New pill targets Hard-to-Treat KRAS cancers in first human trial
NCT ID NCT07458347
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This early-phase trial is testing an experimental oral drug called KST-6051 in adults with advanced or metastatic solid tumors that have a KRAS mutation, including certain lung, pancreatic, and colorectal cancers. The main goal is to check the drug's safety and how the body processes it. About 145 participants will take the pill by mouth, and researchers will also look for any signs that the drug is shrinking tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- KST-6051 (an oral tablet)
- What this could lead to
- If this drug is safe and shows signs of shrinking tumors, it could point toward a new treatment option for people with KRAS-mutant cancers like lung, pancreatic, or colorectal cancer.
- What could go wrong
- This is a very early (Phase 1) trial focused on safety, not effectiveness. The drug may not work or could cause serious side effects. Only a small number of people will receive it at first.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Florida Cancer Specialists
RECRUITINGSarasota, Florida, 34232, United States
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Huntsman Cancer Institute, University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Mass General Brigham Cancer Institute at Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229, United States
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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Sidney Kimmel Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States