Scientists zap brains to unlock joy in depressed patients

NCT ID NCT07467473

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study explores how a specific brain area (the medial prefrontal cortex) influences the ability to savor positive experiences in people with depression. Researchers will use non-invasive brain stimulation (TMS) and brain scans (EEG and fMRI) to see if changing activity in this region alters reward processing. The goal is to understand the brain mechanisms behind impaired positive savoring, not to provide a direct treatment. 48 adults with depression will participate over four sessions.

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Conditions

The condition(s) this trial relates to.

Anhedonia major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Florida State University

    Tallahassee, Florida, 32306, United States