New injection aims to fix choline deficiency in intestinal failure patients

NCT ID NCT06910943

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests an injectable form of choline, a nutrient often missing in people with intestinal failure who rely on IV nutrition. The goal is to see if it can safely raise choline levels and reduce liver injury. About 129 adolescents and adults will receive either a low or high dose of choline or a placebo over several weeks, with long-term follow-up.

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Conditions

The condition(s) this trial relates to.

choline deficiency disease chronic intestinal failure drug-induced liver injury Hyperphagia Intestinal Failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Aalborg University Hospital, Department of Medical Gastroenterology

    RECRUITING

    Aalborg, 9100, Denmark

    Contact

  • Beaujon Hospital - APHP

    RECRUITING

    Clichy, 92110, France

    Contact

  • CHRU Nancy - Barbois Hospital

    NOT_YET_RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

    Contact

  • Charite - University Hospital Berlin

    RECRUITING

    Berlin, 13353, Germany

    Contact

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact

  • Columbia University Medical Center/ New York Presbyterian Hospital

    NOT_YET_RECRUITING

    New York, New York, 10032, United States

    Contact

  • Czerniakowski Hospital Sp. z o.o. (LCC)

    RECRUITING

    Warsaw, 00-739, Poland

    Contact

  • Duke Clinic - Abdominal Transplant Research Office

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact

  • Floridian Clinical Research

    RECRUITING

    Miami Lakes, Florida, 33016, United States

    Contact

  • M. Pirogow Provincial Specialized Hospital in Lodz, Nutritional Treatment Center

    RECRUITING

    Lodz, 90-532, Poland

    Contact

  • Nebraska Medicine

    NOT_YET_RECRUITING

    Omaha, Nebraska, 68105, United States

    Contact

  • Pinnacle Clinical Research- San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact

  • Rennes University Hospital Center - Pontchaillou Site

    NOT_YET_RECRUITING

    Rennes, 35000, France

    Contact

  • Rigshospitalet - University Hospital Copenhagen

    RECRUITING

    Copenhagen, 2100, Denmark

    Contact

  • University Duisburg-Essen, University Hospital Essen

    NOT_YET_RECRUITING

    Essen, 45147, Germany

    Contact

  • University Hospitals Leuven, Campus Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

    Contact

  • University of Colorado School of Medicine

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact