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New hope for liver cancer: Triple-Drug trial launches

NCT ID NCT06921785

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 04, 2026 · Updated 5 times

Summary

This large Phase 3 trial is testing whether a new drug called rilvegostomig, combined with bevacizumab and with or without tremelimumab, can help people with advanced liver cancer live longer. About 1,220 participants who cannot have surgery or other local treatments will be randomly assigned to one of three treatment groups. The study compares these new combinations to the current standard treatment (atezolizumab plus bevacizumab).

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
rilvegostomig, bevacizumab, tremelimumab, atezolizumab
What this could lead to
If successful, this could offer a new first-line treatment option for people with advanced liver cancer, potentially improving survival.
What could go wrong
This is an early-stage Phase 3 trial, so results are not guaranteed. The combination may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,220 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Mar 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Locally advanced or metastatic and/or unresectable HCC * WHO/ECOG performance status of 0 or 1 * BCLC stage B (that is not eligible for locoregional therapy) or stage C. * Child-Pugh Score class A * At least one measurable target lesion * Participants with active HBV infection must receive antiviral therapy for a minimum of 14 days prior to randomization to show evidence of HBV stabilization or signs of viral response. * Participants with active HCV infection must be well controlled. Participants co-infected with HBV and HCV are not eligible. * Adequate organ and bone marrow function measured during the screening period. * Adequate organ and bone marrow function measured during the screening period * Must not have received prior systemic therapy for intermediate, advanced, or metastatic HCC. * Disease that is not amenable to curative surgical and/or locoregional therapies. For participants who received locoregional therapy for HCC, locoregional therapy must have been completed ≥ 28 days prior to the baseline scan for the current study. Exclusion Criteria: Medical condition * Any evidence of uncontrolled intercurrent diseases * Active or prior documented autoimmune or inflammatory disorders requiring chronic treatment with steroids or other immunosuppressive treatment * History of another primary malignancy * Persistent toxicities caused by previous anti-cancer therapy excluding alopecia, not yet improved to Grade ≤ 1 or baseline. * Clinically meaningful ascites, pleural effusion, or pericardial effusion requiring non-pharmacologic intervention to maintain symptomatic control within 6 months prior to the first scheduled dose. * History of active primary immunodeficiency or active infection * History of hepatic encephalopathy * Current or recent (within 10 days of first dose of study treatment) use of aspirin (≥ 325 mg/day) or treatment with dipyridamole, ticlopidine, clopidogrel, and cilostazol * Current or recent (within 10 days prior to study treatment start) use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic (as opposed to prophylactic) purposes is ineligible * History of significant bleeding disorders, vasculitis, or a significant bleeding episode from the GI tract within 6 months prior to study randomization. * Participants with untreated or incompletely treated varices with bleeding or high-risk (red wale signs or other high-risk factors) for bleeding. HCC related * Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC. * Central nervous system metastases or spinal cord compression (including asymptomatic and adequately treated disease) * Prior treatment with anti-CTLA-4 and/or anti-TIGIT. * Radiotherapy within 28 days and abdominal/ pelvic radiotherapy within 60 days prior to initiation of study treatment, except palliative radiotherapy to bone lesions within 7 days prior to initiation of study treatment

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hepatocellular carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    207 sites in 20 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Research Site

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Research Site

    RECRUITING

    Tucson, Arizona, 85719, United States

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    Los Angeles, California, 90095, United States

  • Research Site

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    Palo Alto, California, 94304, United States

  • Research Site

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    New Haven, Connecticut, 06520, United States

  • Research Site

    RECRUITING

    Newark, Delaware, 19713, United States

  • Research Site

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Research Site

    NOT_YET_RECRUITING

    Orlando, Florida, 32804, United States

  • Research Site

    RECRUITING

    Atlanta, Georgia, 30318, United States

  • Research Site

    WITHDRAWN

    Atlanta, Georgia, 30322, United States

  • Research Site

    WITHDRAWN

    Honolulu, Hawaii, 96813, United States

  • Research Site

    RECRUITING

    Chicago, Illinois, 60637, United States

  • Research Site

    NOT_YET_RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Research Site

    NOT_YET_RECRUITING

    Shreveport, Louisiana, 71103, United States

  • Research Site

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Research Site

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • Research Site

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Research Site

    NOT_YET_RECRUITING

    St Louis, Missouri, 63110, United States

  • Research Site

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Research Site

    RECRUITING

    New York, New York, 10029, United States

  • Research Site

    RECRUITING

    New York, New York, 10032, United States

  • Research Site

    NOT_YET_RECRUITING

    New York, New York, 10065, United States

  • Research Site

    WITHDRAWN

    Cleveland, Ohio, 44195, United States

  • Research Site

    NOT_YET_RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Research Site

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Research Site

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Research Site

    RECRUITING

    Amarillo, Texas, 79124, United States

  • Research Site

    RECRUITING

    Austin, Texas, 78705, United States

  • Research Site

    WITHDRAWN

    Dallas, Texas, 75390, United States

  • Research Site

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    Houston, Texas, 77030, United States

  • Research Site

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    San Antonio, Texas, 78240, United States

  • Research Site

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    Tyler, Texas, 75702, United States

  • Research Site

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    Arlington, Virginia, 22201, United States

  • Research Site

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    Salem, Virginia, 24153, United States

  • Research Site

    RECRUITING

    Seattle, Washington, 98101, United States

  • Research Site

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    Milwaukee, Wisconsin, 53226, United States

  • Research Site

    RECRUITING

    Auchenflower, 4066, Australia

  • Research Site

    RECRUITING

    Camperdown, 2050, Australia

  • Research Site

    NOT_YET_RECRUITING

    Clayton, 3168, Australia

  • Research Site

    RECRUITING

    Heidelberg, 3084, Australia

  • Research Site

    RECRUITING

    Randwick, 2031, Australia

  • Research Site

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    Barretos, 14784-400, Brazil

  • Research Site

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    Porto Alegre, 91350-200, Brazil

  • Research Site

    RECRUITING

    Santa Maria, 97015-450, Brazil

  • Research Site

    RECRUITING

    São Paulo, 04014-002, Brazil

  • Research Site

    RECRUITING

    São Paulo, 05652-9000, Brazil

  • Research Site

    RECRUITING

    Vitória, 29043-272, Brazil

  • Research Site

    RECRUITING

    Edmonton, Alberta, T6G 1Z2, Canada

  • Research Site

    NOT_YET_RECRUITING

    Halifax, Nova Scotia, B3H 1V7, Canada

  • Research Site

    RECRUITING

    Barrie, Ontario, L4M 6M2, Canada

  • Research Site

    RECRUITING

    Brampton, Ontario, L6R 3J7, Canada

  • Research Site

    NOT_YET_RECRUITING

    Cambridge, Ontario, N1R 3G2, Canada

  • Research Site

    WITHDRAWN

    Ottawa, Ontario, K1H 8L6, Canada

  • Research Site

    RECRUITING

    Toronto, Ontario, M5G 1X6, Canada

  • Research Site

    RECRUITING

    Montreal, Quebec, H2X 0A9, Canada

  • Research Site

    RECRUITING

    Québec, Quebec, G1J 1Z4, Canada

  • Research Site

    RECRUITING

    Beijing, 100034, China

  • Research Site

    RECRUITING

    Beijing, 100142, China

  • Research Site

    NOT_YET_RECRUITING

    Beijing, CN-100730, China

  • Research Site

    RECRUITING

    Changchun, 130021, China

  • Research Site

    RECRUITING

    Changsha, 410013, China

  • Research Site

    RECRUITING

    Chengdu, 610041, China

  • Research Site

    RECRUITING

    Chifeng, 024000, China

  • Research Site

    RECRUITING

    Chongqing, 400010, China

  • Research Site

    RECRUITING

    Deyang, 618000, China

  • Research Site

    RECRUITING

    Fuzhou, 350005, China

  • Research Site

    RECRUITING

    Guangzhou, 510060, China

  • Research Site

    RECRUITING

    Guangzhou, 510515, China

  • Research Site

    RECRUITING

    Guiyang, 550002, China

  • Research Site

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    Harbin, 150081, China

  • Research Site

    RECRUITING

    Hefei, 230022, China

  • Research Site

    RECRUITING

    Hohhot, 010020, China

  • Research Site

    NOT_YET_RECRUITING

    Kunming, 650118, China

  • Research Site

    RECRUITING

    Linyi, 276000, China

  • Research Site

    RECRUITING

    Lishui, 323000, China

  • Research Site

    RECRUITING

    Luoyang, 471000, China

  • Research Site

    RECRUITING

    Nanchang, 330008, China

  • Research Site

    RECRUITING

    Nanchang, 330029, China

  • Research Site

    RECRUITING

    Nanjing, 210029, China

  • Research Site

    RECRUITING

    Nanning, 530021, China

  • Research Site

    RECRUITING

    Nantong, 226361, China

  • Research Site

    RECRUITING

    Neijiang, 641100, China

  • Research Site

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    Shandong, China

  • Research Site

    RECRUITING

    Shanghai, 201114, China

  • Research Site

    RECRUITING

    Shenyang, 110004, China

  • Research Site

    NOT_YET_RECRUITING

    Shenyang, 110042, China

  • Research Site

    RECRUITING

    Weifang, 261000, China

  • Research Site

    RECRUITING

    Wenzhou, 325000, China

  • Research Site

    RECRUITING

    Wuhan, 430079, China

  • Research Site

    RECRUITING

    Xi'an, 710100, China

  • Research Site

    RECRUITING

    Zhengzhou, 450008, China

  • Research Site

    RECRUITING

    Clichy, 92118, France

  • Research Site

    RECRUITING

    Lille, 59000, France

  • Research Site

    RECRUITING

    Lyon, 69317, France

  • Research Site

    NOT_YET_RECRUITING

    Montpellier, 34090, France

  • Research Site

    RECRUITING

    Nantes, 44093, France

  • Research Site

    RECRUITING

    Nice, 06200, France

  • Research Site

    RECRUITING

    Pessac, 33604, France

  • Research Site

    RECRUITING

    Rennes, 35000, France

  • Research Site

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    Toulouse, 31059, France

  • Research Site

    RECRUITING

    Aachen, 52074, Germany

  • Research Site

    RECRUITING

    Berlin, 13353, Germany

  • Research Site

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    Bonn, 53127, Germany

  • Research Site

    RECRUITING

    Dortmund, 44137, Germany

  • Research Site

    RECRUITING

    Dresden, 01307, Germany

  • Research Site

    RECRUITING

    Essen, 45122, Germany

  • Research Site

    RECRUITING

    Frankfurt, 60488, Germany

  • Research Site

    RECRUITING

    Frankfurt, 60590, Germany

  • Research Site

    SUSPENDED

    Göttingen, 37075, Germany

  • Research Site

    NOT_YET_RECRUITING

    Hamburg, 20246, Germany

  • Research Site

    RECRUITING

    Hanover, 30623, Germany

  • Research Site

    RECRUITING

    Leipzig, 4103, Germany

  • Research Site

    RECRUITING

    Lübeck, 23538, Germany

  • Research Site

    RECRUITING

    Magdeburg, 39120, Germany

  • Research Site

    RECRUITING

    Moers, 47441, Germany

  • Research Site

    RECRUITING

    München, 81377, Germany

  • Research Site

    WITHDRAWN

    Regensburg, 93053, Germany

  • Research Site

    RECRUITING

    Ulm, 89081, Germany

  • Research Site

    RECRUITING

    Hong Kong, 999077, Hong Kong

  • Research Site

    RECRUITING

    Ahmedabad, 380058, India

  • Research Site

    WITHDRAWN

    Bangalore, 560027, India

  • Research Site

    NOT_YET_RECRUITING

    Binnāguri, 734015, India

  • Research Site

    NOT_YET_RECRUITING

    Dehradun, 248016, India

  • Research Site

    NOT_YET_RECRUITING

    Delhi, 110029, India

  • Research Site

    NOT_YET_RECRUITING

    Hyderabad, 500032, India

  • Research Site

    NOT_YET_RECRUITING

    Mumbai, 400012, India

  • Research Site

    NOT_YET_RECRUITING

    Nashik, 422011, India

  • Research Site

    RECRUITING

    Vadodara, 391760, India

  • Research Site

    RECRUITING

    Bologna, 40138, Italy

  • Research Site

    RECRUITING

    Milan, 20132, Italy

  • Research Site

    RECRUITING

    Milan, 20162, Italy

  • Research Site

    RECRUITING

    Palermo, 90127, Italy

  • Research Site

    RECRUITING

    Perugia, 06132, Italy

  • Research Site

    RECRUITING

    Pisa, 56126, Italy

  • Research Site

    RECRUITING

    Roma, 00168, Italy

  • Research Site

    RECRUITING

    Rozzano, 20089, Italy

  • Research Site

    RECRUITING

    Bunkyō City, 113-8655, Japan

  • Research Site

    RECRUITING

    Chiba, 260-8677, Japan

  • Research Site

    RECRUITING

    Fukuoka, 811-1395, Japan

  • Research Site

    RECRUITING

    Hiroshima, 734-8530, Japan

  • Research Site

    RECRUITING

    Hiroshima, 734-8551, Japan

  • Research Site

    RECRUITING

    Iizuka-shi, 820-8505, Japan

  • Research Site

    RECRUITING

    Kashiwa, 227-8577, Japan

  • Research Site

    RECRUITING

    Kita-gun, 761-0793, Japan

  • Research Site

    RECRUITING

    Kobe, 650-0017, Japan

  • Research Site

    RECRUITING

    Kōtoku, 135-8550, Japan

  • Research Site

    RECRUITING

    Kumamoto, 860-8556, Japan

  • Research Site

    RECRUITING

    Kurume-shi, 830-0011, Japan

  • Research Site

    RECRUITING

    Kyoto, 602-8566, Japan

  • Research Site

    RECRUITING

    Matsuyama, 790-0024, Japan

  • Research Site

    RECRUITING

    Mitaka-shi, 181-8611, Japan

  • Research Site

    RECRUITING

    Morioka, 028-3695, Japan

  • Research Site

    RECRUITING

    Musashino-shi, 180-8610, Japan

  • Research Site

    RECRUITING

    Nagoya, 464-8681, Japan

  • Research Site

    RECRUITING

    Okayama, 700-8558, Japan

  • Research Site

    RECRUITING

    Osaka, 541-8567, Japan

  • Research Site

    RECRUITING

    Osakasayama-shi, 589-8511, Japan

  • Research Site

    RECRUITING

    Saga, 849-8501, Japan

  • Research Site

    RECRUITING

    Sapporo, 006-8555, Japan

  • Research Site

    RECRUITING

    Sendai, 981-0914, Japan

  • Research Site

    RECRUITING

    Suita-shi, 565-0871, Japan

  • Research Site

    RECRUITING

    Tokyo, 104-0045, Japan

  • Research Site

    RECRUITING

    Toyoake-shi, 470-1192, Japan

  • Research Site

    RECRUITING

    Tsu, 514-8507, Japan

  • Research Site

    RECRUITING

    Yokohama, 232-0024, Japan

  • Research Site

    RECRUITING

    Yokohama, 241-8515, Japan

  • Research Site

    RECRUITING

    Amsterdam, 1081HV, Netherlands

  • Research Site

    RECRUITING

    Groningen, 9700 RB, Netherlands

  • Research Site

    RECRUITING

    Maastricht, 6229 HX, Netherlands

  • Research Site

    WITHDRAWN

    Rotterdam, 3015 GD, Netherlands

  • Research Site

    SUSPENDED

    Utrecht, 3584 CX, Netherlands

  • Research Site

    RECRUITING

    Gdansk, 80-214, Poland

  • Research Site

    RECRUITING

    Koszalin, 75-581, Poland

  • Research Site

    RECRUITING

    Lublin, 20-090, Poland

  • Research Site

    RECRUITING

    Olsztyn, 10-228, Poland

  • Research Site

    RECRUITING

    Warsaw, 02-034, Poland

  • Research Site

    RECRUITING

    Busan, 48108, South Korea

  • Research Site

    NOT_YET_RECRUITING

    Goyang-si, 410-769, South Korea

  • Research Site

    NOT_YET_RECRUITING

    Gyeonggi-do, 13620, South Korea

  • Research Site

    RECRUITING

    Seongnam-si, 463-712, South Korea

  • Research Site

    NOT_YET_RECRUITING

    Seoul, 03080, South Korea

  • Research Site

    RECRUITING

    Seoul, 03722, South Korea

  • Research Site

    RECRUITING

    Seoul, 06351, South Korea

  • Research Site

    RECRUITING

    Seoul, 5505, South Korea

  • Research Site

    RECRUITING

    Barcelona, 08035, Spain

  • Research Site

    RECRUITING

    Barcelona, 08036, Spain

  • Research Site

    RECRUITING

    Madrid, 28007, Spain

  • Research Site

    RECRUITING

    Madrid, 28027, Spain

  • Research Site

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    Madrid, 28040, Spain

  • Research Site

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    Santander, 39008, Spain

  • Research Site

    RECRUITING

    Changhua, 500, Taiwan

  • Research Site

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    Kaohsiung City, 83301, Taiwan

  • Research Site

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    Taichung, 40447, Taiwan

  • Research Site

    RECRUITING

    Tainan, 70403, Taiwan

  • Research Site

    RECRUITING

    Tainan County, 71044, Taiwan

  • Research Site

    RECRUITING

    Taipei, 10002, Taiwan

  • Research Site

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    Taipei, 112, Taiwan

  • Research Site

    RECRUITING

    Taoyuan, 333, Taiwan

  • Research Site

    WITHDRAWN

    Bangkok, 10210, Thailand

  • Research Site

    RECRUITING

    Bangkok, 10700, Thailand

  • Research Site

    RECRUITING

    Chiang Mai, 50200, Thailand

  • Research Site

    RECRUITING

    Dusit, 10300, Thailand

  • Research Site

    RECRUITING

    Hat Yai, 90110, Thailand

  • Research Site

    RECRUITING

    Muang, 40002, Thailand

  • Research Site

    WITHDRAWN

    Ubonratchathani, 34000, Thailand

  • Research Site

    RECRUITING

    Altındağ, 06230, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Ankara, 06530, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Erzurum, 25240, Turkey (Türkiye)

  • Research Site

    WITHDRAWN

    Istanbul, 34180, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Izmir, 35100, Turkey (Türkiye)

  • Research Site

    NOT_YET_RECRUITING

    Cambridge, CB2 0QQ, United Kingdom

  • Research Site

    RECRUITING

    Leeds, LS9 7TF, United Kingdom

  • Research Site

    RECRUITING

    London, NW3 2QG, United Kingdom

  • Research Site

    RECRUITING

    London, SE5 9RS, United Kingdom

  • Research Site

    RECRUITING

    London, W12 0HS, United Kingdom

  • Research Site

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • Research Site

    RECRUITING

    Hanoi, 100000, Vietnam

  • Research Site

    WITHDRAWN

    Hanoi, 100000, Vietnam

  • Research Site

    RECRUITING

    Ho Chi Minh City, 700000, Vietnam

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