New hope for colorectal cancer: experimental combo trial launches

NCT ID NCT06792695

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This phase 2 trial is testing a new immunotherapy drug called volrustomig, combined with standard chemotherapy (FOLFIRI) and bevacizumab, in 120 people with metastatic colorectal cancer. The goal is to see if the combination is safe and helps control the cancer longer. Participants must have measurable disease and no prior treatment for advanced cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Volrustomig (an experimental immunotherapy) combined with FOLFIRI chemotherapy and bevacizumab
What this could lead to: If successful, this could lead to a new treatment option that helps control metastatic colorectal cancer for longer.
What could go wrong: This is an early phase 2 trial with only 120 participants, so results may not apply to everyone. The experimental drug may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER

Contacts and locations

Locations

Research Site
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Scottsdale, Arizona, 85259, United States
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Los Angeles, California, 90089, United States
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Washington D.C., District of Columbia, 20007, United States
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NOT_YET_RECRUITING

Chicago, Illinois, 60637, United States
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Baltimore, Maryland, 21224, United States
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COMPLETED

Boston, Massachusetts, 02114, United States
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Rochester, Minnesota, 55905, United States
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Trenton, New Jersey, 08690, United States
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Rochester, New York, 14618, United States
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WITHDRAWN

Cleveland, Ohio, 44106, United States
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NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
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WITHDRAWN

Philadelphia, Pennsylvania, 19104, United States
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NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
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Houston, Texas, 77030, United States
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East Melbourne, 3002, Australia
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Wollongong, 2500, Australia
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Woodville South, 5011, Australia
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Victoria, British Columbia, V8R 6V5, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Montreal, Quebec, H3T 1E2, Canada
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NOT_YET_RECRUITING

Beijing, 100142, China
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SUSPENDED

Chengdu, 610041, China
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NOT_YET_RECRUITING

Harbin, 150081, China
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NOT_YET_RECRUITING

Shanghai, 200003, China
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SUSPENDED

Shanghai, 200032, China
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NOT_YET_RECRUITING

Shanghai, 201114, China
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SUSPENDED

Wuhan, 430079, China
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SUSPENDED

Zhengzhou, 450000, China
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NOT_YET_RECRUITING

Bordeaux, 33076, France
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WITHDRAWN

Marseille, 13273, France
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RECRUITING

Montpellier, 34090, France
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NOT_YET_RECRUITING

Montpellier, 34298, France
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Poitiers, 86021, France
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Saint-Priez En Jarez, 42270, France
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Villejuif, 94805, France
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NOT_YET_RECRUITING

Berlin, 10117, Germany
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Dresden, 01307, Germany
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Essen, 45147, Germany
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Hamburg, 22763, Germany
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Marburg, 35043, Germany
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Bologna, 40133, Italy
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NOT_YET_RECRUITING

Castelfranco Veneto, 31033, Italy
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Florence, 50134, Italy
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Milan, 20133, Italy
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NOT_YET_RECRUITING

Milan, 20162, Italy
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NOT_YET_RECRUITING

Naples, 80131, Italy
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NOT_YET_RECRUITING

Pavia, 27100, Italy
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NOT_YET_RECRUITING

Pisa, 56100, Italy
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NOT_YET_RECRUITING

Roma, 00168, Italy
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Amsterdam, 1066 CX, Netherlands
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Maastricht, 6202 AZ, Netherlands
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Zwolle, 8025 AB, Netherlands
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Seoul, 03080, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 5505, South Korea
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Yongin-si, 16995, South Korea
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Barcelona, 08035, Spain
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Barcelona, 8003, Spain
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NOT_YET_RECRUITING

Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Pamplona, 31005, Spain
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Santander, 39008, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 80756, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan, 333, Taiwan
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Yung Kang City, 71044, Taiwan
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Cambridge, CB2 0XY, United Kingdom
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London, NW1 2PG, United Kingdom
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London, W12 0HS, United Kingdom
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Manchester, M20 4GJ, United Kingdom
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Metropolitan Borough of Wirral, CH63 4JY, United Kingdom

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