Intestinal disorder

Researchers are testing ATORM-C, a treatment made from a patient's own adult stem cells grown into tiny intestinal organoids, in adults with Crohn's disease who have not responded well to standard therapies. During a colonoscopy, a single dose of these organoids is applied direct…

Researchers are testing a new CAR-T cell therapy called C402-CD19-CAR in adults with large B-cell lymphoma that has come back or stopped responding to treatment. The therapy is made from each participant's own T cells, which are modified to target CD19, a marker on lymphoma cells…

This trial tests a new way to treat rectal cancer without surgery. People with localized rectal cancer who cannot have or refuse surgery will receive external beam radiation followed by a high-dose internal radiation boost, using a 3D-printed guide and tungsten shielding to prote…

Researchers are testing a new cell therapy called CAR001 in adults with solid tumors that have come back or stopped responding to standard treatment. CAR001 uses donor gamma-delta T cells engineered with a chimeric antigen receptor to recognize and attack cancer cells. The trial …

This phase 2 trial is testing whether a combination of two immunotherapy drugs, botensilimab and balstilimab, can completely eliminate early-stage rectal cancer in people whose tumors are microsatellite stable (MSS). Participants receive one infusion of botensilimab followed by b…

This trial is testing whether adding two immunotherapy drugs—zimberelimab and etrumadenant—to standard chemotherapy and a short course of radiation can completely eliminate rectal cancer. Adults with locally advanced rectal cancer that has not spread will receive the treatment, a…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This early-stage trial tests an experimental oral drug called CSCJC3456 in 102 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any signs that the drug can shrink tumors. Participants take the table…

This study tests whether a higher dose of radiation (58.75 Gy) given before surgery can help more people with locally advanced rectal cancer achieve a complete response (no cancer left) compared to the standard dose (50 Gy). About 156 adults aged 18-79 will receive radiation plus…

Researchers are testing whether adding the immunotherapy drug tislelizumab to standard chemoradiotherapy and chemotherapy can help people with ultra-low rectal cancer avoid surgery that removes the anus. The trial enrolls 196 adults with previously untreated rectal adenocarcinoma…

This study tests whether adding a virus-based drug (pelareorep) to standard chemotherapy can help people with a specific type of advanced colorectal cancer that has stopped responding to initial treatment. About 60 adults whose cancer has spread and has certain genetic features (…

This phase 3 trial is testing whether the experimental drug zanzalintinib, alone or combined with an immunotherapy (pembrolizumab plus berahyaluronidase alfa), can improve disease-free survival in people with stage II or III colorectal cancer who have molecular residual disease (…

This study tests whether combining risankizumab with either trosunilimab or ABBV-701 can safely reduce inflammation and improve symptoms in adults with moderately to severely active Crohn's disease or ulcerative colitis. Participants are randomly assigned to one of the combinatio…

This phase 2 trial tests whether two immunotherapy drugs, botensilimab and balstilimab, can clear tiny amounts of cancer DNA from the blood of people with stage II or III colorectal cancer who have completed standard treatment. The study enrolls 20 adults whose blood still shows …

This study tests whether combining two drugs—vedolizumab and tofacitinib—can quickly bring moderate to severe ulcerative colitis under control. About 65 adults will receive both drugs for 8 weeks, and those who respond will continue on vedolizumab alone for nearly a year. The goa…

This study tests an experimental pill called VS-7375, designed to block a specific cancer-driving protein (KRAS G12D). The trial includes people with metastatic colorectal cancer that has this mutation. Some participants receive VS-7375 alone, others get it combined with an antib…

This study tests an experimental drug called BLU-924 (SAR449336) in people with advanced pancreatic, lung, or colorectal cancers that have specific KRAS mutations. The drug is designed to block the cancer-driving KRAS protein. The trial will enroll about 265 participants to evalu…

This phase 3 trial is testing whether adding the targeted drugs calderasib and cetuximab to standard chemotherapy can help people with a specific gene mutation (KRAS G12C) in advanced colorectal cancer live longer without their cancer growing. About 477 participants will receive …

This phase 2 trial tests a drug called DISC-0974 in 21 adults with inflammatory bowel disease (IBD) who also have anemia caused by inflammation. The study aims to see if the drug safely raises hemoglobin levels compared to a placebo. Participants receive injections of either DISC…

This early-phase trial is testing whether a new drug called ZEN003694, when added to the chemotherapy capecitabine, is safe for people with advanced solid tumors that have spread or can't be removed by surgery. About 30 participants will receive the combination to find the best d…

This Phase 3 study tests a new drug, telisotuzumab adizutecan, combined with bevacizumab, against the standard treatment (LONSURF plus bevacizumab) in 700 adults with advanced colorectal cancer that has stopped responding to prior therapies. The goal is to see if the new combo sh…

This phase 2 trial tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) to standard chemoradiotherapy before surgery can improve outcomes for people with locally advanced rectal cancer. About 108 participants will be randomly assigned to receive either the st…

This study tests an experimental drug called ATH-063 in 120 adults with moderate to severe ulcerative colitis who have not responded to or can no longer use biologic therapies. Participants will receive either the drug or a placebo for 12 weeks to see if it can reduce symptoms an…

This trial tests a new medicine called SOT109 for people with advanced colorectal cancer that cannot be removed by surgery or has spread. SOT109 is designed to find and attack cancer cells that have a specific marker (CDH17) while sparing healthy cells. The study has two parts: t…

This rollover study allows up to 40 people with KRAS G12C-mutated lung or other solid tumors who are already benefiting from opnurasib in a Novartis trial to keep receiving the drug. Participants continue their current dose of opnurasib alone or with TNO155 or trametinib. The goa…

This study looks at people with early-stage gastrointestinal cancers that have a mismatch repair deficiency, a feature that can make tumors respond well to immunotherapy. Part A is a registry that tracks all such patients, whether they have surgery or immunotherapy. Part B follow…

This study tests whether MK-8690, a drug given as a shot, can help people with moderate-to-severe ulcerative colitis achieve remission. About 100 adults who haven't responded well to other treatments will receive either MK-8690 or a placebo. The main goal is to see if more people…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This early-stage trial tests an experimental oral drug called SHY-ONC6 in people with advanced or metastatic solid tumors (including breast, colon, lung, pancreatic, and others) that have stopped responding to standard treatments. The study aims to find a safe dose and check for …

This study tests an experimental oral drug, BPI-572270, in 120 adults with advanced solid tumors (lung, colorectal, or pancreatic cancer) that have specific RAS gene mutations. The trial has two phases: first to find a safe dose and check for side effects, then to see if the drug…

This early-phase trial will test whether adding semaglutide (a GLP-1 drug used for diabetes and weight loss) to standard chemotherapy is safe and tolerable for people with metastatic pancreatic, colorectal, or liver cancer. About 30 participants will receive weekly semaglutide in…

This early-phase trial is testing whether adding an experimental drug called ZEN003694 to two approved cancer drugs (cetuximab and encorafenib) can help patients with a specific type of advanced colorectal cancer that has not responded to prior treatments. The study involves 30 a…

This early-stage study is testing an experimental oral drug, VVD-133214, in people with advanced solid tumors that have specific genetic features (MSI or dMMR). The drug works by blocking a protein that helps these cancers grow. The study will check safety and how well the drug w…

This phase 3 study tests the drug risankizumab in about 120 children aged 2 to 18 with moderate to severe ulcerative colitis. The trial has three parts: an initial 12-week IV treatment period, a 52-week maintenance phase where patients get one of two doses by injection, and a lon…

This early-stage trial tests a radioactive drug (Lu-177 edotreotide) in children aged 2 to 17 with cancers that have a specific marker (SSTR-positive). The goal is to find the right dose and check safety. About 20 children whose cancer has returned or not responded to prior treat…

This phase 2 trial is testing whether adding an immunotherapy drug (adebrelimab) to a chemotherapy combo (NALIRIFOX) and radiation can improve outcomes for people with a certain type of locally advanced rectal cancer (pMMR/MSS). About 84 participants will be randomly assigned to …

This expanded access program provides velzatinib (GSK6042981) to patients with gastrointestinal stromal tumors (GIST) that have a KIT mutation and have already tried at least three prior treatments. The program is for people who have no satisfactory alternative, including approve…

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

This study tests a drug called tislelizumab for people in Nigeria with a specific type of colorectal cancer (mismatch repair deficient). The drug helps the immune system attack cancer cells. The study will check if the drug shrinks tumors and is safe. It includes 40 adults who ha…

This phase 3 trial is testing a drug called tulisokibart in about 1,200 people with moderate-to-severe Crohn's disease who haven't had success with other treatments. The drug is given by IV or injection and aims to reduce symptoms and heal the gut lining. The study compares tulis…

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This study is testing a new biologic drug called sacituzumab tirumotecan (MK-2870), alone or with chemotherapy, in people with advanced colorectal, pancreatic, or biliary tract cancers that cannot be removed by surgery. The main goals are to check safety and see if tumors shrink.…

This early-phase trial is testing a new oral drug called RMC-5127, alone or combined with other drugs, in adults with advanced solid tumors that have a specific KRAS G12V mutation. The study includes people with lung, colorectal, and pancreatic cancers who have already tried stan…

This study tests whether adding celecoxib to TAS-102 can clear tiny amounts of cancer DNA (ctDNA) in the blood of colorectal cancer patients who have finished standard chemotherapy. About 25 adults with stage II-IV colorectal cancer and no visible tumors on scans will take TAS-10…

This trial is testing whether adding a Lactobacillus probiotic or a trace element supplement to standard ulcerative colitis treatment can help keep the disease in remission. About 132 adults with mild to moderate ulcerative colitis will be randomly assigned to one of three groups…

This study compares two schedules of the radioactive drug Lu177-Dotatate in 166 people with slow-growing midgut neuroendocrine tumors. One group gets the drug every 8 weeks (standard), the other every 16 weeks. The goal is to see if the less frequent schedule causes fewer blood-r…

This study tests a new antibody drug called XmAb942 for moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. First, healthy volunteers will receive the drug to check safety. Then, about 270 people with ulcerative colitis will get either XmAb942 or a placeb…

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This study tests an experimental oral drug, GSK5460025, alone or with other cancer drugs, in adults whose solid tumors have specific genetic changes (dMMR or MSI-H). The goal is to see if the drug can shrink tumors and to check its safety. About 47 people with advanced cancers th…

This phase 3 study tests a drug called afimkibart in 600 people with moderate-to-severe Crohn's disease. Participants receive either the drug or a placebo to see if it can reduce symptoms and gut inflammation. The trial is double-blind, meaning neither patients nor doctors know w…

This study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…

This study tests an experimental oral drug called zongertinib, which blocks HER2, a protein that fuels cancer growth. It is given alone or with other cancer drugs to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and not responded to prior treatm…

Researchers are testing a new drug, VVD-133214, combined with pembrolizumab in people with advanced colorectal cancer that has MSI and/or dMMR. These tumors rely on a protein called Werner helicase to survive, and VVD-133214 is designed to block it. The trial compares the combina…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This phase 2 trial is testing whether adding two extra drugs—bevacizumab and sintilimab—to the usual combination of irinotecan and cetuximab can shrink tumors in people with advanced colorectal cancer that no longer responds to irinotecan. The study enrolls 160 adults with RAS wi…

This early-stage trial tests a technique called PIPAC, which turns a chemotherapy drug (mitomycin C) into a mist and sprays it directly onto cancer spread inside the abdomen. It is for people with advanced gastrointestinal cancers that cannot be removed by surgery. The main goal …

This trial tests whether a virtual hub offering personalized exercise, nutrition, psychology, and peer support before and after colorectal cancer surgery can reduce complications within 30 days. About 564 adults in Australia having curative surgery will be randomly assigned to us…

Researchers are testing fecal microbiota transplantation (FMT) for ulcerative colitis, a chronic inflammatory bowel disease. They will compare stool from healthy Han donors with stool from healthy Dai donors, a Yunnan ethnic group with distinct diets, to see if donor background a…

This study tests whether adding the experimental drug INCA33890 to standard chemotherapy and bevacizumab helps people with metastatic colorectal cancer that is microsatellite stable (a type that doesn't respond well to immunotherapy). About 700 adults who have not had prior treat…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…

This study tests an investigational drug called duvakitug in people with moderate-to-severe ulcerative colitis who have already responded to treatment. The goal is to see if duvakitug can help maintain remission better than a placebo over 40 weeks, with an optional long-term exte…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This study is testing whether the immunotherapy drug dostarlimab (TSR-042), followed by standard chemoradiation and surgery, can effectively treat advanced mismatch repair deficient (dMMR) solid tumors. About 212 adults with locally advanced dMMR cancers will receive the drug int…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This trial is investigating whether it is safe to skip the removal of a specific group of lymph nodes (the No.253 lymph nodes) during surgery for mid and low rectal cancer. The standard surgery removes these nodes, but this study compares the long-term survival of patients who ha…

This study is testing whether a combination of three drugs—liposomal irinotecan, TAS102, and bevacizumab—can help people with metastatic colorectal cancer that has not responded to prior treatments. About 50 adults with mismatch repair proficient tumors will receive the drugs in …

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study tests whether a supplement called palmitoylethanolamide (PEA) can help people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity, quality of life, and inflammation markers in 60 participants. The goal is to see if adding PEA …

This study tests whether adding a non-invasive sound wave treatment (histotripsy) to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver. About 100 adults whose cancer cannot be removed by surgery will receive both treatments. The go…

This phase 2 trial tests whether the drug TPST-1495 can reduce the number and size of polyps in the small bowel and colon of people with familial adenomatous polyposis (FAP), an inherited condition that greatly raises colon cancer risk. About 38 participants will take the drug by…

This study tests an experimental drug called HRX215 in people who had part of their liver removed because colon cancer spread there. The drug is meant to help the liver grow back and work better after surgery. About 80 adults will take either HRX215 or a placebo for 28 days, and …

This early-stage study is testing a new drug called calderasib (MK-1084) in people with advanced solid tumors that have a specific KRAS G12C mutation. The drug is given alone or combined with other cancer treatments. The main goals are to check safety and find the right dose. Abo…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study tests a combination of two drugs, nilotinib (a pill) and paclitaxel (given by IV), for people with rare advanced cancers that have not responded to standard treatments. The goal is to see if the drugs can shrink or stop tumor growth. About 82 adults with specific rare …

Researchers are testing whether a combination of two drugs, atezolizumab and bevacizumab, can clear tiny amounts of cancer DNA from the blood of people whose gastrointestinal cancer was treated with curative intent. The trial enrolls 20 adults with colon, rectal, gastric, pancrea…

This study tests an experimental drug called telisotuzumab adizutecan combined with standard chemotherapy in people whose colorectal cancer has spread. The goal is to see if the combination shrinks tumors and is safe. About 390 adults will take part at hospitals worldwide.

This study will test whether a diet rich in protein and fiber can reduce harmful gas-producing bacteria in the gut of people with ulcerative colitis. Forty adults with mild to moderate disease will eat specially prepared frozen meals for two separate week-long periods. Researcher…

This study tests whether a new drug called pumitamig, combined with chemotherapy, works better than the current standard treatment (bevacizumab plus chemo) for people with advanced colorectal cancer that cannot be removed by surgery. About 990 adults who have not yet been treated…

This study tests a combination of up to 4 experimental drugs (retifanlimab, TriAdeno vaccine, N-803, and SX-682) in people with metastatic colorectal cancer that has spread and not responded to prior treatments. The goal is to see if the combination can shrink tumors and improve …

This phase 2 trial compares a rechallenge treatment (irinotecan plus cetuximab) against the current standard (trifluridine/tipiracil plus bevacizumab) for people with metastatic colorectal cancer whose disease has worsened after earlier therapies. Only patients with specific gene…

This study tests a procedure called transarterial infusion chemotherapy (TAIC) for people with colorectal cancer that cannot be removed by surgery. Instead of giving chemo through a vein, TAIC delivers it directly to the tumor's blood supply, which may boost effectiveness and red…

This trial tests an experimental drug called ontunisertib in people with Crohn's disease who have developed scarred, narrowed sections in their bowel that cause pain and blockages. The goal is to see if the drug can reopen these narrowed areas, potentially reducing symptoms and t…

This study tests the safety and effectiveness of targeted therapies or immunotherapies in people with metastatic colorectal cancer (cancer that has spread). Participants are assigned to a treatment based on specific biomarkers found in their tumor. The goal is to see if these per…

This early-phase trial tests whether injecting a medical glue (Histoacryl®) into the pancreas during Whipple surgery can strengthen the connection between the pancreas and intestine and prevent dangerous leaks. The study involves 30 patients with soft pancreases and narrow ducts,…

This study tests whether giving a short course of targeted drugs before surgery can improve outcomes for people with colorectal cancer that can be removed. About 197 participants will receive a treatment matched to their tumor's genetic makeup, followed by standard surgery. The g…

Researchers are testing whether giving chemotherapy before surgery helps people with clearly resectable pancreatic head cancer or periampullary cancer live longer than going straight to surgery. The trial enrolls 262 participants and randomly assigns them to either mFOLFIRINOX ch…

This trial tests whether a 12-week home-based exercise program can alter the gut microbiome in young adults (ages 18-50) with colorectal cancer who are undergoing chemotherapy. Participants are randomly assigned to either the exercise group or a waitlist control group. Researcher…

This trial tests a new drug called TUB-030 in adults with advanced solid tumors, including head and neck, lung, and breast cancers. The goal is to find the safest and most effective dose. Participants receive the drug every three weeks and are monitored for side effects and tumor…

This study tests risankizumab, a drug already used in adults, in children aged 2 to 18 with moderate to severe Crohn's disease. About 110 kids will receive the drug intravenously then by injection over several years. The goal is to see if it safely reduces symptoms and gut inflam…

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This early-phase trial tests the safety and best dose of a drug called ulixertinib when given with cetuximab and/or encorafenib. It is for people with advanced colorectal cancer that has spread and who have already tried treatments targeting EGFR or BRAF. The goal is to find a do…

This phase II trial is testing whether alternating standard chemotherapy and immunotherapy with a targeted drug called pemigatinib can help people with advanced biliary tract cancers that have FGFR2 alterations. The study includes adults with cancer that cannot be removed by surg…

This study tests whether adding the immunotherapy drug atezolizumab to the standard drug imatinib can help control advanced gastrointestinal stromal tumors (GIST) that have stopped responding to other treatments. About 110 adults with inoperable or metastatic GIST will be randoml…

This trial is testing whether adding an experimental antibody called petosemtamab to standard chemotherapy can help people with a certain type of advanced colorectal cancer that has returned or spread. Participants will receive either petosemtamab plus chemotherapy or a standard …

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

Researchers are testing two investigational radiopharmaceuticals in adults with advanced solid tumors, including colorectal, pancreatic, biliary tract, gastric, esophageal, and head and neck cancers. First, participants receive SKL35502, an imaging agent that highlights tumors ca…

This study is testing whether giving radiation therapy along with immunotherapy before surgery can improve outcomes for people with sinonasal or anorectal mucosal melanoma, two rare and aggressive cancers. About 40 participants will receive combination immunotherapy (such as ipil…

This study looks at the safety of a drug called adalimumab in 30 Chinese children aged 6 to 17 with moderate-to-severe Crohn's disease. Researchers will track side effects over 12, 26, and 52 weeks of treatment. The goal is to understand how safe the drug is in real-world use for…

This phase 3 trial tests whether adding the experimental drug SHR-A1811 to standard chemotherapy and bevacizumab works better than standard therapy alone for people with advanced colorectal cancer who have not had prior treatment. About 300 participants will receive either the ne…

This phase 2 trial tests whether transplanting healthy gut bacteria (fecal microbiota transplant) can boost the effects of immunotherapy and chemotherapy in 30 people with advanced colon cancer that has spread to the liver. Participants receive the combination for six cycles, the…

This study tests a wearable patch called MultiSense that tracks heart rate and other vital signs for five days after a patient leaves the hospital following major digestive surgery. The goal is to see if the patch allows high-risk patients to be discharged earlier while still cat…

This phase 2 trial tests the drug velzatinib in people with advanced gastrointestinal stromal tumors (GIST) that have stopped responding to or cannot tolerate several standard treatments. The study aims to see if velzatinib can shrink or control the tumors and how safe it is. Par…

This study is testing whether combining two different biologic drugs can better control moderate to severe Crohn's disease. One hundred adults will first receive either vedolizumab plus adalimumab or vedolizumab plus ustekinumab. Those who respond well will then switch to vedoliz…

This Phase 3 trial tests a new drug called precemtabart tocentecan, alone or with bevacizumab, against a standard treatment for metastatic colorectal cancer that has progressed after prior therapies. About 1,020 participants will be randomly assigned to one of three treatment gro…

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. It is an extension study, meaning participants must have already taken tulisokibart in a previous study. The main goal is to see ho…

This study tests a new drug called TAK-505 in adults with advanced solid tumors that cannot be removed by surgery. The main goals are to check safety, find the best dose, and see if the drug can shrink or slow cancer growth. About 151 people with certain cancers, such as stomach,…

This early-stage study tests a new drug called BBO-10203 in people with advanced solid tumors (breast, lung, or colorectal cancer) that have not responded to standard treatments. The drug is designed to block two cancer-driving proteins (PI3K and RAS). Researchers will check safe…

This study looks at people with colorectal cancer that spread to the liver, who had good results from chemotherapy before surgery. After removing the liver tumors, half will restart the same chemo (FOLFIRI) and half will get no further treatment. The goal is to see if the extra c…

Researchers are testing a procedure called Fistura that uses radiofrequency energy to close complex anal fistulas. A flexible catheter follows the fistula tract and heats the tissue along its length, aiming to seal the tract without cutting the sphincter muscle. The trial enrolls…

This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the dru…

This early-stage trial evaluates an investigational oral drug called ONO-6414 in healthy adults and in people with active ulcerative colitis. The main goals are to assess the drug's safety, tolerability, and how the body processes it. The study includes single and multiple doses,…

This phase 3 trial tests whether a new drug called petosemtamab, combined with chemotherapy, works better than the current standard treatment (cetuximab plus chemotherapy) for people with left-sided colorectal cancer that cannot be surgically removed or has spread. The study incl…

This study tests a new medicine called MH002, which contains live bacteria meant to restore gut health in people with mild-to-moderate ulcerative colitis. About 204 adults whose current treatment isn't working well enough will receive either a low dose, high dose, or placebo caps…

This early-stage trial tests a new drug called IAM1363 in adults with advanced cancers that have HER2 alterations, including breast, lung, and stomach cancers that have spread to the brain. The study aims to find the safest dose and see if the drug can shrink tumors. About 383 pa…

This early-phase trial is testing whether adding an experimental drug called CA-4948 to standard chemotherapy (FOLFOX) and a targeted therapy (bevacizumab) is safe for people with metastatic colorectal cancer. About 24 adults whose cancer has spread and cannot be surgically remov…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

Researchers are testing a three-part treatment for advanced colorectal cancer with a BRAF V600E mutation that has stopped responding to standard BRAF-targeted therapy. The trial combines ivonescimab, a drug that blocks two proteins involved in tumor growth and immune evasion, wit…

This study compares two methods for finding precancerous colon polyps during colonoscopy. Both methods use water instead of air to inflate the colon and an AI system to spot polyps. One group also uses a special light filter called linked-color imaging. The goal is to see if the …

This Phase 3 trial is testing whether a combination of two targeted drugs, tunlametinib and vemurafenib, can help people with a specific genetic mutation (BRAF V600E) in metastatic colorectal cancer. About 165 participants will be randomly assigned to receive either the drug comb…

This trial is testing whether combining pidnarulex (a drug that blocks cancer cell growth) with cemiplimab (an immunotherapy that helps the immune system attack cancer) is safe and effective for people with advanced colorectal cancer that no longer responds to standard treatments…

This phase 2 trial tests whether a series of procedures to remove cancerous tumors, given one after another, can improve outcomes for people with stage IV foregut cancers (like stomach, pancreas, or bile duct cancer) who have no detectable cancer DNA in their blood after initial …

This phase 3 trial tests a drug called afimkibart in 100 children aged 2-17 with moderate-to-severe Crohn's disease. The goal is to see if it can help children feel better and heal their intestines. Participants will receive the drug as an IV infusion or injection, and researcher…

This study tests an oral drug called LY4268989 (MORF-057) in adults with moderate-to-severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo for up to 108 weeks. The goal is to see if the drug can safely help control the disease and improve s…

This trial tests whether completely closing the wound left after removing large flat colon polyps (at least 20 mm) reduces complications like delayed bleeding or perforation. About 686 adults scheduled for polyp removal will be randomly assigned to either have the wound closed wi…

This study tests whether adding a new drug (LY4395089) to an existing treatment (mirikizumab) works better than mirikizumab alone for adults with moderate-to-severe Crohn's disease. About 60 participants will be followed for 62 weeks to check safety and how well the combination r…

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This phase 3 study tests whether a new drug called ivonescimab, combined with standard chemotherapy (FOLFOX), works better than the current standard treatment (bevacizumab plus FOLFOX) for people with metastatic colorectal cancer that has spread. About 600 adults who have not had…

This study tests a new drug, IDRX-42, against the current standard drug sunitinib in adults with advanced gastrointestinal stromal tumors (GIST) that have spread or can't be removed by surgery and have already been treated with imatinib. About 450 participants will be randomly as…

This early-stage trial tests a new drug called ONC-783 in 20 people with advanced solid tumors, including colorectal, ovarian, pancreatic, or breast cancer. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goal is to find a safe d…

This trial compares two ways to treat a single-tract cryptoglandular anal fistula, a condition that can cause pain and discharge. One group receives a loose seton for about 8 weeks before definitive sphincter-preserving surgery, while the other goes straight to surgery without a …

This study tests a new medicine called afimkibart in children aged 2 to 17 with moderate to severe ulcerative colitis, a disease that causes inflammation and sores in the colon. The goal is to see if the drug can safely help children feel better and achieve remission (no symptoms…

This study tests whether capsules containing freeze-dried healthy donor gut bacteria can take root in the intestines of people with Crohn's disease. Researchers will check if the bacteria engraft in the ileum and colon, and explore changes in symptoms and inflammation. The trial …

This phase 2 study is testing two new drugs — mirikizumab (given by IV or injection) and LY4395089 (a pill) — in 60 adults with moderately to severely active ulcerative colitis or Crohn's disease. The goal is to see if these treatments are safe and can help control the disease. T…

This study tests whether adding a new oral drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab plus a placebo fo…

This early-stage trial tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is designed to attach to a protein on cancer cells and trigger their death. The main goals are to check safety and see if the dru…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This phase 2 trial tests whether a combination of three drugs—avutometinib, defactinib, and cetuximab—can help control advanced colorectal cancer that has stopped responding to standard anti-EGFR treatment. About 33 participants will receive the drugs orally and intravenously. Th…

This trial tests whether adding an experimental drug called HDM2017 to standard chemotherapy and bevacizumab can safely shrink tumors in people with advanced colorectal cancer. The study includes adults aged 18 to 75 whose cancer has spread or cannot be removed by surgery. Resear…

This study tests a surgery called total pancreatectomy with islet autotransplantation (TPIAT) in 30 adults with certain pancreatic tumors who are at high risk for a dangerous leak after standard surgery. The procedure removes the entire pancreas and transplants the insulin-making…

This early study tests whether a probiotic called Clostridium butyricum can help prevent or treat scarring in the gut caused by Crohn's disease. About 40 adults with a narrowing form of Crohn's will take the probiotic, a sugar called trehalose, both, or a placebo for two months b…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see…

This study is observing how well the drug fruquintinib works for people with metastatic colorectal cancer who have already tried standard treatments. About 150 participants in Germany will be treated as part of their normal care, and researchers will track tumor response, surviva…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. T…

This early-stage study tests an experimental drug called IMGS-001 in about 105 people with advanced solid tumors that have come back or not improved after standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, t…

This study tests an experimental pill called MORF-057 (zotemtegrast) in 385 adults with moderate-to-severe Crohn's disease. The drug works by blocking a protein that drives gut inflammation. Participants will receive one of three doses of the drug or a placebo for 14 weeks to see…

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This early-phase trial tests two radioactive drugs, [177Lu]Lu-A9-0631 and [225Ac]Ac-A9-0642, in people with advanced solid tumors that have a protein called GRPR on their surface. These cancers include certain breast, prostate, and colorectal cancers that have stopped responding …

This study compares a new technique called total underwater colonoscopy (using water instead of gas) to the standard method in over 1,000 people undergoing screening after a positive stool test. The goal is to see if water helps doctors find more flat, hard-to-spot polyps that ca…

This early-stage study is testing a new treatment for people with metastatic colorectal cancer that has stopped responding to standard therapies. The treatment uses a two-step process to deliver a radioactive particle directly to cancer cells, aiming to control the disease. About…

This Phase 3 study tests whether adding the targeted drug sotorasib and another drug called panitumumab to standard chemotherapy (FOLFIRI) works better than standard chemo alone (with or without bevacizumab) for people with metastatic colorectal cancer that has a specific KRAS G1…

This trial tests whether giving magnesium sulfate through an IV during colorectal cancer surgery can dampen the body's inflammatory response afterward. Researchers will measure blood markers like white blood cells, C-reactive protein, and neutrophils in 52 patients, and also trac…

This early-stage study tests a new drug called MK-4884 in about 120 people with advanced or metastatic solid tumors (colorectal, kidney, lung, or bile duct cancer). The main goal is to check the drug's safety and find the right dose. Researchers will monitor side effects and how …

This phase 2 study tests belzutifan, a daily pill that blocks a protein called HIF-2α, in people with advanced rare cancers like pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, VHL disease-associated tumors, and certain other solid tumors. The goal is to see if …

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This phase III trial is testing whether adding focused treatments—like high-dose radiation, surgery, or heat ablation—to standard chemotherapy can help people with colorectal cancer that has spread to up to four sites. The goal is to see if destroying those metastatic tumors impr…

This study tests if immunotherapy drugs (cemiplimab, fianlimab, and REGN7075) can clear leftover cancer DNA in the blood of colorectal cancer patients after surgery and chemotherapy. The goal is to delay or prevent the cancer from coming back. About 79 adults with stage II/III co…

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study tests whether giving radiation before surgery lowers the chance of rectal cancer returning in the same area. Researchers will follow 100 people with locally advanced proximal rectal cancer who receive either radiation followed by surgery or surgery alone. The main goal…

This study is for people with rectal cancer that didn't fully go away after standard chemotherapy and radiation. Researchers want to see if giving a few extra doses of internal radiation (brachytherapy) can finish off the tumor and let patients keep their rectum instead of needin…

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard chemotherapy delivered directly to the liver can help people with colorectal, bile duct, or adrenal cancer that has spread to the liver. About 70 adults will receive the drug combination along with a s…

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-s…

This study is for people with locally advanced rectal cancer. It tests whether using MRI scans early after chemotherapy can help doctors choose the best next step: surgery or more chemo with radiation. The goal is to improve cancer control and reduce side effects. About 1,075 par…

This phase I/II platform trial tests several drug combinations, including evorpacept, trastuzumab deruxtecan, zanidatamab, tucatinib, and TTX-MC138, in people with advanced solid tumors, especially metastatic breast cancer. The goal is to find safe and promising regimens that cou…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study is for people with stage III colon cancer who have had surgery. It uses a blood test called Signatera to look for leftover cancer DNA. Depending on the results, patients get either immediate or delayed chemotherapy, and the type and length of chemo are tailored to thei…

This trial compares two ways of closing the abdomen after open colorectal surgery: a device-assisted method (SutureTOOL) versus the traditional manual technique. The goal is to see if the device helps reduce the chance of an incisional hernia forming within one year. Participants…

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This phase 2 trial tests whether combining two drugs—fruquintinib and TAS-102—works better than fruquintinib alone for people with advanced colorectal cancer that hasn't responded to prior treatments. About 120 adults will be randomly assigned to one of the two groups. The main g…

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This early-stage trial tests a new drug called CT-202 in people with advanced triple-negative breast cancer, colorectal cancer, or bladder cancer that has come back or spread. The drug is a bispecific antibody designed to help the immune system attack cancer cells that have a pro…

This study tests a new treatment called DB-3Q for people with Crohn's disease that hasn't improved with standard therapies. DB-3Q is made from stem cells and may help reduce inflammation in the gut. The trial will enroll 36 adults and focus on safety and how well the treatment wo…

This early-stage trial tests a new drug called CBP-1019 combined with standard chemotherapy (FOLFOX) and possibly other drugs for people with advanced solid tumors that have not responded to prior treatments. The goal is to find safe and effective doses. About 128 participants wi…

This early-stage trial tests a new oral drug called ERAS-0015, alone or with other cancer drugs, in 600 adults with advanced solid tumors that have certain RAS mutations. The main goals are to check safety, find the right dose, and see how the drug moves through the body. Researc…

This program provides compassionate use of dupilumab (Dupixent) for patients with severe type 2 inflammatory disorders who have no other treatment options. It aims to offer access to this drug outside of a clinical trial. The program is already approved for marketing.

This early-stage trial tests a new drug called JNJ-95437446 in people with advanced solid tumors, including colorectal cancer, that have not responded to standard treatments. The study has two parts: first, finding a safe dose, and second, checking safety more closely in a larger…

This study is testing whether a healthy diet centered around beef can reduce inflammation and improve metabolic health better than a standard U.S.-style diet based on USDA guidelines. Researchers will enroll 56 adults with metabolic syndrome or pre-diabetes and assign them to one…

This phase II trial tests whether adding paclitaxel directly into the abdomen, alongside standard systemic chemotherapy, is feasible for people with gastrointestinal cancers that have spread to the peritoneal lining. The study includes patients with gastric, colorectal, appendice…

This study tests a new drug called RO7790121 (Afimkibart) in people with moderate-to-severe Crohn's disease. The goal is to see if the drug can reduce symptoms and heal the gut lining better than a placebo. About 425 adults who have not responded well to other treatments will tak…

This study tests whether mirabegron (a bladder medication) and tadalafil (used for erectile dysfunction) can improve blood sugar control in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drug…

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This trial tests whether taking 150 mg of grape seed extract (MegaNatural BP) daily for 6 weeks can lower blood pressure and improve heart health in adults aged 40 to 60 with elevated blood pressure and prediabetes. Researchers will measure changes in blood pressure, blood vessel…

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This trial tests whether the probiotic supplement MPRO3 can reduce infectious complications after colon cancer surgery. About 100 patients scheduled for colon cancer surgery will take either MPRO3 or a placebo capsule once daily for 13 weeks, starting one week before surgery. Res…

This phase 2 trial tests whether giving a combination of targeted drugs and chemotherapy before surgery can improve outcomes for people with a specific type of colorectal cancer that has a BRAF V600E mutation. Participants receive encorafenib, cetuximab, and mFOLFOX6 for eight we…

This trial tests whether using ultrasound during surgery to choose where to cut the bowel leads to better outcomes for people with Crohn's disease. About 44 adults with Crohn's disease affecting the last part of the small intestine will be randomly assigned to have their surgery …

This trial compares two standard bowel preparation methods—Fleet enema (given rectally) and Pico-Salax (taken orally)—to see which cleans the rectum better before transanal endoscopic surgery. The study includes adults undergoing this surgery at a single center, and measures clea…

This phase 2 trial is testing whether combining yttrium-90 radioembolization (a procedure that delivers radiation directly to liver tumors) with two drugs—capecitabine (chemotherapy) and atezolizumab (immunotherapy)—can control or shrink liver metastases in people with colorectal…

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This trial tests a streamlined version of radioembolization, a treatment that delivers tiny radioactive beads directly to liver tumors. The standard procedure requires extra imaging beforehand to check for radiation leakage to the lungs, which can delay treatment. For patients wi…

This phase III trial is testing whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy after short-course radiation can improve outcomes for people with a specific type of locally advanced rectal cancer (pMMR/MSS). Participants receive eith…

This trial asks whether removing a wider set of lymph nodes (D3) during left colon cancer surgery improves 5-year survival compared to the standard removal (D2). It enrolls about 1,381 people with adenocarcinoma located between the splenic flexure and rectosigmoid junction. Resea…

This trial tests whether delivering chemotherapy directly to the liver through a pump, combined with standard systemic chemotherapy, can shrink liver tumors from colorectal cancer enough to allow surgery. The study enrolls people whose liver metastases are initially inoperable bu…

This trial tests an experimental oral drug called TT-702 in people with advanced solid tumors. The drug works by blocking a protein that tumors use to hide from the immune system. The study aims to find the safest dose of TT-702 when given alone and in combination with an immunot…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This trial is testing whether giving a stronger chemotherapy regimen (mFOLFIRINOX) early can improve outcomes for people with stage II-III colon cancer who still have signs of cancer DNA in their blood during standard adjuvant chemo. Participants are randomly assigned to either r…

This trial is testing whether proton beam radiation, a more precise form of radiation, causes fewer stomach and bowel side effects than standard photon radiation when given before surgery for high-risk rectal cancer. About 254 patients will be randomly assigned to receive either …

This trial tests whether a combination of contact X-ray brachytherapy and short-course radiotherapy can preserve the rectum in people with early-stage rectal cancer. Participants receive this experimental radiation regimen, with some also getting chemotherapy. The goal is to see …

This study looks at people with inflammatory bowel disease (Crohn's or ulcerative colitis) who feel fine but still have moderate to severe inflammation inside their gut. It compares two approaches: switching to a different targeted medication versus staying on the current one. Th…

This trial tests whether a 12-week dietary intervention can improve gut health, reduce inflammation, and enhance quality of life in adults with ulcerative colitis who are in remission. Participants are randomly assigned to a Mediterranean diet, a Mediterranean diet combined with …

This phase II trial is testing whether giving a combination of two immunotherapies (sintilimab and IBI-310) along with chemotherapy before surgery can improve outcomes for people with a specific type of locally advanced rectal cancer (MSI-H/dMMR). The main goal is to see how ofte…

This trial compares two weight-loss surgeries in people with severe obesity (BMI 50-60). One is the standard Roux-en-Y gastric bypass, the other a newer sleeve gastrectomy with duodenojejunal bypass. The goal is to see which procedure leads to healthier hormone responses after me…

This trial is testing a device called COLO-BT™, a temporary balloon tube placed inside the bowel after colorectal surgery. The goal is to see if it can safely divert stool away from the surgical connection, potentially avoiding the need for a temporary ileostomy (a stoma bag). Th…

This phase 3 trial is testing whether apraglutide, a synthetic version of a natural gut hormone, can help adults with short bowel syndrome and intestinal failure reduce their need for intravenous nutrition (parenteral support). Participants receive either apraglutide or a placebo…

This trial tests whether adding regular MRI scans to standard monitoring (stool tests and symptom checks) can improve outcomes for people with Crohn's disease who are starting biotherapy. Crohn's is a chronic inflammatory bowel disease that can damage the full thickness of the in…

This trial tests whether a short course of azithromycin, taken before starting anti-TNF therapy, can reduce the body's tendency to develop antibodies against the biologic drug. Antibodies can make the treatment less effective over time. The study enrolls adults with Crohn's disea…

This pilot study tests whether a specific probiotic, given as a rectal enema, can improve gut health in people with mild-to-moderate ulcerative colitis. Researchers will measure changes in the gut microbiome and signs of rectal healing. The trial enrolls 20 adults aged 18 to 80 w…

This trial investigates whether giving a higher dose of radiotherapy can safely control locally recurrent rectal cancer that cannot be surgically removed. Around 30 adults with this condition will receive either stereotactic body radiotherapy or hyperfractionated chemo-reirradiat…

This trial tests an experimental oral drug called BRS201 in people with active mild ulcerative colitis. Participants take the drug or a placebo for four weeks each in a crossover design, and researchers measure changes in gut inflammation markers and symptoms. The study involves …

This study tests whether a lab-grown mini-tumor (tumouroid) from a patient's biopsy can help doctors pick the more effective chemotherapy between two standard options (FOLFOX or FOLFIRI) for metastatic colorectal cancer. The trial enrolls adults with a specific type of colorectal…

This trial investigates whether giving oral antibiotics before elective colorectal surgery reduces complications like infections and bowel leaks in children. About 74 children scheduled for procedures such as colostomy closure or pull-through for conditions like Hirschsprung dise…

This study looks at whether adding an immune-modulating drug called Astragalus polysaccharide (APS) to standard cancer treatments can help people with colorectal cancer live longer. The drug is already approved in Taiwan for cancer-related fatigue. Researchers will review medical…

This study compares delayed cord clamping (waiting at least 30 seconds after birth) with immediate clamping in preterm infants born between 32 and 37 weeks. The goal is to see if the extra time improves early health outcomes such as breathing, anemia risk, and survival. Researche…

This study tests whether repeated fecal microbiota transplants (FMT) combined with a special liquid diet can safely control active Crohn's disease in children aged 2–16 who are newly diagnosed. The goal is to see if this approach can achieve remission and heal the gut lining with…

This study tests whether repeated fecal microbiota transplants (FMT) from healthy donors, combined with a special liquid diet, can safely help children aged 2–16 with active Crohn's disease that hasn't improved with standard treatments. The goal is to see if this approach can red…

This phase I trial tests a modified vaccinia virus (BT-001) injected directly into rectal tumors, followed by a single dose of the immunotherapy drug pembrolizumab. The study enrolls about 20 adults with localized pMMR rectal cancer who are candidates for surgery. The main goal i…

This trial investigates whether a blood test that detects tiny bits of tumor DNA (circulating tumor DNA) can help decide which patients with stage II colon cancer need chemotherapy after surgery. Patients whose blood test is positive for tumor DNA receive chemotherapy (mFOLFOX6),…

This trial investigates whether adjusting radiation doses based on early tumor shrinkage seen on daily MRI scans can improve outcomes for people with locally advanced rectal cancer. Participants receive standard chemoradiation, but those whose tumors shrink slowly get a higher ra…

This study tests whether giving children with active ulcerative colitis a series of fecal microbiota transplants (FMT) along with a special liquid diet (partial enteral nutrition) can help control the disease. The trial includes children aged 2 to 16 who either have not responded…

This study tests an experimental oral drug called INT-210 in adults with active ulcerative colitis, a chronic inflammatory bowel disease. Participants take either 200 mg or 400 mg of INT-210 twice daily for 12 weeks. The main goals are to check the drug's safety and how the body …

This study explores whether people with inactive inflammatory bowel disease (IBD) can safely stop taking proton pump inhibitors (PPIs), a common acid-reducing medication. Evidence suggests PPIs may make IBD treatments less effective and increase hospital visits. The trial will re…

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive ei…

This study tests whether adding a targeted, tumor-destroying treatment (like focused radiation or heat ablation) can help people with certain gastrointestinal cancers—such as colorectal, small bowel, or pancreatic cancer—continue their current systemic therapy longer when only a …

This study tests whether combining a precise form of radiation (SBRT) with an immunotherapy drug (PD-1 monoclonal antibody) can help people whose colorectal cancer has spread to the liver and cannot be removed surgically. The trial enrolls adults aged 18 to 75 with a specific typ…

This phase 2 trial compares two treatment plans for people with locally advanced rectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS). One group receives standard short-course radiation followed by chemotherapy. The other group receives a newer a…

This phase 1 trial tests a new two-drug combination for people with metastatic colorectal cancer that is microsatellite stable (MSS), a type that typically does not respond to immunotherapy alone. The study combines LB-100, which blocks a protein called PP2A to increase stress si…

This trial tests whether close follow-up (active surveillance) is as good as chemoradiotherapy for preventing cancer return after early-stage rectal cancer removal. About 480 adults with intermediate-risk T1 rectal cancer will be randomly assigned to either regular checkups and s…

This study compares a new treatment approach for high-risk rectal cancer: short-course radiation followed by immunotherapy (toripalimab) and chemotherapy (FOLFOX) versus the standard long-course chemoradiation. The goal is to see if the new approach leads to more complete tumor r…

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive…

This study tests whether a simple esophageal string test (EST) can diagnose eosinophilic esophagitis (EoE) in people who have trouble swallowing. Participants swallow a capsule with a nylon string that collects fluid from the esophagus, which is then analyzed. The results will be…

Researchers are building a computer model that combines detailed features from preoperative MRI scans with routine clinical information to estimate the risk of cancer returning after surgery for colorectal liver metastases. The study includes adults who had surgery for these live…

Researchers are comparing a fully autonomous artificial intelligence system with AI-assisted human diagnosis for identifying colorectal polyps during colonoscopy. The trial enrolls 540 adults scheduled for full colonoscopy, excluding those with inflammatory bowel disease, active …

Researchers are studying whether a laboratory test called ChemoINTEL can predict how a patient's colorectal cancer will respond to chemotherapy. The study enrolls 100 adults with colorectal cancer, including those receiving adjuvant chemotherapy, those with high-risk stage II dis…

This study tests a device called Gixam to see if it can find precancerous growths or colon cancer in people aged 45-84 who had a negative stool test (FIT). About 1,436 participants will use the Gixam device, take a home stool test, and then get a standard colonoscopy. The goal is…

Researchers compare selective imaging guided by clinical scores to routine imaging in adults with suspected appendicitis. Participants are assigned to one of three groups: selective imaging based on the Adult Appendicitis Score, selective observation plus selective imaging, or ro…

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build …

This study is testing new, easy-to-use screening tools for colorectal cancer (CRC) in over 4,000 adults across Europe. Participants provide blood, breath, stool, and cheek swab samples, which are analyzed for biomarkers, genetic risks, and chemical patterns. The goal is to develo…

Researchers test whether giving people education materials and free access to screening helps them get checked for colorectal cancer and hepatitis C. The trial enrolls adults ages 45 to 75 who receive care at community health centers and are not up to date on these screenings. Pa…

This phase 2 study tests whether a radioactive tracer called [68Ga]BED003 can improve PET/CT scans for detecting cancer in the peritoneum (the lining of the abdomen). The trial includes adults with colorectal, ovarian, gastric, pancreatic, or a type of breast cancer. Researchers …

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

Researchers are studying whether a blood test called Guardant360 can measure how well cancer treatment is working in people with advanced lung, colorectal, or breast cancer. The test looks for tumor DNA that cancer cells release into the bloodstream. Participants give blood sampl…

This study is testing a simple breath test to help detect gastrointestinal cancers—including cancers of the esophagus, stomach, pancreas, liver, and bowel—at an earlier stage. The test measures tiny molecules in exhaled breath that may be linked to these cancers. Participants pro…

Researchers are testing whether a camera pill that travels through the whole bowel can diagnose Crohn's disease without the need for colonoscopy and a separate small bowel exam. The trial enrolls people aged 18 to 40 who have symptoms and lab signs suggesting Crohn's disease. Par…

This study is testing whether a blood test can accurately identify colorectal cancer or polyps in adults referred for suspected lower GI cancer. Participants provide a blood sample during their routine diagnostic visit, and their results are compared to their final diagnosis. The…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This trial tests whether an AI system called SmartScan can match standard reading when reviewing capsule endoscopy videos for signs of Crohn's disease. Adults with suspected Crohn's but unclear colonoscopy results will swallow a camera capsule that records images of the small int…

This study asks how well different imaging tests detect and describe perianal fistulas, painful tunnels near the anus that can affect people with Crohn's disease or arise without a known cause. Researchers will compare transperineal ultrasound (TPUS) and MRI against two other met…

This study explores whether a common blood test that measures how well blood clots (called TEG) can also act as a biomarker for cancer. Researchers will compare TEG results from patients with several types of cancer (liver, pancreas, bile duct, esophagus, colorectal, and lung) ag…

This study is looking at whether the mix of bacteria in the gut can serve as a warning sign for colorectal cancer and advanced polyps. Researchers will collect stool samples from people aged 50-74 who are part of a national screening program and have had a positive fecal immunoch…

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This study is testing whether artificial intelligence can analyze photos of stool to help assess colorectal cancer risk. Adults referred for a colonoscopy will take pictures of their stool using a mobile app, and the AI's analysis will be compared with standard fecal immunochemic…

This study is testing whether two simple stool tests—fecal calprotectin and a fecal immunochemical test (FIT)—can predict early on if biologic therapy will help people with moderate-to-severe ulcerative colitis. Researchers will measure these markers at weeks 2 and 4 after starti…

This trial compares two bowel-cleansing solutions used before screening colonoscopy for colorectal cancer. One contains simethicone, an anti-gas agent, while the other does not. The study aims to see if the simethicone-containing solution helps doctors detect more adenomas (preca…

This study explores whether measuring heart rate variability—the natural ups and downs in heartbeat timing—can help detect complications like leaks or abscesses after planned colorectal surgery. Researchers will monitor patients for a week after surgery and compare heart rate pat…

This study is testing whether eating a high-fiber, low-fat diet for three weeks before colorectal cancer surgery can change gut bacteria to help prevent the cancer from returning or spreading. About 80 adults with colorectal cancer will follow this diet and provide blood, stool, …

This study tests whether the drug etrasimod can prevent pouchitis, a common inflammation of the internal pouch created after colon removal surgery. Researchers will give either etrasimod or a placebo to 40 high-risk patients for 48 weeks and track how many develop pouchitis. The …

This study tests whether giving people a personalized report about their cancer risk and screening options helps them complete recommended cancer tests. Adults aged 45 to 74 who are at high risk for lung, breast, colorectal, upper gastrointestinal, or liver cancer are invited to …

Large colorectal polyps can turn into cancer, so doctors remove them during a colonoscopy. Even after removal, polyps often grow back. This trial compares two methods for sealing the area where the polyp was removed: one uses a water jet to lift tissue and then burns it with argo…

This trial tests whether two natural supplements—quercetin (from foods like apples and onions) and coenzyme Q10 (a substance your body makes)—can reduce inflammation and improve metabolic health in older adults. Over 12 weeks, participants aged 50 to 75 who are sedentary will tak…

This phase II trial tests whether a special form of nicotinic acid (a B vitamin) can reverse prediabetes and prevent type 2 diabetes. About 390 adults with prediabetes will take either a low or high dose of the drug or a placebo daily for 26 weeks, along with lifestyle advice. Th…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This early-phase study tests the safety of a drug called ONC201 (dordaviprone) in 36 adults at high risk for colorectal cancer due to familial adenomatous polyposis (FAP) or a history of many polyps. The drug aims to kill precancerous cells without harming normal ones. Researcher…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

Researchers are testing whether tributyrin, a dietary supplement, can prevent radiation-induced rectal injury in people receiving chemoradiotherapy for locally advanced rectal cancer. About 23 participants will take tributyrin three times daily alongside standard treatment. The s…

This study looks at whether people who have had 1 or 2 small, non-cancerous polyps removed can safely wait 10 years for their next colonoscopy instead of the usual 5 years. About 9,500 adults aged 45-69 will be randomly assigned to one of two schedules: a colonoscopy at 5 and 10 …

This study looks at whether antibiotics are truly needed for mild diverticulitis. About 100 adults with left-sided diverticulitis will take either two antibiotics or a placebo daily for 10 days, along with standard pain relief and diet changes. The main goal is to see if a larger…

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This Phase 2 study tests whether brenipatide, given as an injection under the skin, can safely reduce abdominal pain and improve stool consistency in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). About 531 participants will receive either the drug or a placeb…

This study compares two treatments for abdominal pain in people with irritable bowel syndrome with constipation (IBS-C): a home-use device that delivers mild electrical stimulation (TEA) and the drug escitalopram (Lexapro). About 160 participants will be randomly assigned to one …

This study tests an injected drug called brenipatide in 342 adults with irritable bowel syndrome with constipation (IBS-C). Participants will receive either the drug or a placebo for about 35 weeks. The goal is to see if brenipatide safely reduces abdominal pain and improves bowe…

Researchers test whether the location used to pull out the appendix (near the belly button versus the lower left abdomen) and numbing medicine injected into the small incisions change pain after laparoscopic appendectomy. Adults with acute appendicitis having emergency surgery jo…

This study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…

This Phase 3 trial tests whether the experimental drug paltusotine can reduce flushing and diarrhea in adults with carcinoid syndrome caused by neuroendocrine tumors. About 141 participants will receive either paltusotine or a placebo daily for 12 weeks. The study measures how mu…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

Researchers are testing whether giving nimodipine through an IV before, during, and after open colectomy can reduce the amount of anesthetic and opioid painkillers patients need. The trial enrolls 40 adults with bowel cancer scheduled for open surgery. Participants receive either…

Cancer treatment often leaves patients with a deep, lasting tiredness that few treatments can fix. Researchers are testing whether guarana, a caffeine-rich Amazonian plant, can reduce that fatigue and improve daily life. The study gives 60 people with breast, lung, colorectal, ce…

This phase II trial tests whether a standardized acupuncture protocol can reduce peripheral neuropathy, a common and often lasting side effect of oxaliplatin chemotherapy. Participants are adults with gastrointestinal solid tumors who stopped oxaliplatin-based treatment and still…

Researchers are testing whether a compression belt worn around the lower abdomen, combined with water exchange colonoscopy, can lower how often endoscopy staff must press on a patient's belly during the procedure. The trial enrolls 400 adults aged 45 to 80 at average risk for col…

This study tests whether a prehabilitation (prehab) exercise program can reduce memory loss, forgetfulness, and brain fog caused by chemotherapy in older adults with colorectal cancer. Researchers will enroll 86 physically inactive people aged 60-85 who are about to start chemoth…

Adults with inflammatory bowel disease often face psychological distress, especially during transitions like a new diagnosis, a flare, or surgery. Researchers are testing IBD Strong Peer, a program where trained peer mentors provide emotional support through up to 10 virtual call…

This study tests a 'fast-track' recovery plan for children aged 2 to 17 who had surgery for a burst appendix. The goal is to see if they can go home sooner without raising the risk of problems like infection or needing another surgery. About 772 children will take part, and their…

This pilot study tests whether a community health worker (promotora) can help Latinx patients recently diagnosed with colorectal cancer. Sixty participants will either get a navigator for up to 6 months or just a list of social services. The goal is to see if this support improve…

This study tests whether personalized self-management training helps people with gastrointestinal cancer adopt healthier habits like better diet and more exercise. 120 participants will be randomly assigned to either personalized or standard training for 6 weeks. The goal is to s…

This trial tests whether remimazolam, an anesthetic drug, can improve sleep quality in older adults after laparoscopic colorectal cancer surgery, compared with the standard anesthetic propofol. Participants aged 65-80 will be randomly assigned to receive one of the two anesthetic…

This study tests whether a special algorithm called PAGODA can reduce unplanned delays during FOLFOX chemotherapy for gastrointestinal cancers like colon, stomach, and esophageal cancer. About 420 participants will be randomly assigned to either standard care or the algorithm-gui…

This trial tests a program that screens cancer survivors for fear of recurrence and refers those who need help to psychological services. The program is being rolled out in cancer clinics in Hong Kong, with nurses trained to identify at-risk patients. Researchers will measure how…

This study tests whether regularly checking imatinib levels in the blood can reduce side effects and improve quality of life for people with gastrointestinal stromal tumors (GIST). About 28 adults starting or recently starting imatinib will participate. The goal is to see if this…

This trial tests a stepped-care program to help cancer survivors manage fear of their cancer returning. The program starts with an online intervention called eConquerFear, which teaches strategies to control worry and accept uncertainty. If needed, participants receive additional…

This pilot trial tests a new approach to support cancer patients and their caregivers. The intervention combines social prescriptions—connecting people to community resources—with short online learning modules and regular symptom check-ins. The goal is to see if this package can …

This trial tests whether a supervised moderate-intensity exercise program, done at least 30 minutes three times a week, can improve quality of life in adults with inflammatory bowel disease (IBD) that is currently in remission. Over six months, researchers will compare those who …

This phase 4 trial tests whether taking a 2 mg prolonged-release melatonin tablet before bed can improve sleep quality in adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) whose disease is in remission. Participants must have poor sleep (PSQI score >5…

This study aims to find out how often exocrine pancreatic insufficiency (EPI) occurs in people with Alagille syndrome who have had a liver transplant. About 30 participants aged 7 to 50 will eat a high-fat diet and collect stool samples for lab testing. The results will help doct…

Researchers collect small tissue samples from the inflamed and non-inflamed intestines of people with Crohn's disease or ulcerative colitis, as well as from people without inflammatory bowel disease. They grow these cells into tiny three-dimensional structures called organoids th…

This study tests a simple web-based tool that helps doctors predict whether a large colon polyp contains invasive cancer. The tool uses only standard endoscopic images and basic information like polyp size and location. Doctors of varying experience will use the tool to assess po…

This study tests a new imaging method using a special dye (FAPI) to detect bowel scarring in people with Crohn's disease. Scarring affects up to half of patients and often leads to surgery, but current tests can't spot it early. The study will involve 30 adults starting biologic …

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

This early-phase study is testing whether afimkibart, an experimental drug for ulcerative colitis, changes how the body processes common medications like caffeine, warfarin, and omeprazole. About 25 people with moderate to severe active ulcerative colitis will receive afimkibart …

Researchers are building a tool to predict which Crohn's disease patients will have their disease return after intestinal surgery. The study follows 250 people who undergo intestinal resection as part of routine care, collecting leftover surgical tissue, clinical data, and blood …

This study follows 150 adults with eosinophilic esophagitis (EoE) who are starting dupilumab as part of their normal care. Researchers will collect information on medical history, symptoms, and quality of life over two years to see how well the treatment works in real-world setti…

This trial tests whether an AI tool can help surgeons better predict risks for patients undergoing colorectal cancer surgery. About 1,200 patients across Denmark will be randomly assigned to have their risk assessed by a surgeon using standard methods or with AI assistance. The g…

Researchers are exploring whether an experimental compound called BPR001-615 can reduce the growth of colorectal cancer cells taken directly from patients during surgery. The study also measures levels of a protein called BiP in blood and tumor tissue to see whether it could serv…

This study looks at families where multiple members have had small bowel carcinoid tumors, a rare and slow-growing cancer. Researchers want to learn how the disease develops, improve early detection, and find the genes that may cause it. Participants, including those with and wit…

This study aims to understand what causes primary sclerosing cholangitis (PSC), a rare chronic liver disease. About 143 adults with PSC will provide blood, saliva, urine, stool, and tissue samples, plus undergo imaging and procedures like colonoscopy and liver biopsy. No treatmen…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This study looks at whether a simple blood test can help doctors decide if rectal cancer patients can avoid surgery and keep their rectum. Researchers will measure tiny bits of tumor DNA in the blood (ctDNA) before, during, and after standard treatment. The goal is to see if chan…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

This study is testing a new approach to personalize cancer treatment for people with colorectal or pancreatic cancer. Researchers will take a small sample of a patient's tumor, grow it in the lab, and test different drugs on it to see which one works best. The goal is to see if t…

This study looks at proteins and bacteria in the gut of people with Crohn's disease compared to healthy individuals. Researchers will analyze samples from colonoscopies to understand what goes wrong in Crohn's. The goal is to find new ways to diagnose and treat the disease. 40 ad…

This study tests whether sending text messages can encourage homeless adults aged 45-75 to complete colorectal cancer screening. About 588 participants from shelter clinics in New York City will be randomly assigned to receive SMS reminders or standard care. The goal is to see if…

This study tests whether people with prediabetes and obesity change their eating and activity habits when they can see their glucose levels in real time versus when the data is hidden. Thirty-four adults will wear a continuous glucose monitor during both an open and a blinded pha…

This study looks at whether preserving the left colic artery during colon or rectal cancer surgery helps keep the remaining colon well-supplied with blood. Surgeons will temporarily clamp the main artery and use a green dye to measure blood flow. The goal is to see if this techni…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

OPERA is a large observational database that collects health records from people treated for chronic conditions such as HIV, liver disease, inflammatory bowel disease, heart disease, rheumatic disease, and neurodegenerative disease. Researchers use the records to study how these …

This trial in 8 healthy men aged 30–65 examines how the body absorbs, breaks down, and eliminates ontunisertib, an experimental oral drug for fibrostenotic Crohn's disease. Participants receive a single dose of the drug with a radioactive label, allowing researchers to track its …

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study looks at people who have a gene variant (called a secondary finding) that was found during genetic testing for another reason. Researchers want to understand how these variants affect health, how people respond to the news, and whether they follow medical advice. Up to…

This study follows 106 people who had weight-loss surgery using the MagDI system, a device that uses magnets to create a new connection between parts of the intestine. The main goal is to see how often internal hernias or bowel blockages happen within one year after surgery. Rese…

This study looks at whether a new drug called UCB8600 can stop mast cells in the gut from overreacting, which may cause pain in people with irritable bowel syndrome (IBS). Researchers will take gut tissue from 60 people (some with IBS, some healthy) and treat it with UCB8600 in t…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This study aims to learn more about Hermansky-Pudlak Syndrome (HPS), a rare inherited disease that causes light skin/eye color, bleeding problems, and often deadly lung scarring. Researchers will follow 600 people with HPS and their family members to track how the disease progres…

This study compares using one doctor versus two doctors to perform a procedure called single-balloon enteroscopy, which looks deep into the small intestine. About 228 adults with suspected small bowel disease will be randomly assigned to either technique. The goal is to see if on…

This observational study will compare teens with celiac disease who follow a gluten-free diet strictly versus those who don't, along with healthy peers. Researchers will test walking while doing mental tasks, memory, attention, muscle strength, quality of life, and fatigue. The g…

This study collects tissue samples from people with solid tumors who are already scheduled for surgery or biopsy at the NIH Clinical Center. Researchers will use the samples to study the biology of cancer and identify new targets for therapy. Up to 1,800 adults and children (age …

Researchers are building a large, diverse group of adults with varying body sizes, ethnicities, and diabetes risk. They will collect blood, stool, and fat tissue samples to study how obesity relates to diabetes and other health issues. The goal is to create a rich resource for fu…

This observational study in Vietnam looks at archived tumor samples from patients with several solid cancers, including liver, colorectal, gastric, breast, lung, endometrial, melanoma, and pancreatic cancer. Researchers will measure the presence of two proteins, ENPP1/cGAS and FA…

This study screens adults with certain cancers (like melanoma, lung, or colorectal cancer) to see if they qualify for experimental treatments being tested by the NCI Surgery Branch. These treatments involve taking a patient's own immune cells, growing them in a lab, and giving th…

This study will measure how much of the drug mirikizumab passes into breast milk in 14 breastfeeding women who take it for inflammatory bowel disease. Participants will provide milk samples over several weeks. The goal is to understand potential exposure to nursing infants, helpi…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This pilot study tests whether a tool called ClassIntra, used to grade unexpected events during surgery, can be applied to children having their appendix removed. Researchers will record the operations of 80 children aged 5 to 17 and have two independent surgeons review the video…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

Researchers are building an international registry to collect health information from people with congenital central hypoventilation syndrome (CCHS), a rare condition that affects breathing control. The study asks patients with a confirmed PHOX2B gene mutation to fill out surveys…

This study explores whether people with Lynch syndrome can use a self-collected vaginal swab at home to detect early signs of uterine cancer. Researchers will enroll 30 participants who will collect samples and answer surveys. The main goal is to see if this approach is practical…

This study collects follow-up data from 125 people with peritoneal surface cancers, including colorectal-origin carcinomatosis, pseudomyxoma peritonei, and peritoneal mesothelioma, who are scheduled for cytoreductive surgery combined with HIPEC. The goal is to track their outcome…

This study tests a clinic-wide program called Primary Care-GI Connect to improve follow-up colonoscopy rates in people who had an abnormal stool-based colorectal cancer screening test (FIT). The program helps coordinate care, standardize referrals, and educate patients. Researche…

This study follows about 1,400 people with coronary heart disease who undergo a stent procedure, called PCI, to open blocked arteries. Even with standard treatment, these patients still face a risk of major heart events. Researchers will measure levels of a protein called hsCRP, …

This study follows children aged 0 to 14 with suspected non-IgE food allergies, which cause digestive symptoms like reflux, colic, or constipation rather than immediate allergic reactions. Researchers will track symptoms, triggers, and growth over time, and analyze blood samples …

This study follows 392 people with stage I-III colon cancer who have had surgery to remove their tumor. Researchers will take blood samples at regular intervals over three years to look for tiny pieces of tumor DNA, called molecular residual disease (MRD). The goal is to see if a…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study will follow 150 people with radiation rectal injury to see if different subtypes of the condition lead to different outcomes. Researchers will collect medical records, endoscopy images, and test results but will not change any treatments. The goal is to fill gaps in kn…

This study looks at whether having a healthcare provider directly contact close relatives of people with newly diagnosed colorectal cancer leads to more genetic testing than having the patient share the information themselves. About 4,186 patients and their relatives will take pa…

This study tests whether a digital chatbot can help more adolescents and young adults (AYA) with cancer get genetic counseling and testing compared to standard remote services. About 535 participants aged 18-39 will use either a chatbot or standard telehealth. The goal is to see …

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study looks at the care paths of 300 people with anal cancer to find out what causes delays in diagnosis. Researchers will track the time from first symptoms to diagnosis and check how screening and access to care affect outcomes. The goal is to improve awareness and help ca…

This study looks at whether patient navigation services, an interactive website, or both can help people who had stage I-III colorectal cancer get the recommended follow-up tests after surgery. About 75 survivors will be assigned to one of three groups to see which approach works…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study looks at children with functional gut disorders, like stomach pain or irritable bowel syndrome, to see how many are also allergic to nickel or certain plant proteins called LTPs. Researchers will test for these allergies and also check in the lab whether a supplement c…

This study asks whether compounds in ultra-processed foods, like advanced glycation end-products, might play a role in eosinophilic esophagitis, a chronic inflammatory condition of the esophagus. Researchers will compare the diets of 100 people with and without the disease, using…

This study collects blood and other biospecimens from adults with cancer to analyze immune-suppressing cells and genetic changes. Up to 1,750 participants will provide samples before and after chemotherapy. The goal is to better understand how cancer affects the immune system, bu…

This study follows 430 people with stage I-IV rectal cancer to measure their quality of life after surgery. Participants fill out questionnaires about their well-being and daily function. The goal is to learn how surgery impacts patients over time, not to test a new treatment.

This pilot study compares two ways of collecting blood to detect circulating tumor DNA (ctDNA) in people with liver or pancreatic cancers. Researchers will take blood from a standard arm vein and also from the vein that drains directly from the tumor during a biopsy. The goal is …

This study follows 7,000 healthy relatives of people with inflammatory bowel disease, including siblings and children, to find early clues that might predict who will later develop Crohn's disease or ulcerative colitis. Researchers collect blood, urine, stool, saliva, and tissue …

This study tests whether tumor organoids grown from biopsies can predict how well patients with gastric or colon cancer and peritoneal carcinomatosis respond to hyperthermic intraperitoneal chemotherapy (HIPEC). Researchers collect tumor samples during standard surgery, grow them…

This study explores whether methane gas produced by gut microbes is linked to the progression of Parkinson's disease and related conditions like dementia. Researchers will measure breath methane levels in 200 adults—including those with Parkinson's, those at high risk (REM sleep …

This study looks back at 1,000 patients who had endoscopic resection—a minimally invasive procedure to remove abnormal growths—in the duodenum or ampulla over a 15-year period. The goal is to see how often the lesions come back, how often cancer develops, and what complications o…

This study aims to create a collection of tissue and blood samples from people with digestive cancers or inflammatory bowel disease (IBD). Researchers will use these samples to build lab models that mimic how tumors grow and respond to treatments. The goal is to better understand…

This study looks at whether medical imaging can predict the growth patterns of liver metastases from colorectal and breast cancer. Researchers will take removed liver tumors and map them in 3D, comparing the tissue details with CT and MRI scans taken before surgery. The goal is t…

This study asks whether modern fermented vegan products—like plant-based yogurt and meat substitutes—are healthier for the gut than the dairy and meat they replace. Researchers will compare these diets in healthy volunteers and in people with inflammatory bowel disease (IBD), loo…

This study is looking at why some people with advanced cancer lose weight and muscle, a condition called cachexia. Researchers will follow 800 patients with advanced lung, pancreatic, or colorectal cancer to see if there are distinct subtypes of cachexia based on symptoms, biomar…

This study is building a large national registry to track the safety and effectiveness of fecal microbiota transplantation (FMT) in patients with Clostridium difficile infections. It will follow adult patients receiving FMT as part of their routine care, as well as stool donors, …

This study tests whether a laser-based device called AccuMeasure can measure the size of polyps and ulcers during gastrointestinal endoscopy more accurately than traditional methods like visual estimation or using tools as references. Researchers will compare AccuMeasure's readin…

This trial compares two methods of examining colon cancer tissue after surgery: the European method, which relies solely on pathologists, and the Japanese method, which involves surgeons in finding lymph nodes. The goal is to see if the Japanese method is as accurate as the Europ…

This study looks at how chemotherapy for colon or rectal cancer affects thinking and memory. Researchers will track changes in brain function and blood proteins in 60 patients during and after treatment. The goal is to find tests that could identify who is at risk for 'chemo brai…

This study is building a registry of adults undergoing advanced therapeutic endoscopy—minimally invasive procedures like EMR, ESD, and polypectomy—to treat conditions such as Zenker diverticulum, colon polyps, and colorectal cancer. The goal is to measure complication rates, comp…

This study aims to create a large library of recorded endoscopy procedures from adults undergoing upper or lower gastrointestinal exams. The goal is to use these videos to develop and validate artificial intelligence tools that can automatically detect and report quality metrics,…

This study follows 1,500 children newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, to understand why some respond well to treatments while others develop complications. Researchers will collect medical data and biological sa…

This study looks at whether measuring the amount of certain targeted cancer drugs in the blood can help find the best dose for each patient. It involves adults with advanced digestive cancers like colorectal, liver, and stomach tumors who are already taking these medications. By …

This study follows 1,500 women with mullerian anomalies — differences in the shape or structure of the uterus, cervix, or vagina. Researchers aim to learn how these variations affect fertility, pregnancy, and the success of surgical treatments. The goal is to improve diagnosis an…

This trial tests whether a new type of MRI, called hyperpolarized carbon-13 MRI, can better predict how rectal cancer responds to chemoradiotherapy. By tracking how cancer cells use energy, along with blood and tissue analysis, researchers hope to identify complete tumor response…

This study is testing whether changes in two stool markers — a fecal immunochemical test (qFIT) and calprotectin (FC) — measured two weeks after starting standard therapy can predict whether people with ulcerative colitis will relapse or need stronger medication within a year. Re…

This study aims to characterize the gut microbiome and immune markers of 400 adults visiting a specialized gut microbiota clinic. By analyzing stool and saliva samples alongside blood cytokine profiles, researchers hope to build a database linking microbial patterns to intestinal…

This trial investigates healthy volunteers who donate stool for fecal microbiota transplantation (FMT), a procedure used to treat certain gut disorders. Researchers aim to identify factors that lead to valid donations, such as donor health and lifestyle, to streamline the donatio…

This study screens children and adolescents aged 5 to 18 who have chronic conditions like congenital heart disease, inflammatory bowel disease, celiac disease, or rheumatic diseases for lipid metabolism disorders. Participants provide a blood sample and complete a questionnaire a…

This study tests whether a new laboratory method—staining for a protein called claudin 2—can more accurately measure healing in the gut of people with ulcerative colitis or Crohn's disease. Researchers will compare this method with standard scoring systems and track whether it pr…

This study looks at whether monitoring bowel sounds before and after colorectal cancer surgery can help doctors assess how well the intestines are recovering. Researchers will track 172 patients and compare bowel sound patterns with outcomes like time to first gas, ability to eat…

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or …

This observational study compares inflammatory markers in the blood and tissue of people with active Crohn's disease or ulcerative colitis versus healthy volunteers. Researchers aim to identify differences in the IL-23/Th17 inflammatory pathway and other immune signals. The study…

This study aims to develop a test that uses DNA methylation patterns from tumor samples to predict whether stage II or III colorectal cancer will return after surgery and chemotherapy. Researchers will analyze tissue from 400 patients who are currently cancer-free after treatment…

This observational study is collecting blood, stool, and tissue samples from 6,000 people with inflammatory bowel disease (Crohn's disease or ulcerative colitis), along with their relatives and healthy volunteers. Researchers aim to identify biomarkers that can assess intestinal …

This study looks at the bacteria living in the mouth, stool, and tumors of Colombian adults with advanced cancers of the stomach, colon, breast, cervix, or head and neck who are starting immunotherapy as standard care. Researchers will compare these microbial profiles to those of…

This study looks at 100 people who have had a Whipple procedure (pancreaticoduodenectomy) for cancers of the pancreas or nearby areas. The goal is to find factors before, during, and after surgery that raise the risk of a pancreatic fistula—a leak of digestive fluid that can caus…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study explores whether a blood test that detects circulating tumor DNA (ctDNA) can help doctors personalize treatment for people with five types of advanced cancer: non-small cell lung cancer, gastrointestinal stromal tumors, colorectal cancer, biliary tract cancer, and ovar…

This study looks at how children with Crohn's disease or ulcerative colitis burn energy at rest. Researchers will measure resting energy expenditure using a special breathing test and compare it to standard formulas. The goal is to see if energy use is linked to disease activity …

This study uses a homemade device with electrodes placed on the belly to record electrical signals from the stomach and intestines. Researchers will compare these signals in healthy volunteers, people with Crohn's disease (with or without fibrosis), and people with functional gas…