New hope for Hard-to-Treat colorectal cancer? denikitug trial launches

NCT ID NCT07527858

Recruiting now Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 4 times

Summary

This phase 2 trial tests a new drug called denikitug, alone or combined with other treatments, in 170 people with advanced microsatellite stable (MSS) colorectal cancer. MSS colorectal cancer is a common type that often does not respond to standard immunotherapy. The study aims to see if denikitug can shrink tumors and improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Denikitug (also called GS-1811), given alone or with nivolumab, trifluridine-tipiracil, or bevacizumab
What this could lead to: If successful, this could offer a new treatment option for people with advanced MSS colorectal cancer, a type that typically does not respond to immunotherapy.
What could go wrong: This is an early phase 2 trial with a small number of participants. The drug may not shrink tumors or improve survival, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MICROSATELLITE STABLE COLORECTAL CANCER

Contacts and locations

Locations

Asan Medical Center
NOT_YET_RECRUITING

Seoul, 138-736, South Korea
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Chris O'Brien Lifehouse
RECRUITING

Camperdown, CA, 2050, Australia
Dana-Farber Cancer Institute
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Hospital General Universitario Gregorio Maranon
NOT_YET_RECRUITING

Madrid, 28050, Spain
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Royal Brisbane and Women's Hospital
RECRUITING

Herston, Queensland, 4029, Australia
Samsung Medical Center
NOT_YET_RECRUITING

Busan, 48775, South Korea
Seoul National University Hospital
NOT_YET_RECRUITING

Seoul, 03080, South Korea
University of Virginia,
RECRUITING

Charlottesville, Virginia, 22908, United States
Washington University School of Medicine
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
Yale-New Haven Hospital - Yale Cancer Center
RECRUITING

North Haven, Connecticut, 06473 2195, United States
Yonsei University Severance Hospital ( aka Yonsei Cancer Center)
NOT_YET_RECRUITING

Seoul, 03722, South Korea