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Yale study tests if a pep talk boosts depression drug – but only one person joined

NCT ID NCT05910775

Terminated Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to see if giving patients extra encouragement before and after esketamine treatment could improve their depression symptoms. Researchers planned to compare a group that received a positive presentation and follow-up session with a group that did not. However, the trial was terminated after enrolling only one participant, so no meaningful conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
esketamine
What this could lead to
If successful, this could show that adding simple encouragement sessions makes esketamine work better for depression.
What could go wrong
The trial was terminated with only 1 participant, so results are not reliable. It is too early to draw any conclusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSIVE EPISODE

Contacts and locations

Locations

  • Yale Psychiatry Hospital Interventional Psychiatry Services (IPS) unit

    New Haven, Connecticut, 06520, United States

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