New hope for advanced bowel cancer: experimental drug combo enters major trial

NCT ID NCT07221357

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether a new drug called pumitamig, combined with chemotherapy, works better than the current standard treatment (bevacizumab plus chemo) for people with advanced colorectal cancer that cannot be removed by surgery. About 990 adults who have not yet been treated for their metastatic disease will take part. The goal is to see if the new combination shrinks tumors, delays cancer growth, and helps people live longer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UNTREATED, UNRESECTABLE, OR METASTATIC COLORECTAL CANCER

Contacts and locations

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ASST Grande Ospedale Metropolitano Niguarda
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Milan, Milano, 20162, Italy

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AZ Delta vzw
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Roeselare, West-Vlaanderen, 8800, Belgium

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Antwerp University Hospital
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Edegem, Antwerpen, 2650, Belgium

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Asan Medical Center
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Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea

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Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
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Azienda Ospedaliera Garibaldi
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Catania, 95124, Italy

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Azienda Ospedaliero Universitaria Pisana
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Pisa, Tuscany, 56126, Italy

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Baylor College of Medicine Medical Center
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Houston, Texas, 77030, United States

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CHU Bordeaux Haut-Leveque
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Pessac, Aquitaine, 33600, France

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CHU Charles Nicolle
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Rouen, Haute-Normandie, 76031, France

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CHU Rangueil
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Toulouse, Haute-Garonne, 31059, France

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Cabrini Hospital - Malvern
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Malvern, Victoria, 3144, Australia

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Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
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Centre Hospitalier de l'Université de Montréal
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Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUS
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Sherbrooke, Quebec, J1H 5N4, Canada

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Centro Médico Fleischer
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1414, Argentina

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Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
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Buenos Aires, C1431FWO, Argentina

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Centrul de Oncologie "Sfântul Nectarie"
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Craiova, Dolj, 200542, Romania

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Chang Gung Medical Foundation-Linkou Branch
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Taoyuan, 333, Taiwan

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Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin
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Berlin, 10117, Germany

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Chiba cancer center
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Chiba, Chiba, 260-8717, Japan

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Cliniques universitaires Saint-Luc
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Brussels, Bruxelles-Capitale, Région de, 1200, Belgium

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Complejo Hospitalario de Navarra
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Pamplona, Navarre, 31009, Spain

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Curie Oncology - Farrer
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Singapore, Central Singapore, 217562, Singapore

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Facharztzentrum Eppendorf
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Hamburg, 20249, Germany

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Fakultni nemocnice Hradec Kralove
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Hradec Králové, 500 05, Czechia

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Fakultni nemocnice Motol a Homolka
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Prague, Praha 5, 150 06, Czechia

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Flinders Medical Centre
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Adelaide, South Australia, 5042, Australia

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Florida Cancer Specialists - East
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Cape Coral, Florida, 33990, United States

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Florida Cancer Specialists - North
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St. Petersburg, Florida, 33705, United States

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Fundeni Clinical Institute
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Bucharest, Bucharest, 022328, Romania

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Gallipoli Medical Research Ltd
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Brisbane, Queensland, 4120, Australia

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GenesisCare St Leonards
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St Leonards, New South Wales, 2065, Australia

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Goulburn Valley Health
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Shepparton, Victoria, 3630, Australia

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Grampians Health
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Ballarat Central, Victoria, 3350, Australia

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H.R.U Málaga - Hospital General
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Málaga, 29011, Spain

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Highlands Oncology Group
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Springdale, Arkansas, 72762, United States

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Hokkaido University Hospital
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Sapporo, Hokkaido, 0608648, Japan

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Hospital Británico de Buenos Aires
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CABA, Buenos Aires, CP1280AEB, Argentina

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Hospital General Universitario Gregorio Marañon
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Madrid, 28007, Spain

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Hospital Italiano de Buenos Aires
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ABB, Buenos Aires F.D., C1199ABB, Argentina

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Hospital Universitari Vall d'Hebron
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Barcelona, Barcelona [Barcelona], 08035, Spain

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Hospital Universitario Virgen Del Rocio
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Seville, 41013, Spain

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Hôpital Saint Antoine
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Paris, 75571, France

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IRCCS Casa Sollievo della Sofferenza
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San Giovanni Rotondo, Foggia, 71013, Italy

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Institut Català d'Oncologia (ICO) - Badalona
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Badalona, 08916, Spain

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Instituto Alexander Fleming
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

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Institutul Oncologic Cluj
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Cluj-Napoca, 400015, Romania

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Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
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Cluj-Napoca, Cluj, 400162, Romania

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Institutul Regional de Oncologie
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Iași, 700483, Romania

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Istituto Nazionale Tumori IRCCS Fondazione Pascale
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Naples, 80131, Italy

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Istituto Oncologico Veneto IRCCS
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Padova, Veneto, 35128, Italy

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Jewish General Hospital
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Montreal, Quebec, H3T 1E2, Canada

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Kaohsiung Medical University Chung-Ho Memorial Hospital
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Kaohsiung City, 807, Taiwan

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Klinikum Neuperlach
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München, 81737, Germany

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Kobe City Medical Center General Hospital
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Kobe, Hyōgo, 650-0047, Japan

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Krankenhaus Der Barmherzigen Schwestern Linz
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Linz, 4010, Austria

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Krankenhaus Nordwest GmbH
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Frankfurt, 60488, Germany

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Laura and Isaac Perlmutter Cancer Center at NYU Langone
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Mineola, New York, 11501, United States

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Lehigh Valley Health Network
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Allentown, Pennsylvania, 18103, United States

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Liverpool Hospital
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Liverpool, New South Wales, 2170, Australia

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Nashik, Dādra and Nagar Haveli and Damān and Diu, 422001, India

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Erzurum, 25070, Turkey (Türkiye)
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Adana, 1370, Turkey (Türkiye)

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Ulm, 89081, Germany

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Pune, 411001, India

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Sunto-gun, 411-8777, Japan

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Yokohama, Kanagawa, 2418515, Japan

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Mannheim, 68167, Germany

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Bochum, 44791, Germany

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Ankara, 06100, Turkey (Türkiye)

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Sendai, 980-8574, Japan

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Vienna, 1090, Austria

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Villejuif, 94805, France

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Milan, 20133, Italy

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Amsterdam, North Holland, 1081 HV, Netherlands
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Brussels, 1000, Belgium

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Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France
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Nantes, Pays de la Loire Region, 44093, France

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Guangzhou, Guangdong, 510555, China

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Floresti/ Cluj, 407280, Romania

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Feldkirch, 6800, Austria
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Utrecht, 3543 AZ, Netherlands
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Groningen, 9713 GZ, Netherlands
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Recoleta, Santiago Metropolitan, 8420391, Chile

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Eindhoven, North Brabant, 5623 EJ, Netherlands
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Santiago, Santiago Metropolitan, 7620002, Chile

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Sankt Pölten, 3100, Austria

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Saint-Herblain, Loire-Atlantique, 44805, France

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Veszprém, 8200, Hungary

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Tilburg, 5022 GC, Netherlands
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Madrid, Madrid, Comunidad de, 28041, Spain

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Reggio Emilia, 42123, Italy

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Seattle, Washington, 98109, United States

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Grand Rapids, Michigan, 49546, United States

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Ottawa, Ontario, K1H 8L6, Canada

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Baltimore, Maryland, 21287, United States

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São José do Rio Preto, 15090-000, Brazil

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Barretos, São Paulo, 14784400, Brazil

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Curitiba, Paraná, 81480-580, Brazil

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São Paulo, 01246-000, Brazil

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Fairfax, Virginia, 22031, United States

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Singapore, 308442, Singapore

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Charlotte, North Carolina, 28207, United States

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Kadiköy/Istanbul, 41380, Turkey (Türkiye)
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Istanbul, 34214, Turkey (Türkiye)

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Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan

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Glasgow, G12 0YN, United Kingdom

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Newcastle upon Tyne, NE7 7DN, United Kingdom

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San Francisco, California, 94115, United States

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Kansas City, Missouri, 64111, United States

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Atlanta, Georgia, 30318, United States

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Santa Monica, California, 90404, United States

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Natal/RN, Rio Grande do Norte, 59062-000, Brazil

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Nashville, Tennessee, 37203, United States

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Iowa City, Iowa, 52242, United States

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São Paulo, 01308-060, Brazil

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Porto Alegre, Rio Grande do Sul, 90610000, Brazil

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Shenyang, Liaoning, 110001, China
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Harbin, Heilongjiang, 150081, China

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Fuzhou, Fujian, 350014, China

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Shenyang, Liaoning, 110042, China

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Shanghai, 200032, China

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Hangzhou, Zhejiang, 310003, China

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Koszalin, West Pomeranian Voivodeship, 75-581, Poland

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Brzozów, Podkarpackie Voivodeship, 36-200, Poland

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Santa Cruz do Sul, Rio Grande do Sul, 96810-110, Brazil

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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

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Changsha, Hunan, 410013, China

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Shanghai, Shanghai Municipality, 200120, China

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Nanchang, Jiangxi, 330006, China

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Jinan, Shandong, 250117, China

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Hangzhou, Zhejiang, 310022, China
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Nanyang, Henan, 473009, China

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Fuzhou Fujian, Fujian, 350001, China

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Tianjin, Hebei, 300060, China

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Wuhan, Hubei, 430079, China

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Yangzhou, Jiangsu, 225001, China

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Beijing, 100034, China

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Changsha, Hunan, 410031, China

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Wuhan, Hubei, 430022, China

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Guangzhou, Guangdong, 510000, China

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Nanjing, Jiangsu, 210009, China

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Toronto, Ontario, M5G 2M9, Canada

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Toronto, Ontario, M4N 3M5, Canada

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Salt Lake City, Utah, 84102, United States

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Tucson, Arizona, 85724, United States

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Ann Arbor, Michigan, 48109, United States

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Chicago, Illinois, 60637, United States

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Chapecó, Santa Catarina, 89812-211, Brazil

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Gliwice, Silesian Voivodeship, 44-101, Poland
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Hangzhou, 310009, China

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Santiago, Santiago Metropolitan, 7500921, Chile

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Olomouc, 77520, Czechia

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Boston, Massachusetts, 02114, United States
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Elche (alicante), 03203, Spain

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Chikusa-ku, 464-8681, Japan

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Kurashiki, Okayama-ken, 710-8602, Japan

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Prague, Praha 10, 10034, Czechia
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Edmonds, Washington, 98026-8032, United States

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Chengdu, Sichuan, 610041, China

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Chongqing, Chongqing Municipality, 400030, China

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Birmingham, West Midlands, B15 2TT, United Kingdom

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Calgary, Alberta, T2N 5G2, Canada

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Mumbai, Maharashtra, 400036, India
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Delhi, 110029, India

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Puducherry, 605006, India
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Tlalpan, 14080, Mexico

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Chemnitz, 09113, Germany

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Besançon, Doubs, 25000, France

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Erlangen, Bavaria, 91054, Germany

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Santiago de Compostela, A Coruña [La Coruña], 15706, Spain
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Hamburg, 22763, Germany

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Hefei, Anhui, 230601, China

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Metropolitan Borough of Wirral, Merseyside, L63 4JY, United Kingdom

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Enfield, London, EN28JL, United Kingdom

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Cardiff, CF14 2TL, United Kingdom

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Dorchester, DT1 2JY, United Kingdom

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Pittsburgh, Pennsylvania, 15232, United States

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Hanover, Lower Saxony, 30161, Germany

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Avellino, 83100, Italy

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Bari, 70124, Italy

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Ravenna, 48121, Italy

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Lille, Nord, 59020, France

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Aviano, Pordenone, 33081, Italy

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La Spezia, 19124, Italy

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Limoges, 87042, France

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Castellana Grotte, Bari, 70013, Italy

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Lorient, Morbihan, 56100, France

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Tricase, Lecce, 73039, Italy

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Charleroi, Hainaut, 6060, Belgium
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Bonheiden, Antwerpen, 2820, Belgium

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Madrid, Madrid, Comunidad de, 28034, Spain

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Salamanca, 37007, Spain

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Gdansk, Pomeranian Voivodeship, 80-219, Poland

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Spokane, Washington, 99218, United States

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Córdoba, X5000JHQ, Argentina

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San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina

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Suresnes, 92151, France

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Goyang-si, Kyǒnggi-do, 10408, South Korea

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Deagu, Taegu-Kwangyǒkshi, 41404, South Korea

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Seoul, Seoul-teukbyeolsi [Seoul], 02841, South Korea

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Fort Wayne, Indiana, 46805, United States

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Local Institution - 0639
NOT_YET_RECRUITING

London, SW170QT, United Kingdom

Contact
Local Institution - 0640
NOT_YET_RECRUITING

Norwich, East, NR47UY, United Kingdom

Contact
Local Institution - 0641
NOT_YET_RECRUITING

Toyoake, Aichi-ken, 470-1192, Japan

Contact
Local Institution - 0642
NOT_YET_RECRUITING

Yamagata, Yamagata, 990-9585, Japan

Contact
Local Institution - 0643
NOT_YET_RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact
Local Institution - 0644
NOT_YET_RECRUITING

Guildford, South East, GU27XX, United Kingdom

Contact
Local Institution - 0653
NOT_YET_RECRUITING

Chihuahua City, 31207, Mexico

Contact
Luxmed Onkologia sp. z o. o.
RECRUITING

Warsaw, Masovian Voivodeship, 01-748, Poland

Contact Phone: •••-•••-••••
Lyell McEwin Hospital
RECRUITING

Elizabeth Vale, South Australia, 5112, Australia

Contact Phone: •••-•••-••••
Maidstone and Tunbridge Wells NHS Trust
RECRUITING

Maidstone, ME16 9QQ, United Kingdom

Contact Phone: •••-•••-••••
Marien Hospital Düsseldorf
RECRUITING

Düsseldorf, 40479, Germany

Contact Phone: •••-•••-••••
Maryland Oncology Hematology - Silver Spring
RECRUITING

Silver Spring, Maryland, 20904, United States

Contact
Masarykuv onkologicky ustav
RECRUITING

Brno, Brno-město, 656 53, Czechia

Contact Phone: •••-•••-••••
Mazowiecki Szpital Onkologiczny
RECRUITING

Wieliszew, Masovian Voivodeship, 05-135, Poland

Contact Phone: •••-•••-••••
Minnesota Oncology
RECRUITING

Maple Grove, Minnesota, 55369, United States

Contact
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-••••
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan

Contact Phone: •••-•••-••••
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan

Contact Phone: •••-•••-••••
National Cancer Centre Singapore
RECRUITING

Singapore, Central Singapore, 168583, Singapore

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan

Contact Phone: •••-•••-••••
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan

Contact Phone: •••-•••-••••
National Hospital Organization Shikoku Cancer Center
RECRUITING

Matsuyama, Ehime, 791-0280, Japan

Contact Phone: •••-•••-••••
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan

Contact Phone: •••-•••-••••
National University Hospital
RECRUITING

Singapore, 119074, Singapore

Contact Phone: •••-•••-••••
New York Cancer and Blood Specialists
RECRUITING

Shirley, New York, 11967, United States

Contact Phone: •••-•••-••••
Northern Hospital
RECRUITING

Epping, Victoria, 3076, Australia

Contact Phone: •••-•••-••••
Northside Hospital
RECRUITING

Atlanta, Georgia, 30342, United States

Contact
Northwell Health/ RJ Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States

Contact Phone: •••-•••-••••
Northwest Cancer Specialists, P.C.
RECRUITING

Vancouver, Washington, 98684, United States

Contact Phone: •••-•••-••••
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
RECRUITING

Marietta, Georgia, 30060, United States

Contact Phone: •••-•••-••••
Osaka International Cancer Institute
RECRUITING

Osaka, 541-8567, Japan

Contact Phone: •••-•••-••••
Osaka Medical and Pharmaceutical University Hospital
RECRUITING

Takatsuki, Osaka, 569-8686, Japan

Contact Phone: •••-•••-••••
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy

Contact Phone: •••-•••-••••
Oxford University Hospitals NHS Trust
RECRUITING

Oxford, Oxfordshire, OX3 7LJ, United Kingdom

Contact Phone: •••-•••-••••
Państwowy Instytut Medyczny MSWiA
RECRUITING

Warsaw, Masovian Voivodeship, 02-507, Poland

Contact Phone: •••-•••-••••
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, Queensland, 4029, Australia

Contact Phone: •••-•••-••••
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom

Contact Phone: •••-•••-••••
Royal Marsden Hospital Sutton
RECRUITING

London, SM2 5PT, United Kingdom

Contact Phone: •••-•••-••••
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania

Contact Phone: •••-•••-••••
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-••••
SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
RECRUITING

Opole, Opole Voivodeship, 45-061, Poland

Contact Phone: •••-•••-••••
Saitama Medical University International Medical Center
RECRUITING

Hidaka, Saitama, 350-1298, Japan

Contact Phone: •••-•••-••••
Saitama Prefectural Cancer Center
RECRUITING

Ina-machi, Saitama, 362-0806, Japan

Contact Phone: •••-•••-••••
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

Contact Phone: •••-•••-••••
Sanford Cancer Center
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Phone: •••-•••-••••
Sanford Fargo Medical Center
RECRUITING

Fargo, North Dakota, 58102, United States

Contact Phone: •••-•••-••••
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Gyeonggido, 13620, South Korea

Contact Phone: •••-•••-••••
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

Contact Phone: •••-•••-••••
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea

Contact Phone: •••-•••-••••
St. John of God Murdoch Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia

Contact Phone: •••-•••-••••
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia

Contact Phone: •••-•••-••••
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
RECRUITING

Krakow, Lesser Poland Voivodeship, 31-826, Poland

Contact Phone: •••-•••-••••
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan

Contact Phone: •••-•••-••••
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States

Contact Phone: •••-•••-••••
Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North
RECRUITING

Arlington, Texas, 76012, United States

Contact
Texas Oncology, PA
RECRUITING

Austin, Texas, 78705, United States

Contact Phone: •••-•••-••••
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan

Contact Phone: •••-•••-••••
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06591, South Korea

Contact Phone: •••-•••-••••
The Christie NHS Foundation Trust
RECRUITING

Manchester, Lancashire, M20 4BX, United Kingdom

Contact
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

Contact Phone: •••-•••-••••
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan

Contact Phone: •••-•••-••••
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Phone: •••-•••-••••
UZ Leuven
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium

Contact Phone: •••-•••-••••
Universitaetsklinik Salzburg
RECRUITING

Salzburg, 5020, Austria

Contact Phone: •••-•••-••••
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, Saxony, 01307, Germany

Contact Phone: •••-•••-••••
Universitaetsmedizin Goettingen
RECRUITING

Göttingen, 37075, Germany

Contact Phone: •••-•••-••••
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
RECRUITING

Mainz, 55131, Germany

Contact Phone: •••-•••-••••
Universitatsklinikum Leipzig
RECRUITING

Leipzig, D-04103, Germany

Contact
University Of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

Contact Phone: •••-•••-••••
University of California, Irvine (UCI) Health - UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States

Contact Phone: •••-•••-••••
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

Contact Phone: •••-•••-••••
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 128 08, Czechia

Contact Phone: •••-•••-••••
Washington University School OF Medicine-Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States

Contact Phone: •••-•••-••••
Western Health-Sunshine & Footscray Hospitals
RECRUITING

St Albans, Victoria, 3021, Australia

Contact Phone: •••-•••-••••
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

Contact Phone: •••-•••-••••
Wojewódzkie Centrum Szpitalne Kotliny Jeleniogórskiej
RECRUITING

Jelenia Góra, 58-506, Poland

Contact Phone: •••-•••-••••

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