian patients

NCT ID NCT07330245

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 218 adults with systemic lupus erythematosus (SLE) in Italy who are starting anifrolumab (Saphnelo) for the first time. Researchers want to see if the drug helps patients reach a state of low disease activity while taking 5 mg or less of steroids daily. The study lasts 52 weeks and is observational, meaning no extra treatments are given—just real-world tracking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

anifrolumab (Saphnelo), a biologic drug that blocks type I interferon

What this could lead to

If successful, this study could show that anifrolumab helps lupus patients achieve better disease control with fewer steroids.

What could go wrong

This is an observational study, not a controlled trial, so results may be less reliable. It is also early-stage and focused only on Italian patients, so findings may not apply broadly.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS ERYTHEMATOSUS, SYSTEMIC

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AOU Ospedali Riuniti di Ancona - Presidio Torrette
RECRUITING

Ancona, 60126, Italy
AOUI Verona - Ospedale Borgo Roma
RECRUITING

Verona, 37134, Italy
ASST Spedali Civili di Brescia
RECRUITING

Brescia, 25123, Italy
ASU Friuli Centrale - Ospedale Santa Maria della Misericordia di Udine
RECRUITING

Udine, 33100, Italy
Azienda Ospedaliera Ordine Mauriziano Umberto I
NOT_YET_RECRUITING

Torino, 10128, Italy
Azienda Ospedaliera Universitaria "Luigi Vanvitelli"
NOT_YET_RECRUITING

Naples, Italy
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone"
RECRUITING

Palermo, 90127, Italy
Azienda Ospedaliera di Padova
NOT_YET_RECRUITING

Padova, 35128, Italy
Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Ospedaliero-Universitaria Pisana Ospedale Santa Chiara
NOT_YET_RECRUITING

Pisa, 56126, Italy
Azienda Ospedaliero-Universitaria Policlinico di Bari
WITHDRAWN

Bari, 70124, Italy
Azienda Ospedaliero-Universitaria di Cagliari Presidio di Monserrato
RECRUITING

Monserrato, CA, 09032, Italy
Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant'Anna
RECRUITING

Cona, Ferrara, 44124, Italy
Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) - Ospedale di Cattinara
RECRUITING

Trieste, 34128, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20122, Italy
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
IRCCS Casa Sollievo della Sofferenza
RECRUITING

San Giovanni Rotondo, Foggia, Italy
IRCCS Humanitas Research Hospital
RECRUITING

Rozzano, Milano, 20089, Italy
IRCCS Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, Italy
Policlinico Tor Vergata
NOT_YET_RECRUITING

Roma, 00133, Italy
Policlinico Umberto I - Sapienza Università di Roma
RECRUITING

Roma, 00161, Italy
Policlinico di Modena - AOU di Modena
NOT_YET_RECRUITING

Modena, 41124, Italy