New drug aims to plug leaky kidneys in APOL1 disease

NCT ID NCT06824987

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an injectable drug called AZD2373 in 136 people with APOL1-mediated kidney disease, a genetic condition that mainly affects people of African descent. The goal is to see if the drug can reduce protein leakage into urine, a sign of kidney damage. Participants will receive either AZD2373 or a placebo for 30 weeks, and researchers will measure changes in urine protein levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AZD2373 (an injectable drug)

What this could lead to

If it works, this could point toward a treatment that slows kidney damage in people with APOL1-related kidney disease, potentially delaying the need for dialysis or transplant.

What could go wrong

This is an early Phase 2b trial with only 136 participants, so results may not apply to everyone. The drug may not reduce protein in urine enough, or could have side effects not yet seen.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

focal segmental glomerulosclerosis 4, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APOL1-MEDIATED KIDNEY DISEASE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Alabaster, Alabama, 35007, United States
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Birmingham, Alabama, 35205, United States
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Irondale, Alabama, 35210, United States
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Surprise, Arizona, 85374, United States
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Beverly Hills, California, 90211, United States
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Concord, California, 94520, United States
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Fremont, California, 94538, United States
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Gardena, California, 90247, United States
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Los Angeles, California, 90095, United States
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Valencia, California, 91355, United States
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Boca Raton, Florida, 33487, United States
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Brandon, Florida, 33511, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33173, United States
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Orlando, Florida, 32808, United States
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Pompano Beach, Florida, 33060, United States
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Atlanta, Georgia, 30322, United States
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Augusta, Georgia, 30904, United States
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Augusta, Georgia, 30909, United States
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Augusta, Georgia, 30912, United States
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Columbus, Georgia, 31901, United States
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Columbus, Georgia, 31904, United States
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Duluth, Georgia, 30096, United States
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Hinesville, Georgia, 31313, United States
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Lawrenceville, Georgia, 30046, United States
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Macon, Georgia, 31210, United States
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Macon, Georgia, 31217, United States
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Marietta, Georgia, 30067, United States
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Savannah, Georgia, 31406, United States
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Stockbridge, Georgia, 30281, United States
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Chicago, Illinois, 60612, United States
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Hinsdale, Illinois, 60521, United States
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Rockford, Illinois, 61107, United States
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Baton Rouge, Louisiana, 70808, United States
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Lafayette, Louisiana, 70508, United States
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New Orleans, Louisiana, 70112, United States
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Shreveport, Louisiana, 71103, United States
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Bethesda, Maryland, 20889, United States
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Potomac, Maryland, 20854, United States
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Boston, Massachusetts, 02114, United States
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Lansing, Michigan, 48911, United States
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Roseville, Michigan, 48066, United States
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Minneapolis, Minnesota, 55455, United States
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Tupelo, Mississippi, 38801, United States
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Brooklyn, New York, 11203, United States
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Brooklyn, New York, 11221, United States
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Laurelton, New York, 11413, United States
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New York, New York, 10010, United States
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Rockville Centre, New York, 11570, United States
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Cary, North Carolina, 27511, United States
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Durham, North Carolina, 27705, United States
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Fayetteville, North Carolina, 28304, United States
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Gastonia, North Carolina, 28054, United States
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Greenville, North Carolina, 27834, United States
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Jacksonville, North Carolina, 28546, United States
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Kinston, North Carolina, 28501, United States
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Winston-Salem, North Carolina, 27103, United States
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Winston-Salem, North Carolina, 27157, United States
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Cincinnati, Ohio, 45246, United States
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Columbus, Ohio, 43210, United States
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Butler, Pennsylvania, 16001, United States
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Exton, Pennsylvania, 19341, United States
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Philadelphia, Pennsylvania, 19104, United States
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Anderson, South Carolina, 29621, United States
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Columbia, South Carolina, 29203, United States
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Orangeburg, South Carolina, 29118, United States
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Spartanburg, South Carolina, 29306, United States
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Chattanooga, Tennessee, 37404, United States
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Nashville, Tennessee, 37232, United States
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Conroe, Texas, 77384, United States
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Dallas, Texas, 75234, United States
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Dallas, Texas, 75235, United States
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Houston, Texas, 77054, United States
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Mesquite, Texas, 75149, United States
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Pearland, Texas, 77584, United States
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San Antonio, Texas, 78212, United States
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WITHDRAWN

Alexandria, Virginia, 22311, United States
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Norfolk, Virginia, 23510, United States
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Richmond, Virginia, 23298, United States
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Birmingham, B15 2WB, United Kingdom
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Leicester, Le5 4PW, United Kingdom
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Liverpool, L22 0LG, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SE5 8AZ, United Kingdom
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London, SM5 1AA, United Kingdom
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London, SW17 0QT, United Kingdom
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London, SW7 2AZ, United Kingdom
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Manchester, M13 9WL, United Kingdom