Milk thistle extract may help repair Medication-Damaged livers
NCT ID NCT05144217
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether different doses of silymarin, a natural extract from milk thistle, can lower elevated liver enzymes caused by medications. Nineteen adults with drug-induced liver injury took either a placebo or one of three silymarin doses for 35 days. Researchers measured changes in liver enzyme levels to see if higher or more frequent doses offered better liver protection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
silymarin (milk thistle extract)
What this could lead to
If successful, this could point toward a safe, natural supplement to help protect the liver from damage caused by medications.
What could go wrong
This is a small, early-phase trial with only 19 participants, so results may not apply broadly. Higher doses may cause side effects, and the benefit over placebo is uncertain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CIRI
Frankfurt, Hessia, 60596, Germany
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Universtity Hospital - clinic for dermatology, venerology and allergology
Frankfurt, Hessia, 60590, Germany