New cocktail of drugs shows promise for tough stomach cancer
NCT ID NCT05702229
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial is testing several new drug combinations in people with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread. The study aims to see if these combinations can shrink tumors and keep them from growing for at least 6 months. About 163 participants will receive different combinations of immunotherapy and chemotherapy drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rilvegostomig, Volrustomig, FOLFOX, XELOX, AZD0901, 5-Fluorouracil, Capecitabine
- What this could lead to
- If successful, this could point toward more effective combination treatments for advanced gastric cancer, potentially improving tumor shrinkage and delaying disease progression.
- What could go wrong
- This is an early Phase 2 trial with a small number of participants, so results may not apply to all patients. The drug combinations may cause significant side effects or fail to show benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
RECRUITINGLos Angeles, California, 90017, United States
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Research Site
WITHDRAWNLos Angeles, California, 90095, United States
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Research Site
RECRUITINGBaton Rouge, Louisiana, 70817, United States
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Research Site
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Research Site
WITHDRAWNNew Hyde Park, New York, 11042, United States
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Research Site
WITHDRAWNNew York, New York, 10028, United States
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Research Site
RECRUITINGNew York, New York, 10065, United States
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Research Site
WITHDRAWNNew York, New York, 11210, United States
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Research Site
WITHDRAWNShirley, New York, 11967, United States
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Research Site
WITHDRAWNThe Bronx, New York, 10469, United States
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Research Site
WITHDRAWNPittsburgh, Pennsylvania, 15212, United States
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Research Site
RECRUITINGBeijing, 100142, China
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Research Site
RECRUITINGHangzhou, 310003, China
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Research Site
RECRUITINGHangzhou, 310020, China
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Research Site
RECRUITINGHarbin, 150081, China
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Research Site
RECRUITINGHefei, 230031, China
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Research Site
COMPLETEDKunming, 650118, China
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Research Site
RECRUITINGWuhan, 430079, China
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Research Site
RECRUITINGYinchuan, 750004, China
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Research Site
RECRUITINGZhengzhou, 450052, China
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Research Site
RECRUITINGChūōku, 104-0045, Japan
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Research Site
RECRUITINGKashiwa, 227-8577, Japan
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Research Site
RECRUITINGSunto-gun, 411-8777, Japan
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Research Site
RECRUITINGSeoul, 03080, South Korea
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Research Site
RECRUITINGSeoul, 03722, South Korea
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Research Site
RECRUITINGSeoul, 05505, South Korea
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Research Site
RECRUITINGSeoul, 06351, South Korea
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Research Site
RECRUITINGBarcelona, 08035, Spain
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Research Site
RECRUITINGElche(Alicante), 03202, Spain
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Research Site
RECRUITINGL'Hospitalet de Llobregat, 08908, Spain
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Research Site
RECRUITINGMadrid, 28007, Spain
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Research Site
RECRUITINGMadrid, 28040, Spain
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Research Site
RECRUITINGSantander, 39008, Spain
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Research Site
RECRUITINGHsinchu, 300, Taiwan
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Research Site
RECRUITINGKaohsiung City, 80756, Taiwan
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Research Site
RECRUITINGTaichung, 404, Taiwan
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Research Site
RECRUITINGTainan, 70403, Taiwan
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Research Site
RECRUITINGTaipei, 10002, Taiwan
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Research Site
RECRUITINGTaipei, 11259, Taiwan
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Research Site
RECRUITINGTaoyuan, 333, Taiwan
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Research Site
WITHDRAWNEdinburgh, EH4 2XU, United Kingdom
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Research Site
RECRUITINGLeeds, LS9 7TF, United Kingdom
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Research Site
RECRUITINGLondon, EC1M 6BQ, United Kingdom
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Research Site
RECRUITINGOxford, OX3 7LE, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can AI-Guided home training boost recovery from gastric cancer surgery?
- Can a new drug combo revive Immunotherapy's power against resistant tumors?
- Can a new infusion drug shrink Hard-to-Treat tumors?
- A high-tech camera may take the guesswork out of spotting a dangerous surgery complication
- Can surgery for stomach or esophageal cancer cloud the mind?
- Can an immunotherapy combo shrink stomach tumors before surgery?