Major depressive disorder

This study tested whether adding the drug aticaprant to standard antidepressants could prevent depression from returning in people with major depressive disorder who also experience a loss of interest or pleasure (anhedonia). The study enrolled 47 adults who had responded well to…

This study looked at whether people with treatment-resistant depression who got better with electroconvulsive therapy (ECT) could switch to a less intense treatment called transcranial magnetic stimulation (TMS) to stay well. TMS is done in a clinic without anesthesia and has few…

This study tested the long-term safety of a drug called aticaprant when added to a standard antidepressant for adults with major depression. The trial planned to enroll 871 people but was terminated early, so the full safety and effectiveness data are not available. Researchers w…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study tested an experimental drug called MIJ821, given as an IV infusion, to see if it could quickly reduce depression symptoms in people with major depressive disorder who also have active suicidal thoughts. About 199 adults aged 18 to 65 took part, receiving either MIJ821 …

This study followed 26 people with major depressive disorder for one year after they received a single dose of psilocybin or a niacin control. Researchers used web surveys and phone interviews to track depression symptoms over time. The study was terminated early, so results are …

This study aimed to see if a telephone-supported self-help program called Bounce Back could help people with mild to moderate depression. Participants used cognitive behavioral therapy (CBT) materials at home with coaching over the phone. The study was stopped early and only incl…

This small pilot study tested a noninvasive brain stimulation technique called tDCS in 5 adults with major depression that hadn't improved after at least 3 antidepressant trials. Participants received up to 20 sessions of higher-than-usual electrical current over 4 to 6 weeks. Th…

This study tested whether adding aticaprant to standard antidepressants could help people with major depression who still feel no pleasure (anhedonia). The trial was stopped early after enrolling only 101 participants. No results are available, so it is unknown if aticaprant work…

This study looked at the long-term safety and symptom relief of an experimental drug called AXS-05 in 181 adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants took the drug and were monitored for side effects and mood ch…

This study tested the drug tianeptine in 38 adults with major depression that did not improve after at least two other treatments. Participants took tianeptine three times a day for 8 weeks. The goal was to see if it reduced depression symptoms and changed how the brain processes…

This study tested a new drug called REL-1017 as an extra treatment for adults with major depression who didn't get enough help from standard antidepressants. The trial was stopped early and included only 27 participants. The main goal was to see if the drug could reduce depressio…

This study tested a new drug called REL-1017 (esmethadone) as an add-on treatment for people with major depression who weren't helped enough by their current antidepressant. The trial was a Phase 3, double-blind, placebo-controlled study with 236 participants. However, the study …

This study tested whether adding a type of talk therapy (behavioral activation) to esketamine treatment helps people with depression that hasn't improved with other treatments. Six adults with major depression or bipolar disorder took part. The goal was to see if practicing new b…

This study tested a new medicine called fosigotifator for adults with major depressive disorder. The goal was to see if it is safe and helps with depression symptoms. About 20 people were enrolled before the study was stopped early. Participants took either the drug or a placebo,…

This pilot study tested whether using brain scans to personalize magnetic stimulation (rTMS) could improve treatment for people with depression that hasn't responded to medication. 27 participants received either personalized rTMS, standard rTMS, or a different type of brain stim…

This study tested whether real-time fMRI neurofeedback could help young adults with major depression reduce repetitive negative thinking. Participants received either real or fake feedback while their brain activity was monitored. The trial was terminated early, so the findings a…

This study aimed to see if a simple brain-wave test (LDAEP) could predict which veterans with PTSD or depression would improve with the SSRI medication sertraline (Zoloft). Participants took sertraline or a placebo for 14 weeks while researchers measured their brain activity and …

This study looked at how noninvasive brain stimulation techniques like rTMS, tDCS, and ECT change BDNF levels in people with depression or schizophrenia. Researchers took blood samples before and after stimulation to measure BDNF, a protein linked to brain health. The study was t…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…

This study aimed to see if giving patients extra encouragement before and after esketamine treatment could improve their depression symptoms. Researchers planned to compare a group that received a positive presentation and follow-up session with a group that did not. However, the…

This study looked at why some people have more suicidal thoughts when they start or switch antidepressants. 38 adults with major depression used a smartphone app to rate their dark thoughts and mood daily for 30 days. The goal was to better understand and monitor this early risk …