New hope for advanced colon cancer: experimental drug combo enters phase 3 trial

NCT ID NCT07228832

Recruiting now Disease control Sponsor: Summit Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This phase 3 study tests whether a new drug called ivonescimab, combined with standard chemotherapy (FOLFOX), works better than the current standard treatment (bevacizumab plus FOLFOX) for people with metastatic colorectal cancer that has spread. About 600 adults who have not had prior treatment for their advanced cancer will take part. The main goal is to see if the new combination delays cancer growth and improves survival.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER (CRC)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

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Mobile, Alabama, 36604, United States
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Tuscaloosa, Alabama, 35487, United States
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Goodyear, Arizona, 85338, United States
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Beverly Hills, California, 90211, United States
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Beverly Hills, California, 90212, United States
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Cerritos, California, 90703, United States
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Corona, California, 92882, United States
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Duarte, California, 91010, United States
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Fountain Valley, California, 92708, United States
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Huntington Beach, California, 92648, United States
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Irvine, California, 92612, United States
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Irvine, California, 92618, United States
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Los Angeles, California, 90027, United States
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Los Angeles, California, 90067, United States
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Los Angeles, California, 90404, United States
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Murrieta, California, 92562, United States
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Oakland, California, 94611, United States
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Orange, California, 92868, United States
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Pasadena, California, 91030, United States
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Roseville, California, 95661, United States
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San Francisco, California, 94115, United States
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Santa Clara, California, 94115, United States
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Stanford, California, 94305, United States
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Torrance, California, 90503, United States
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Upland, California, 91786, United States
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Vallejo, California, 94589, United States
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West Hollywood, California, 90048, United States
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Hartford, Connecticut, 06106, United States
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New Haven, Connecticut, 06520-8028, United States
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Norwich, Connecticut, 06360, United States
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Newark, Delaware, 19713, United States
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Hialeah, Florida, 33013, United States
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Miami, Florida, 33176, United States
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Miami Beach, Florida, 33140, United States
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Ocala, Florida, 34474, United States
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Orlando, Florida, 32806, United States
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Plantation, Florida, 33322, United States
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Port Saint Lucie, Florida, 34952, United States
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St. Petersburg, Florida, 33705, United States
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Tamarac, Florida, 33321, United States
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Atlanta, Georgia, 30303, United States
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Atlanta, Georgia, 30322, United States
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Newnan, Georgia, 30265, United States
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Chicago, Illinois, 60611, United States
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Elmhurst, Illinois, 60540, United States
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O'Fallon, Illinois, 62269, United States
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Fort Wayne, Indiana, 46804, United States
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Indianapolis, Indiana, 46202, United States
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Westwood, Kansas, 66205, United States
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Edgewood, Kentucky, 41017, United States
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New Orleans, Louisiana, 70121, United States
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Baltimore, Maryland, 21201, United States
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Detroit, Michigan, 48201, United States
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Saint Louis Park, Minnesota, 55426, United States
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Springfield, Missouri, 65804, United States
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Billings, Montana, 59102, United States
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Lincoln, Nebraska, 68506, United States
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Lebanon, New Hampshire, 03766, United States
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New Brunswick, New Jersey, 08901, United States
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Mineola, New York, 11501, United States
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New York, New York, 10016, United States
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Rochester, New York, 14642, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10461, United States
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White Plains, New York, 10601-5000, United States
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Akron, Ohio, 44032, United States
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Canton, Ohio, 44703, United States
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Cincinnati, Ohio, 45219, United States
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Cincinnati, Ohio, 45220, United States
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Cleveland, Ohio, 44111, United States
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Cleveland, Ohio, 44195, United States
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Mayfield Heights, Ohio, 44124, United States
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Oklahoma City, Oklahoma, 73120, United States
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Lebanon, Pennsylvania, 17042, United States
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Philadelphia, Pennsylvania, 19111, United States
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Philadelphia, Pennsylvania, 19140, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Sellersville, Pennsylvania, 18960, United States
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Providence, Rhode Island, 02903, United States
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Greenville, South Carolina, 29605, United States
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Germantown, Tennessee, 38138, United States
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Hermitage, Tennessee, 37129, United States
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Dallas, Texas, 75235, United States
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Dallas, Texas, 75390, United States
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Fort Worth, Texas, 76104, United States
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Tyler, Texas, 75701, United States
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Salt Lake City, Utah, 84106, United States
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Charlottesville, Virginia, 22908, United States
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Fairfax, Virginia, 22031, United States
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Spokane, Washington, 99208, United States
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Tacoma, Washington, 98405, United States
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Charleston, West Virginia, 25304, United States
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Madison, Wisconsin, 53792, United States
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Brussels, 1000, Belgium
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Ghent, 9000, Belgium
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Haine-Saint-Paul, 7100, Belgium
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Kortrijk, 8500, Belgium
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Toronto, Ontario, M4N 3M5, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Regina, Saskatchewan, S4T7T1, Canada
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Hradec Králové, 50005, Czechia
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Olomouc, 779 00, Czechia
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Prague, 128 00, Czechia
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Prague, 14059, Czechia
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Lille, 59000, France
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Lyon, 69374, France
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Montpellier, 34298, France
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Nantes, 44000, France
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Nice, 06189, France
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Paris, 75015, France
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Paris, 75020, France
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Pierre-Bénite, 69495, France
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Poitiers, 86000, France
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Strasbourg, 67033, France
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Bonn, 53113, Germany
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Hamburg, 20249, Germany
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Hamburg, 22763, Germany
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Florence, 50134, Italy
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Meldola, 47014, Italy
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Verona, 37134, Italy
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Osaka, Ontario, 565-0871, Japan
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Aichi, 464-8681, Japan
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Chiba, 260-8717, Japan
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Ehime, 791-0280, Japan
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Fukuoka, 812-8582, Japan
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Gifu, 501-1194, Japan
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Hiroshima, 734-8551, Japan
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Hokkaido, 060-8648, Japan
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Kawasaki, 216-8511, Japan
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Osaka, 541-8567, Japan
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Saitama, 362-0806, Japan
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Sendai, 980-0872, Japan
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Shizuoka, 411-8777, Japan
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Tokyo, 104-0045, Japan
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Tokyo, 135-8550, Japan
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Toyama, 930-0194, Japan
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Yokohama, 241-8515, Japan
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Rzeszów, Podkarpackie Voivodeship, 35-021, Poland
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Olsztyn, 10-228, Poland
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Warsaw, 02-781, Poland
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Warsaw, 04-141, Poland
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Rio Piedras, 00935, Puerto Rico
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A Coruña, 15006, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, 08908, Spain
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Barcelona, 08916, Spain
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Granada, 18014, Spain
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Madrid, 28009, Spain
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Madrid, 28046, Spain
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Madrid, 28050, Spain
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Madrid, 28222, Spain
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Málaga, 29010, Spain
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Palma de Mallorca, 07198, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Valencia, 46014, Spain
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Valencia, 46026, Spain
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Canterbury, England, CT13NS, United Kingdom
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London, England, EC1M 6BQ, United Kingdom
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Aberdeen, Scotland, AB25 2ZN, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Liverpool, L7 8YA, United Kingdom
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Manchester, M20 4BX, United Kingdom

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