Brain zap test may forecast depression return

NCT ID NCT05579015

Ongoing Knowledge-focused Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a brain stimulation technique, called theta-burst stimulation, can help predict if depression will come back in people who are currently in remission. Researchers will measure brain activity changes during stimulation using a special imaging cap. The goal is to find a way to identify who is at risk of relapse, so they can get help sooner.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Theta-burst stimulation (TBS) using a device
What this could lead to: If successful, this could lead to a way to predict who will have a depression relapse, allowing for earlier intervention.
What could go wrong: This is an early-stage observational study, not a treatment trial. The brain stimulation is used only to measure brain activity, not to treat depression. Results may not lead to a reliable prediction method.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY MAJOR DEPRESSION IN REMISSION

Contacts and locations

Locations

The Hong Kong Polytechnic University

Hong Kong, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.