New lupus drug aims to cut steroid use in italian patients
NCT ID NCT07330245
First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times
Summary
This study follows 218 adults with systemic lupus erythematosus (SLE) in Italy who are starting anifrolumab (Saphnelo) for the first time. Researchers want to see if the drug helps patients reach a state of low disease activity while taking 5 mg or less of steroids daily. The study lasts 52 weeks and is observational, meaning no extra treatments are given—just real-world tracking.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- anifrolumab (Saphnelo), a biologic drug that blocks type I interferon
- What this could lead to
- If successful, this study could show that anifrolumab helps lupus patients achieve better disease control with fewer steroids.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be less reliable. It is also early-stage and focused only on Italian patients, so findings may not apply broadly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AOU Ospedali Riuniti di Ancona - Presidio Torrette
RECRUITINGAncona, 60126, Italy
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AOUI Verona - Ospedale Borgo Roma
RECRUITINGVerona, 37134, Italy
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ASST Spedali Civili di Brescia
RECRUITINGBrescia, 25123, Italy
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ASU Friuli Centrale - Ospedale Santa Maria della Misericordia di Udine
RECRUITINGUdine, 33100, Italy
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Azienda Ospedaliera Ordine Mauriziano Umberto I
NOT_YET_RECRUITINGTorino, 10128, Italy
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Azienda Ospedaliera Universitaria "Luigi Vanvitelli"
NOT_YET_RECRUITINGNaples, Italy
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Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone"
RECRUITINGPalermo, 90127, Italy
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Azienda Ospedaliera di Padova
NOT_YET_RECRUITINGPadova, 35128, Italy
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Azienda Ospedaliero-Universitaria Careggi
RECRUITINGFlorence, 50134, Italy
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Azienda Ospedaliero-Universitaria Pisana Ospedale Santa Chiara
NOT_YET_RECRUITINGPisa, 56126, Italy
-
Azienda Ospedaliero-Universitaria Policlinico di Bari
WITHDRAWNBari, 70124, Italy
-
Azienda Ospedaliero-Universitaria di Cagliari Presidio di Monserrato
RECRUITINGMonserrato, CA, 09032, Italy
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Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant'Anna
RECRUITINGCona, Ferrara, 44124, Italy
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Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) - Ospedale di Cattinara
RECRUITINGTrieste, 34128, Italy
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
RECRUITINGMilan, 20122, Italy
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Fondazione IRCCS Policlinico San Matteo
RECRUITINGPavia, 27100, Italy
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IRCCS Casa Sollievo della Sofferenza
RECRUITINGSan Giovanni Rotondo, Foggia, Italy
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IRCCS Humanitas Research Hospital
RECRUITINGRozzano, Milano, 20089, Italy
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IRCCS Ospedale San Raffaele
NOT_YET_RECRUITINGMilan, Italy
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Policlinico Tor Vergata
NOT_YET_RECRUITINGRoma, 00133, Italy
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Policlinico Umberto I - Sapienza Università di Roma
RECRUITINGRoma, 00161, Italy
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Policlinico di Modena - AOU di Modena
NOT_YET_RECRUITINGModena, 41124, Italy
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