Could this powder tame dangerous potassium levels in kids?

NCT ID NCT03813407

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called sodium zirconium cyclosilicate (SZC) in about 140 children under 18 who have high potassium levels (hyperkalaemia). The drug works by trapping extra potassium in the gut so the body can get rid of it. The trial has three phases: a short correction phase to quickly lower potassium, a 28-day maintenance phase to keep it normal, and a long-term extension. Researchers are testing different doses based on age and weight to find the safest and most effective approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Sodium zirconium cyclosilicate (SZC), a powder that binds excess potassium in the gut so it can be removed from the body

What this could lead to

If successful, this could provide a safe, effective treatment option for children with dangerously high potassium levels, helping to prevent heart problems and other complications.

What could go wrong

This is an early-phase study in children, and results from adults may not fully apply. Dosing is still being figured out, and side effects or lack of effectiveness are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Hyperkalemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERKALAEMIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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RECRUITING

Birmingham, Alabama, 35233, United States
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Atlanta, Georgia, 30322, United States
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Baltimore, Maryland, 21287, United States
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Grand Rapids, Michigan, 49503, United States
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St Louis, Missouri, 63104, United States
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COMPLETED

Hackensack, New Jersey, 07601, United States
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New York, New York, 10029, United States
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Stony Brook, New York, 11794, United States
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Charlotte, North Carolina, 28207, United States
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Winston-Salem, North Carolina, 27157, United States
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COMPLETED

Akron, Ohio, 44308, United States
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Cincinnati, Ohio, 45229, United States
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Columbia, South Carolina, 29203, United States
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Morgantown, West Virginia, 26506-7900, United States
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Campinas, 13060-904, Brazil
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São Paulo, 01228-200, Brazil
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São Paulo, 04038-002, Brazil
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Calgary, Alberta, T3B 6A8, Canada
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Edmonton, Alberta, T6G 1C9, Canada
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Vancouver, British Columbia, V6H 3N1, Canada
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Montreal, Quebec, H3T1C5, Canada
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Beijing, 100034, China
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Beijing, 100045, China
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Changsha, 410007, China
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Chengdu, 610000, China
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Chengdu, 610041, China
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Chongqing, 400014, China
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Hangzhou, 310052, China
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Hefei, 230001, China
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Shanghai, 200062, China
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Shanghai, 201102, China
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Berlin, D-13353, Germany
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Essen, 45147, Germany
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Heidelberg, 69120, Germany
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Bhubaneswar, 751019, India
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Gurgaon, 122001, India
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New Delhi, 110060, India
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Bunkyō City, 113-8431, Japan
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Fuchu-shi, 183-8561, Japan
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Fukuoka, 813-0017, Japan
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Kawasaki-shi, 211-0063, Japan
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Kobe, 650-0047, Japan
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Matsumoto-shi, 390-8621, Japan
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Nakagami-gun, 903-0215, Japan
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Saitama-Shi, 330-8777, Japan
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Sendai, 989-3126, Japan
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RECRUITING

Shinjuku-ku, 162-8666, Japan
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Shizuoka, 420-8660, Japan
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COMPLETED

Bialystok, 15-274, Poland
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Krakow, 30-663, Poland
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COMPLETED

Lodz, 93-338, Poland
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Warsaw, 02-097, Poland
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Bucharest, 022322, Romania
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Bucharest, 077120, Romania
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Cluj-Napoca, 400370, Romania
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Târgu Mureş, 540136, Romania
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Timișoara, 300011, Romania
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Samara, 443095, Russia
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RECRUITING

Esplugues de Llobregat, 08950, Spain
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Madrid, 28041, Spain
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SUSPENDED

Dnipropetrovsk, 49100, Ukraine
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SUSPENDED

Kharkiv Region, 61075, Ukraine
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SUSPENDED

Kyiv, 04050, Ukraine
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WITHDRAWN

Odesa, 65038, Ukraine
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SUSPENDED

Sumy, 40031, Ukraine
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COMPLETED

Zaporizhzhia, 69063, Ukraine
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Glasgow, G51 4TF, United Kingdom
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RECRUITING

Hampshire, SO16 6YD, United Kingdom
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COMPLETED

Manchester, M13 9WL, United Kingdom
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TERMINATED

Nottingham, NG7 2UH, United Kingdom