Can a phone app explain why depression hits girls harder in puberty?
NCT ID NCT06072677
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how sex hormones during puberty might affect mood differently in boys and girls. Researchers are testing a 4-week smartphone training program called Healthy Minds Program in 60 adolescents aged 11-14. The goal is to understand the brain and hormone changes that could explain why depression rates rise more in girls during this time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Healthy Minds Program (smartphone-based training)
- What this could lead to
- If successful, this could reveal why depression rates differ between boys and girls during puberty, pointing toward sex-specific prevention strategies.
- What could go wrong
- This is a small, early-stage study (60 participants) focused on understanding mechanisms, not testing a treatment. Results may not apply to all teens.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Carolina Crossing B, Suite 1
RECRUITINGChapel Hill, North Carolina, 27517, United States
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