Drug-induced liver injury
MONDO:0005359A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to acute liver failure, caused by drugs, drug metabolites, and chemicals from the environment.
Also known as: drug induced hepatotoxicity, drug-induced disorder of liver
23 clinical trials for this condition and its sub-types.
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Broader categories
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Artificial liver device tested in humans for first time
Disease control CompletedThis early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recove…
Phase: PHASE1 • Sponsor: Miromatrix Medical Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Milk thistle extract may help repair Medication-Damaged livers
Disease control CompletedThis study tested whether different doses of silymarin, a natural extract from milk thistle, can lower elevated liver enzymes caused by medications. Nineteen adults with drug-induced liver injury took either a placebo or one of three silymarin doses for 35 days. Researchers measu…
Phase: PHASE2, PHASE3 • Sponsor: Prof. Dr. Frank Behrens • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Liver cancer showdown: which combo causes less harm?
Disease control CompletedThis study looked at 562 people with advanced liver cancer to compare two treatment combinations: one using HAIC (chemotherapy directly into the liver) plus immunotherapy and targeted drugs, and the other using TACE (a procedure that blocks blood flow to the tumor) plus the same …
Sponsor: Nanfang Hospital, Southern Medical University • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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AI may solve tricky liver diagnosis puzzle
Knowledge-focused CompletedThis study tests whether artificial intelligence can help doctors tell the difference between drug-induced liver injury and autoimmune hepatitis, two conditions that look very similar. Researchers are building a machine learning model using data from over 2,500 patients. If it wo…
Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated Jul 08, 2026 00:00 UTC
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New Free-Breathing MRI could make liver scans easier for kids
Knowledge-focused CompletedThis study tested new MRI and MRE techniques that let children breathe normally during scans, instead of holding their breath. The goal was to measure liver fat and stiffness more comfortably and accurately in kids with fatty liver disease. 135 children aged 6-17 took part, and t…
Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC