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Experimental drug aims to rapidly lift depression in those at risk of suicide

NCT ID NCT04722666

Terminated Symptom relief Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen May 20, 2026 · Last updated May 22, 2026 · Updated 1 time

Summary

This study tested an experimental drug called MIJ821, given as an IV infusion, in addition to standard care for people with major depression who were having active suicidal thoughts. The goal was to see if it could quickly reduce depression symptoms. The trial involved 199 adults aged 18 to 65 and was stopped early by the sponsor.

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Contacts and locations

Locations

  • Atlanta Center for Medical Research

    Atlanta, Georgia, 30331, United States

  • Centers for Behavioral Research

    Rockville, Maryland, 20850, United States

  • InSite Clinical Research

    DeSoto, Texas, 75115, United States

  • Novartis Investigative Site

    Buenos Aires, C1429DUC, Argentina

  • Novartis Investigative Site

    Fortaleza, Ceará, 60430-270, Brazil

  • Novartis Investigative Site

    São Paulo, 09726-150, Brazil

  • Novartis Investigative Site

    Toronto, Ontario, M5B 1W8, Canada

  • Novartis Investigative Site

    Munich, Bavaria, 81377, Germany

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60590, Germany

  • Novartis Investigative Site

    Toyoake, Aichi-ken, 470-1168, Japan

  • Novartis Investigative Site

    Bunkyo-ku, Tokyo, 1138519, Japan

  • Novartis Investigative Site

    Kodaira, Tokyo, 187-8551, Japan

  • Novartis Investigative Site

    Seremban, Negeri Sembilan, 70300, Malaysia

  • Novartis Investigative Site

    Kuala Lumpur, 59100, Malaysia

  • Novartis Investigative Site

    Monterrey, Nuevo León, 64460, Mexico

  • Novartis Investigative Site

    Mazatlán, Sinaloa, 82103, Mexico

  • Novartis Investigative Site

    San Luis Potosí City, 78213, Mexico

  • Novartis Investigative Site

    Groningen, 9713 GZ, Netherlands

  • Novartis Investigative Site

    Pruszków, Masovian Voivodeship, 05-802, Poland

  • Novartis Investigative Site

    Bialystok, 15 276, Poland

  • Novartis Investigative Site

    Gdansk, 80-214, Poland

  • Novartis Investigative Site

    Gmina Świecie, 86-100, Poland

  • Novartis Investigative Site

    Lodz, Łódź Voivodeship, 91-229, Poland

  • Novartis Investigative Site

    Moscow, 107258, Russia

  • Novartis Investigative Site

    Moscow, 115419, Russia

  • Novartis Investigative Site

    Palma, Balearic Islands, 07120, Spain

  • Novartis Investigative Site

    Barcelona, Catalonia, 08003, Spain

  • Novartis Investigative Site

    Araba, 01004, Spain

  • Novartis Investigative Site

    Barcelona, 08025, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Barcelona, 08041, Spain

  • Novartis Investigative Site

    Taipei, 10002, Taiwan

  • Novartis Investigative Site

    Taipei, 11217, Taiwan

  • Novartis Investigative Site

    Istanbul, Fatih, 34098, Turkey (Türkiye)

  • Novartis Investigative Site

    Bursa, Nilufer, 16059, Turkey (Türkiye)

  • Novartis Investigative Site

    Izmir, 35100, Turkey (Türkiye)

  • Research Centers of America LLC

    Oakland Park, Florida, 33334, United States

  • Univ of Alabama at Birmingham

    Birmingham, Alabama, 35294-3300, United States

  • University of Connecticut Health Center

    Farmington, Connecticut, 06030-3100, United States

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER WITH SUICIDAL IDEATION WITH INTENT