Artificial liver device tested in humans for first time

NCT ID NCT06285253

Completed Disease control Sponsor: Miromatrix Medical Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recovery or a transplant. Results are not yet available, but the study is complete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bioengineered liver graft (miroliverELAP)
What this could lead to: If successful, this device could provide temporary liver support for patients with acute liver failure, giving the liver time to heal or bridging to a transplant.
What could go wrong: This is a very early phase 1 trial with only 10 participants, focused on safety. The device may not work as hoped, and there are risks of serious side effects from the blood-circulation procedure.

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Conditions

The condition(s) this trial relates to.

acute liver failure Acute-On-Chronic Liver Failure alcoholic hepatitis drug-induced liver injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ALCOHOLIC HEPATITIS ACUTE LIVER FAILURE ACUTE LIVER INJURY, DRUG INDUCED ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)

Contacts and locations

Locations

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Intermountain Healthcare

Salt Lake City, Utah, 84103, United States
Mayo Clinic

Rochester, Minnesota, 55902, United States
Mount Sinai Recanati/Miller Transplantation Institute

New York, New York, 10029, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
University of Michigan Medical School

Ann Arbor, Michigan, 48109, United States
University of Minnesota Medical School

Minneapolis, Minnesota, 55455, United States
Virginia Commonwealth University Medical Center

Richmond, Virginia, 23970, United States

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