New hope for Hard-to-Treat lymphoma: experimental drug surovatamig enters phase 2 trial

NCT ID NCT06526793

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This Phase 2 trial is testing an investigational drug called surovatamig (AZD0486) in adults with relapsed or refractory B-cell non-Hodgkin lymphoma, including follicular lymphoma and large B-cell lymphoma. Participants must have tried at least two prior treatments. The study aims to see how well the drug shrinks tumors and how safe it is. About 270 people will take part across multiple centers worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Surovatamig (AZD0486), an investigational drug given by intravenous infusion
What this could lead to: If successful, this could provide a new treatment option for people with relapsed or refractory B-cell non-Hodgkin lymphoma who have run out of standard therapies.
What could go wrong: This is an early Phase 2 study with no placebo group, so results are preliminary. The drug may cause serious side effects, and not all participants may respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm B-cell non-Hodgkin lymphoma follicular lymphoma large B-cell lymphoma non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL NON-HODGKIN LYMPHOMA FOLLICULAR LYMPHOMA (FL) LARGE B-CELL LYMPHOMA (LBCL)

Contacts and locations

Locations

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Phoenix, Arizona, 85054, United States
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Duarte, California, 91010, United States
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Jacksonville, Florida, 32224, United States
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Tampa, Florida, 33612, United States
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Chicago, Illinois, 60637, United States
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Iowa City, Iowa, 52242, United States
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Waukee, Iowa, 50263, United States
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Overland Park, Kansas, 66204, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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New Brunswick, New Jersey, 08901, United States
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New York, New York, 10016, United States
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Charlotte, North Carolina, 28204, United States
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Columbus, Ohio, 43210, United States
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Portland, Oregon, 97239, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 78704, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78229, United States
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Milwaukee, Wisconsin, 53226, United States
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Heidelberg, 3084, Australia
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Kogarah, NSW 2217, Australia
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Macquarie University, 2109, Australia
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Nedlands, 6009, Australia
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Porto Alegre, 90035903, Brazil
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São Paulo, 01401-002, Brazil
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São Paulo, 05652-900, Brazil
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Barrie, Ontario, L4M 6M2, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Chengdu, 610041, China
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Chengdu, 610072, China
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Guangzhou, 510060, China
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Nanchang, 330029, China
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Nanjing, 210029, China
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Nantong, 226001, China
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Shandong, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Tianjin, 300020, China
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Zhengzhou, 450008, China
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Aalborg, 9100, Denmark
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Copenhagen, 2100, Denmark
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Vejle, 7100, Denmark
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Montpellier, 34295, France
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Paris, 75010, France
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Pierre-Bénite, 69495, France
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Rouen, 76038, France
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Berlin, 10967, Germany
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Chemnitz, 9116, Germany
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Essen, 45147, Germany
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Jena, 07747, Germany
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Würzburg, 97080, Germany
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Hong Kong, 999077, Hong Kong
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Shatin, Hong Kong
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Alessandria, 15121, Italy
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Bologna, 40138, Italy
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Busto Arsizio, 21052, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Roma, 161, Italy
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Chiba, 260-8717, Japan
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Kashiwa, 277-8577, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-0008, Japan
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Niigata, 951-8520, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Yokohama, 241-8515, Japan
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Seoul, 03080, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 3722, South Korea
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Seoul, 5505, South Korea
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Barcelona, 08035, Spain
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Madrid, 28040, Spain
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Pozuelo de Alarcón, 28223, Spain
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Gothenburg, 41345, Sweden
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Stockholm, 17176, Sweden
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 833401, Taiwan
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Taichung, 404, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 106, Taiwan
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London, SE5 9RS, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Norwich, NR4 7UY, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Plymouth, PL6 8DH, United Kingdom

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