Major depressive disorder

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with multiple treatments. Researchers will implant a device that sends electrical pulses to a specific brain area. The trial includes 100 adults and compares active s…

This study tests deep brain stimulation (DBS) in 20 people with severe depression that hasn't improved with other treatments. The device delivers electrical pulses to a brain region called the subcallosal cingulate, which may reset mood circuits. Researchers will record brain sig…

This study tests whether a combination of physical activity, cognitive training, and dietary supplements can reduce depression symptoms and prevent memory or thinking problems in people with Major Depressive Disorder (MDD). Researchers will enroll 120 adults aged 50-80 who have M…

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, p…

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

Stanford University is studying whether the drug pramipexole can help people with depression, and if its effects depend on specific brain circuits. Sixty adults with recent depressive symptoms will take pramipexole for 8 weeks, then taper off over 2 weeks. The study uses brain im…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a long-acting injection of cariprazine given once a month, instead of daily pills, for people with schizophrenia, bipolar I disorder, or major depression. The trial involves 24 clinically stable adults and will check safety, side effects, and how well the drug wo…

This study tests whether reducing the frequency of rTMS sessions can maintain the antidepressant effect in people with treatment-resistant depression who already responded to daily rTMS. 75 participants will receive either standard maintenance, clustered, or sham rTMS over 6 mont…

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study tests a small brain implant for people with severe depression that hasn't improved with standard treatments. The device is placed under the skull and stimulates a mood-related brain area. Researchers will track changes in depression and thinking skills over one year in…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This study tests whether measuring drug levels in the blood can help doctors give the right dose of antidepressants (sertraline, escitalopram, or fluoxetine) to hospitalized children and adults with major depression. About 180 participants will receive one of these medications, a…

This Phase 3 study tests whether adding NBI-1065845 to standard antidepressants can delay the return of depressive symptoms in adults with major depression. About 550 people who have not fully responded to current antidepressants will take either the study drug or a placebo pill.…

This study tests whether giving stronger medications earlier can help people with schizophrenia, major depression, or bipolar depression who did not get better with their first treatment. Over 1,200 participants will receive either standard second-line treatment or an intensified…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This Phase 2 trial tests whether dexamfetamine, a stimulant used for ADHD, can safely and effectively treat both ADHD and moderate to severe depression in adults. 105 participants will receive either a fast-acting or long-acting version of the drug, or a placebo. The study is cur…

This study tests a program called Taking Action, where trained peers help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia learn to manage their condition. About 300 students will be randomly assigned to either the program or just…

This study tests whether long-term use of ketamine (given by IV) followed by esketamine (a nasal spray) can reduce suicide risk in people with major depression who are at high risk. One hundred adults hospitalized for depression will receive up to 8 ketamine infusions, then 13 we…

This study tests whether a coordinated care program called I-CONNECT can improve the health and well-being of older adults (65+) who have depression or bipolar disorder and at least two chronic physical conditions like diabetes or high blood pressure. Participants receive persona…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This pilot study tests whether a portable, at-home brain stimulation device (tDCS) can help people with depression maintain the improvements they achieved during hospital treatment with esketamine, rTMS, or ECT. Thirty adults will use the device for 30 minutes a day, five days a …

This study is testing whether combining internet-based cognitive behavioural therapy (i-CBT) with intravenous ketamine can quickly reduce suicidal thoughts and behaviors in people with treatment-resistant depression. All 110 participants will receive weekly i-CBT for 13 weeks, an…

This study looks at whether a non-invasive brain stimulation technique called iTBS can help prevent depression from returning. 60 adults who already improved with iTBS will receive maintenance sessions, either once a day for a week or all in one day. The goal is to see which sche…

This study tests simple methods to help adults with depression take their antidepressant medication regularly. Researchers will use electronic pill bottles to track adherence and measure depression symptoms over 12 weeks. The goal is to find practical ways to improve both medicat…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This study in Zimbabwe tests whether adding antidepressants (fluoxetine or sertraline) to a proven talk therapy program (Friendship Bench) works better than talk therapy alone for adults with moderate to severe depression. About 296 participants will be randomly assigned to one o…

This study is testing a digital app called QbMobile that measures attention, impulsivity, and activity levels through two 10-minute tests. Researchers want to see if the app can help distinguish ADHD from conditions like bipolar disorder, autism, depression, and anxiety. About 30…

This study tests a new iPhone app called Senseye DT that uses artificial intelligence to diagnose Post-Traumatic Stress Disorder (PTSD) in adults. Participants will use the app while it records video of their face, and the AI looks for signs of PTSD. The goal is to see if the app…

This study is testing a new tool that combines a blood test with a questionnaire to help primary care doctors correctly identify bipolar disorder in people who are currently experiencing depression. The goal is to see if this tool can accurately tell the difference between bipola…

This study tests a therapy called Positive Affect Treatment (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more adverse childhood events. The therapy involves 15 weekly sessions focused on building positive emotions and coping skills…

This study is testing whether lifestyle changes—like following a Mediterranean diet, exercising regularly, or doing cognitive training—can prevent cognitive decline and improve mood in people aged 50 to 80 who have depressive symptoms or major depression but no current memory pro…

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This study tests whether a specially designed bright light can improve cognitive problems like memory and attention in people with major depressive disorder. 120 adults with depression and cognitive issues will receive either the bright light or a dim red placebo light for four w…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better for adults over 60 with depression. Eighty participants will receive either clemastine or a placebo alongside their antidepressant. The goal is to see …

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This small study tests if a non-invasive device that stimulates the brain during sleep can increase deep sleep in adults with depression. Researchers want to see if better deep sleep helps with memory, thinking, and mood. Participants wear a headband and activity tracker at home …

This study is testing whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with mindfulness-based therapy can help people with PTSD. Thirty adults with PTSD will receive psilocybin along with either standard support or extra mindfulness training…

This study is testing whether a single session that combines two types of brain stimulation (TMS and tACS) with psychotherapy can safely and feasibly help people with major depression that hasn't improved with standard treatments. The researchers will enroll 30 adults aged 18-70 …

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This Phase 3 study is testing the long-term safety of an experimental drug called NBI-1065845 (TAK-653) in 850 adults with major depressive disorder who haven't gotten enough relief from standard antidepressants. Participants take the drug alongside their usual antidepressant for…

This pilot study tests whether adding brief guided mindfulness exercises (via a smartphone app) between sessions of accelerated brain stimulation (aiTBS) is feasible and acceptable for people with major depression. Twenty adults already receiving aiTBS as standard care will pract…

This study tests whether using a gentle brain stimulation device (tDCS) twice a day at home can help people with depression who are not on medication. Thirty participants will be split into three groups: one gets real stimulation, one gets a sham (placebo) device, and one waits w…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce depression symptoms in people who have had a heart attack or related heart problem and a stent placed. About 120 adults will use the device at home for 8 weeks, and their mood…

This Phase 1 study is testing the safety and brain effects of DMT, a psychedelic drug, in 60 adults with depression and healthy volunteers. Participants receive low or medium doses of DMT, THC, or a placebo, and researchers monitor mood, anxiety, and brain activity. The goal is t…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study tests whether adding a probiotic (Lactobacillus crispatus) to the antidepressant sertraline helps reduce depression symptoms more than sertraline alone in teens aged 12-18 with major depressive disorder. Sixty participants will take either the probiotic or a placebo fo…

This study looks at whether adding a magnesium supplement (magnesium bisglycinate) to standard antidepressant medication can help adults with major depression feel better. About 84 people aged 18-65 who are already on a stable antidepressant will receive either the supplement or …

This study tests an experimental drug, icalcaprant, for adults with major depressive disorder who are currently having a depressive episode. About 195 participants will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms an…

This study tests a non-invasive brain stimulation technique called tACS to treat anhedonia (loss of interest or pleasure) in people aged 60 and older with major depression. Eighty participants will receive either real or sham stimulation over two weeks, with follow-up at three mo…

This study tests whether adding multi-strain probiotics to the antidepressant sertraline helps teenagers aged 12-18 with major depression feel better than sertraline alone. Over 8 weeks, 120 participants will take either the combination or sertraline with a placebo. Researchers w…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests a smartphone app that shares stories from teens who have overcome suicidal thoughts. The goal is to see if these stories help other at-risk teens feel less suicidal and more connected. The study involves 46 adolescents in The Bronx who have had recent suicidal th…

This study tests whether a non-invasive brain stimulation technique called tDCS can help adults with Down syndrome who have depression with catatonia (a state of being unresponsive or stuck). 62 participants will receive either real or fake (sham) tDCS for 15 sessions over 5 days…

This study tests whether combining a brain stimulation technique called rTMS with a computer-based thinking exercise (CBM) can reduce negative thinking and depressive symptoms in people with mild-to-moderate depression. About 180 adults will receive either real or fake rTMS, and …

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This Phase 3 trial tests whether adding seltorexant (a drug that targets sleep) to standard antidepressants can improve mood and sleep in adults with major depression and insomnia who haven't fully responded to their current antidepressant. About 752 participants will receive eit…

This study tests a new drug called seltorexant for people with major depression who also have trouble sleeping. About 600 adults will receive either the drug or a placebo to see if it improves mood and sleep. The goal is to find a new treatment option that targets both depression…

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study looks at whether two different exercise programs can help reduce depression in people with multiple sclerosis (MS) who also have major depressive disorder. Researchers will enroll 146 adults aged 18 to 64. One group will do a structured exercise program, while the othe…

This study tests whether a nasal spray containing esketamine, given alongside standard care, can rapidly reduce symptoms of major depression and suicidal thoughts in adolescents. About 258 teens with acute suicidal ideation or behavior will receive either esketamine or a psychoac…

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers …

This study compares group-based Acceptance and Commitment Therapy (ACT) to standard individual therapy for young people aged 16-25 with depression, anxiety, or stress. About 212 participants will be randomly assigned to either group ACT or individual therapy. The goal is to see i…

This study tests whether a brief, culturally adapted form of behavioral activation therapy, delivered by psychologists in primary care clinics, can reduce depressive symptoms in adults. 96 participants with depression will receive the therapy and be compared to usual care. The st…

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue t…

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study looks at how Behavioral Activation (BA) therapy affects the brains of depressed teenagers. 136 teens aged 15-17 with depression will receive up to 16 therapy sessions focused on increasing rewarding activities. Researchers will use brain scans (fMRI) to see if BA thera…

This phase 2 trial tests whether DT-101 can ease depression symptoms in adults with major depressive disorder who are already on antidepressant medication. About 118 participants will receive either DT-101 or a placebo, and researchers will track changes in depression scores over…

This study tests whether a new oral drug called zelquistinel can reduce depression symptoms in adults with major depressive disorder. Participants take one tablet weekly for 6 weeks and have their depression severity checked at each clinic visit. The trial compares the drug again…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start a telehealth counseling program. About 30 adults being treated for lung cancer at Penn Medicine will…

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This study tests a smartphone app called Matter Neuroscience that uses neurofeedback from brain scans to help people with mild to moderate depression better understand positive emotions. Researchers will enroll 240 adults to see if the app is safe and effective at reducing depres…

This study tests a new oral drug called zelquistinel to see if it can reduce symptoms of major depressive disorder in adults. About 164 people aged 18 to 64 will take either the drug or a placebo once a week for 6 weeks. Researchers will measure changes in depression severity usi…

This pilot study tests whether MRI-guided repetitive transcranial magnetic stimulation (rTMS) is safe and feasible for treating depression in 45 adolescents aged 12-18. Participants are randomly assigned to receive either targeted brain stimulation, standard stimulation, or a sha…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with major depression that hasn't improved with medication. Over five days, 35 adults will receive multiple sessions of targeted brain stimulation. Researchers will track changes in depress…

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests whether a daily medication called vortioxetine can safely reduce depression symptoms in Japanese teenagers aged 12 to 17 with major depressive disorder. About 180 participants will receive either the drug or a placebo for 14 weeks, with follow-up for 4 more weeks…

This study tests whether four intravenous ketamine infusions over two weeks can reduce suicidal thoughts in 36 adults with major depression. Participants will also have two MRI brain scans to see if changes in brain structure relate to symptom improvement. The goal is to both tre…

This Phase 2 trial tests LV232, a new capsule for major depressive disorder, in 400 adults aged 18-65. Participants are randomly assigned to receive one of two doses of LV232, the active comparator escitalopram, or a placebo for 8 weeks. The main goal is to find the best dose and…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This study tests whether a noninvasive magnetic stimulation technique called TMS can improve symptoms in people with major depressive disorder. Researchers will target a brain region involved in emotion and reward processing. The study will enroll 80 adults with moderate to sever…

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people with non-small cell lung cancer who also have major depression. Ten participants will receive psilocybin in a controlled setting along with cou…

This study tests a type of talk therapy called acceptance and commitment therapy (ACT) for people with mild dementia and their care partners. The goal is to see if it helps reduce depression, anxiety, and grief. About 100 pairs will take part, either in person or online.

This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. Th…

This study tests a 100% remote education program for adults with moderate depression who recently started antidepressants. The program aims to help them stick with their medication and improve their symptoms. Researchers will compare the program to usual care in 220 participants …

This study tests a new type of talk therapy that is personalized for each person's emotional, relationship, and self-image struggles. It is for adults with depression that also involves personality problems or past trauma. 150 people in Chile's public health system will get eithe…

This study looks at people with depression that hasn't improved with other treatments. If they don't get better after four sessions of one type of ECT (right unilateral), they will either continue with that type or switch to another type (bitemporal). The goal is to see which app…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study tests whether a higher dose of a gentle brain-zapping technique called tDCS can safely help people with major depression. About 20 adults will receive mild electrical pulses on their scalp over 5 days. Researchers will check for side effects and see if mood improves.

This phase 3 trial tests whether adding a low dose of ketamine to electroconvulsive therapy (ECT) can better relieve depression and reduce memory problems in people with treatment-resistant major depressive disorder. Thirty hospitalized adults will receive either ketamine or a pl…

This study tests a new medicated film placed inside the cheek (VLS-01) for people whose depression hasn't improved with at least two other treatments. About 142 adults aged 18-65 will receive either the film or a placebo to see if it safely eases depression symptoms. The goal is …

This study is testing two types of talk therapy for major depression: supportive-expressive therapy and emotion-focused therapy. The goal is to see if people do better when the therapy matches their personal style—whether they tend to think deeply about their problems (insight) o…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study tests whether an AI-guided cognitive behavioral therapy program can reduce symptoms of mild depression and anxiety in adults. Over 10 weeks, 120 participants will either receive AI-guided therapy through a digital platform or standard care. The goal is to see if AI can…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This study is testing whether an online, self-guided dialectical behavior therapy (DBT) course is practical and helpful for adults with mild-to-moderate depression or anxiety. Up to 40 participants will take the 8-week course, which teaches skills like mindfulness and emotion reg…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This pilot study tests whether a home-use device that sends a mild electrical current to the brain (tDCS) can reduce depressive symptoms in people with borderline personality disorder (BPD). Sixty participants will receive either real or sham stimulation twice daily for one week.…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This phase 3 trial tests whether adding roflumilast (a COPD drug) to the antidepressant fluoxetine helps people with major depression who haven't responded well to treatment. Sixty adults with moderate-to-severe depression will take either the combination or a placebo for 8 weeks…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression in 200 adults. Participants will do either high or low dose strength training. Researchers will measure changes in mood, thinking, and blood flow in the brain to see if exerc…

This study tests a new drug called mitizodone phosphate in 600 adults with major depression. The goal is to see if it reduces depression symptoms better than a placebo over 8 weeks. The trial has two phases: first to find the best dose, then to confirm how well it works and if it…

This pilot study will put a portable transcranial magnetic stimulation (TMS) device into a van and test it at three locations in South Carolina. Thirty adults with treatment-resistant depression will receive five days of TMS. Researchers will check if this mobile approach is feas…

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…

This study tests a new treatment called Prism for people with major depression who have lost interest or pleasure in activities (anhedonia). Prism is a software device that uses neurofeedback to train the brain's reward system. About 170 participants will receive either real Pris…

This Phase 2 trial tests whether DT-101 can reduce depression symptoms in adults with major depressive disorder. About 300 participants will receive either DT-101 or a placebo for 6 weeks, and researchers will track mood changes using standard depression scales. The study is curr…

This study compares the safety and effectiveness of using a mild electrical brain stimulation device (tDCS) at home versus at a clinic for treating major depression. About 198 adults with moderate to severe depression will use the device daily for a few weeks. Researchers will me…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study tests a smartphone app called Edra PRO that lets doctors check in on patients with moderate to severe depression remotely. About 594 adults will either use the app plus usual care or just usual care for 6 months. The goal is to see if the app helps reduce symptoms and …

This study tests a smartphone app that prompts people with depression to reach out to friends or family for support at the right moments. Over 21 days, 120 adults awaiting therapy will be randomly assigned to different versions of the app or no app at all. The goal is to see if t…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) on the forehead to help people with treatment-resistant depression. About 40 adults who still have moderate-to-severe depression despite taking antidepressants will receive tPBM at differe…

This study is testing whether a daily practice of Tao Calligraphy meditation and drinking so-called 'energized water' can improve symptoms of unipolar depression in adults. Fifty participants will be split into two groups to compare the effects over 12 weeks. The goal is to see i…

This study is testing a virtual reality (VR) program called bWell to see if it is a practical and enjoyable way to help people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will either use the bWell cognitive training or experience VR sc…

This study tests whether combining mindfulness meditation with real-time brain scan feedback can help teens with depression. Researchers will train 90 adolescents aged 13-18 to control brain circuits linked to rumination (repetitive negative thinking). The goal is to see if this …

This study tests whether tocilizumab, a drug that blocks inflammation, can help people with major depression who have lost interest or pleasure in things (anhedonia). About 20 adults with depression and signs of immune activation will receive the drug for 8 weeks, while 20 health…

This study tests a new, non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can reduce non-suicidal self-injury (like cutting) in adolescents with major depression. About 60 teens aged 12-22 will receive either real TIS or a sham t…

This study tests whether inhaling ketamine through a nebulizer can quickly reduce symptoms of moderate to severe depression in hospitalized adults. About 40 participants will receive either ketamine or a placebo (midazolam) and be monitored for changes in depression scores over 8…

This study tests whether using a bright light device at home for 40 minutes each morning can help teens aged 13-17 with major depression. Participants are split into three groups: high-intensity light, medium-intensity light, or a dim red light placebo. The goal is to see if ligh…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This study tests whether a keto-like supplement, taken as a drink three times daily for 8 weeks, changes brain activity in people with moderate to severe depression. Researchers will use brain scans to compare the supplement to a placebo in 75 adults. The goal is to see if the su…

This study tests whether peer recovery specialists—people who have themselves recovered from mental health or substance use problems—can effectively deliver a therapy called behavioral activation to reduce depression and substance use. The trial will enroll 250 low-income adults …

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests whether a single 25 mg dose of psilocybin can relieve major depression in 100 adults with cancer, compared to a very low 1 mg dose. Participants must be 20–80 years old, have had depression for at least a month after their cancer diagnosis, and stop other antidep…

This study tests whether a medication called dextromethorphan-bupropion (Auvelity) can change brain activity related to reward and motivation in adults with major depression. Thirty participants will take the pill daily for two weeks and undergo brain scans to see if the drug aff…

This study tests whether a type of talk therapy called Interpersonal Psychotherapy (IPT), delivered in groups by trained non-specialists, can reduce depressive symptoms in young adults aged 18-24 in Porto Alegre, Brazil. Half of the 50 participants will receive the 8-week group t…

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This study aims to find the best dose of a safe, non-invasive brain stimulation technique called accelerated TMS to improve both depression and thinking skills in people aged 60-85 with mild cognitive impairment and depression. About 60 participants will receive different doses o…

This study aims to find out whether DMT, a psychedelic drug, helps with depression because of the 'trip' itself or because of biological changes in the brain. 112 adults with major depression will receive DMT or a placebo, and some will also be sedated with propofol to block the …

This study is testing whether a structured breathing practice is a practical and acceptable option for teenagers aged 12 to 17 who have been diagnosed with anxiety or depression. The program, called Seokmun Hoheup, starts with 15-minute sessions and gradually increases to 36 minu…

This study tests an AI-driven online cognitive-behavioral therapy (iCBT) for people with major depressive disorder. 100 adults will receive either the AI therapy or a sham relaxation session over 8 weeks. Researchers will track mood, stress, and quality of life to see if the digi…

This study tests whether a 9-week therapy called Engage & Connect can improve brain function related to social reward and reduce suicidal thoughts in older adults with depression. Researchers will use brain scans to measure changes in key brain networks. The study involves 128 pe…

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study looks at whether a specific yoga practice can help improve memory, attention, and mental flexibility in people whose depression is in remission. Researchers will compare a group doing yoga plus their usual care to a group receiving usual care alone. The goal is to see …

This study tests whether a single dose of psilocybin mushrooms, combined with therapy, can help adults with treatment-resistant depression. Half of the 24 participants will also take the antidepressant fluoxetine to see if it changes the effects. The main goal is to measure mood …

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study tests whether a new drug called SPN-821 can help adults with major depressive disorder who are already taking an antidepressant. About 230 participants will receive either SPN-821 or a placebo for 29 days. The main goal is to see if the drug reduces depression symptoms…

This study looks at whether a Mediterranean diet or a Mediterranean diet combined with time-restricted eating (eating only during a 10-hour window) can help college students with mild to moderate depression. Researchers will track sleep, mood, and daily activity to see if these d…

This study explores whether psilocybin, the active ingredient in magic mushrooms, can help people with depression who have lost the ability to feel pleasure (anhedonia). Researchers will give 85 participants two doses of psilocybin, sometimes blocking its psychedelic effects with…

This study tests if a noninvasive, at-home brain stimulation device (tDCS) can safely ease symptoms of major depression. Two hundred adults with depression will use the device themselves at home for 10 weeks, with video check-ins. The goal is to see if this approach reduces depre…

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This study tests a drug called solriamfetol in adults with major depressive disorder who also struggle with excessive daytime sleepiness. About 508 participants will first receive the drug openly, then some will switch to a placebo to see if the drug helps prevent depressive symp…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely and effectively reduce depression in autistic youth aged 16-24. Eighty participants will receive either real or sham rTMS over 30 sessions. The goal is to see if this approach, already used…

This study tests a three-stage mental health plan for breast cancer survivors in Pakistan who also have depression. Over 26,000 women will start with guided self-help, then move to therapy or medication if needed. The goal is to see if this step-by-step approach can reduce depres…

This study tests if bright light therapy can ease depression in teens (ages 12-19) who tend to stay up late. 90 participants will receive either bright light or a placebo light to see if symptoms improve. The goal is to find a simple, drug-free way to help teens feel better.

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—in 200 people with major depression. The goal is to see which one works better and has fewer side effects. Participants must be 12 to 80 years old and on a stab…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests a special mental health program for people who have been in the ICU. It includes coaching, digital tools, and psychiatric support to help with anxiety, depression, and PTSD. The goal is to see if this program works better than usual care. About 150 adults who vis…

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and suicidal thoughts. Over 5 days, participants receive 10 sessions of magnetic pulses per day, guided by MRI scans. Researchers want to see if this fas…

This pilot study tests a behavioral health program designed to support family members of ICU survivors. The program includes telehealth check-ins and a digital platform to track mood and stress. Researchers want to see if this approach is practical and helpful for reducing anxiet…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can improve pain and depression in people with knee osteoarthritis. Thirty adults aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also ta…

This study tests whether guanfacine, a medication typically used for blood pressure, can improve brain network function and reduce cognitive problems in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) for depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive daily rTMS sessions for four weeks. The go…

This study tests whether real-time brain feedback can help people with major depression. Participants learn to increase activity in the amygdala, a brain region linked to emotion, by recalling positive memories. The goal is to see if this training can reduce depressive symptoms a…

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 adults who have both alcohol use disorder and treatment-resistant depression. Participants will receive weekly ketamine infusions and ACT sessions for 8 weeks. The…

This study looks at whether doing moderate aerobic exercise right before a therapy session (CBT) helps people with major depression get more out of their treatment. One hundred adults will be randomly assigned to either exercise or rest quietly before each of 8 weekly therapy ses…

This study tests whether a device that shines 40 Hz flickering light can help reduce depression symptoms. Sixty adults with major depression will use the device at home for one hour each day over six weeks. Half will get the active flickering light, and half will get a sham light…

This study tests whether adding virtual reality (VR) mindfulness sessions to standard treatment can help people with treatment-resistant depression feel better. Thirty adults who haven't responded to multiple antidepressants will either get usual care alone or usual care plus 8 V…

This Phase 3 study tests whether adding milsaperidone to standard antidepressant therapy helps adults with major depressive disorder who still have symptoms. About 500 participants will receive either milsaperidone or a placebo, and researchers will measure changes in depression …

This study tests whether taking omega-3 (EPA) supplements for 12 weeks can reduce depressive symptoms in overweight or obese adults who have depression and low omega-3 levels. Half of the 50 participants will receive EPA, and half will receive a placebo. Researchers will also loo…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This study tests a smartphone app called mSITE that encourages people with schizophrenia or schizoaffective disorder to have more social interactions. Researchers will track participants' social activity and symptoms over time. The goal is to see if the app helps reduce social wi…

This study tests whether advancing sleep timing (going to bed and waking up earlier) can improve depression symptoms. 150 adults with moderate to severe depression, recently discharged from a psychiatric ward, will either receive usual care or a psychotherapeutic program focused …

This study tests whether using a brain scan (fMRI) to guide magnetic stimulation (rTMS) can better treat depression that hasn't improved with medication. About 348 adults aged 22-65 with major depression will receive rTMS, and researchers will track changes in depression scores. …

This study tests whether using a virtual reality (VR) headset can make behavioral activation therapy more effective for older adults (65+) with major depression. Thirty participants will use VR to engage in activities that boost mood, and researchers will measure changes in depre…

This study tests whether personalized music playlists can reduce stress, anxiety, and depression in adults. 2,000 participants will either receive music designed to match and gradually shift their mood, or no music. The goal is to see if this simple, non-invasive approach can imp…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teens aged 14-18 who are hospitalized with major depression and suicidal thoughts. About 60 participants will receive either real or sham dTMS alongside their usual care. The goal is to…

This study tests whether a three-week virtual reality cognitive training program, combined with a daily supplement (sodium butyrate), can improve memory, attention, and thinking speed in 160 adults aged 50+ who have had depression or bipolar disorder but are currently stable. Par…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness and reduce anxiety and depression. About 70 adults who have been in mental health treatment for at least 6 months will take part. …

This study tests whether combining psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy can help people with major depression. Fifty adults aged 21-60 with current depression will receive two doses of psilocybin and either 12 sessions of CBT or …

This study tests two new group therapies for adults with major depression. One therapy helps change rigid negative expectations, while the other boosts sensitivity to positive experiences. 150 participants will be randomly assigned to one of the therapies or a waiting list, and t…

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

This study tests whether shining near-infrared light on the forehead can change blood flow in the brains of people with major depression. Researchers will measure brain activity using fMRI and track mood changes with a standard depression questionnaire. The goal is to see if this…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help improve mood in people with major depression who are also overweight or obese. Over 26 weeks, 116 participants will receive either semaglutide or a placebo added to their usual depression tre…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests a new psychological therapy designed for people whose depression is linked to difficult childhood experiences. The therapy aims to improve mood, emotional control, and distressing thoughts. Researchers will also look at biological changes in the blood. The trial …

This study tests a free, online single-session therapy for children and teens (ages 12-17) in Hong Kong who are waiting for in-person psychotherapy. The goal is to quickly reduce symptoms of depression and anxiety while they wait. Participants will be randomly assigned to either …

This study tests whether giving multiple sessions of magnetic brain stimulation each day works better than the usual one-session-per-day approach for treating depression in people aged 60 and older. About 280 participants will receive active treatment, with some getting the accel…

This study tests whether online group cognitive behavioral therapy (CBT) can reduce depression, anxiety, and other mental health symptoms in adults with cystic fibrosis and their caregivers. Participants will attend 13 sessions via Zoom and be compared to those receiving supporti…

This study is for teenagers aged 13 to 18 with depression that hasn't gotten better after their first treatment. It will test different common antidepressants to find which one works best next. The goal is to help teens feel better and provide doctors with clear evidence on what …

This study tests whether adjusting the electrical amplitude of ECT (electroconvulsive therapy) to each person can better treat depression and reduce memory problems. Researchers will compare a personalized amplitude approach to the standard fixed 800 mA setting in 50 older adults…

This study looks at whether omega-3 fatty acids can reduce depression symptoms in young people aged 12-25 with major depressive disorder. Over 12 weeks, 60 participants will take either omega-3 supplements or a placebo. Researchers will track mood changes, gut bacteria, and blood…

This study tests a safe, non-invasive brain stimulation treatment called tDCS that people can use at home to ease depression. About 438 adults with major depression will either receive active tDCS plus their usual care, or just usual care alone. The goal is to see if adding tDCS …

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether a therapy called Imagery Rescripting (ImRs) can help reduce depressive symptoms when delivered by mental health assistants in primary care. Twelve adults with depression will wait 2-4 weeks, then receive 5 sessions of ImRs over 10 weeks, where they work w…

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

This trial tests a new, accelerated form of brain stimulation for people with severe depression that hasn't improved with medication. Over five days, 78 participants will receive 25 sessions of magnetic stimulation, either targeting a standard brain area or a new one, or a sham (…

This study tests a program called 'Need to Be Needed' (N2BN) that uses volunteering to help adults with serious mental illness feel more connected and less lonely. 120 participants will either join the volunteering program or receive weekly listening support. Researchers will mea…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This study tests whether adding ABX-002 to a current antidepressant can improve symptoms in adults with moderate to severe major depression. About 230 participants will receive either ABX-002 or a placebo for 6 weeks, with follow-up for up to 6 months. The goal is to see if ABX-0…

This study is for people with spinal cord injury who also have depression. It tests a new method to dose a brain stimulation treatment called rTMS, which is already approved for depression but usually requires a thumb movement to set the dose. Since many with spinal cord injury h…

This study tests a 10-session meditation practice combined with real-time brain feedback to help ease depression. Twenty-seven adults with moderate depression will participate. The goal is to see if this approach can improve mood and reduce symptoms.

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether a safe, at-home brain stimulation device called tDCS can help people with depression that hasn't improved with standard treatments. Ten participants will use the device at home under remote supervision for two weeks. The goal is to see if the approach is …

This pilot study tests whether a physical therapy program—including gentle exercise, strength training, and relaxation—plus education about physical activity can improve quality of life and health in adults hospitalized for major depression. About 50 participants will receive the…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esk…

This study tests whether adding a 12-week exercise program (daily walking plus two weekly combined aerobic and strength sessions) to standard antidepressant treatment can improve depression symptoms in 124 adults with major depressive disorder. Researchers will also use brain sca…

This study tests whether PROSE treatment—a custom contact lens that soothes the eye surface—can also improve mental health in people with major depression. Researchers will track depression scores and eye symptoms in 200 adults over time. The goal is to see if treating severe dry…

This study tests whether giving transcranial magnetic stimulation (TMS) right before electroconvulsive therapy (ECT) can lower the amount of electricity needed for ECT and speed up its antidepressant effects. Fifty adults with major depression that hasn't responded to other treat…

This study tests a 12-session group program called 'Better Together' for young adults with severe mental illness (like schizophrenia, bipolar disorder, or major depression) who are single and want to improve their romantic relationships. The program teaches communication, emotion…

This study tests whether chronotherapy—a combination of staying awake for 34 hours, light therapy, and a fixed sleep schedule—can quickly improve depression symptoms when added to standard care. 76 adults with moderate to severe depression will be randomly assigned to get chronot…

This study tests whether listening to music before and after electroconvulsive therapy (ECT) can reduce postictal agitation—a common side effect where patients become restless or confused after treatment. Researchers will enroll 92 adults with severe depression undergoing ECT. Ha…

This study tests whether using a person's own brain scan to guide a non-invasive treatment called iTBS works better than the standard one-size-fits-all approach. About 210 adults with major depression will receive 6 weeks of iTBS, with the treatment spot chosen either by standard…

This study tests if adding structured exercise to a brain stimulation treatment called iTBS can help people with depression that hasn't improved with medication. Twenty physically inactive adults with difficult-to-treat depression will either get iTBS alone or iTBS plus exercise.…

This study is testing whether structured nature-based tourism activities can improve symptoms of major depressive disorder. Researchers will compare an intervention group that takes part in these activities with a control group receiving usual care, while both groups continue the…

This study compares two non-invasive brain stimulation techniques for treating depression: right-sided 1-Hz rTMS and left-sided iTBS. Researchers want to see if the right-sided method works as well as the standard left-sided one. The trial will involve 350 adults with unipolar or…

This study tests whether fampridine, a drug used for walking problems in multiple sclerosis, can improve working memory in people with mild to moderate depression. About 38 adults will receive both fampridine and a placebo in random order to see if the drug helps them perform bet…

This study compares three ways to treat moderate depression in adults aged 18-65: usual care from a general practitioner, behavioral therapy from a psychologist, or a structured step-by-step treatment plan from a GP. The goal is to see if the structured plan works better at easin…

This study tests whether enoxolone, a compound from licorice, can improve depression symptoms in 80 adults with unipolar depression. Researchers will measure biomarkers like hormone levels and blood pressure to see if they predict who responds better to enoxolone versus a placebo…

This small study tests whether empagliflozin (Jardiance), a diabetes medication, can reduce symptoms of major depression. The drug helps the body produce ketones, which may provide an alternative energy source for the brain. Sixteen adults with moderate to severe depression will …

This study tests whether a fecal microbiota transplant (FMT) — transferring healthy gut bacteria from a donor — can help adults with major depression who aren't getting better with standard antidepressants. About 214 participants will receive either FMT or a placebo, and research…

This study tests a new therapy that uses real-time brain scans (fMRI) to help people with major depression shift their attention away from negative thoughts. 80 adults aged 18-65 with depression will receive either real or fake neurofeedback while doing a task. The goal is to see…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can safely and effectively treat depression in adults with autism spectrum disorder. Twenty-five participants will receive 20 sessions of rTMS over five days. The main goal is to see if mood improves aft…

This pilot study is testing whether a brief, culturally adapted form of behavioral activation therapy is acceptable and practical for adults with depression in primary care settings. Twelve participants will receive three individual therapy sessions delivered by a psychologist. T…

This Phase 3 trial tests whether adding NBI-1065845 to standard antidepressants can better ease depression symptoms in 200 adults who haven't fully responded to current treatments. Participants take the drug or a placebo for 8 weeks, and doctors measure changes in mood and daily …

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depre…

This study tests whether heart rate data can help guide a non-invasive brain stimulation technique called tDCS for people with mild to moderate depression. One hundred participants will receive either real or sham tDCS at home over 10 sessions. Researchers will monitor heart rate…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether dapagliflozin, a drug normally used for diabetes, can help reduce depression symptoms when added to standard antidepressant treatment. Sixty adults with moderate to severe depression will receive either dapagliflozin plus fluoxetine or fluoxetine alone. T…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study looks at whether minocycline, an antibiotic that reduces inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if this approach is practical and acceptable for 35 participants. The goal is t…

This study tests whether a single session of whole-body heat therapy (using an infrared sauna) with or without a cold water plunge can reduce depression symptoms. Researchers will enroll 162 adults with depressive symptoms and track their mood changes over two weeks. The goal is …

This study compares heated yoga, sauna sessions, and a mindfulness app to see which best reduces symptoms of depression. Researchers at Massachusetts General Hospital are recruiting 120 adults aged 18-65 with moderate to severe depression. Participants will attend twice-weekly se…

This study tests a device that delivers mild electrical stimulation to the brain (tDCS) while people practice mindfulness, all done remotely via video calls. The goal is to see if this combination can reduce depression symptoms in 25 adults with major depressive disorder. Partici…

This study tests whether yoga alone can reduce symptoms of mild-to-moderate depression. 180 adults with depression will either take 90-minute yoga classes or attend health education classes twice a week for 12 weeks. Researchers will measure changes in depression and stress level…

This study tests whether adding NBI-1065845 to standard antidepressants can better relieve depression symptoms in adults who haven't gotten enough help from their current medication. About 200 participants will receive either the study drug or a placebo for 8 weeks. The main goal…

This study tests whether a 5-day course of deep transcranial magnetic stimulation (dTMS) can safely reduce depression in adults aged 60-85 who haven't improved with medication. Participants receive either real or placebo stimulation to the brain's anterior cingulate cortex. The g…

This study tests a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. Participants receive daily d…

This study tests whether a new medication called azetukalner can reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 450 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug improves mood…

This study tests whether a 4-week digital brain-training program can reduce apathy (lack of motivation) in older adults with depression. Researchers will measure changes in brain scans and apathy scores. The goal is to see if this non-drug approach can improve brain function and …

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This study tests whether bezafibrate, a drug currently used for high cholesterol, can safely improve depression in people with bipolar disorder. Thirty adults with bipolar I or II who are already on a mood-stabilizing medication will take bezafibrate for 8 weeks. Researchers will…

This study tests a new type of talk therapy called Correct Self-Identification Program for people with major depression. 86 adults will be randomly assigned to either this new therapy or a standard therapy (ACT). The goal is to see if the new therapy reduces depression symptoms m…

This study tests a new depression treatment that combines cognitive behavioral therapy with faith-based principles, delivered by therapists and pastors in church settings. It aims to reduce depressive symptoms in African American adults. The trial will enroll 50 participants and …

This pilot study tests whether a non-invasive brain stimulation technique called TMS can reduce rumination—repetitive negative thinking—in adults with treatment-resistant depression. Twenty participants will receive 20 TMS sessions targeting a specific brain region and undergo br…

This phase 2 trial tests whether suvorexant (Belsomra), a drug approved for insomnia, is safe and tolerable for veterans with major depression who are at high risk for suicide. Thirty veterans will take the drug nightly for four weeks, with in-person and remote check-ins. The stu…

This study tests whether a 6-week intensified drug treatment can help people with major depression who did not get better on their first antidepressant. About 418 adults aged 18–65 will receive either the stronger treatment or usual care. The goal is to reduce depression symptoms…

This study tests a single injection of apimostinel, a fast-acting antidepressant, in 150 adults with major depression. Half also receive digital cognitive training sessions to see if it extends the drug's effects. The trial is placebo-controlled and double-blind, meaning neither …

This study tests a type of talk therapy called schema therapy for people whose depression has lasted a long time or hasn't gotten better with medication. 129 participants will either get 30 sessions of schema therapy or standard psychotherapy. The goal is to see if schema therapy…

This study tests whether a daily probiotic blend (called psychobiotics) can help ease depression and improve metabolic health in adults with pre-metabolic or metabolic syndrome. Sixty participants will take either the probiotic or a placebo for 12 weeks. Researchers will measure …

This study uses PET scans to measure levels of COX-1 and COX-2, enzymes linked to inflammation, in the brains of people with major depressive disorder (MDD) during a depressive episode. Researchers will compare these levels between MDD participants and healthy volunteers. The goa…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study investigates how depression and antidepressants influence the way older adults update their beliefs about future events. Researchers compare 31 patients aged 65+ with major depression who are switching antidepressants to 31 healthy volunteers of the same age. Participa…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study looks at whether parents of people with bipolar II disorder or major depressive disorder have certain personality traits (called Type D, which involves negative emotions and social inhibition) and lower life satisfaction. Researchers compare these parents to parents of…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they w…

This early-stage study at Stanford tests whether giving magnetic brain stimulation during sleep is safe and practical for people with major depression. Fifteen adults who have not gotten better with at least one antidepressant will receive both real and fake stimulation in separa…

This study looks at how tiny changes in your RNA (a molecule that reads your DNA) might help predict whether depression treatments will work. Researchers will follow 120 adults with unipolar or bipolar depression to see if these RNA changes match up with improvements in mood. The…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study looks at how mindfulness and fantasizing affect repetitive negative thinking in 100 adults whose depression is in remission. Participants will try both techniques and researchers will measure changes in thinking patterns, heart activity, and brain waves. The goal is to…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at how ketamine, a fast-acting antidepressant, affects the brain. Researchers want to understand if a specific brain receptor (AMPA) is key to its effects. Seventy adults with treatment-resistant depression will take part, receiving ketamine and a drug that block…

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This early-stage study involves 18 healthy men to see how well the experimental drug MSP-2020 attaches to serotonin receptors in the brain. Researchers will also measure how much drug stays in the blood and check for side effects. The goal is to understand the drug's activity in …

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study aims to find out if a special algorithm can predict which antidepressant will work best for each person with major depression. Researchers will use brain scans, EEGs, and blood tests from 400 adults to see if they can match people to the right medication faster. The go…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study aims to improve MRI imaging methods to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to refine these techniques …

This study tests a technique called real-time fMRI neurofeedback, where people with depression learn to control brain activity by watching a visual pattern change in real time during an MRI scan. Researchers want to see if this can help regulate brain networks linked to depressio…

This study tests a non-invasive brain stimulation technique called tDCS for depression. Researchers use MRI scans to see how the stimulation affects brain networks. 144 adults with depression will receive either real or sham tDCS while performing a memory task. The goal is to fin…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at how a single dose of ketamine changes brain chemistry and decision-making in people with major depression. Researchers will measure brain glutamate levels and stress responses in 140 participants. The goal is to understand why ketamine helps some people with d…

This study checks how well a new version of a mental health interview (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers in Hong Kong will interview 300 adults and compare the results with a detailed clinical assessm…

This study follows 252 people whose major depression is in remission to find early warning signs of relapse. Researchers will track symptoms, physical activity, sleep, thinking skills, and brain activity. The goal is to build a model that tells doctors who is likely to relapse an…

This study tests three types of non-invasive brain stimulation (intermittent, continuous, and sham) in 200 adults with major depression. Participants receive each type in separate sessions while undergoing MRI scans and mood assessments. The goal is to understand how different st…

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study looks at how stress and a sense of control affect brain activity in teenage girls with major depression. Researchers will use brain scans and smartphone surveys to understand these connections. The goal is to learn more about depression, not to test a new treatment. Ab…

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…

This study aims to understand how a specific type of brain stimulation, called continuous theta-burst stimulation (cTBS), affects brain activity in people with depression. Researchers will give participants a single dose of one of four FDA-approved drugs (or a placebo) that eithe…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study will test if cameras, microphones, and wearable sensors can help doctors measure how severe a person's depression is. About 300 adults hospitalized for severe depression will be recorded during interviews and while wearing devices that track movement, heart rate, and b…

This study aims to identify different types of depression by tracking how people manage their emotions in daily life and how their nervous system responds. Researchers will test whether a simple biofeedback exercise done at home for 10 days can improve emotional regulation. The s…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity an…

This study looks at whether treating depression with a common antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memory prob…

This study looks at how ketamine works in the brain to relieve depression. Researchers are giving people with hard-to-treat depression either a placebo or a drug called perampanel before a dose of ketamine. They will use brain scans to see if blocking certain brain receptors chan…

This study aims to find brain-based markers that can predict how individuals with major depression will respond to the antidepressant sertraline (Zoloft). Researchers will use fMRI and EEG brain scans to measure brain activity and connections before treatment. Fifty adults with c…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study explores why ketamine, a fast-acting antidepressant, works better in people with a family history of alcohol use disorder. Researchers will give a single low-dose ketamine infusion to 60 adults with treatment-resistant depression while scanning their brains with powerf…

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study looks at how nitrous oxide (laughing gas) changes brain connections in people with hard-to-treat depression compared to healthy volunteers. About 50 participants will get either the gas or a placebo and have their brains scanned with MRI. The goal is to understand how …

This Mayo Clinic study uses a safe, noninvasive light-based device called fNIRS to measure brain activity in 200 adults with major depression, bipolar disorder, or mild cognitive impairment. By comparing brain blood flow patterns across these groups, researchers hope to better un…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study aims to understand how ketamine produces rapid antidepressant effects by using a special brain scan (GluCEST) to measure changes in glutamate, a key brain chemical. Ten adults with treatment-resistant depression will receive a single ketamine infusion and undergo imagi…

This study looks at how the immune system and brain talk to each other in people with major depression. Researchers will give a harmless substance (LPS) to temporarily activate the immune system and then measure brain activity and mood changes. The goal is to understand the links…

This study looks at why people with mood disorders may be at risk for suicide. Researchers will collect blood, urine, and survey answers from 300 participants to find patterns and build a model that predicts suicide risk. The goal is to better understand the factors involved so d…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study will collect data from 5,000 adults with depressed mood who are receiving esketamine, TMS, or SAINT therapy in routine care. Researchers will analyze this information to build models that could one day predict which treatment is most likely to help a given patient. The…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…

This study looks at why women with PTSD have a higher chance of heart disease later in life. Researchers will test if beetroot juice, a natural source of nitric oxide, can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal is to understa…

This study looks at how childhood trauma and stress affect tiny genetic molecules called microRNAs in the blood. Researchers will compare people with major depression and healthy volunteers to see if these molecules can help explain the link between early life stress and suicidal…

This study tests whether psilocybin, the active ingredient in magic mushrooms, changes brain activity in people with depression. Fifty participants will receive either psilocybin or a placebo and undergo MRI scans to measure blood flow and brain network connections. The goal is t…

This study looks at how depression affects men and women differently. Researchers will measure depression severity, stigma, and psychological resilience in 90 adults diagnosed with major depressive disorder. The goal is to better understand gender-specific symptoms and help creat…

This study uses brain imaging (fMRI) to investigate why people with schizophrenia or depression often have trouble with memory and managing emotions. Researchers will scan the brains of 90 adults aged 18-60 while they perform tasks and at rest. The goal is to better understand th…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study explores whether a single dose of L-dopa, a drug used for Parkinson's, can improve motivation and motor function in people with major depression who have signs of low-grade inflammation. Researchers will compare L-dopa to a placebo in 165 participants (patients and hea…

This study aims to understand why some people with depression don't get better with standard medications. Researchers will use brain scans to compare dopamine receptors in 45 people: those with treatment-resistant depression, those whose depression responds to treatment, and heal…

This study looks at how electroconvulsive therapy (ECT) affects brain connections and sleep in 50 people with treatment-resistant depression. Researchers will measure brain activity during sleep and wakefulness to understand how ECT works. The goal is to learn more, not to test a…

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will use special electrodes placed inside the brain (in people with epilepsy) and noninvasive recordings to track these changes. The goal is to find reliable brain markers tha…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults and people with depression. Participants will have brain scans while receiving single and repeated magnetic pulses. The goal is to understand the brain mechanisms behind TMS, …

This study looks at how people with bipolar disorder or major depression process social cues, remember things, and think flexibly. Researchers will test 180 adults using tasks like recognizing emotions in faces. The goal is to better understand these cognitive challenges so that …

This study tests whether a non-invasive brain stimulation technique called tACS can improve goal-directed behavior in people with depression who have lost interest in activities (anhedonia). 72 participants will receive five daily sessions of stimulation. The goal is to see if th…

This study looks at how brain structure and gene activity in the blood are linked in people with early schizophrenia. About 1,899 participants, including healthy volunteers, will have brain scans and blood tests at the start and after one year of regular medication. The goal is t…

This study checks if a simple online cognitive test (Creyos) can accurately track memory and thinking changes in older adults with mild cognitive impairment or past depression. About 150 participants will take both online and in-person tests over up to 5 years. The goal is to see…

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 who have both conditions. The goal is to identify targets for future treatments, not to test a new therap…

This study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study is a registry that will follow up to 1,000 adults with treatment-resistant depression or obsessive-compulsive disorder (OCD) who receive electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine/esketamine. Researchers will collect data from…

This study uses transcranial magnetic stimulation (TMS) to explore how the brain controls social motivation in adults who avoid social situations due to depression or social anxiety. Forty participants will undergo MRI scans, computer tasks, and personalized TMS over four visits.…

This study tests whether low-intensity focused ultrasound can temporarily change brain activity in people with treatment-resistant depression. Researchers will scan participants' brains before and after ultrasound to see how it affects mood-related circuits. The goal is not to tr…

This study observes 100 people with depression who are already receiving transcranial magnetic stimulation (TMS) therapy. Researchers use brain scans and symptom questionnaires to see how brain networks change during treatment and whether these changes can predict who gets better…

This study at the University of Oxford is testing how the antidepressant fluoxetine (Prozac) influences the way healthy young people process anger. Eighty participants aged 18-24 will take either fluoxetine or a placebo for 7 days and complete tasks involving angry faces, words, …

This study uses virtual reality and eye-tracking to measure how pupils react during memory tasks. Researchers hope to find a simple, non-invasive way to detect early cognitive decline in Alzheimer's disease, mild cognitive impairment, and depression. 140 adults will be tested at …

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at how cognitive behavioral therapy for insomnia (CBT-I) changes a specific brain receptor (mGluR5) in people with major depression. 42 adults with depression and insomnia will receive online CBT-I and undergo PET brain scans before and after treatment. The goal …

This study is testing whether a smartphone app called EMOCARE can accurately track emotional changes in people with mild to severe depression. About 104 adults will use the app for 6 weeks while also filling out standard depression questionnaires. The goal is to see if the app gi…

This study is looking at how a non-invasive brain stimulation treatment called TMS changes the brain in people with depression. 100 adults will receive 20 TMS sessions over four weeks and have MRI scans at several points. The goal is to find brain imaging markers that can predict…

This study uses PET and MRI scans to look at brain changes in people who developed depression within three months after a mild or moderate COVID-19 infection. Researchers will compare brain scans of 90 participants to see if key brain chemicals are altered. The goal is to better …

This Stanford study is testing new ways to measure brain activity in people with depression using transcranial magnetic stimulation (TMS). The goal is to find better markers that could make TMS treatment more effective. The study involves 145 adults with moderate-to-severe depres…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study looks at how adults with depression respond to heat stress compared to those without depression. Researchers will measure skin blood flow, sweating, and core temperature during passive heating. The goal is to understand if depression or antidepressant medications like …

This study is observing how the medication trazodone helps older adults (55+) who have both major depression and mild memory or thinking problems. Researchers will track changes in depression symptoms and thinking skills during routine care in Italy, Poland, and Romania. The goal…

This study aims to find brain-based markers that can predict how well people with major depression respond to repetitive transcranial magnetic stimulation (rTMS) therapy. Researchers will use MRI and EEG to track brain changes in 50 adults with moderate to severe depression who h…

This study looks at how thinking skills (like memory and focus) are linked to sick leave in people with depression or anxiety. Researchers will give metacognitive therapy with a work focus to 200 patients at risk of sick leave. They want to see if the therapy improves symptoms an…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at 55 women who have a chronic (long-term) infection with the Toxoplasma parasite and also have a mental health condition like schizophrenia, depression, or bipolar disorder. Researchers want to see if tiny molecules called microRNAs in the blood can help tell th…

This study looks at how sex hormones during puberty might affect mood differently in boys and girls. Researchers are testing a 4-week smartphone training program called Healthy Minds Program in 60 adolescents aged 11-14. The goal is to understand the brain and hormone changes tha…

Latino teens are less likely to get depression treatment than their peers. This study asks teens, parents, and doctors which of three strategies—peer support groups, parent-teen training, or care navigation—they prefer. Researchers will interview 15 teens, 15 parents, and 5 healt…

This study looks at whether brain activity tests can tell if it's safe for people with depression to stop taking antidepressants. About 204 people will have brain scans, sleep tests, and blood draws to see if their brains return to normal with treatment. The goal is to find a way…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study looks at how a new, non-invasive brain stimulation technique called temporal interference (TI) affects social reward processing in people with depression. Researchers will use brain scans and tests to see if TI can change brain activity linked to social function. The g…

This study tests whether a mild, non-invasive electrical stimulation of the vagus nerve through the ear can improve motivation and mood in people with depression. Researchers will compare 60 depressed patients and 60 healthy controls, looking at how insulin sensitivity affects th…

This study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…

This study looks at whether a recovery-focused program can help people with severe mental illness living in supported housing. About 72 participants will either receive the new program or standard care. The goal is to see if focusing on personal goals improves daily functioning a…

This study uses brain imaging to explore how severe childhood stress may cause chemical changes in the brain that increase depression risk. Researchers will scan the brains of 160 women aged 20-32, some with a history of childhood adversity and some without. The goal is to unders…

This study looks at sleep inertia—the grogginess and poor attention right after waking—in people with major depression. Researchers will test reaction times and monitor sleep in 110 participants, including depressed patients with and without sleep inertia, plus healthy controls. …

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This study looks at how depression in older adults (late-life depression) may speed up memory and thinking problems. Researchers will follow 120 participants for 30 months, using brain scans and memory tests. The goal is to understand the link between depression and cognitive dec…

This study looks at how the natural rhythm of connection between a therapist and patient—called synchrony—might help treat depression. Researchers will track 78 adults with major depressive disorder over 16 weeks of supportive-expressive therapy. The goal is to see if each person…

This study is tracking 1,000 teenagers hospitalized for depression or bipolar disorder. Researchers will collect blood samples, brain scans, wearable device data, and psychological tests to identify patterns that predict how well a teen responds to treatment. The goal is to find …

This study looks at how the 24-hour patterns of sleep and social activity relate to mood and suicidal thoughts in older adults who recently lost a spouse or life partner. Researchers will track 169 participants for 12 months using surveys and activity monitors. The goal is to und…

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…

This study looks at how natural ups and downs of estrogen and progesterone during the menstrual cycle affect mood and the ability to feel pleasure in women whose depression gets worse before their period. Researchers will give 75 women hormone patches and pills to temporarily sta…

This study looks at how teen girls with a family history of depression respond to stress compared to those without. Researchers will use brain scans, smartphone surveys, and smartwatches to track stress reactions in real time. The goal is to find early warning signs that could le…

This study investigates how a brain chemical system called nociceptin/orphanin FQ relates to major depression. Researchers will use PET and MRI scans, along with behavioral tasks, to examine brain activity and decision-making in people with current or past depression. The goal is…

This study uses MRI scans to observe how the brain changes in people with depression during a 5-day accelerated transcranial magnetic stimulation (TMS) treatment. Researchers aim to see if a new imaging method called INSCAPE can track individual recovery patterns. Twenty adults w…

This study tests how a single dose of intravenous ketamine changes brain chemicals like GABA and glutamate in people with treatment-resistant depression. Thirty adults will receive either ketamine or a placebo, and researchers will measure brain activity and depression symptoms. …

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This observational study will collect genetic and health information from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will link this data to electronic health records to find patterns and risk facto…

This study uses a non-invasive brain stimulation technique called iTBS to explore how stimulating specific brain networks changes mood, thinking, and brain activity in people with major depression and healthy volunteers. Researchers aim to understand the brain mechanisms behind t…

This pilot study tests whether an intensified schedule of repetitive transcranial magnetic stimulation (iTBS) — six sessions a day for five days — works better than the standard one-session-a-day for six weeks in people with depression and Post-COVID condition. Researchers will m…

This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from epilepsy patients who also have depression while they play a gambling task. The goal is to identify abnormal brain signals that could guide future …

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study is looking for ways to predict which patients with severe depression will respond well to electroconvulsive therapy (ECT). Researchers will use brain scans, blood tests, and spinal fluid samples from 30 patients before and after ECT. The goal is to find biological mark…

This observational study follows 300 adults receiving strategic psychotherapy—a short-term, goal-focused talk therapy—in private practice. Participants fill out questionnaires about their symptoms and well-being before and after treatment. The goal is to see if this therapy leads…