Major depressive disorder

This study tests whether a rapid form of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can relieve depression in people with bipolar II disorder whose depression has not responded to other treatments. Participants receive either real or sham …

This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to ident…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This study in India tests two common depression treatments—a talk therapy called the Healthy Activity Program and the antidepressant fluoxetine—in 1,500 adults with moderate to severe depression. The goal is to see which treatment works best for different people and to compare co…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tested a new approach for people with severe depression that hasn't improved with other treatments. A small wire was placed on the surface of the brain to send gentle electrical pulses to areas that control mood. The goal was to see if this is safe and could help reduc…

This study tests whether the anti-inflammatory drug celecoxib can help people with a specific type of depression linked to inflammation, called immuno-metabolic depression (IMD). Researchers will give 140 people with IMD either celecoxib or a placebo, in addition to their usual d…

This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive funct…

This study tests whether taking fecal microbiota transplantation (FMT) pills can improve symptoms of major depressive disorder (MDD) and irritable bowel syndrome (IBS). About 133 adults with MDD, with or without IBS, will either receive FMT or continue their usual treatment. Rese…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study is a long-term follow-up for people with major depressive disorder who already completed a previous trial with CYB003, a drug similar to psilocybin. It will test how safe and effective CYB003 is over time, with optional extra doses. About 468 participants will be monit…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The g…

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Sixteen adults aged 22 to 70 will have electrodes implanted in a brain region called the medial forebrain bundle. The device delivers mild elec…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study compares two treatments—electroconvulsive therapy (ECT) and intravenous ketamine—for quickly reversing acute suicidal depression in 1,500 adults aged 18 to 90. Participants are randomly assigned to receive either ECT or ketamine twice a week for up to four weeks. The m…

This large study compares four FDA-approved medications for bipolar depression to see which one helps people feel better. Over 2,700 adults with bipolar I or II disorder and current depression will be randomly assigned to one of the drugs. The goal is to find which treatment lead…

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matche…

This study explores whether a taste test can serve as a diagnostic tool for depression. Participants with untreated major depressive disorder will take a taste test before and after starting an antidepressant prescribed by their doctor, and again six to eight weeks later. The goa…

This study tests whether a Samsung smartwatch can detect signs of depression by analyzing heart rate, sleep, and step count. About 220 adults with and without depression will wear the watch for 3 months and complete daily mood surveys. The goal is to see if the watch's 'Mindfulne…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study is testing whether artificial intelligence can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, autism, and schizophrenia. Researchers will record 500 people speaking and compare the AI's predictions to standard clinical dia…

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current …

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This study tests a non-invasive device that uses gentle electrical currents to stimulate the right amygdala, a brain area linked to emotion. Fifty adults with major depression will receive either real or sham stimulation for six weeks. Researchers will measure changes in mood, th…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 1…

This study tests whether an accelerated form of transcranial magnetic stimulation (TMS) can safely and effectively reduce depression symptoms in people with major depressive disorder. About 50 participants aged 15 and older will receive the treatment in an open-label design. The …

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study looks at whether Behavioral Activation (BA) therapy can change the habit of repetitive negative thinking (rumination) in people with major depression. Up to 120 adults will receive 12 sessions of BA over 11 weeks. Researchers will measure symptom changes and explore wh…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study tests whether a wearable headband that shines near-infrared light can improve depression and sleep in adults aged 60 and older with major depression. Participants will wear the device for up to 8 weeks, and researchers will track sleep, mood, and daily activity using a…

This study tests whether adding ketamine tablets to a new antidepressant can reduce depression symptoms faster in adults with major depression. Twelve participants will take four doses of ketamine over one week while starting a standard antidepressant. The goal is to see if sympt…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study aimed to see if a web-based self-help program called Deprexis could help orthopedic patients with major depressive disorder. The plan was to offer the 8-week online program to patients with depression and see if they would use it and if their mood and physical function…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and a…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study explores whether individualized transcranial magnetic stimulation (TMS) can improve symptoms in adults with irritable bowel syndrome (IBS). Participants receive 10 TMS sessions over two weeks, with brain scans and stool tests before and after to understand how the trea…

This study tests whether a device that sends mild electrical pulses to facial muscles can help treat major depression. Twenty adults with depression will use the device at home for 45 minutes daily over four weeks. The main goal is to see if the approach is feasible and safe, wit…

This Phase 3 study tests whether a single 25 mg dose of synthetic psilocybin can reduce depression symptoms in 238 adults with major depressive disorder. Participants receive either psilocybin or a placebo, and their depression severity is measured over 43 days. The trial also lo…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This study tests whether a daily oral drug called SP-624 can safely reduce depression symptoms in adults with major depressive disorder. About 456 participants will receive either SP-624 or a placebo for several weeks. The main goal is to see if SP-624 leads to a greater improvem…

This study looks at how a fast form of brain stimulation called iTBS affects the brains of 22 adults with major depression. Participants receive both real and fake stimulation in a blinded setup, followed by 6 weeks of daily treatment. The goal is to understand how iTBS changes b…

This study tests a new device that uses mild electrical currents to stimulate the brain in people with major depression. The device adjusts the stimulation in real time based on brain activity. The goal is to see if the device works correctly and if it can help reduce depression …

This study aimed to see if nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. Participants would have received four weekly sessions of the gas or a placebo. However, the study was withdrawn before any …

This study looks at whether giving vitamin D supplements to women with depression and low vitamin D levels can change their brain waves. Researchers will measure brain activity using a non-invasive EEG scan before and after supplementation. The trial includes 34 women aged 20-40 …

This study tests whether giving different numbers of daily brain stimulation sessions (rTMS) can safely improve symptoms in people with moderate to severe depression that hasn't responded to other treatments. One hundred adults will receive 4, 6, 8, or 10 sessions per day for 5 d…

This pilot study tests whether a wearable device that delivers intermittent white light at 60 Hz can safely help people with moderate to severe depression. Thirty adults on stable antidepressant medication will wear the goggles for 30 minutes daily over two weeks. The main goal i…

This study tests whether up to two doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive either psilocybin or a placebo in a first session, and t…

This small pilot study tests whether Imagery Rescripting, a therapy that helps people change negative mental images, can reduce depression and negative beliefs. Ten adults with major depressive disorder will receive weekly sessions after a waiting period. The study tracks depress…

This pilot study tests whether a type of brain stimulation called accelerated continuous theta-burst stimulation (acTBS) can reduce suicidal thoughts in people hospitalized for depression. Forty inpatients will receive either real or sham (fake) stimulation up to 5 times a day fo…

This study aimed to see if transcranial magnetic stimulation (TMS) combined with talk therapy could help teens aged 13–17 whose depression didn't improve with standard treatments. Participants would have daily TMS sessions for two weeks and weekly therapy. However, the study was …

This study tests whether combining a mild electrical brain stimulation (tDCS) with virtual reality meditation can help ease anxiety. 52 adults with generalized anxiety disorder or related conditions will receive 12 sessions over two weeks. Researchers will measure anxiety levels …

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study tests whether Compound Ciwujia Granules, a traditional Chinese herbal medicine, can help reduce depression symptoms in people with a specific syndrome (heart-spleen deficiency). About 60 adults with major depressive disorder will take either the granules or a placebo t…

This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do eithe…

This study tests whether bright light therapy can help ease depression symptoms in adults aged 60 and older who are hospitalized for unipolar depression. Twenty participants will receive either active light therapy or a dim placebo light. The main goals are to see if the treatmen…

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area with depression, anxiety, or PTSD. The program uses outreach workers to connect people to mental health care and support. Researchers will measure if symptoms improve after six…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. The goal is to see if the drug reduces depression symptoms over 6 weeks. Participants are randomly assigned to receive either the drug or a placebo, and …

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using standard rating scales. The goal is to see if the drug can safely reduce depressio…

This study aimed to compare online group cognitive behavioral therapy (CBT) with in-person group CBT for adults with major depression. The goal was to see if online therapy is just as effective and more cost-effective. However, the trial was withdrawn before enrolling any partici…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study tests whether a 12-week physical activity program can reduce depressive symptoms in adults with major depressive disorder. 110 participants are split into two groups: one continues antidepressant treatment alone, the other adds a tailored exercise routine. Researchers …

This pilot study tests a therapy called Positive Affect Treatment (PAT) for Spanish-speaking adults with depression, anxiety, and low positive affect (a lack of joy or interest). Twelve participants will attend 15 therapy sessions over about 4 months, focusing on pleasant activit…

This pilot study tests whether a personalized form of transcranial magnetic stimulation (TMS) is feasible and safe for people with severe major depressive disorder who haven't improved with multiple medications or therapy. Ten participants will receive up to 30 TMS sessions over …

This study explores whether low intensity focused ultrasound (LIFU) can safely change brain activity linked to depression and anxiety in 25 veterans. Participants receive LIFU during MRI scans, and researchers monitor for side effects and brain changes. The goal is to see if this…

This phase 2 trial tests whether adding magnesium to a standard SSRI antidepressant works better than the SSRI alone for adults with major depressive disorder. Fifty participants will be randomly assigned to receive either the combination or just the SSRI. The main goal is to see…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively sui…

This study tests a new medicine called ONO-1110 in 100 Japanese adults with major depressive disorder. Participants receive either the drug or a placebo for 8 weeks. The main goal is to see if the drug reduces depression symptoms more than placebo.

This study tests two non-invasive brain stimulation methods to help people with major depression who haven't gotten better with medication. Ninety adults will receive either standard or deep brain stimulation daily for four weeks. Researchers will check if the deep method reduces…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This study tests a new way of doing electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to target the brain more precisely to reduce side effects like memory loss while still helping with depression. Twenty participants will receive the new…

This study tests whether a type of brain stimulation called rTMS can reduce depression in people with autism. Twenty-four participants aged 13 to 26 will receive either real or sham (fake) stimulation to see if it helps. The goal is to find a new way to treat depression that hasn…

This study looks at whether following an anti-inflammatory diet for 4 months can improve symptoms of anxiety and depression in 60 adults. Participants will either follow the special diet or their usual eating habits. The study also uses artificial intelligence to analyze speech a…

This study tests whether adding group mindfulness-based therapy to usual treatment helps people with serious mental illnesses like schizophrenia, bipolar disorder, or major depression. Researchers will randomly assign 160 patients to either usual care alone or usual care plus min…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This early study tests whether adding Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms more than rTMS plus a placebo. Thirty adults with treatment-resistant major depressive disorder will take either Adderall or a su…

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 adults will either join the writing groups plus their usual care, or stay on a waiting list wit…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests whether a faster version of transcranial magnetic stimulation (TMS) can safely treat major depressive disorder. Instead of the usual 30 sessions over six weeks, participants receive three 19-minute sessions in a single day. The trial includes 37 adults aged 22-85…

This early-stage study tests a new tablet called LY03021 in 98 healthy adults aged 18 to 45. The main goal is to check safety and how the body processes the drug. It is a first step before testing the drug in people with depression.

This study aimed to see if a mild electrical current applied to the scalp (transcranial direct current stimulation) could help people with severe depression that didn't improve after at least five treatments or electroconvulsive therapy. Participants would have received 30 sessio…

This study tests whether a smartphone app called MENTINA can help people with depression or mental distress better manage their symptoms. About 660 adults from Denmark, Germany, and Spain will use the app daily to track mood, sleep, and activity, and receive personalized tips. Th…

This small pilot study tested whether low-intensity focused ultrasound can safely ease symptoms in people with treatment-resistant depression. The device targets a brain region linked to mood. Only 1 person was enrolled, and the trial is currently suspended, so results are very l…

This study tests whether taking postbiotics (a dietary supplement) for 8 weeks can reduce depressive symptoms and improve mood in Korean adults aged 19-39 with mild to moderate mood issues. Fifty-two participants will receive either postbiotics or a placebo, and their mood will b…

This study tests a new way to deliver an FDA-approved treatment called TMS (transcranial magnetic stimulation) for depression in adults aged 60 to 79. Researchers use fMRI brain scans to personalize the treatment target. The goal is to improve depression symptoms and brain connec…

This study is testing a device called SAINT® that delivers a special type of brain stimulation (accelerated TMS) to treat major depression. It involves 1000 adults who haven't gotten enough relief from standard antidepressants. Participants get 10 treatments each day for 5 days, …

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in people hospitalized for depression. Fifty adults with major depression and active suicidal ideas will receive either nitrous oxide or a placebo gas, plus their usual treatment. …

This study tests a quick, non-invasive brain stimulation method called accelerated intermittent theta-burst stimulation (aiTBS) to see if it can improve mood in people with borderline personality disorder (BPD) who are also experiencing a major depressive episode. About 45 adults…

This study tests whether a smartphone app based on cognitive behavioral therapy (CBT) can help adults who are already taking antidepressants feel better. 150 participants in Sweden will use the app for 9 weeks, with extra online materials and therapist support available. The goal…

This study tests whether taking D-cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive daily iTBS …

This small pilot study tests whether deep brain stimulation (DBS) aimed at a specific brain region called the lateral habenula can safely reduce symptoms in 6 adults with severe, treatment-resistant depression. Participants have either major depressive disorder or bipolar I and h…

This study tests whether a robot that can be personalized by older adults helps reduce loneliness and depression. 90 people aged 65+ in a care home will either get a personalized robot, a standard robot, or usual care. The goal is to see if a co-designed robot buddy improves well…

This small pilot study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin. Researchers will measure brain ac…

This study tests a type of brain stimulation called theta-burst rTMS in 54 adults with depression that hasn't responded to other treatments. The goal is to see if it eases depression and thinking problems, and to use brain scans to predict who will benefit. Participants receive d…

This study tests whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with major depression who are already on medication but still have symptoms. About 30 adults will receive either real or sham stimulation to see if it improves …

This early-phase study tests whether giving a single intravenous dose of the antidepressant citalopram together with 10 sessions of theta burst stimulation (a form of transcranial magnetic stimulation) can quickly improve depression symptoms. Thirty adults with major depressive d…

This study tests a new type of brain stimulation for people with treatment-resistant depression. Ten participants will receive both real and sham stimulation in a random order, with a break in between. The goal is to see if this personalized, closed-loop approach can safely impro…

This study looks at whether taking vitamin D supplements for six months can improve depression symptoms. About 319 adults with depression are getting either a low or high dose of vitamin D daily, while continuing their usual treatment. Researchers will track their mood and health…

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study looks at whether adding aripiprazole to the antidepressant escitalopram can reduce pathological rumination—repetitive, intrusive negative thoughts—in people with major depressive disorder. 108 participants will receive either escitalopram alone or escitalopram plus ari…

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at sleep patterns in 94 adults with major depressive disorder, comparing those with moderate-to-severe insomnia to those with mild or no insomnia. Participants wear a headband at home that records brain activity during sleep and also fill out sleep diaries and qu…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study aims to find which patients with treatment-resistant depression are most likely to get relief from a single low dose of IV ketamine. Researchers will use interviews, questionnaires, brain wave tests, and computer tasks to look for clues. The goal is to make this treatm…

This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…

This study gives ketamine to 120 people with major depression and suicidal thoughts who are not on other psychiatric medications. Researchers use brain scans and a gentle nose swab to see how ketamine changes brain connections and neuron activity. The goal is to understand why ke…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study explores how a specific brain area (the medial prefrontal cortex) influences the ability to savor positive experiences in people with depression. Researchers will use non-invasive brain stimulation (TMS) and brain scans (EEG and fMRI) to see if changing activity in thi…

This study aimed to see if measuring sertraline (Zoloft) levels in the blood and checking a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. The goal was to reduce side effects and improve treatment. However, the study was withdrawn …

This study is collecting data from 350 people with major depression to build an AI tool that helps doctors choose the best antidepressant for each patient. Researchers are analyzing blood, gut bacteria, brain activity, and genetics to find patterns that predict treatment success.…

This study aimed to see if electronic cigarettes could help people with depression smoke less or quit. It planned to follow smokers for 12 months, measuring how many cut down or stopped. However, the study was withdrawn before enrolling anyone, so no results were collected.

This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions …

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This study looks at how things like social support, income, and health habits are linked to mental health and brain diseases such as depression, Alzheimer's, and Parkinson's. Researchers will collect surveys, blood samples, and optional brain scans from over 1,300 adults in Europ…

This study looks at two treatments for severe depression: electroconvulsive therapy (ECT) and antidepressant medication. Researchers want to see which one works better and is more cost-effective in the long run. The study involves 220 adults in the Netherlands who have not gotten…

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study explores why Black, Indigenous, and People of Color (BIPOC) may have lower rates of starting and sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects whether they get…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study looks at how older adults with major depression handle emotions and make choices compared to healthy adults. Researchers will use brain scans and computer tasks to measure emotional recognition, reward processing, and impulsivity. The goal is to better understand the b…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depressi…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

This study observes 65 adults with major depression or bipolar depression who are receiving electroconvulsive therapy (ECT) as part of their routine care. Researchers track how two different anesthetics—ketamine plus propofol versus propofol alone—affect depression severity, suic…

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study explores whether highlighting certain words in questionnaire instructions (like 'bothered by') affects how people with depression or anxiety respond. Two hundred U.S. adults who have been treated for these conditions in the past year will take the same survey twice in …

This study aims to understand how the brain's pain-processing systems relate to a person's ability to attempt suicide. Researchers will use fMRI scans to measure brain activity in 90 adults with depression while they experience pressure pain. The goal is to identify neural patter…

This study aimed to track brain activity in people with depression over time and see how a single dose of ketamine might change it. It was withdrawn before any participants were enrolled, so no results are available.

This study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 26 weeks in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…

This study was designed to test a new computer-based tool that uses pictures of food to measure how much pleasure and motivation people with major depression feel. The goal was to compare these responses between depressed patients and healthy volunteers to better understand depre…

This study is analyzing blood samples from 1,799 people with Alzheimer's, dementia, depression, bipolar disorder, schizophrenia, or Parkinson's disease. Researchers want to see if certain substances in the blood can help doctors diagnose and manage these conditions more accuratel…

This study was designed to see if low-intensity focused ultrasound could safely change brain activity related to emotion and thinking. It planned to test the device on healthy volunteers using brain scans. However, the study was withdrawn before enrolling any participants, so no …

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study was designed to understand why electroconvulsive therapy (ECT) sometimes causes temporary memory problems. Researchers planned to measure brain waves in people with severe depression or bipolar disorder receiving ECT. The study was withdrawn before any participants wer…

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

This study looks at whether a hormone called oxytocin, measured in saliva during a psychedelic therapy session, can help predict how well people with major depression respond to treatment. Researchers will track changes in depression symptoms, flexibility in thinking, and anxiety…

This study uses brain scans and magnetic stimulation to compare brain activity in 160 adults with autism, depression, both, or neither. Researchers want to understand how brain inflammation and the balance of excitation and inhibition relate to social and emotional symptoms. No t…

This study looks at whether brain scans can help predict which veterans with hard-to-treat depression will get better with a treatment called transcranial magnetic stimulation (TMS). Researchers will use MRI scans to measure brain activity before and during TMS therapy. The goal …

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …

This study will survey 25,000 people in China with mood disorders like bipolar disorder or major depression. Researchers want to understand what factors increase the risk of suicide or self-harm. They will follow 1,000 participants for one year to see if their predictions hold tr…

This study aims to find brain activity patterns that can predict how people with major depression will respond to different treatments. Researchers will use a non-invasive brain imaging device (TD-fNIRS) to measure brain function in 540 adults before they start treatment. The goa…

This study looks at how people who have had major depression in the past make decisions when faced with choices that involve risk or reward. Researchers use brain scans (MRI) and computer tasks to understand which brain areas are involved. The goal is to find patterns that might …

This study looks at how transcranial magnetic stimulation (TMS) changes brain connections in people with major depression. Researchers will use MRI scans to measure brain activity before and after TMS treatment. The study involves 54 adults aged 18-80 who are already receiving TM…

This study looks at brain tissue and lab-grown nerve cells from people with schizophrenia, depression, bipolar disorder, frontotemporal dementia, and Alzheimer's. Researchers want to find out how problems with synapses—the connections between brain cells—differ in these condition…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This study looks at whether mild whole-body hyperthermia (raising body temperature to about 101.3°F) can help treat major depression by affecting the immune system. Researchers will give some participants a drug that blocks IL-6 (tocilizumab) and others a placebo before the heati…

This study looks at how a nasal spray called esketamine can quickly reduce suicidal thoughts in people with severe depression. Researchers want to find out if symptoms like loss of pleasure (anhedonia) or emotional pain can predict who will benefit most. The study re-analyzes dat…

This study looks back at 376 patients who received psychedelic-assisted therapy with LSD or psilocybin for depression, anxiety, PTSD, or substance use disorders. Researchers want to see if the intensity of the psychedelic experience is linked to better outcomes. All data comes fr…

This study aimed to see if a fast-acting form of brain stimulation (called accelerated TMS) could change brain activity linked to suicidal thinking in adults hospitalized for major depression. The researchers planned to measure changes in suicidal thoughts using a standard questi…

This study aimed to see if a drug called LY-2940094 could protect healthy adults from developing depression- or anxiety-like symptoms after stress. Researchers planned to give the drug to participants and then measure their brain responses to rewards and fear. However, the trial …

This study explores a personalized form of brain stimulation called resonant frequency rTMS for people with major depression. Researchers will test different stimulation frequencies to see which one best engages brain circuits. The goal is to develop a more targeted treatment app…

This study examines blood samples from 46 people with treatment-resistant depression who took psilocybin in a previous trial. Researchers will measure markers of inflammation (cytokines and mRNA) to see if they relate to how well the treatment worked. The goal is to understand wh…

This study tests whether a brain stimulation technique, called theta-burst stimulation, can help predict if depression will come back in people who are currently in remission. Researchers will measure brain activity changes during stimulation using a special imaging cap. The goal…

This study looks at why depression often comes back in older adults and how it affects memory and thinking. Researchers will follow 210 people aged 60 and older, some currently depressed and some in remission, using brain scans and daily mood tracking. The goal is to find biologi…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…

This study is testing whether data from smartphones and wearable devices can predict when a person with depression or bipolar disorder might have another episode. Over 12 months, 540 participants will wear a Fitbit, log daily moods, and complete five check-ins. Researchers will u…