New hope for stomach cancer: targeted drug combo trial launches

NCT ID NCT04379596

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called trastuzumab deruxtecan (T-DXd), alone or with chemotherapy and immunotherapy, in people with advanced HER2-positive stomach or esophageal cancer. The goal is to see if these combinations are safe and can shrink tumors. About 450 adults with cancer that has spread or cannot be removed by surgery will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

trastuzumab deruxtecan (Enhertu) alone or with chemotherapy and/or immunotherapy

What this could lead to

If successful, this could provide a new treatment option for people with advanced HER2-positive gastric cancer, potentially shrinking tumors and delaying disease progression.

What could go wrong

This is an early-phase trial (Phase 1b/2) with a small number of participants, so results may not apply to all patients. Side effects from the drug combinations could be serious, and the treatment may not work for everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma carcinoma esophageal adenocarcinoma Esophageal Neoplasms gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Santa Monica, California, 90404, United States
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Westwood, Kansas, 66205, United States
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Baltimore, Maryland, 21287, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48109, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27710, United States
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Houston, Texas, 77090, United States
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Fairfax, Virginia, 22031, United States
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Florianópolis, 88020-210, Brazil
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COMPLETED

Londrina, 86015-520, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90160-093, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Rio de Janeiro, 22793-080, Brazil
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Santa Maria, 97015-450, Brazil
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São Jose Do Rio Preto, 15090-000, Brazil
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São Paulo, 01509-900, Brazil
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São Paulo, 03102-002, Brazil
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ACTIVE_NOT_RECRUITING

São Paulo, 045202-001, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Chengdu, 610042, China
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Guangzhou, 510062, China
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Guiyang, 550002, China
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Hangzhou, 310022, China
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Hefei, 230001, China
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Hefei, 230601, China
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Shanghai, 200025, China
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Shanghai, 200031, China
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Shanghai, 200032, China
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Shanghai, 200050, China
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Shenyang, 110001, China
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Ürümqi, 830000, China
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Wuhan, 430000, China
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Xiamen, 361003, China
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Zhengzhou, 450008, China
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Frankfurt, 60488, Germany
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Frankfurt, 60590, Germany
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Hamburg, 20249, Germany
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Leipzig, 04103, Germany
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Mannheim, 68167, Germany
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München, 81675, Germany
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Milan, 20133, Italy
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Milan, 20162, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Roma, 00168, Italy
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Verona, 37134, Italy
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Chūōku, 104-0045, Japan
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Kashiwa, 277-8577, Japan
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Kita-gun, 761-0793, Japan
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Ota-shi, 373-8550, Japan
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Amsterdam, 1066CX, Netherlands
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Amsterdam, 1081 HV, Netherlands
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Utrecht, 3584CG, Netherlands
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Gdansk, 80-214, Poland
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Konin, 62-500, Poland
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Koszalin, 75-581, Poland
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Krakow, 31-501, Poland
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Lublin, 20-090, Poland
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Opole, 45-061, Poland
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Tomaszów Mazowiecki, 97-200, Poland
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Warsaw, 02-034, Poland
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SUSPENDED

Kostroma, 156005, Russia
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Moscow, 115478, Russia
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TERMINATED

Moscow, 125284, Russia
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Moscow, 143423, Russia
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TERMINATED

Moscow, 143442, Russia
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Novosibirsk, 630099, Russia
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Saint Petersburg, 195271, Russia
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Saint Petersburg, 196603, Russia
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SUSPENDED

Saint Petersburg, 197022, Russia
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COMPLETED

Saint Petersburg, 197758, Russia
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08035, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 83301, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 333, Taiwan
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Cambridge, CB2 0QQ, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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London, NW1 2PG, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Sutton, SM2 5PT, United Kingdom