New drug combo aims to extend life in bile duct cancer

NCT ID NCT07221253

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This global Phase 3 trial is testing whether adding the experimental immunotherapy rilvegostomig to standard chemotherapy helps people with advanced biliary tract cancer live longer, compared to adding the approved drug durvalumab. About 1,100 participants with inoperable or metastatic cancer will receive one of the two combinations. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rilvegostomig (AZD2936) and durvalumab (IMFINZI), both given with chemotherapy (gemcitabine/cisplatin)
What this could lead to: If successful, this could provide a new first-line treatment option that extends survival for people with advanced biliary tract cancer.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. Adding immunotherapy to chemo may increase side effects, and the benefit over current treatments may be modest or absent.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer Biliary Tract Neoplasms extrahepatic bile duct carcinoma gallbladder carcinoma gallbladder neoplasm intrahepatic cholangiocarcinoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT CANCER

Contacts and locations

Locations

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Birmingham, Alabama, 35205, United States
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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85719, United States
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Duarte, California, 91010, United States
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Orange, California, 92868, United States
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Palo Alto, California, 94304, United States
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Santa Monica, California, 90404, United States
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Aurora, Colorado, 80045, United States
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Hartford, Connecticut, 06102, United States
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New Haven, Connecticut, 06510, United States
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Washington D.C., District of Columbia, 20007, United States
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Washington D.C., District of Columbia, 20037, United States
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Gainesville, Florida, 32610, United States
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Jacksonville, Florida, 32224, United States
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Marietta, Georgia, 30060, United States
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Chicago, Illinois, 60612, United States
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Chicago, Illinois, 60637, United States
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Indianapolis, Indiana, 46202, United States
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Louisville, Kentucky, 40217, United States
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Baltimore, Maryland, 21231, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48202, United States
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Rochester, Minnesota, 55905, United States
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Omaha, Nebraska, 68198-5885, United States
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Santa Fe, New Mexico, 87505, United States
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New York, New York, 10016, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Portland, Oregon, 97239, United States
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Lancaster, Pennsylvania, 17601, United States
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Philadelphia, Pennsylvania, 19111, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Providence, Rhode Island, 02903, United States
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Pierre, South Dakota, 57501, United States
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Sioux Falls, South Dakota, 57105, United States
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Houston, Texas, 77030, United States
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Clayton, 3168, Australia
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Darlinghurst, 2010, Australia
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Gosford, 2250, Australia
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Murdoch, 6150, Australia
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Anderlecht, 1070, Belgium
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Edegem, 2650, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Roeselare, 8800, Belgium
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Barretos, 14784-400, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 91350-200, Brazil
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Ribeirão Preto, 14026-040, Brazil
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São Paulo, 01246-000, Brazil
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Vitória, 29043-272, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Vancouver, British Columbia, VSZ 4E6, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Beijing, 100020, China
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Beijing, 102218, China
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Changchun, 130021, China
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Changde, 415000, China
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Changsha, 410005, China
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Changsha, 410013, China
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Chengdu, 610078, China
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Fuzhou, 350005, China
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Guangzhou, 510515, China
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Hangzhou, 310022, China
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Hefei, 230001, China
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Kunming, 650101, China
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Lishui, 323000, China
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Luoyang, 471023, China
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Nanchang, 330000, China
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Nanning, 530000, China
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Shandong, China
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Shanghai, 200032, China
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Shenyang, 110016, China
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Weifang, 261000, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Clichy, 92118, France
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Grenoble, 38043, France
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Marseille, 13385, France
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Vandœuvre-lès-Nancy, 54511, France
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Aachen, 52074, Germany
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Berlin, 10365, Germany
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Berlin, 13353, Germany
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Bonn, 53127, Germany
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Düsseldorf, 40225, Germany
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Essen, 45122, Germany
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Frankfurt, 60488, Germany
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Freiburg im Breisgau, 79106, Germany
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Hamburg, 20249, Germany
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Hamburg, 22763, Germany
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Heidelberg, 69120, Germany
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Heilbronn, 74078, Germany
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Karlsruhe, 76133, Germany
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Magdeburg, 39120, Germany
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München, 81675, Germany
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München, 81737, Germany
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Ulm, 89081, Germany
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Delhi, 110029, India
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Hyderabad, 500032, India
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Kolhāpur, 416234, India
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Kolkata, 700063, India
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Mumbai, 400012, India
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Nashik, 422002, India
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Surat, 395002, India
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Castellana Grotte, 70013, Italy
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Milan, 20132, Italy
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Pisa, 56126, Italy
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Rome, 00168, Italy
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Rozzano, 20089, Italy
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Chiba, 260-8717, Japan
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Kashiwa, 227-8577, Japan
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Kawasaki-shi, 216-8511, Japan
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Kōtoku, 135-8550, Japan
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Matsuyama, 790-0024, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 466-8560, Japan
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Osaka, 541-8567, Japan
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Suita-shi, 565-0871, Japan
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Takatsuki-shi, 569-8686, Japan
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Ube, 755-8505, Japan
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Yokohama, 241-8515, Japan
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Amsterdam, 1081 HV, Netherlands
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Groningen, 9713 GZ, Netherlands
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Maastricht, 6202 AZ, Netherlands
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Utrecht, 3584 CX, Netherlands
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Koszalin, 75-581, Poland
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Krakow, 31-501, Poland
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Lodz, 92-213, Poland
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Olsztyn, 10-228, Poland
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Warsaw, 02-034, Poland
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Busan, 48108, South Korea
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Daegu, 41404, South Korea
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Seongnam-si, 13496, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barcelona, 08036, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28007, Spain
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Madrid, 28040, Spain
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Santander, 39008, Spain
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, 833, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 34000, Thailand
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Ongkharak, 26120, Thailand
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Ankara, 06100, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Seyhan, 1060, Turkey (Türkiye)
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Birmingham, B15 2GW, United Kingdom
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Glasgow, G12 OYN, United Kingdom
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Greater London, SW3 6JJ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, NW3 2QG, United Kingdom
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Manchester, M20 4BX, United Kingdom

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