New hope for colorectal cancer: experimental drug combo enters final trial phase

NCT ID NCT07228832

Recruiting now Disease control Sponsor: Summit Therapeutics Source: ClinicalTrials.gov ↗

First seen Nov 15, 2025 · Last updated May 15, 2026 · Updated 24 times

Summary

This study tests whether a new drug called ivonescimab, combined with standard chemotherapy, works better than the current standard treatment (bevacizumab plus chemo) for people with metastatic colorectal cancer that has spread. About 600 adults who have not had prior treatment for advanced disease will participate. The goal is to see if the new combination can delay cancer growth and improve survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Goodyear, Arizona, 85338, United States
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Beverly Hills, California, 90211, United States
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Beverly Hills, California, 90212, United States
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Cerritos, California, 90703, United States
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Corona, California, 92882, United States
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Duarte, California, 91010, United States
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Fountain Valley, California, 92708, United States
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Huntington Beach, California, 92648, United States
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Irvine, California, 92612, United States
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Irvine, California, 92618, United States
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Los Angeles, California, 90027, United States
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Los Angeles, California, 90067, United States
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Los Angeles, California, 90404, United States
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Murrieta, California, 92562, United States
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Orange, California, 92868, United States
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Pasadena, California, 91030, United States
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Torrance, California, 90503, United States
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Upland, California, 91786, United States
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West Hollywood, California, 90048, United States
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Hartford, Connecticut, 06106, United States
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New Haven, Connecticut, 06520-8028, United States
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Norwich, Connecticut, 06360, United States
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Hialeah, Florida, 33013, United States
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Miami, Florida, 33176, United States
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Orlando, Florida, 32806, United States
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Plantation, Florida, 33322, United States
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Port Saint Lucie, Florida, 34952, United States
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Tamarac, Florida, 33321, United States
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Newnan, Georgia, 30265, United States
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Chicago, Illinois, 60611, United States
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Elmhurst, Illinois, 60540, United States
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O'Fallon, Illinois, 62269, United States
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Fort Wayne, Indiana, 46804, United States
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Indianapolis, Indiana, 46202, United States
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Edgewood, Kentucky, 41017, United States
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Saint Louis Park, Minnesota, 55426, United States
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Billings, Montana, 59102, United States
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Lincoln, Nebraska, 68506, United States
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New Brunswick, New Jersey, 08901, United States
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Mineola, New York, 11501, United States
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New York, New York, 10016, United States
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The Bronx, New York, 10461, United States
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Akron, Ohio, 44032, United States
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Canton, Ohio, 44703, United States
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Cincinnati, Ohio, 45219, United States
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Cincinnati, Ohio, 45220, United States
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Cleveland, Ohio, 44111, United States
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Cleveland, Ohio, 44195, United States
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Mayfield Heights, Ohio, 44124, United States
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Philadelphia, Pennsylvania, 19111, United States
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Philadelphia, Pennsylvania, 19140, United States
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Hermitage, Tennessee, 37129, United States
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Fort Worth, Texas, 76104, United States
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Salt Lake City, Utah, 84106, United States
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Charlottesville, Virginia, 22908, United States
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Spokane, Washington, 99208, United States
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Tacoma, Washington, 98405, United States
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Charleston, West Virginia, 25304, United States
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Montreal, Quebec, H4A 3J1, Canada
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Aichi, 464-8681, Japan
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Chiba, 260-8717, Japan
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Fukuoka, 812-8582, Japan
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Gifu, 501-1194, Japan
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Hiroshima, 734-8551, Japan
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Hokkaido, 060-8648, Japan
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Kawasaki, 216-8511, Japan
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Osaka, 541-8567, Japan
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Sendai, 980-0872, Japan
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Shizuoka, 411-8777, Japan
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Tokyo, 104-0045, Japan
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Tokyo, 135-8550, Japan
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Toyama, 930-0194, Japan
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Rio Piedras, 00935, Puerto Rico
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Canterbury, England, CT13NS, United Kingdom
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London, England, EC1M 6BQ, United Kingdom
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Aberdeen, Scotland, AB25 2ZN, United Kingdom

Conditions

Explore the condition pages connected to this study.

METASTATIC COLORECTAL CANCER (CRC)