Drug-induced liver injury

This study tests an injectable form of choline, a nutrient often missing in people with intestinal failure who rely on IV nutrition. The goal is to see if it can safely raise choline levels and reduce liver injury. About 129 adolescents and adults will receive either a low or hig…

This study tests whether a steroid drug (methylprednisolone) can help people with severe liver injury caused by medications. The trial includes 232 adults with high bilirubin levels. Participants receive either steroids plus standard care or standard care alone, and doctors track…

This Phase 2 trial is testing an experimental drug called F573 in 97 people with acute liver failure or acute-on-chronic liver failure. Participants receive daily injections of F573 or a placebo for 7 days. The main goal is to check safety and side effects, while also looking at …

This study observes 50 adults with drug-induced liver injury to track how common and how long itching lasts. Researchers will compare them to patients with other liver conditions. The goal is to gather data needed for a future clinical trial to treat this distressing symptom.

This study looks at liver inflammation (hepatitis) that can occur in cancer patients treated with immune checkpoint inhibitors, a type of immunotherapy. Researchers aim to describe the different patterns of liver injury and how they respond to treatment. By collecting real-world …

This study aims to create a nationwide registry of 400 people who have experienced drug-induced liver injury (DILI). Researchers will collect medical information and biological samples like blood and DNA to build a resource for future studies. The goal is to better understand why…

This study aims to collect detailed information from 4,000 people who have experienced liver injury possibly caused by prescription drugs or complementary and alternative medicines. Researchers will track participants over time, using blood tests and liver scans to better underst…

This study observes 160 cancer patients to understand why some develop liver injury from checkpoint inhibitor drugs. Researchers will track blood markers and genetic factors to identify who is at risk. No new treatment is tested; the goal is to improve diagnosis and monitoring.

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study follows up to 30 adults with tenosynovial giant cell tumor (TGCT) who had liver test abnormalities while taking TURALIO. The goal is to track long-term liver failure risk and understand how the drug may cause liver injury. Participants will be monitored after stopping …

This study will follow 3000 people in China who have drug-induced liver injury (DILI) to understand what factors affect their recovery. Researchers will collect blood samples and health data to create a model that predicts serious outcomes like liver failure or death. The goal is…