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New injection aims to fix choline deficiency in intestinal failure patients

NCT ID NCT06910943

Recruiting now Disease control Sponsor: Protara Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests an injectable form of choline, a nutrient often missing in people with intestinal failure who rely on IV nutrition. The goal is to see if it can safely raise choline levels and reduce liver injury. About 129 adolescents and adults will receive either a low or high dose of choline or a placebo over several weeks, with long-term follow-up.

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Conditions

The condition(s) this trial relates to.

choline deficiency disease chronic intestinal failure drug-induced liver injury Hyperphagia Intestinal Failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLINE DEFICIENCY LIVER INJURY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Aalborg University Hospital, Department of Medical Gastroenterology

    RECRUITING

    Aalborg, 9100, Denmark

  • Beaujon Hospital - APHP

    RECRUITING

    Clichy, 92110, France

  • CHRU Nancy - Barbois Hospital

    NOT_YET_RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • Charite - University Hospital Berlin

    RECRUITING

    Berlin, 13353, Germany

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Columbia University Medical Center/ New York Presbyterian Hospital

    NOT_YET_RECRUITING

    New York, New York, 10032, United States

  • Czerniakowski Hospital Sp. z o.o. (LCC)

    RECRUITING

    Warsaw, 00-739, Poland

  • Duke Clinic - Abdominal Transplant Research Office

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Floridian Clinical Research

    RECRUITING

    Miami Lakes, Florida, 33016, United States

  • M. Pirogow Provincial Specialized Hospital in Lodz, Nutritional Treatment Center

    RECRUITING

    Lodz, 90-532, Poland

  • Nebraska Medicine

    NOT_YET_RECRUITING

    Omaha, Nebraska, 68105, United States

  • Pinnacle Clinical Research- San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Rennes University Hospital Center - Pontchaillou Site

    NOT_YET_RECRUITING

    Rennes, 35000, France

  • Rigshospitalet - University Hospital Copenhagen

    RECRUITING

    Copenhagen, 2100, Denmark

  • University Duisburg-Essen, University Hospital Essen

    NOT_YET_RECRUITING

    Essen, 45147, Germany

  • University Hospitals Leuven, Campus Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

  • University of Colorado School of Medicine

    RECRUITING

    Aurora, Colorado, 80045, United States

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