Major depressive disorder

This study tests whether brain imaging and clinical data can help select the best treatment for people with depression that hasn't improved with standard therapies. Participants receive either repetitive transcranial magnetic stimulation (rTMS) or ketamine, and researchers check …

This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This early study tests a new device called the Motif XCS System for people with severe depression that hasn't improved with multiple medications. The device is implanted in the skull and stimulates a key brain area without piercing the brain's protective covering. The main goal i…

This study tests whether a personalized program of exercise, diet, sleep support, social activities, and a weight-loss drug (semaglutide) can improve mental functioning in 140 adults with depression, bipolar disorder, or schizophrenia. Participants are randomly assigned to the pe…

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study looks at whether extra education from a pharmacist can help people aged 18-60 who are starting a new antipsychotic medication for conditions like schizophrenia or bipolar disorder. The goal is to see if this support reduces weight gain and other metabolic side effects.…

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This study tests a new, intensive form of brain stimulation for elderly people (65 and older) who have depression that hasn't improved with medication and also have memory or thinking problems. The treatment uses magnetic pulses targeted to a specific brain area, guided by brain …

This pilot study tests whether a non-invasive brain stimulation technique called tACS can help teens (ages 12-18) with major depression when added to their usual medication. Thirty participants will receive either real or sham stimulation daily for several weeks. The goal is to s…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in university students. Researchers will enroll 80 students aged 16 to 25 and compare the app's results with standard questionnaires. The goal is to see if voice pattern…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study tests whether digital exercises on a smartphone can help teens aged 16-19 avoid relapse of depression or anxiety. Participants who have recovered from a past episode will use a research app to work through thoughts and feelings while they feel well. Some will join onli…

This study tests whether mindfulness-based cognitive therapy (MBCT) delivered through video calls can prevent depression from coming back. 315 adults with recurrent depression in partial remission will be randomly assigned to group MBCT, a self-help manual with minimal video supp…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study investigates whether a single session of whole-body hyperthermia (using an infrared sauna) can quickly improve symptoms of depression and anxiety. Researchers will measure brain activity, inflammation, and mood changes in four groups: healthy postpartum women, postpart…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive flexibility—the ability to adapt thinking—in people with major depression. 105 participants will receive either active stimulation to two brain areas, active stimulation to one a…

This study tests a new non-invasive brain stimulation tool called kTMP to treat anhedonia, the loss of interest or pleasure, in people with major depressive disorder. 104 participants will receive either active or sham stimulation. The main goal is to see if kTMP changes brain ac…

This study tests whether taking a probiotic supplement called Ecologic® Barrier for 16 weeks can reduce depressive symptoms and change brain activity in adults aged 25-40 with mild-to-moderate depression. Participants will be randomly assigned to receive the probiotic or a placeb…

Many Asian Americans with depression also suffer from physical symptoms like pain or fatigue, but no proven treatment addresses both together. This study will test whether combining a stress management program with Qigong/Tai Chi movements is practical and acceptable for 70 adult…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether 5 days of accelerated transcranial magnetic stimulation (TMS) can quickly reduce depression symptoms. 264 adults with major depressive disorder will receive either real or sham stimulation, along with brain scans and mood tracking. The goal is to see if t…

This study tests whether adding a special fish oil supplement (CreNeuroS) to the antidepressant escitalopram helps reduce depression symptoms more than escitalopram alone. Eighty adults with moderate to severe major depressive disorder will take either the fish oil or a placebo f…

This study tests a digital cognitive behavioral therapy (CBT) program with weekly phone coaching for pregnant women with depression. Researchers will enroll 1,000 women between 12 and 22 weeks pregnant who have depressive symptoms. The goal is to see if the program is easy to use…

This pilot study will test a stepped-care approach for depression in 40 adults from primary care clinics. Participants will either use a mood-tracking app (Moodivate) alone, receive telehealth therapy, or start with the app and step up to therapy if needed. The main goal is to se…

This study tests whether Functional Electrical Stimulation (FES) of facial muscles is a safe and effective way to reduce depression symptoms in people with major depressive disorder (MDD). About 60 adults with MDD who have not responded to up to two treatments will receive FES or…

This study tests whether a high-dose version of a gentle brain-stimulation device (tDCS) used at home works better than the standard dose for easing major depression. About 270 adults with depression will use the device daily and be monitored for changes in mood and thinking. The…

This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The g…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it red…

This trial compares two short, one-session therapies for teens aged 12-17 hospitalized for suicidal thoughts or attempts. One therapy (CAMS-BI) focuses on understanding and addressing the personal reasons behind suicidal feelings, while the other (Stanley-Brown Safety Planning) b…

This study looks at whether aerobic exercise (like brisk walking) and mindful breathing can help adults with major depressive disorder feel better and improve their quality of life. Participants are split into three groups: one does 45 minutes of moderate exercise three times a w…

This study tests whether a drug called allopregnanolone can reduce depression and pain in veterans who have had a mild traumatic brain injury (TBI). About 132 participants will receive either the drug or a placebo through an IV. Researchers will check symptoms during the infusion…

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

This study tests a non-invasive brain stimulation technique called tTIS for adults with major depressive disorder. Sixty participants will receive either active stimulation targeting specific brain areas or a sham (fake) treatment over 5 days. Researchers will measure changes in …

This early-stage study tests whether a single 25 mg dose of psilocybin can help people who still feel emotionally flat or uninterested in things despite taking antidepressants. About 90 adults aged 18-65 will receive either psilocybin or a placebo, and researchers will use brain …

This study tests whether baricitinib, an anti-inflammatory drug, can improve depression and cognitive symptoms in 30 male former football players aged 40-55 with at least 10 years of play. Participants take the drug every other week for 6 weeks, and researchers use brain scans an…

This study will test an internet-based therapy program for 366 adults with anxiety or depression. The program starts with self-guided modules, and based on early progress, some participants will also get live sessions with a therapist. The goal is to see if personalizing the trea…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TI) to see if it can improve mood in people with depression. Forty-three adults with moderate to severe depression will receive 10 sessions of TI over two weeks. Researchers will us…

This study tests whether combining whole-body hyperthermia (a controlled rise in body temperature) with cognitive behavioral therapy (CBT) can help adults with major depressive disorder. Sixty participants will receive either CBT, heat sessions, both, or neither, to see if the co…

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This phase 2 trial tests whether a single infusion of tocilizumab, a drug that blocks the inflammatory molecule IL-6, can reduce depressive symptoms in 32 adults with treatment-resistant major depression. Participants must have high inflammation levels (CRP ≥3 mg/L) and will rece…

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with prolonged grief after losing a loved one. Participants will complete three guided writing sessions over six days, with some receiving personalized AI feedback. …

This study tests whether adding allopurinol, a drug usually used for gout, to the antidepressant sertraline can better relieve symptoms of major depressive disorder. Researchers will enroll 70 adults with moderate to severe depression and measure changes in their depression score…

This study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can reduce suicidal thoughts more effectively than a placebo plus DBT. About 120 adults with borderline personality disorder and treatment-resistant depression or bipolar disorder wil…

This phase 2 trial will test whether giving psilocybin (the active ingredient in magic mushrooms) along with group cognitive behavioral therapy is acceptable and feasible for people with major depression. Thirty adults with current depressive symptoms will receive two doses of ps…

This study tests whether giving psilocybin—a psychedelic drug being studied for depression—under general anesthesia can hide its mind-altering effects. That would allow researchers to run a truly blinded trial where neither patients nor doctors know who got the real drug. Ten adu…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can ease depression in people with bipolar II disorder who haven't improved with standard treatments. About 90 adults aged 19-65 will receive either the full dose or a very low placebo dose, and their…

This study compares doing brain stimulation (tDCS) at home versus in the hospital for people with moderate to severe depression. The goal is to see if home treatment works just as well, making care more accessible. Sixty-six adults will receive 20 sessions over two weeks, with nu…

This study tests whether daridorexant, a sleep medication, can help people who have both major depression and insomnia. Researchers want to see if it improves sleep quality and also eases depressive symptoms. About 134 adults will take either daridorexant or a placebo for three m…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This pilot study tests whether tailoring psilocybin-assisted therapy to a person's preferences (music or mindfulness) is practical and helpful for treatment-resistant depression. Sixteen adults will receive two doses of psilocybin, each paired with a different therapy style, to s…

This study tests whether two anti-inflammatory medications, celecoxib or minocycline, can reduce depression symptoms in adults with major depressive disorder or bipolar depression. About 42 participants will take one of the drugs for 8 weeks and have their depression levels measu…

This study tests a new drug called PDC-1421 to see if it is safe and helps with depression in people who have cancer. About 12 adults with mild to severe depression and stage I-III cancer will take the drug for up to 5 weeks. Doctors will check mood changes using a standard depre…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…

This study tests an experimental tablet called JS1-1-01 in 180 adults with moderate to severe depression. Participants will take either a low dose, high dose, or placebo for 8 weeks. The goal is to see if the drug safely reduces depression symptoms better than a placebo.

This early-phase study tests whether a shortened LSD experience, combined with the drug risperidone, can safely ease symptoms of major depression. Ten adults with moderate to severe depression will receive LSD followed by risperidone 45 minutes later. Researchers will monitor saf…

This study tests whether intradermal acupuncture (tiny needles left under the skin for days) can help people with depression safely reduce or stop their SSRI medication. 114 adults planning to taper off SSRIs will be split into three groups: tapering alone, tapering with sham acu…

This study tests whether an 8-week mindfulness-based psychoeducation program can reduce depression symptoms, improve stress tolerance, and help with emotion regulation in adults diagnosed with major depression. About 70 outpatients aged 18-65 who have been treated for depression …

This study looks at how well and safely the antidepressant escitalopram works in people experiencing their first episode of major depression who have never taken medication for it. Two hundred adults aged 18 to 65 will take escitalopram for 8 weeks, and researchers will track the…

This study aims to see if acupuncture is more effective than a placebo for treating major depression. Researchers will compare acupuncture to the antidepressant escitalopram in 216 adults who are not currently taking any depression medication. The goal is to find out if this anci…

This pilot study will test a type of brain stimulation called accelerated intermittent theta-burst stimulation (a-iTBS) in 45 adolescents aged 12-18 with major depressive disorder. Participants will get either real or sham stimulation, guided by MRI scans. The goal is to see if i…

This study tests whether an 8-week psychoeducation program, based on Acceptance and Commitment Therapy, can help people with depression feel more meaning in life and take better care of themselves. About 46 adults receiving TMS treatment will either join the program or continue u…

This study tests whether a Mediterranean diet, adapted for Hong Kong, can reduce depression symptoms in 90 adults with moderate to severe depression. Participants will receive meal deliveries and track their mood and diet via phone surveys. The study also looks at how gut bacteri…

This study tests an enhanced version of depression treatment (COMBEX) for youth aged 15-24 with HIV. It combines therapy, medication management, and extra support strategies to improve mood and HIV care. Researchers will compare it to standard combination therapy over 72 weeks in…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This study tests whether a dietary supplement called GynMDD, taken alongside weekly supportive therapy, can improve symptoms of mild to moderate depression more than therapy plus a placebo. 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks, c…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This study tests whether a mental health app called Intellect can reduce depression and improve resilience in medical students. 220 students will be split into two groups: one gets full app access, the other gets basic access. Researchers will check changes in mood, anxiety, and …

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This study tests if the drug lumateperone can reduce depression symptoms in adults aged 21 to 70 who have major depressive disorder and a history of early life trauma. Half of the 50 participants will get the drug, and half will get a placebo, with results measured after 6 weeks.…

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

This study tests a new computer task that trains your eye movements to help treat major depression. The task uses a gaze-contingent feedback system to retrain attention patterns. Researchers will enroll 60 adults with depression to see if this approach reduces symptoms. The goal …

This pilot study will test whether a smartphone app that teaches cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants will use the app for five weeks, and researchers will measure changes in insomnia severity, depress…

This Phase 1 trial is the first time SP-101 is being tested in humans. It will enroll 80 healthy adults to check the drug's safety, tolerability, and how the body processes it. SP-101 works by blocking NMDA receptors in the brain, a different approach from standard antidepressant…

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This Phase 2 trial will test whether adding selenium supplements to standard antidepressant medication (fluoxetine) can improve depression symptoms in 172 children and adolescents aged 12-18 with major depressive disorder. Participants will receive either selenium or a placebo fo…

This study will test an adapted form of cognitive behavior therapy (CBT) in 80 adults aged 18–50 who have had multiple episodes of major depression. The therapy is designed to help people manage depression and anxiety, improve quality of life, and build skills to prevent future e…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This study tests a new method of delivering repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, the new method uses brain surface mapping to target a specific area. The trial will compare the two me…

This study tests a device that sends gentle electrical currents to the brain, automatically adjusting to your brain's own rhythms, to ease depression symptoms. It involves 214 adults who have tried at least one antidepressant without enough relief. Participants will receive eithe…

This Phase 3 trial tests whether inhaling nitrous oxide (laughing gas) can reduce depression symptoms in 120 adults with treatment-resistant major depressive disorder. Participants will receive either nitrous oxide plus a placebo or oxygen plus a mild sedative, and their mood wil…

This study tests a non-invasive brain stimulation technique called iTBS to help ease depression in young women aged 16 to 24. Eight female participants will receive the treatment to see if it improves mood and brain function. The goal is to find a new way to reduce depression sym…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests whether structured group therapy, including cognitive behavioral therapy and mindfulness, can reduce symptoms of depression and anxiety in adults in Pakistan. About 108 participants will attend 12 weekly group sessions. The goal is to see if this approach improve…

This study will test if using an AI chatbot like ChatGPT can help people with generalized anxiety disorder or major depressive disorder who are already in regular therapy. Researchers plan to recruit 204 adults in the U.S. who are currently in individual therapy. Participants wil…

This study will test a mobile app designed to help veterans who have both PTSD and depression. The app teaches skills to manage emotions and relationships, based on a proven talk therapy. Forty veterans will use the app and answer surveys to see if it improves their daily functio…

This study tests whether a digital monitoring device called Dalia can improve depression symptoms when added to usual care. About 644 adults with moderate-to-severe depression will use the device for 3 months. The main goal is to see if more people feel significantly better compa…

This phase 2 trial tests whether adding the antidepressant trazodone to psilocybin can reduce the intense psychedelic effects while keeping the mood-lifting benefits. 112 adults with treatment-resistant depression will receive either psilocybin alone, psilocybin plus a low or hig…

This study tests a self-help program for 200 post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. The program teaches healthy coping skills and how to find support services. Researchers will compare the self-help group to those receiving standard resour…

This study tests whether an 8-week internet-based cognitive behavioral therapy (ICBT) program can help adults with generalized anxiety disorder or major depressive disorder. Participants in Taiwan will either receive standard care alone or standard care plus the online program, w…

This pilot study tests whether a non-invasive device that sends a mild alternating current to the brain (tACS) can safely ease depression symptoms in 30 teenagers who have never taken antidepressants. Participants will receive daily sessions over several weeks, and researchers wi…

This study tests whether bupropion hydrobromide (Aplenzin) can safely ease depression symptoms in children and adolescents aged 7 to 17. About 246 participants will receive either the drug or a placebo. The main goal is to see if depression scores improve by the end of treatment.

This study tests whether low-dose laser acupuncture (LLA) can safely improve sleep in 120 adults with major depressive disorder and insomnia. Participants will receive either real or sham laser acupuncture five times a week for six weeks, while continuing their usual depression m…

This study compares two add-on treatments—esketamine nasal spray and aripiprazole pills—for older adults (60-74) whose depression hasn't improved with standard antidepressants. Around 220 participants will receive either esketamine once or twice weekly or daily aripiprazole, alon…

This study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …

This study looks at how a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) affects symptoms and blood markers in people with treatment-resistant depression. Fifty patients will receive iTBS sessions over four weeks, while fifty healthy v…

This study looks at how exercise affects a natural cell cleanup process called autophagy, which may be linked to depression. Researchers will have 120 healthy adults do a cycling test and take blood samples to measure changes in autophagy and related genes. The goal is to better …

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study will measure how different types of transcranial magnetic stimulation (TMS) change brain activity in 250 military veterans with major depressive disorder. Researchers hope to use this information to develop more personalized brain stimulation treatments. Participants w…

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study will test the long-standing theory that depression is caused by low serotonin levels in the brain. Researchers will give a single dose of fenfluramine (a drug that releases serotonin) to 46 people—half with depression and half healthy—and use PET brain scans to measure…

This pilot study will examine whether certain genes related to serotonin are linked to gut bacteria that process tryptophan in adults with depression, anxiety, PTSD, or panic disorder. Thirty participants will provide saliva and stool samples from home. The goal is to gather info…

This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …

This study uses a virtual reality task to measure how people with depression make decisions involving physical effort and reward. Participants will walk on a treadmill in a VR environment while researchers track brain activity, heart rate, and energy use. The goal is to better un…

This study looks at whether a single dose of modafinil or D-serine can improve decision-making and thinking in people who have had psychosis for less than five years. Twenty-four participants will play computer brain games and have brain scans before and after taking the drugs. T…

This study looks at how acupuncture might quickly improve symptoms of depression and uses brain scans to understand why. Researchers will enroll 80 adults with mild to moderate depression who will receive acupuncture treatment. Before and after treatment, participants will have b…

This study looks at 130 people with major depression who have suicidal thoughts. Researchers will use brain scans, genetic tests, and other biological measures to see how rapid treatments like Esketamine and electroconvulsive therapy (ECT) change the brain. The goal is to find ea…

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study will use brain scans (MEG and MRI) to look at brain activity in 60 young people aged 14-24 who have either attempted suicide, have ongoing suicidal thoughts, or are healthy. The goal is to find brain patterns linked to suicide risk. High-risk participants will also rec…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find th…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful technique. The goal is to see if the new method wor…

This study looks at how natural hormone changes during the menstrual cycle may make some teenage girls more irritable or depressed, especially those at risk for suicide. Researchers will give 50 girls ages 12-16 either a birth control pill to keep hormones steady or a placebo for…

This study tests whether a brain stimulation treatment for depression called iTBS can be improved by customizing it to each person's brain signals. Researchers will use EEG to measure brain responses and find the best stimulation settings for 80 adults with treatment-resistant de…

This study will use a brain imaging technique called fNIRS to see how electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) change brain activity in people with major depression. Researchers will compare the two treatments in 60 adults to understand their effects on …

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This study tests whether using a person's genetic information can help doctors choose the best antidepressant for major depressive disorder. 570 adults in Morocco will be randomly assigned to either genetic-guided treatment or standard care. Researchers will track depression symp…

This study looks at whether using a conversational AI to collect medical history can make people with depression feel more understood by their doctors. About 130 adults with moderate to severe depression will try the AI at home before a regular visit and rate how empathetic the e…

This study will use brain scans and thinking tests to compare how people with bipolar disorder and major depression control their impulses. Researchers want to find differences in brain activity that could help doctors make a more accurate diagnosis. The study involves 120 adults…

This study explores whether simple eye tests (electroretinography) can predict how well a person with major depression will respond to common antidepressants. Researchers will measure electrical signals from the eyes of 108 participants before and after starting medication. The g…

This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain s…

This study looks at how different treatments for depression—medication, talk therapy, or both—change the way symptoms like sadness, sleep problems, and low energy are connected. Researchers will track 90 adults with mild to moderate depression using smartphone surveys to see whic…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…

This study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…

This study aims to find biological markers that predict how well people with major depressive episodes respond to light therapy. Researchers will treat 173 adults with unipolar or bipolar depression using a bright light box for 4 weeks. By measuring sleep, mood, and circadian rhy…

This study compares a new selegiline skin patch to an existing one (EMSAM®) to see how well the skin tolerates it. Researchers will apply both patches to 230 healthy adults and check for irritation or allergic reactions. The goal is to ensure the new patch is safe for the skin be…

This research looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. The goal is to use brain imaging to better assess cognitive issues, improve diagnosis, and predict how well treatments might work.…

This study will use brain scans to see how cognitive behavioural therapy (CBT) affects the brains of 30 people aged 40-60 with major depression. Participants will receive 12 weeks of CBT, with follow-ups up to 9 months. The goal is to understand how CBT improves mood and thinking…

This study aims to find out how common depression is among medical students at Sohag University. Researchers will survey 300 students aged 18 to 25 to measure depression rates and understand the factors that contribute to it. The goal is to raise awareness and improve mental heal…

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes might happen. Researchers will track sleep, activity, and decision-making in 600 people with bipolar disorder, major depression, or healthy controls using smartwatches and computer tas…

This study looks at how two types of noninvasive brain stimulation affect brain activity and the body's stress system in people with both PTSD and major depression. Fifty adults will receive both active and sham stimulation in random order, with brain and heart measurements taken…

This study looks at whether a tailored exercise program can improve how quickly muscles recover oxygen after activity in menopausal women with depression. Researchers will compare exercise to a non-physical activity in 52 women. The goal is to understand the link between depressi…

This study aims to find better ways to treat depression by testing two ideas: whether having therapy twice a week instead of once leads to better results, and whether matching the type of therapy (CBT or psychodynamic) to a person's personality helps. Researchers will enroll 200 …

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study looks at how S-ketamine, a treatment for severe depression, affects tiny energy centers (mitochondria) in blood cells. Researchers will take blood samples from 30 adults with treatment-resistant depression before and after treatment. They hope to find markers that pred…

This study compares two strategies for safely stopping antidepressants in adults whose depression is in remission. Participants will be randomly assigned to either a standard gradual dose reduction or a more precise hyperbolic tapering method. The goal is to see which approach le…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…

This study looks at whether teaching people in the hospital about their psychiatric medications helps them stick to their treatment and handle side effects. Researchers will work with 64 adults who have serious mental illnesses like schizophrenia or bipolar disorder. The goal is …

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study aims to develop a brain wave (EEG) test that can measure how ketamine affects depression symptoms. Researchers will give ketamine infusions to 20 adults with treatment-resistant depression and track changes in their mood and brain signals. The goal is to find a reliabl…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will measure drug levels in the blood of 94 women aged 40-60 who are premenopausal or menopausal and taking the medication for depression or anxiety. The goal i…

This study explores whether data from your smartphone can warn doctors when depression symptoms are about to return. Researchers will collect phone data from 320 adults who have been treated for depression and are currently well. They will compare this data with monthly mood ques…

This study tests whether short online videos can reduce stigma about depression and improve help-seeking attitudes in teens aged 8-18. About 500 participants, both depressed and non-depressed, will watch either a stigma-reduction video or a neutral video. The goal is to see if th…

This study checks if an AI software can accurately measure depression and anxiety symptoms in 650 adults. Participants will have their symptoms rated by both the AI and human experts to see if the AI works well across different groups. The study does not provide any treatment—it …

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This study will give 40 adults with major depression and moderate-to-severe anxiety a single dose of CYB003 (a synthetic version of psilocin, the active ingredient in magic mushrooms) or a placebo. Researchers will use brain scans (fMRI, EEG) and questionnaires to see how the dru…

This study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…

This study looks at whether low magnesium levels are linked to sleep problems in people with major depressive disorder. Researchers will measure magnesium in the blood of 90 adults and compare it to their sleep quality. The goal is to better understand this possible connection, n…

This study aims to better understand why young people (ages 18-25) with mood disorders may be at risk for suicide. Researchers will collect clinical, brain imaging, genetic, and microbiome data from 180 participants to identify risk factors. They will also test whether a non-inva…