New lung cancer drug rilvegostomig takes on pembrolizumab in major trial

NCT ID NCT06868277

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 24 times

Summary

This study compares a new drug, rilvegostomig, to the current standard treatment, pembrolizumab, for people with advanced non-small cell lung cancer that has high levels of PD-L1. The goal is to see if the new drug works better at helping people live longer or stopping the cancer from growing. About 830 participants will receive either rilvegostomig or pembrolizumab as their first treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Study contacts

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Locations

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La Mesa, California, 91942, United States
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Los Alamitos, California, 90720, United States
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Newark, Delaware, 19713, United States
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Bay Pines, Florida, 33744, United States
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Clearwater, Florida, 33756, United States
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St. Petersburg, Florida, 33705, United States
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Marietta, Georgia, 30060, United States
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Chicago, Illinois, 60612, United States
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Decatur, Illinois, 62526, United States
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Des Moines, Iowa, 50309, United States
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Waterloo, Iowa, 50702, United States
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Leawood, Kansas, 66209, United States
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Lexington, Kentucky, 40536, United States
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Owensboro, Kentucky, 42303, United States
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Bethesda, Maryland, 20817, United States
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Frederick, Maryland, 21702, United States
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Silver Spring, Maryland, 20910, United States
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Towson, Maryland, 21204, United States
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Bridgeton, Missouri, 63044, United States
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Lincoln, Nebraska, 68506, United States
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Paramus, New Jersey, 07652, United States
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Buffalo, New York, 14215, United States
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East Syracuse, New York, 13057, United States
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Fresh Meadows, New York, 11366, United States
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Rochester, New York, 14642, United States
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Westbury, New York, 11590, United States
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Canton, Ohio, 44718, United States
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Fountain Hill, Pennsylvania, 18015, United States
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Kittanning, Pennsylvania, 16201, United States
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Philadelphia, Pennsylvania, 19104, United States
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Round Rock, Texas, 78665, United States
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Aberdeen, Washington, 98520, United States
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Renton, Washington, 98055, United States
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Charleston, West Virginia, 25304, United States
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Morgantown, West Virginia, 26506, United States
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CABA, 1425, Argentina
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Córdoba, 5000, Argentina
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Pilar, B1629AHJ, Argentina
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Rosario, 2000, Argentina
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Rosario, S2000CVB, Argentina
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Viedma, R8500ACE, Argentina
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WITHDRAWN

Hobart, 7000, Australia
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Woolloongabba, 4102, Australia
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Edegem, 2650, Belgium
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Jette, 1090, Belgium
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Libramont-Chevigny, 6800, Belgium
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Liège, 4000, Belgium
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Mechelen, 2800, Belgium
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Roeselaere, 8800, Belgium
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Blumenau, 89010-340, Brazil
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Fortaleza, 60336-550, Brazil
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Ijuí, 98700-000, Brazil
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Itajaí, 88301-220, Brazil
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Londrina, 86015-520, Brazil
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Passo Fundo, 99010-260, Brazil
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Porto Alegre, 90035-903, Brazil
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Porto Alegre, 90610-000, Brazil
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Porto Velho, 76834-899, Brazil
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Salvador, 41253-190, Brazil
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Salvador, 41950-640, Brazil
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Santo André, 09060-650, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 04501-000, Brazil
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Teresina, 64049-200, Brazil
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Burgas, 8000, Bulgaria
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Panagyurishte, 4500, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1618, Bulgaria
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Sofia, 1756, Bulgaria
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Varna, 9010, Bulgaria
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Edmonton, Alberta, T6G 1Z2, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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Cambridge, Ontario, N1R 3G2, Canada
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Newmarket, Ontario, L3Y 2P9, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Québec, Quebec, G1V 4G5, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Conception, 4070196, Chile
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Santiago, 7500653, Chile
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Santiago, 7500713, Chile
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Santiago, 8420383, Chile
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Baoding, 071000, China
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Beijing, 100021, China
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Beijing, 100142, China
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Beijing, 101149, China
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Bengbu, 233004, China
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Changchun, 130000, China
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Changchun, 130033, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400030, China
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Chongqing, 400042, China
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Fuzhou, 350001, China
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Fuzhou, 350014, China
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Guangzhou, 510080, China
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Haerbin, 150081, China
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Hangzhou, 310022, China
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Hefei, 133500, China
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Hefei, 230022, China
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Jiamusi, 154007, China
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Jinan, 250117, China
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Lanzhou, 730050, China
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Linyi, 276001, China
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Liuzhou, 545007, China
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Nanchang, 330006, China
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Nanchang, 330029, China
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Nanjing, 210006, China
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Nanjing, 210008, China
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Nanning, 530021, China
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Ningbo, 315010, China
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Qingdao, 266071, China
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Shanghai, 200092, China
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Shenyang, 110042, China
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Suzhou, 215004, China
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Taiyuan, 030000, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xuzhou, 221002, China
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Yantai, 264000, China
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Zhengzhou, 450008, China
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Cali, 760032, Colombia
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Floridablanca, 680001, Colombia
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Medellín, 050034, Colombia
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Valledupar, 200001, Colombia
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San José, 1000, Costa Rica
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San José, 10108, Costa Rica
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San José Capital, 1000, Costa Rica
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Santa Ana, 10903, Costa Rica
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Angers, 49100, France
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Avignon, 84000, France
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Boulogne-Billancourt, 92100, France
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Caen, 14000, France
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Chambéry, 73011, France
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Dijon, 21000, France
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La Tronche, 38700, France
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Limoges, 87042, France
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Nantes, 44093, France
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Paris, 75020, France
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Pau, 64046, France
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St-Malo, 35403, France
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Toulouse, 31300, France
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Tbilisi, 0112, Georgia
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Tbilisi, 0159, Georgia
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Tbilisi, 160, Georgia
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Tbilisi, 177, Georgia
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Amberg, 92224, Germany
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Augsburg, by, 86156, Germany
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Bad Saarow, 15526, Germany
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Berlin, 12351, Germany
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Berlin, 13359, Germany
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Bonn, 53127, Germany
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Braunschweig, 38114, Germany
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Essen, 45147, Germany
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Flensburg, 24939, Germany
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Frankfurt am Main, 60431, Germany
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Hamburg, 21075, Germany
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Heidelberg, 69126, Germany
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Heilbronn, 74078, Germany
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Immenhausen, 34376, Germany
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Koblenz, 56073, Germany
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Leipzig, 04103, Germany
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München, 80336, Germany
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Offenbach, 63069, Germany
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Oldenburg, 26121, Germany
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Remscheid, 42859, Germany
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Rotenburg (Wümme), 27356, Germany
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Schweinfurt, 97421, Germany
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Trier, 54292, Germany
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Velbert, 42551, Germany
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Wuppertal, 42283, Germany
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Würselen, 52146, Germany
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Würzburg, 97080, Germany
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Athens, 115 27, Greece
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Athens, 11527, Greece
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Athens, 12462, Greece
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Piraeus, 185 37, Greece
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Piraeus, 185 47, Greece
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Thessaloniki, 55236, Greece
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Thessaloniki, 55236, Greece
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Thessaloniki, 56429, Greece
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Thessaloniki, 57001, Greece
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Dublin, D07 R2WY, Ireland
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Dublin, D08 NHY1, Ireland
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Dublin, D09 V2N0, Ireland
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Dublin, D24 NR0A, Ireland
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Dublin, DO4YN63, Ireland
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Galway, H91 YR71, Ireland
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Afula, 1834111, Israel
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Beersheba, 8410101, Israel
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Hadera, 38100, Israel
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Haifa, 34362, Israel
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Haifa, 91096, Israel
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Jerusalem, 91031, Israel
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Jerusalem, 91120, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 64239, Israel
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Tel Aviv, 69710, Israel
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Candiolo, 10060, Italy
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Lecco, 23900, Italy
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Lucca, 55100, Italy
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Naples, 80131, Italy
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Peschiera del Garda, 37019, Italy
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Pisa, 56126, Italy
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Roma, 00144, Italy
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Torrette Di Ancona, 60126, Italy
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Udine, 33100, Italy
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Verona, 37126, Italy
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Akashi, 673-8558, Japan
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Bunkyō City, 113-8603, Japan
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Bunkyō City, 113-8677, Japan
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Fukuoka, 811-1395, Japan
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Fukuoka, 812-8582, Japan
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Hamamatsu, 431-3192, Japan
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Iwakuni-shi, 740-8510, Japan
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Izumi-shi, 594-0073, Japan
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Kashihara-shi, 634-8522, Japan
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Kobe, 650-0046, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 602-8566, Japan
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Matsuyama, 791-0280, Japan
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Nankoku-shi, 783-8505, Japan
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Niigata, 951-8566, Japan
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Osaka, 534-0021, Japan
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Sakaishi, 591-8555, Japan
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Sayama, 589-8511, Japan
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Sendai, 980-0873, Japan
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Shinagawa-ku, 142-8666, Japan
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Takarazuka-shi, 665-0827, Japan
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Toon-Shi, 791-0295, Japan
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Toyoake-shi, 470-1192, Japan
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Toyonaka-shi, 560-8552, Japan
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George Town, 10350, Malaysia
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Kota Bharu, 15586, Malaysia
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Kuala Lumpur, 50586, Malaysia
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Kuala Selangor, 62250, Malaysia
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Perai, 13700, Malaysia
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Alcabideche, 2755-009, Portugal
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Braga, 4710-243, Portugal
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Coimbra, 3000-075, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1500-650, Portugal
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Lisbon, 1769-001, Portugal
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Loures, 2674-514, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Porto, 4100-180, Portugal
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Porto, 4200-072, Portugal
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Porto, 4200-319, Portugal
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Bucharest, 010626, Romania
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Bucharest, 013812, Romania
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Bucharest, 022328, Romania
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Bucharest, 30167, Romania
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Craiova, 200385, Romania
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Craiova, 200542, Romania
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Iași, 700106, Romania
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Otopeni, 075100, Romania
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Piteşti, 110283, Romania
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Sibiu, 550253, Romania
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Timișoara, 300239, Romania
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Jinju, 52727, South Korea
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Seoul, 135-710, South Korea
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Seoul, 5505, South Korea
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Badajoz, 06080, Spain
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Badalona, 8916, Spain
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Barcelona, 08028, Spain
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Castellon, 12002, Spain
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Granada, 18016, Spain
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Jaén, 23007, Spain
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Lugo, 27003, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28050, Spain
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Málaga, 29010, Spain
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Oviedo, 33006, Spain
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Palma de Mallorca, 07198, Spain
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Valencia, 46015, Spain
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Vigo (Pontevedra), 36312, Spain
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NOT_YET_RECRUITING

Zaragoza, 50009, Spain
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Lausanne, 1011, Switzerland
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Ankara, 06010, Turkey (Türkiye)
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Bakırköy, 34147, Turkey (Türkiye)
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Çankaya, 06680, Turkey (Türkiye)
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İzmit, 41380, Turkey (Türkiye)
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Küçükçekmece, 34295, Turkey (Türkiye)
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Yüreğir, 01240, Turkey (Türkiye)
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Blackpool, FY3 8NR, United Kingdom
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Glasgow, G12 0YN, United Kingdom
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Guildford, GU2 7XX, United Kingdom
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Hull, HU16 5JQ, United Kingdom
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Oxford, OX4 6LB, United Kingdom
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Stevenage, SG1 4AB, United Kingdom

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG