Substance dependence

This study tests whether combining varenicline (a medication that helps people stop smoking) with financial rewards for clean urine samples can reduce alcohol and tobacco use in adults who both drink heavily and smoke daily. Participants are randomly assigned to receive either re…

This phase 2 trial tests whether mirtazapine, an antidepressant, can help adults who are already receiving medication for opioid use disorder to stop or reduce their methamphetamine use. Participants are randomly assigned to receive either mirtazapine or a placebo for 10 weeks, a…

This study tests whether adding a gentle brain stimulation technique (tDCS) along with computer-based thinking exercises can improve brain function and self-control in people being treated for opioid use disorder with buprenorphine. About 160 adults will either get real or fake s…

This study tests a mobile health app called uMAT-R, designed to help Black adults recover from opioid or stimulant use and manage depression or anxiety. Participants are recruited from community treatment centers and use the app to track substance use and mental health symptoms. …

This study looks at whether follow-up care for opioid use disorder via telehealth works as well as in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person clini…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce opioid cravings and prevent relapse. Researchers will compare active stimulation to a sham (fake) version in 100 adults with opioid use disorder who recently started medication like bupreno…

This study tests an updated computer tool for emergency room doctors that includes information about a patient's social risks—like unstable housing or food insecurity—alongside standard opioid use disorder treatment guidance. The goal is to see if this social-risk-informed tool h…

This study tests whether psilocybin, a psychedelic substance, can help people stop smoking. Sixty-six daily smokers who have tried and failed to quit before will receive either psilocybin or niacin (a vitamin) in two sessions one week apart. Researchers will check if participants…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study tests whether a long-acting buprenorphine injection can be used to start treatment for opioid use disorder without causing severe withdrawal. Thirty adults with opioid use disorder will stay in a hospital for three days, receive fentanyl to prevent withdrawal, and then…

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measure…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study tests a new, non-invasive treatment using low-intensity focused ultrasound (LIFU) to help people quit smoking. It targets deep brain areas linked to nicotine addiction without surgery or needles. The study will enroll 100 adults who have smoked for at least 5 years and…

This study tests a smartphone app designed to help young adults aged 18 to 25 who want to reduce their combined use of alcohol and opioids. The app sends timely tips based on users' daily reports. The goal is to see if the app is usable, satisfying, and worth testing in larger st…

This study tests a combination of two treatments for people with cocaine use disorder: deep transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, and contingency management, a program that rewards participants for staying cocaine-free. The go…

This study tests a new type of brain stimulation that sends paired pulses to the cerebellum and prefrontal cortex. The goal is to reduce cravings and improve cognitive flexibility in 90 adults with moderate to severe methamphetamine use disorder. Participants will receive either …

This study tests whether a smartphone app can help people reduce their use of illegal opioids while they are in treatment for opioid addiction. The app uses a short test to predict the chance of relapse in the next week and adjusts medication doses accordingly. About 225 adults w…

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck, combined with a nicotine patch, can help people stop smoking. Researchers at Mayo Clinic will enroll 150 motivated smokers who smoke at least 10 cigarettes a day. Participants use the d…

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

This trial tests a short virtual therapy called IMPROVE, designed to help people on medication for opioid use disorder who also drink heavily. Participants attend three one-hour online sessions and use a mobile app to learn skills for managing emotional distress that can trigger …

This pilot study tests whether deep brain stimulation (DBS) of the nucleus accumbens can help people with opioid use disorder who keep relapsing despite standard treatments. Only 3 participants will receive the implanted device. The main goal is to see if it is safe and whether i…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study tests a program that combines community health worker visits with a smartphone app to help low-income women stop smoking. About 344 women in Brazil will either get the app plus health worker support or just a referral to a standard quit-smoking clinic. The goal is to s…

This study is testing whether giving rural smokers a two-week supply of nicotine patches or lozenges can help them quit. Researchers are recruiting 272 adults from rural areas across the U.S. who smoke at least 5 cigarettes daily. The main goal is to see how many people stop usin…

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests whether full-spectrum or broad-spectrum CBD can help people with alcohol use disorder drink less. 180 adults who want to reduce or quit drinking will receive either CBD or a placebo for 12 weeks. Researchers will track changes in drinking habits, cravings, and an…

This study tests whether cannabidiol (CBD) can slow the progression of Alzheimer's disease in people aged 55-85 with mild cognitive impairment (early memory loss). Over 236 participants will receive either CBD or a placebo for a period, and researchers will measure changes in mem…

This study tests a digital tool called EMBED that helps emergency doctors identify patients with opioid use disorder and start them on buprenorphine, a medication that reduces cravings and withdrawal. The tool is built into the electronic health record and guides doctors through …

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how ca…

This study tests new ways to help people with opioid use disorder continue their buprenorphine medication after starting it in the emergency department. About 3,500 adults will take part. The goal is to see if better coordination between the ER and outpatient clinics helps patien…

This study is for people who smoke cigarettes but aren't ready to quit. It tests whether giving them a choice of harm-reduction products like e-cigarettes or nicotine pouches helps them smoke less or stop altogether. Participants will use their chosen product for 28 days and be f…

This study tests whether hemp-derived CBD (with or without a tiny amount of THC) can help people who use cannabis concentrates regularly to cut down or stop. 165 adults who want to reduce their cannabis use will take either CBD or a placebo for 8 weeks, plus attend therapy. Resea…

This study tests whether a drug called troiluzole can reduce the appeal of methamphetamine for people with methamphetamine use disorder. About 40 adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal…

This study tests whether a 12-week group therapy program called Mom Power can help new mothers with opioid use disorder improve their mood, reduce stress, and strengthen the bond with their child. About 160 mothers with a child aged 5 or younger will be assigned to either the Mom…

This study tests whether pentoxifylline, an anti-inflammatory drug, can reduce how rewarding cocaine feels. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine and money. The goal is to see if calming immune inf…

This study tests whether reducing methamphetamine use—without requiring complete abstinence—can improve health and quality of life. Researchers will give 300 adults with methamphetamine use disorder payments for providing drug-free urine samples over 12 weeks. They will measure b…

This study tests whether a monthly extended-release buprenorphine injection works better than daily sublingual tablets for adults with opioid use disorder who are about to be released from jail. 240 participants will be randomly assigned to one of the two treatments while still i…

This study tests whether a behavioral sleep intervention combined with the drug varenicline can help heavy smokers quit. Researchers will measure sleep quality, smoking habits, and brain activity in 114 participants. The goal is to see if improving sleep reduces negative emotions…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This Phase 3 trial tests whether a combination of extended-release naltrexone (Vivitrol) and bupropion XL (Wellbutrin) can help people with moderate to severe methamphetamine use disorder reduce their drug use. About 360 participants will receive either the active drugs or placeb…

This study tests whether giving smokers a choice of e-cigarette flavors (tobacco, menthol, mint, or other) helps them stop smoking regular cigarettes. About 1,280 adult smokers will use a provided e-cigarette device for 13 weeks, and researchers will check who stays away from cig…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study compares a once-monthly injection of buprenorphine to daily sublingual buprenorphine for treating opioid use disorder in people who use fentanyl or other strong synthetic opioids. About 60 adults aged 18–65 will be enrolled and followed for 4 weeks after starting treat…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study tests whether semaglutide (Wegovy), a drug used for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder cut back or stop using. The trial has two parts: a small pilot study with 25 people, followed by a larger randomized trial…

This study tests whether a slow-release form of dexamphetamine, a drug used for ADHD, can help people with cocaine and opioid addiction reduce their cocaine use. About 204 adults who are already on methadone for opioid addiction will receive either dexamphetamine or a placebo for…

This pilot study tests whether offering financial incentives (contingency management) can help people who started medication for opioid use disorder in the emergency department keep attending outpatient treatment. Thirty adults will be randomly assigned to receive either standard…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This study aims to reduce racial disparities in opioid overdose deaths by training peer recovery coaches and using an AI-driven texting tool. The coaches will send personalized texts to participants (Black and Latinx adults with opioid use disorder) to help them connect with trea…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenor…

This study tests whether adding buprenorphine (a partial opioid) to the standard shot XR-naltrexone helps people with opioid use disorder stay in treatment and avoid relapse. 180 adults will receive either the combo or a placebo for 24 weeks. The goal is to see if the combo impro…

This study tests a health system strategy called SAIA to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with jail and clinic staff to identify bottlenecks and improve treatment continuity. The study invo…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This study is testing a tailored tobacco cessation program for cancer survivors and their caregivers. The program includes four sessions delivered by phone or video, focusing on quitting techniques and support. Researchers want to see how many people enroll and complete the progr…

This phase 4 trial tests whether giving the NSAID ketorolac (Toradol) for the first five days after orthopedic trauma surgery can reduce the chance of patients still needing opioids six months later. About 458 adults aged 18–70 with acute musculoskeletal injuries requiring surger…

This study tests whether semaglutide (Wegovy), a drug used for weight loss, can help adults with cannabis use disorder use less cannabis. 100 participants will receive either semaglutide or a placebo injection weekly for 20 weeks. The main goal is to see if the drug reduces total…

This pilot trial tests two long-acting injectable buprenorphine medications (Sublocade and Brixadi) in 60 incarcerated individuals with opioid use disorder who are about to be released from prison. Participants either choose their preferred medication or are randomly assigned one…

This study looks at whether different e-cigarette flavors can help people who smoke cigarettes and are being treated for opioid use disorder with buprenorphine to smoke fewer cigarettes. About 90 adults who smoke at least 5 cigarettes daily will try either a tobacco, sweet-coolin…

This study is testing whether a private Facebook group, called Wiidookaage'Win, can help Native American women in Minnesota stay off opioids. The group includes social support, mindfulness, and cultural practices. Sixty women who are already on medication for opioid use and have …

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study tests a program that combines brief advice, nicotine replacement therapy (like patches or gum), and text-message support to help smoking parents quit. The goal is to reduce children's exposure to secondhand smoke. About 1,200 smoking parents in Hong Kong who live with …

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery will either receive the program or standard care. The goal is to see if the pr…

This study tests a simple program for smokers visiting emergency rooms. Participants get a $300 gift card for nicotine replacement products, self-help materials, and six months of phone support from a specialist. The goal is to see if this approach helps more people quit smoking …

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This study tests whether adding financial coaching to standard smoking cessation counseling helps low-income smokers quit. 602 participants will receive either standard counseling or integrated financial-smoking counseling, plus nicotine patches. The goal is to see if addressing …

This phase II trial tests whether adding a cannabis-based mouth spray (nabiximols) to standard chemotherapy helps people with recurrent glioblastoma live longer. About 120 adults whose brain tumor has returned after initial treatment will receive either the cannabis spray or a pl…

This study tests whether hemp-derived CBD can reduce the harmful effects of cannabis in young adults aged 18-25 who use cannabis at least five days a week but aren't looking to quit. Participants will take either CBD or a placebo for 8 weeks, and researchers will measure changes …

This study tests whether cannabidiol (CBD), a non-psychoactive compound from cannabis, can reduce cannabis concentrate use and cravings in people who use concentrates regularly but aren't trying to stop. 120 participants will take either 200 mg or 400 mg of CBD or a placebo daily…

This study tests a new approach called SINI to help people with opioid use disorder start buprenorphine treatment more comfortably. Participants receive small doses of naloxone to trigger mild withdrawal, then take buprenorphine to ease symptoms, followed by a long-acting injecti…

This study tests a program called Peer Activate, where trained peer recovery specialists help people with opioid addiction stay on their medication and cut down on other drug use. The program teaches skills like finding rewarding activities without drugs. Researchers will compare…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests whether bringing mobile health clinics to rural communities and pairing patients with a certified peer support specialist (someone who has personally recovered from opioid use disorder) can help more people start and stay on medication for opioid use disorder. Re…

This study is testing two counseling approaches—Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE)—to help people on methadone treatment reduce their use of tobacco, opioids, and other drugs. Researchers will enroll 420 adults who are currently on…

This study tests whether a 5-day course of accelerated deep transcranial magnetic stimulation (aTMS) can help adults aged 18–65 quit smoking. Participants receive 4 brain stimulation sessions per day for 5 days. The main goal is to see if the treatment is tolerable and practical,…

This study tests a vaccine that helps the body produce antibodies against oxycodone, a commonly abused prescription opioid. The goal is to reduce the drug's ability to reach the brain and lower its pleasurable effects. The trial involves 45 adults with opioid use disorder and foc…

This pilot study is testing whether a noninvasive brain stimulation device, used at home along with guided mindfulness, can help people with cannabis use disorder reduce their use. Forty-six adults who want to cut back on cannabis will receive either real or sham stimulation over…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This study tests a new way to help people stop smoking by combining standard quit-smoking programs with a computer task that retrains unconscious urges to approach cigarettes. About 300 adults who want to quit will be randomly assigned to one of three groups: standard treatment p…

This study looks at how to bring a program called Just Care for Families to more counties in Oregon. The program helps parents who use opioids or methamphetamine reduce their substance use and improve family outcomes, like being reunited with their children. Researchers will test…

This pilot study is testing whether mailing buprenorphine to people with opioid use disorder after a hospital stay can help them stay in treatment. The goal is to overcome common barriers like lack of transportation or trouble getting to a pharmacy. Researchers will track whether…

This study tests whether cannabidiol (CBD), a compound from hemp, can help people who want to quit smoking reduce their cigarette use. 120 adults with tobacco use disorder will receive either CBD or a placebo twice daily for 56 days. Researchers will measure nicotine levels and c…

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This study tests whether a mobile app can help adults in Singapore quit smoking. About 100 participants will be randomly assigned to receive the app-based support or standard care, and researchers will track how many stay smoke-free for 6 months. The goal is to see if this approa…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This pilot study tests whether metformin, a diabetes drug, can help protect brain white matter in young adults (18-25) with early psychosis who use cannabis. Participants will take metformin for 6 months and undergo brain scans and questionnaires. The goal is to see if this appro…

This early-stage study tests the safety of nalmefene implants in 24 healthy adults. Participants receive one or two implants that stay in place for 4 or 12 weeks. Researchers monitor side effects and how the drug moves through the body to plan future studies in people with opioid…

This study tests whether varenicline (Chantix), a drug already used to help people quit smoking, can also help them reduce cannabis use. Two hundred adults in South Carolina who smoke cigarettes and use cannabis will receive either varenicline or a placebo, plus counseling. The g…

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This study tests a program that gives rewards (like gift cards) to people in Hawaii who are trying to stop using methamphetamine after a serious injury. 40 adults who were hospitalized and tested positive for meth will visit a clinic up to three times a week for urine tests. Rese…

This study tests a smartphone app that lets people with severe opioid use disorder take their daily methadone at home while being recorded. The app helps clinics monitor safe use and cravings. Researchers will compare this approach to standard care in 100 adults to see if it keep…

This study tests a new type of brain stimulation (rTMS) as a treatment for cannabis use disorder. Researchers will enroll 46 adults who use cannabis frequently and want to cut back or quit. The goal is to see if the treatment is safe, tolerable, and can reduce cravings and use.

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This study tests whether gentle brain stimulation (tVNS or CLAM-tACS) during mindfulness exercises can help people recovering from alcohol dependence stay sober. 140 detoxified patients will take part in a mindfulness-based relapse prevention program, with some receiving stimulat…

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follic…

This study looks at what happens when adults with cannabis use disorder cut back on cannabis. Over 8 weeks, participants get counseling, computer-based therapy, and small rewards for reducing use. The goal is to see if cutting back leads to fewer cannabis-related problems, better…

This study tests whether an 8-week culturally responsive harm reduction program helps Black and Latinx people who use drugs engage more with services and reduce opioid or stimulant use. Researchers will compare the program to standard harm reduction services in 200 participants. …

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This study tests whether e-cigarettes or nicotine pouches help adult smokers reduce their cigarette use. 256 participants who smoke will be given one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This pilot study at Johns Hopkins University is testing whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder. Twelve adults will receive two doses of psilocybin along with counseling over 12 weeks. Researchers will track cannabi…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cocaine use. About 75 adults will receive semaglutide along with counseling. Researchers will measure changes in brain responses, cravings, and d…

This small study is testing whether MDMA-assisted therapy can help new mothers who have both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive MDMA in a controlled setting along with therapy sessions. The goal is to see if this appro…

This study tests a new program to help people quit smoking by teaching them how to handle withdrawal symptoms and negative feelings. Researchers will enroll 400 adult smokers who want to quit. The goal is to see if this training helps more people stay smoke-free compared to stand…

This study compares e-cigarettes to standard counseling and nicotine patches/lozenges for reducing smoking in people with opioid use disorder. About 300 participants who smoke at least 5 cigarettes daily and are in treatment for opioid addiction will be followed for 6 months. The…

This study tests whether low-dose ketamine can reduce cravings and withdrawal symptoms in adults starting methadone treatment for opioid use disorder. Fifty participants will receive either a low or very low dose of ketamine four times over two weeks. Researchers will track cravi…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests a non-invasive brain stimulation technique (tDCS plus ultrasound) to help people with opioid use disorder and chronic pain reduce drug use. Researchers will compare active stimulation to a sham (fake) treatment in 126 adults already on methadone. The goal is to s…

This study compares three approved smoking cessation products—nicotine replacement therapy (patch plus gum or lozenge), cytisine, and varenicline—combined with coaching and home delivery from a virtual pharmacy. Researchers will track how well 150 Ontario adults who smoke use the…

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests a program called THRIVE, where a trained peer (someone with lived experience) meets with patients in the hospital and sends weekly texts for 12 weeks after discharge. The goal is to see if this support helps reduce non-fatal overdoses and skin infections compared…

This study looks at whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks is feasible and acceptable for people with moderate to severe methamphetamine use disorder. About 80 participants will receive either the drug or a placebo alongside their usual …

This study tests a combination of telehealth, peer support, buprenorphine medication, and connections to addiction treatment programs for people who have had an opioid overdose and visited the emergency department. The goal is to help participants stay in treatment and prevent fu…

This study looks at whether adding addiction counseling and a community peer helper to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep coming to their doctor visits. About 70 adults with opioid dependence and other medi…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether support from trained peers who have personal experience with addiction can help people stay in medication treatment for opioid use disorder. About 218 adults starting treatment will either receive standard care alone or standard care plus up to 6 months o…

This study tests different treatment plans to help adults with opioid use disorder stay on buprenorphine longer. About 500 people from the emergency department will take part. Researchers will compare approaches to see which works best for keeping patients on medication and reduc…

This study tests if low intensity focused ultrasound (LIFU) can help people with severe opioid addiction who haven't improved with other treatments. About 34 adults aged 22-60 will receive either real or sham ultrasound to specific brain areas. Researchers will monitor safety and…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking d…

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study tests a program called Tabapsy to help people with mental health conditions who smoke. The program includes information meetings, assessments, and workshops on quitting. Researchers will compare it to usual care in 6,500 adults from psychiatric clinics, measuring if th…

This pilot study tests a new way to help adults aged 50 and older quit smoking. Participants interact with a virtual counselor on a computer, receive nicotine patches and gum or lozenges, and get support from a community health worker who also helps them schedule lung cancer scre…

This Phase 2 trial tests whether adding cannabidiol (CBD) to standard naltrexone treatment can reduce alcohol cravings in people with alcohol addiction. 150 participants will receive either a high or low dose of CBD plus naltrexone, or a placebo plus naltrexone, for 14 days. The …

This study looks at whether helping clinics offer more take-home doses of methadone (instead of daily visits) helps people stay in treatment for opioid use disorder. Researchers will work with 36 clinics and about 318 patients to see if this approach reduces emergency visits and …

This phase 2 trial tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder who continue using illicit opioids even while on methadone. Up to 480 participants will receive either a low (1 mg), medium (20 mg), or…

This study tests whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stay on track with their treatment. About 60 adults who recently started or restarted methadone or buprenorphine will receive texts for up to 6 months …

This study is testing a smartphone app called MiREA-AC designed to help college students who have been mandated to reduce their alcohol and cannabis use. The app provides personalized feedback on their consumption and social norms. Researchers will enroll 150 students to see if t…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study compares a once-monthly injectable buprenorphine to the standard daily sublingual tablet (with naloxone) for treating opioid use disorder in 952 veterans. The goal is to see which formulation better keeps people in treatment and helps them stay opioid-free over 48 week…

This study tests an experimental drug called CS-1103 in 40 healthy adults with methamphetamine use disorder who are not seeking treatment. Participants receive a single dose of methamphetamine along with CS-1103 to see if the drug can safely reduce the effects of intoxication. Th…

This study at Duke University is testing whether a brain scan (MRI) can predict who will successfully quit opioids using buprenorphine, and whether adding brain stimulation (rTMS) to the treatment helps more than a sham version. 80 adults with opioid use disorder who are starting…

This study is testing whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in people who smoke daily, have chronic pain, and are on buprenorphine for opioid use disorder. Sixty participants will be randomly assigned to either very low nicoti…

This study tests a proactive approach to help people living with HIV quit smoking. A pharmacist calls participants, offers counseling, and sends cessation medication unless they opt out. The goal is to see if this method works better than standard care. The trial involves 231 adu…

This study tests the VapeAway system, a drug-free program that uses special filters to slowly lower nicotine intake, a sensory tool called the Fix Bar, and digital support to help people stop vaping. About 70 motivated adults who vape daily will use the system for 42 days. Resear…

This study tests a computer training called Approach Bias Modification (ABM) to see if it can reduce cocaine cravings and increase days of abstinence. Sixty adults with cocaine use disorder will either receive ABM training plus usual care or usual care alone. The training involve…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study tests a new approach where nurses, rather than doctors, adjust methadone doses for people starting treatment for opioid addiction. The goal is to see if this makes it easier for patients to stay in care for at least three months. The trial will enroll 182 adults in Fre…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests whether the medication varenicline can help adults quit using e-cigarettes. Researchers will compare varenicline to a placebo in 326 people who vape daily. The main goal is to see if more participants can stop vaping for at least a week by the 12-week mark, with …

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This phase 3 trial tests whether adding cannabidiol (CBD) to standard opioid addiction treatment can reduce cravings and prevent relapse. About 450 adults with opioid use disorder who are already on methadone or buprenorphine will receive CBD or a placebo for 24 weeks. The goal i…

This study tests whether a single dose of ketamine, combined with real-time brain training (neurofeedback), can help people with alcohol use disorder drink less. 75 participants will receive either ketamine or placebo, plus real or fake neurofeedback. The goal is to see if the co…

This study looks at whether sending free meals to the home can improve food security for adults who are on medication for opioid use disorder. Forty participants will either get nutrition education alone or education plus weekly meal deliveries for 24 weeks. Researchers will trac…

This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least four heavy drinking days per month will be randomly assigned to receive either ps…

This study tests whether nicotine replacement therapy (patches, gum, or lozenges) plus wellness coaching over the phone can help people experiencing homelessness quit smoking. Researchers will enroll 150 adults in San Francisco and Los Angeles who smoke at least 5 cigarettes a da…

This study tests a program called Youth Opioid Recovery Support (YORS) to help teenagers with opioid use disorder stay on their medication and avoid relapse. The program includes family involvement, easy access to medication, and regular check-ins. Researchers will enroll 80 teen…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study works with 300 women in rural Kentucky jails who have opioid or stimulant use disorders. The goal is to lower their risk of overdose when they return to their communities. The program offers support and connects them to treatment options before and after release.

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a program called CHORUS+ that helps people who inject opioids get HIV prevention medication (PrEP) and treatment for opioid use disorder (MOUD). Participants receive HIV self-testing, rapid access to medications, and 6 months of support from a peer coach. The goa…

This study tests whether people who use opioids can be trained as peer educators to teach their friends and family how to prevent overdoses. Researchers will enroll 600 participants in Baltimore and compare those who receive overdose prevention training with those who get standar…

This study tests a smartphone-based program called RISE Guide for women who have just been sexually assaulted. The goal is to see if it can reduce anxiety sensitivity and prevent posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD). 68 women who seek emergency car…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and visit a participating clinic will be assigned to either a program that uses personalized reminders and support (ELEVATE-S) or standard quit-focused care (ELEVATE…

This study tests whether combining text message support with financial incentives helps low-income pregnant women quit smoking more than text messages alone. Thirty pregnant women who smoke will be split into two groups to see which approach is more acceptable and effective. The …

This study tests a behavioral program called QuitVaping, which combines counseling sessions with text message support, to help teenagers aged 14-18 quit vaping. About 400 participants who vape nicotine at least weekly will be randomly assigned to either the QuitVaping program or …

This study compares two versions of a smartphone app called Living Free from Tobacco (LiFT) to help young adults ages 18-30 quit using nicotine and tobacco products. About 140 participants will use one of two app versions: one focuses on building mental flexibility to support qui…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This study tests whether adding alcohol-related smells to virtual reality (VR) scenes is feasible and tolerable for people with alcohol dependence. Twenty participants will experience VR cue exposure with scents like beer or wine, and researchers will measure craving, side effect…

This study tests a smartphone chatbot designed to help Black adults quit smoking. The chatbot sends alerts during times when a person is most likely to smoke and suggests ways to handle triggers. 120 participants will be randomly assigned to use the chatbot or not, and researcher…

This study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers…

This study is testing a short, values-based therapy for Veterans who have recently started medication for opioid use disorder (like buprenorphine). The therapy focuses on helping them clarify their personal values, set goals, and improve social connections. The study has three ph…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This early-stage study is testing whether inhaled cannabis can reduce withdrawal symptoms in people with opioid use disorder who are not currently seeking treatment. Researchers will give participants either cannabis or a placebo and measure how they feel, including withdrawal se…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This Canadian study is testing whether cannabinoid oils (CBD and THC) can safely help manage symptoms like pain in children aged 4-17 with relapsed or refractory cancer. The trial will enroll 60 kids across three hospitals, giving them different ratios of CBD to THC oils to see w…

This study tests whether bright light therapy can help people going through cocaine withdrawal in a hospital. Cocaine withdrawal often disrupts sleep, mood, and daily rhythms, making it hard to stay drug-free. The therapy uses a special lamp to mimic daylight, which may improve s…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study tests a new program where community health workers provide extra support to pregnant women who smoke. The goal is to help them quit smoking during pregnancy. About 105 women in San Bernardino County will take part and receive coaching to stop tobacco use.

This study tests a social media program called Quit the Hit Toolkit to help teens and young adults stop vaping. Coaches are trained to lead small support groups for 5 weeks. The goal is to see if this approach is practical and helpful for quitting nicotine.

This study tests whether yoga can lower tobacco cravings in men aged 18-65 who want to quit. 96 participants will either do low-impact yoga or receive standard quitting advice. Researchers will measure cravings and relapse over three months to see if yoga is a helpful addition.

This study is testing a wearable device called Sparrow Link that sends gentle electrical pulses to nerves in the ear to help reduce opioid withdrawal symptoms. About 50 hospitalized adults with opioid use disorder will receive either the active device or a sham version, along wit…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers aim to see if coaching improves pain, anxiety, and overall well-being. The trial is recruiting 468 veterans across the U.S.

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people with opioid and alcohol use disorders. Sixty adults enrolled in an intensive outpatient program will receive daily TMS sessions for four weeks, alongside their usual ther…

This study tests whether a type of talk therapy for insomnia, delivered via telemedicine, can improve sleep and reduce cannabis use in adults who have trouble sleeping and use cannabis regularly. 200 participants will be randomly assigned to either cognitive behavioral therapy fo…

This study tests whether IGC-AD1, a THC-based oral medication, can safely reduce agitation in people with mild to severe Alzheimer's dementia. About 164 participants will receive either the drug or a placebo twice daily for several weeks. Researchers will measure changes in agita…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study looks at whether a therapy called prolonged exposure, given through video calls, can help people with both opioid use disorder and PTSD. About 135 adults on stable medication for opioid use will take part. The goal is to see if this approach improves therapy attendance…

This study tests whether a personalized exercise program can help smokers who are afraid of bodily sensations (like a racing heart) quit smoking. 360 adults will take part at YMCA locations. The goal is to see if exercise reduces smoking relapse and helps people stay smoke-free f…

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests four different approaches—behavioral therapy, physical therapy, medication changes, and buprenorphine rotation—to help cancer survivors reduce their opioid use while keeping pain under control. It involves 294 veterans who have finished cancer treatment but still…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study is testing a smartphone app designed to help people who are starting medication for opioid use disorder get better sleep. The app uses proven sleep therapy techniques and daily sleep diaries. Researchers will enroll 40 adults who are stable on buprenorphine and have po…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This Phase 2 trial tests whether adding buspirone (an anxiety medication) to lofexidine (a withdrawal drug) can reduce opioid withdrawal symptoms and cravings during detox. About 100 adults with opioid use disorder will stay in a residential setting for 10–12 days, undergo a step…

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This early-phase study tests whether a device that delivers specific smells can reduce cigarette cravings and help people stop smoking. About 132 smokers will use a smartphone app with or without the scent device for a week, then report cravings and quit attempts. The goal is to …

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This study tests whether a natural hormone called pregnenolone can reverse the effects of cannabis intoxication. Researchers at Johns Hopkins will give 20 healthy adults who have used cannabis before either pregnenolone or a placebo, then measure changes in drug effects, thinking…

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This pilot study tests a smartphone app called eMind that delivers an 8-week mindfulness programme to help smokers quit. Researchers want to see if smokers find the app acceptable and easy to use. The study involves 40 adult smokers motivated to quit, who will use the app and pro…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce cravings and opioid use in people with opioid use disorder. One hundred participants will receive either real or sham TMS sessions over 8 weeks, with follow-up visits for about 5 months. The…

This study tests whether dronabinol, a synthetic form of THC (the psychoactive compound in cannabis), can reduce severe breathlessness in people with advanced COPD. Thirty participants will receive both dronabinol and a placebo in random order to compare effects. The goal is to s…

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a …

This study tests whether a non-invasive brain stimulation technique called rTMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to brain areas involved in craving and self-control. The trial involves 64 smokers who will receive either real or…

This study partners with community organizations to adapt a smoking cessation program for adults who smoke and receive care at behavioral health clinics. Researchers will enroll 24 participants to test whether the program is feasible and acceptable. The goal is to learn how to be…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study is testing whether a social media and smartphone app program can help teens and young adults who vape to cut back or quit. Participants will be recruited through social media, screened by a chatbot, and given a mobile app with tailored tips and encouragement. The goal …

This study compares two brief behavioral interventions for emerging adults aged 18-25 who use cannabis frequently (at least 20 days per month). Participants attend two 40-50 minute sessions a week apart and are followed for 6 months. The goal is to see if either program helps red…

This study tests whether a continuous pump delivering numbing medicine into the belly can reduce pain and the need for narcotics after minimally invasive hysterectomy. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive either a numbing drug…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the real patch or a placebo, along with standard pain…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study tests if a marijuana-based drug (mostly CBD with a little THC) can reduce anxiety in adults with autism. About 108 people aged 18 to 45 will take the drug or a placebo daily for 8 weeks. Researchers will track anxiety, social skills, and repetitive behaviors through we…

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can help daily smokers quit. rTMS uses magnetic pulses to stimulate brain areas involved in addiction and decision-making. Forty participants will receive daily sessions f…

This study tests whether a non-invasive device that stimulates the vagus nerve in the neck can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for a week, receive either active or sham stimulation, and have brain sca…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard education helps people who take opioids for chronic pain taper off them before spine surgery. About 45 adults scheduled for major spine surgery at least four weeks ahead will be split into two group…

This study tests whether specific chest exercises can improve breathing, chest expansion, and exercise capacity in university students who smoke. Thirty smokers aged 18-24 will be split into two groups: one doing chest PNF techniques and the other doing chest mobility exercises. …

This study is testing whether 12 weeks of group cognitive behavioral therapy (CBT) can help people reduce their alcohol or cannabis use. Researchers will enroll 400 adults with alcohol use disorder or cannabis use disorder. Participants will attend weekly CBT sessions, and the st…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study tests whether a non-invasive brain stimulation technique called tDCS can help people who vape nicotine daily to cut back. Forty adults aged 18-65 who vape regularly will receive either real or fake tDCS for 10 sessions over two weeks. Researchers will measure changes i…

This early-phase trial at Yale tests whether dronabinol (Marinol), a synthetic form of THC, can reduce pain sensitivity and improve attention and mood in 36 adults with opioid use disorder who are stable on methadone or buprenorphine. Participants receive either 2.5 mg, 5 mg of d…

This study tests whether a specific injection technique called erector spinae plane block (ESPB) reduces pain and opioid use after lumbar spinal fusion better than standard subcutaneous anesthesia. Researchers will enroll 66 adults scheduled for one- or two-level lumbar fusion. P…

This study tests a program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. The program includes counseling sessions, family coaching, nicotine replacement therapy (like patches or gum), and information about lung cancer screenin…

This study tests whether a brief motivational interviewing session during a primary care visit can reduce alcohol and cannabis use among diverse teens aged 12 to 17. Researchers will enroll 500 participants who are at risk for substance use and track changes in how often they dri…

This early study tests whether combining a non-invasive brain stimulation technique (rTMS) with a mental exercise called Episodic Future Thinking (imagining positive future events) can help people with methamphetamine use disorder make less impulsive choices and reduce their desi…

This study tests whether a gentle brain stimulation technique (tDCS) combined with cognitive training can reduce cravings in people with cocaine addiction. 120 participants will receive either real or sham stimulation for 20 minutes a day, three times a week, for five weeks. Rese…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study tests whether clonidine, a blood pressure medicine, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will receive either clonidine or an active placebo (clonazepam) to compare effects. The main goal is to see if craving…

This study tests whether a dental health evaluation using AI can help people stop smoking. 300 adult smokers who want to quit will get an AI analysis of their mouth and teeth. The main goal is to see if more people have quit smoking after 6 months, confirmed by a breath test.

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study tests whether adding pregabalin to the standard withdrawal drug lofexidine helps people with opioid use disorder feel less sick while quitting. About 150 adults who want to start long-acting naltrexone will take either the combination or a placebo for 8 days. The goal …

This study is adapting a friendly text-message chatbot called Penny to support pregnant and postpartum women who are recovering from opioid use disorder. The chatbot sends helpful messages and allows two-way conversations to reduce loneliness and keep women engaged in their care.…

This study tests whether a smartphone app that uses augmented reality (AR) can help people quit smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users manage cravings. The trial will enroll 3,600 adult daily smokers and measure …

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI stimulation to deep brain areas linked to addiction or a sham (fake) treatment during a …

This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to m…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will be randomly assigned to one of the two dosing schedules. Researchers will trac…

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adults who smoke at least 5 cigarettes a day and want to quit will take part for 4 mont…

This study tests whether nabilone, a synthetic cannabinoid, can safely reduce agitation in people with Alzheimer's disease. Agitation is common and distressing, with few good treatment options. About 112 participants will receive either nabilone or a placebo for 8 weeks, and rese…

This study tests whether a smartphone app called Kick-Nic! can help high school students (ages 13-19) quit vaping. About 306 participants who want to quit will either use the app or visit a standard quit-vaping website for 8 weeks. Researchers will check if they've stopped vaping…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This pilot study is testing whether a high-dose nicotine patch can reduce pain and the need for opioid painkillers in male smokers who are having chest surgery. The patch is given before and after surgery. The study will track how much pain medication participants use. It include…

This study tests whether a type of brain stimulation called cTBS can reduce cravings for alcohol in people with alcohol addiction. 34 adults will receive 15 stimulation sessions over 5 days, and researchers will measure changes in their cravings, heart rate, and brain activity. T…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study tests whether mindfulness meditation in virtual reality can reduce cigarette cravings and help people quit smoking. Two hundred smokers will be split into two groups: one gets six VR meditation sessions over six weeks, and the other uses nicotine patches and gum. Resea…

This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether a daily oral dose of cannabidiol (CBD) can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take CBD during several practice quit attempts. The goal is to see if CBD increases short-term abstinen…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help relieve severe pain in people with advanced cancer when opioids don't work. Fifteen participants will receive psilocybin capsules along with therapy sessions. The goal is to see if this approa…

This study tests whether reducing loneliness can help people with opioid use disorder. 300 adults who feel lonely and use opioids will receive 6 weekly sessions. Researchers will measure changes in loneliness and opioid use over time.

This study tests whether adding cannabidiol (CBD) to standard alcohol detox treatment helps people with severe alcohol use disorder stay sober longer. About 210 adults will receive either CBD or a placebo for 11 days during a hospital stay. Researchers will check if participants …

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder (like Suboxone or methadone). Over 10-12 weeks, they will attend therapy sessions and complete surveys to see if their …

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study investigates how THC and CBD in cannabis affect recognition memory in healthy adults who use cannabis regularly. Participants perform a memory task after smoking cannabis and on a separate sober day, while their brain activity is recorded via EEG. Blood samples measure…

This study is testing whether simple saliva tests done at home can accurately show when someone has not used cannabis. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples over 3-4 weeks, and resea…

This study is creating and testing simple computer tasks that can be done inside an MRI scanner to measure brain activity related to behavior. Researchers want to better understand how alcohol use disorder affects the brain. The study involves up to 400 healthy volunteers and peo…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study is developing a way to measure resilience in people with opioid use disorder. Researchers will have 125 adults complete tasks that test thinking, emotions, and sense of control, both with and without stress. The goal is to see if these tasks match how resilient people …

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This early-phase study at the University of Maryland is testing whether suvorexant, a sleep medication, can reduce the desire for drugs in people with opioid use disorder. Researchers will measure how much participants are willing to 'pay' for a study drug in a lab task, and whet…

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study looks at how cooling ingredients like WS-3 and menthol in e-cigarettes affect how much people like them and find them addictive. Researchers will have 66 adult e-cigarette users try different e-liquid mixtures and report their feelings of liking, craving, and harshness…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This observational study at Yale University aims to understand how people with opioid use disorder (OUD) learn to avoid pain compared to healthy individuals. About 180 participants will perform a learning task inside an fMRI scanner to measure brain activity. Those with OUD will …

This study looks at how smoking little cigars affects levels of harmful chemicals called oxidants in the body. Researchers will compare three types of smoking: high-oxidant little cigars, low-oxidant little cigars, and regular cigarettes. Fifty daily smokers will provide breath, …

This early-phase study is looking at how cannabidiol (CBD) affects the appeal and pain-relieving effects of cannabis. Researchers will give 23 healthy adults different doses of CBD for 14 days and then measure how much they like active cannabis and how it changes their pain sensi…

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study follows 32 people with cocaine use disorder as they go through detox. Researchers use wearable sleep monitors, questionnaires, and urine tests to track sleep quality and body rhythms during active use, early withdrawal, and late withdrawal. The goal is to understand ho…

This study looks at young adults aged 18 to 25 who use both tobacco/nicotine products and cannabis. Researchers want to understand what happens to cannabis use when participants try to quit nicotine. All participants receive remote counseling and incentives to stop using nicotine…

This study looks at whether regular cannabis users can adjust how much they vape when using high-potency concentrates (30%, 60%, and 90% THC). Researchers will measure blood THC levels, puffing behavior, and subjective feelings of intoxication. The goal is to understand if people…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study uses brain scans to see how stress hormones interact with certain brain receptors in people with cocaine use disorder. Researchers will compare 80 adults with and without the disorder to understand these interactions and whether they predict relapse. The goal is to lea…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study uses brain scans (PET) to measure how much dopamine is released after a low dose of amphetamine in people with cocaine use disorder. Researchers want to understand brain changes linked to addiction. About 30 adults aged 18-55 with cocaine use disorder will participate.…

This study looks at how strong desires (cravings) change the way people make decisions. Researchers will use brain scans and decision-making tasks to see how craving for opioids or a specific snack affects what people are willing to pay for items. The study involves 160 adults, i…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study is testing whether a smartwatch can pick up on body changes—like skin temperature—that happen during opioid withdrawal and cravings. Twenty people with opioid use disorder will wear the device for 14 days while their symptoms are tracked. The goal is to see if the watc…

This study looks at how psilocybin, the active ingredient in magic mushrooms, affects brain circuits linked to motivation and self-control in people with opioid use disorder. Twenty-four adults in the Philadelphia area will receive either a low or high dose of psilocybin, then un…

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study looks at whether older adults (55+) in methadone treatment for opioid use disorder can use smartphone-based cognitive games to track and possibly improve their thinking skills. Thirty participants will play short brain-training tasks twice a day for 15 days. The main g…

This study adapts a parenting program called 'Proud of Baby and Me' for new mothers who are receiving medication for opioid use disorder. The goal is to see if the program helps mothers stay in treatment, reduce stress, and improve bonding with their baby. Ten women will particip…

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study uses repeated fMRI brain scans to track changes in people receiving medication for opioid use disorder. Ten participants will be scanned every two weeks for six months while performing tasks. The goal is to understand how the brain changes during recovery and identify …

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors…

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disor…

This study uses brain scans (MRI, MRS, EEG) to see how ibogaine affects the brain in 20 people with moderate to severe opioid use disorder. Participants will already be receiving legal ibogaine treatment outside the U.S. The research team only observes and measures brain activity…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study looks at how a single session of exercise changes blood markers related to brain health in people who use cannabis regularly compared to those who don't. Researchers will measure endocannabinoids and other substances in the blood, along with cognitive tests. The goal i…

This study looks at how romantic partners who both smoke can support each other when trying to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while attempting to quit, tracking their smoking, cravings, and stress. The goal is to understand which ty…

This study is testing how the drugs alprazolam (Xanax) and oxycodone (an opioid) interact when taken together. Researchers will give small, non-therapeutic doses to 25 healthy adults who already use these drugs. They will measure how much participants like the drug combination, a…

This study looks at how the body handles synthetic nicotine compared to natural nicotine from tobacco. Eighteen experienced e-cigarette users will vape three different nicotine blends in a controlled setting. Researchers will measure nicotine levels in the blood, heart effects, c…

This early-stage study is testing a new implantable pellet (BICX104) that slowly releases naltrexone over 3 months. Researchers want to see how the body processes the drug and if it's safe, comparing it to a standard monthly naltrexone shot. The study involves 30 healthy adults a…

This study tests a program that combines help with quitting smoking and getting a lung cancer screening (a special CT scan) for African American smokers. The goal is to reduce the high rate of lung cancer in this group. About 250 people will take part, and researchers will track …

This study recruits 600 adults who want to quit smoking. Participants use a smartphone app to take photos of their environment when they smoke and at random times. Researchers use artificial intelligence to analyze these images and identify environmental triggers that lead to rel…

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate how changing flavor availability mi…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study tests whether combining neurofeedback with integrative body-mind training can change brain function and reduce cravings and substance use in adults who regularly use alcohol, cannabis, and cigarettes. Researchers will use brain scans to measure changes in connectivity …

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study tests whether a non-invasive brain stimulation technique called TMS can change how people with severe cannabis use disorder recognize their cannabis-related problems. Twenty-four participants will receive real and sham TMS while researchers measure brain activity and e…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This study is investigating how common cannabis use is among lung cancer patients under 60 and whether it is linked to more aggressive tumors. Researchers will collect blood and hair samples from 150 participants across three French hospitals. The goal is to better understand if …

This study uses brain scans (fMRI) to see what happens in the brain just before a smoker lapses (takes a cigarette during a quit attempt). Researchers will have 150 smokers complete a task where they can delay smoking for money, while their brain activity and feelings are measure…

This study is testing a new center in Seattle where people who have had an opioid overdose can stay for up to 24 hours. The center offers monitoring, medication for opioid use disorder, and connections to ongoing care. Researchers will compare outcomes like repeat overdoses and t…

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app sends rem…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and complete thinking tests and brain flu…

This study is collecting information on lifestyle, quality of life, and health markers from 2,000 adults in Greece, including people with chronic diseases, opioid use disorders, and those in prison. The goal is to understand why some groups have worse health and to suggest polici…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study looks at how the drug propranolol and nicotine patches, alone or together, change brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers will undergo brain scans while viewing these cues. The goal is to understand the brain mechanisms b…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at whether oral nicotine pouches (like ZYN) can be a good substitute for cigarettes or smokeless tobacco. Researchers will test different nicotine levels and forms to see which ones reduce cravings and appeal to users. 160 adult tobacco users will try the pouches…

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers will give THC to 100 healthy adults who have used cannabis before and measure their feelings of being 'high' and memory performance. The goal is to understand why men an…

This study looks at whether giving opioid treatment programs (OTPs) regular reports on how well they retain patients, plus a quality-improvement toolkit, can help more people stay in treatment for at least 90 days. Some clinics will also get extra help from an outside facilitator…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study looks at how THC, the active part of cannabis, changes people's desire for e-cigarettes and their body's response. Researchers will give different doses of THC to 100 adults who use both e-cigarettes and cannabis, then measure how much they vape, their cravings, heart …

This study looks at how the brains of teens (ages 15-18) with cannabis use disorder change when they stop using cannabis for 6 weeks. Researchers will use MRI scans to measure brain activity related to reward and impulse control. Some teens will be paid to stay cannabis-free, whi…

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study looks at how difficult childhood experiences might change brain function and make people more likely to start smoking. Researchers will give a small dose of nicotine or a placebo to 150 nonsmoking young adults aged 18-21, then use brain scans and questionnaires to meas…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study looks at how age and how often someone uses cannabis affect driving skills. Researchers will compare young (19-25) and middle-aged (35-45) drivers who use cannabis occasionally or frequently. Participants will smoke a cannabis cigarette or a placebo and then drive in a…

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track health outcomes for both mothers and babies, such as relapse and withdrawal symptoms. The goal is to find better ways to predict and prevent complic…

This study follows 20,000 adolescents aged 12-17 who receive opioids after major surgery. Researchers track pain, opioid use, and other factors for one year to identify early warning signs of opioid use disorder. Participants complete surveys and allow access to their medical rec…

This study aims to help Oregon decision-makers—like health officials, community leaders, and policymakers—use up-to-date, easy-to-understand data to improve substance use services and prevent overdoses. About 341 adults who have authority over substance use policies or programs w…

This study looks at whether virtual reality (VR) can measure how smokers pay attention to smoking-related cues, which may help understand nicotine addiction. Two hundred daily smokers will take either a medication (varenicline) or a placebo, and their eye movements and cravings w…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study is developing and testing a simple decision aid for people with opioid use disorder who visit the emergency department. The tool helps them understand their options for starting buprenorphine treatment. About 20 adults will try the aid and share whether it helped them …

This study looks at whether e-cigarettes or oral nicotine pouches can help people who smoke cigarettes cut down or switch completely. Two hundred adult smokers who have tried to quit before will be randomly assigned to use one of these products instead of cigarettes for six weeks…

This study is building a Canada-wide registry of people who come to emergency departments with opioid poisoning. Researchers will track treatments and outcomes for up to 7,200 patients. The goal is to learn what works best and create a tool to predict who is at highest risk of dy…

This study looks at brain changes in people who use cannabis heavily and want to quit. Researchers will use brain scans to measure a protein linked to brain cell connections, both before and after at least 4 weeks of not using cannabis. They will also test memory to see if brain …

This study looks at how daily vapers and cigarette smokers experience withdrawal when they stop using nicotine for 24 hours. Researchers will measure mood, cravings, attention, and other symptoms in 370 participants. The goal is to better understand nicotine dependence and help d…

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study looks at whether Native American adults who smoke can lower their risk of chronic pain by quitting smoking for 4 weeks. Researchers will measure pain sensitivity and other health markers before and after a stop-smoking program. The goal is to see if this approach is fe…

This study looks at how the amount of nicotine and the pH level in nicotine pouches influence how appealing and addictive they feel to young adult users. Researchers will have 84 participants try different pouches and rate their experience. The goal is to help regulators understa…

This study is testing a new way to reduce opioid overdoses on Chicago's West Side. Researchers will train friends and family members of people who use opioids to become harm reduction champions. These champions will learn about tools like naloxone and fentanyl test strips, and th…

This study looks at whether a new quality measurement and coaching strategy can improve treatment for people with opioid use disorder in New York State. Researchers will work with clinic staff to improve how they track and use quality measures. The study involves 35 participants …

This study is testing whether a smartwatch can detect when someone uses opioids or experiences withdrawal. Researchers will collect biometric data from 420 people with opioid use disorder who wear the watch for 14 days. The goal is to train a machine learning algorithm to recogni…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study at Johns Hopkins University is testing nicotine pouches (like Zyn) in 120 adults—60 regular smokers and 60 people who rarely use nicotine. Participants will use the pouches in two lab sessions while researchers measure how much nicotine gets into the blood, how appeali…

This study looks at how stress and oral health habits relate to inflammation in people with alcohol use disorder (AUD). Researchers will test a new questionnaire about oral care and collect saliva, blood, and dental X-rays from 72 participants (AUD patients and healthy volunteers…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. 210 smokers who have tried to quit before will use fruit, tobacco, or menthol flavored e-cigarettes for 6 weeks. Researchers will track how many cigarettes they smoke and how sati…

This study looks at how natural changes in female sex hormones during the menstrual cycle affect the way women feel and think after using cannabis. Researchers will give 21 women a set dose of THC (the active part of cannabis) or a placebo at different points in their cycle. They…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study looks at how to get more medications for opioid use disorder (MOUD) to people in prison. Researchers will work with 120 prison sites to see which methods work best for increasing access to these life-saving drugs. The goal is to improve health and reduce harm for incar…

This study aims to understand why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will analyze blood and skin samples from 40 participants to look for unique immune and genetic markers linked to pain. The goal is to find bett…

This study looks at how the brain activity of people with opioid use disorder aligns with a therapist during meditation. Researchers will measure brain synchrony and feelings of connection to see if they relate to opioid cravings. The goal is to better understand the brain proces…

This study aims to understand if relighting a cigarette (smoking it in parts) produces more harmful chemicals than smoking it all at once. Researchers will observe 30 smokers who already relight their cigarettes, measuring their smoking habits and collecting cigarette butts. No t…

This study tests whether a brief online video about cannabis withdrawal can increase awareness and insight in people who use cannabis daily. Researchers will recruit 100 heavy users (at least 25 days per month and 3.5 grams per week) through an online platform. Participants will …

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study looks at how THC, the active part of cannabis, affects cigarette cravings and smoking habits. Researchers will give 100 adults who smoke both tobacco and cannabis different doses of THC or a placebo, then measure how many cigarette puffs they take and how they feel. Th…

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study looks at how oral THC (the main psychoactive ingredient in cannabis) affects driving performance, both alone and with alcohol. 48 healthy adults aged 21-55 will use a driving simulator after taking different doses of THC with or without alcohol. The goal is to understa…

This study tests whether low-dose buccal buprenorphine (a film placed in the cheek) can provide pain relief similar to a standard dose of oxycodone but with less potential for abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or placebo in separa…

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body…

This study looks at what happens when people who regularly use both marijuana and tobacco use them together. Researchers will measure how much THC and nicotine get into the blood and how the body responds. The goal is to better understand the health effects of using both substanc…

This study works with Black teens on probation and their families to adapt alcohol and drug treatment to better address experiences of racial discrimination. Researchers will interview teens and hold focus groups with parents and community advocates to learn what works. The goal …

This study enrolls 40 healthy smokers to compare how addictive five new oral nicotine products are compared to their usual cigarettes and Nicorette gum. Participants will use each product in a clinic setting, and researchers will measure their feelings of liking and nicotine leve…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study is testing how opioids (morphine) and benzodiazepines (alprazolam) affect mood, anxiety, and thinking when taken alone or together. Researchers will give 24 people with a history of using these drugs single doses in a lab and measure their responses. The goal is to und…

This pilot study compares regular cannabis users to non-users to find biomarkers that can estimate when someone last inhaled cannabis. Researchers will measure chemicals in blood and look at genetic factors. The goal is to improve road safety by developing a more accurate test fo…

This study is testing whether different doses of cannabidiol (CBD) can reduce the psychoactive effects of THC in healthy adults who use cannabis occasionally. One hundred participants will inhale various combinations of CBD and THC and report their experiences. The goal is to fin…

This study follows 600 pregnant women who are taking buprenorphine for opioid use disorder. Researchers will collect genetic samples, perform MRIs, and track health outcomes to better understand why some mothers and babies have complications. The goal is to improve treatment and …

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the compound that makes you high). Researchers will give both substances to 30 regular cannabis users who are not seeking treatment. They want to see if CBD can reduce the abuse potenti…

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study looks at how opioid use disorder affects thinking skills like memory and attention, and whether these changes can predict how well people do in treatment. Researchers will use brain scans, computer-based cognitive tests, and machine learning to analyze data from 192 ad…

This study tests whether the drug cytisinicline changes how the brain reacts to seeing smoking-related images in daily smokers who are not trying to quit. Sixty-four participants will receive either the drug or a placebo and undergo brain scans while watching videos of smoking an…

This study looks at whether a patient navigation program called NavSTAR can help people with opioid use disorder start treatment after a hospital stay and avoid going back to the hospital. Researchers will first test the program with 32 people at four hospitals in Philadelphia, t…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study looks at how quitting smoking temporarily increases pain in people with chronic pain, and how the brain processes this. Researchers will use brain scans and daily reports from 132 smokers—some with chronic back pain, some without—to understand these changes. The goal i…

This study tests whether a non-invasive brain stimulation technique called TMS can change how the brain processes rewards in smokers. Researchers will compare different targeting methods to see which best boosts brain signals related to reward and decision-making. The goal is to …