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Experimental drug MIJ821 aims to quickly ease depression and suicidal urges

NCT ID NCT04722666

Terminated Symptom relief Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called MIJ821, given as an IV infusion, to see if it could quickly reduce depression symptoms in people with major depressive disorder who also have active suicidal thoughts. About 199 adults aged 18 to 65 took part, receiving either MIJ821 or a placebo alongside standard care. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
MIJ821
What this could lead to
If it works, this could point toward a fast-acting treatment for severe depression with suicidal thoughts.
What could go wrong
The trial was terminated early, so results are limited. It is a Phase 2 study, and the drug may not prove effective or safe in larger groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder mood disorder psychiatric disorder Self-Injurious Behavior Suicidal Ideation Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER WITH SUICIDAL IDEATION WITH INTENT

Contacts and locations

Locations

  • Atlanta Center for Medical Research

    Atlanta, Georgia, 30331, United States

  • Centers for Behavioral Research

    Rockville, Maryland, 20850, United States

  • InSite Clinical Research

    DeSoto, Texas, 75115, United States

  • Novartis Investigative Site

    Buenos Aires, C1429DUC, Argentina

  • Novartis Investigative Site

    Fortaleza, Ceará, 60430-270, Brazil

  • Novartis Investigative Site

    São Paulo, 09726-150, Brazil

  • Novartis Investigative Site

    Toronto, Ontario, M5B 1W8, Canada

  • Novartis Investigative Site

    Munich, Bavaria, 81377, Germany

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60590, Germany

  • Novartis Investigative Site

    Toyoake, Aichi-ken, 470-1168, Japan

  • Novartis Investigative Site

    Bunkyo-ku, Tokyo, 1138519, Japan

  • Novartis Investigative Site

    Kodaira, Tokyo, 187-8551, Japan

  • Novartis Investigative Site

    Seremban, Negeri Sembilan, 70300, Malaysia

  • Novartis Investigative Site

    Kuala Lumpur, 59100, Malaysia

  • Novartis Investigative Site

    Monterrey, Nuevo León, 64460, Mexico

  • Novartis Investigative Site

    Mazatlán, Sinaloa, 82103, Mexico

  • Novartis Investigative Site

    San Luis Potosí City, 78213, Mexico

  • Novartis Investigative Site

    Groningen, 9713 GZ, Netherlands

  • Novartis Investigative Site

    Pruszków, Masovian Voivodeship, 05-802, Poland

  • Novartis Investigative Site

    Bialystok, 15 276, Poland

  • Novartis Investigative Site

    Gdansk, 80-214, Poland

  • Novartis Investigative Site

    Gmina Świecie, 86-100, Poland

  • Novartis Investigative Site

    Lodz, Łódź Voivodeship, 91-229, Poland

  • Novartis Investigative Site

    Moscow, 107258, Russia

  • Novartis Investigative Site

    Moscow, 115419, Russia

  • Novartis Investigative Site

    Palma, Balearic Islands, 07120, Spain

  • Novartis Investigative Site

    Barcelona, Catalonia, 08003, Spain

  • Novartis Investigative Site

    Araba, 01004, Spain

  • Novartis Investigative Site

    Barcelona, 08025, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Barcelona, 08041, Spain

  • Novartis Investigative Site

    Taipei, 10002, Taiwan

  • Novartis Investigative Site

    Taipei, 11217, Taiwan

  • Novartis Investigative Site

    Istanbul, Fatih, 34098, Turkey (Türkiye)

  • Novartis Investigative Site

    Bursa, Nilufer, 16059, Turkey (Türkiye)

  • Novartis Investigative Site

    Izmir, 35100, Turkey (Türkiye)

  • Research Centers of America LLC

    Oakland Park, Florida, 33334, United States

  • Univ of Alabama at Birmingham

    Birmingham, Alabama, 35294-3300, United States

  • University of Connecticut Health Center

    Farmington, Connecticut, 06030-3100, United States