New hope for liver cancer: Triple-Drug trial launches

NCT ID NCT06921785

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This large Phase 3 trial is testing whether a new drug called rilvegostomig, combined with bevacizumab and with or without tremelimumab, can help people with advanced liver cancer live longer. About 1,220 participants who cannot have surgery or other local treatments will be randomly assigned to one of three treatment groups. The study compares these new combinations to the current standard treatment (atezolizumab plus bevacizumab).

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rilvegostomig, bevacizumab, tremelimumab, atezolizumab
What this could lead to: If successful, this could offer a new first-line treatment option for people with advanced liver cancer, potentially improving survival.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The combination may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85719, United States
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Los Angeles, California, 90095, United States
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Palo Alto, California, 94304, United States
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New Haven, Connecticut, 06520, United States
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Newark, Delaware, 19713, United States
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Jacksonville, Florida, 32224, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Honolulu, Hawaii, 96813, United States
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Chicago, Illinois, 60637, United States
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Indianapolis, Indiana, 46202, United States
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Shreveport, Louisiana, 71103, United States
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Detroit, Michigan, 48202, United States
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Grand Rapids, Michigan, 49503, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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New Brunswick, New Jersey, 08901, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Cleveland, Ohio, 44195, United States
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Oklahoma City, Oklahoma, 73104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Amarillo, Texas, 79124, United States
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Austin, Texas, 78705, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78240, United States
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Tyler, Texas, 75702, United States
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Arlington, Virginia, 22201, United States
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Salem, Virginia, 24153, United States
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Seattle, Washington, 98101, United States
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Milwaukee, Wisconsin, 53226, United States
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Auchenflower, 4066, Australia
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Camperdown, 2050, Australia
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Clayton, 3168, Australia
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Heidelberg, 3084, Australia
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Shatin, 00000, Australia
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Barretos, 14784-400, Brazil
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Porto Alegre, 91350-200, Brazil
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Santa Maria, 97015-450, Brazil
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São Paulo, 04014-002, Brazil
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São Paulo, 05652-9000, Brazil
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Vitória, 29043-272, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Cambridge, Ontario, N1R 3G2, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Beijing, 100034, China
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Beijing, 100142, China
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Beijing, CN-100730, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chifeng, 024000, China
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Chongqing, 400010, China
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Deyang, 618000, China
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Fuzhou, 350005, China
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Guangzhou, 510060, China
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Guangzhou, 510515, China
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Guiyang, 550002, China
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Harbin, 150081, China
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Hefei, 230022, China
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Hohhot, 010020, China
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Kunming, 650118, China
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Linyi, 276000, China
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Lishui, 323000, China
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Luoyang, 471000, China
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Nanchang, 330008, China
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Nanchang, 330029, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Nantong, 226361, China
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Neijiang, 641100, China
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Shandong, China
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Shanghai, 201114, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Weifang, 261000, China
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Wenzhou, 325000, China
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Wuhan, 430079, China
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Xi'an, 710100, China
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Zhengzhou, 450008, China
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Clichy, 92118, France
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Lille, 59000, France
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Lyon, 69317, France
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Montpellier, 34090, France
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Nantes, 44093, France
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Nice, 06200, France
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Pessac, 33604, France
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Rennes, 35000, France
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Toulouse, 31059, France
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Aachen, 52074, Germany
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Berlin, 13353, Germany
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Bonn, 53127, Germany
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Dortmund, 44137, Germany
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Dresden, 01307, Germany
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Essen, 45122, Germany
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Frankfurt, 60488, Germany
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Frankfurt, 60590, Germany
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Göttingen, 37075, Germany
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Hamburg, 20246, Germany
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Hanover, 30623, Germany
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Leipzig, 4103, Germany
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Lübeck, 23538, Germany
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Magdeburg, 39120, Germany
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Moers, 47441, Germany
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München, 81377, Germany
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Regensburg, 93053, Germany
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Ulm, 89081, Germany
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Hong Kong, 999077, Hong Kong
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Shatin, 00000, Hong Kong
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Ahmedabad, 380058, India
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Bangalore, 560027, India
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Binnāguri, 734015, India
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Dehradun, 248016, India
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Delhi, 110029, India
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Hyderabad, 500032, India
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Mumbai, 400012, India
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Nashik, 422011, India
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Vadodara, 391760, India
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Bologna, 40138, Italy
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Milan, 20132, Italy
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Milan, 20162, Italy
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Palermo, 90127, Italy
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Perugia, 06132, Italy
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Pisa, 56126, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Bunkyō City, 113-8655, Japan
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Chiba, 260-8677, Japan
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Fukuoka, 811-1395, Japan
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Hiroshima, 734-8530, Japan
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Hiroshima, 734-8551, Japan
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Iizuka-shi, 820-8505, Japan
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Kashiwa, 227-8577, Japan
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Kita-gun, 761-0793, Japan
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Kobe, 650-0017, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 602-8566, Japan
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Matsuyama, 790-0024, Japan
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Mitaka-shi, 181-8611, Japan
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Morioka, 028-3695, Japan
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Musashino-shi, 180-8610, Japan
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Nagoya, 464-8681, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Osakasayama-shi, 589-8511, Japan
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Saga, 849-8501, Japan
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Sapporo, 006-8555, Japan
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Sendai, 981-0914, Japan
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Suita-shi, 565-0871, Japan
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Tokyo, 104-0045, Japan
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Toyoake-shi, 470-1192, Japan
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Tsu, 514-8507, Japan
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Yokohama, 232-0024, Japan
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Yokohama, 241-8515, Japan
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Amsterdam, 1081HV, Netherlands
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Groningen, 9700 RB, Netherlands
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Maastricht, 6229 HX, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Utrecht, 3584 CX, Netherlands
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Gdansk, 80-214, Poland
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Koszalin, 75-581, Poland
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Lublin, 20-090, Poland
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Olsztyn, 10-228, Poland
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Warsaw, 02-034, Poland
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Busan, 48108, South Korea
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Goyang-si, 410-769, South Korea
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Gyeonggi-do, 13620, South Korea
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Seongnam-si, 463-712, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 5505, South Korea
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Madrid, 28007, Spain
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Madrid, 28027, Spain
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Madrid, 28040, Spain
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Santander, 39008, Spain
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Changhua, 500, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 70403, Taiwan
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Tainan County, 71044, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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Muang, 40002, Thailand
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Ubonratchathani, 34000, Thailand
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Altındağ, 06230, Turkey (Türkiye)
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Ankara, 06530, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Istanbul, 34180, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Cambridge, CB2 0QQ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE5 9RS, United Kingdom
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London, W12 0HS, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Hanoi, 100000, Vietnam
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

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