New hope for colorectal cancer: amivantamab trial launches

NCT ID NCT05379595

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 25 times

Summary

This study tests a drug called amivantamab, either alone or with standard chemotherapy, in people with advanced or metastatic colorectal cancer. The goal is to see if the drug can shrink tumors and to find the safest dose when combined with chemo. About 225 adults whose cancer has spread and who have certain genetic markers will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A O Ospedale Niguarda Ca Granda
RECRUITING

Milan, 20162, Italy
Ad Vance Medical Research
RECRUITING

Ponce, 00717, Puerto Rico
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asklepios Klinik Altona
RECRUITING

Hamburg, 22763, Germany
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
BC Cancer Agency - Vancouver BC
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Beacon Hospital Sdn Bhd
RECRUITING

Petaling Jaya, 46050, Malaysia
Changhua Christian Hospital
RECRUITING

Changhua, 500, Taiwan
Chi Mei Medical Center Liu Ying
RECRUITING

Liou Ying Township, 736, Taiwan
Cliniques Universitaires Saint Luc
RECRUITING

Brussels, 1200, Belgium
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
H Lee Moffitt Cancer Center
COMPLETED

Tampa, Florida, 33612, United States
Hattiesburg Clinic
RECRUITING

Hattiesburg, Mississippi, 39401, United States
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Hosp Univ Fund Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hosp Univ Hm Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hosp. Clinico Univ. de Valencia
RECRUITING

Valencia, 46010, Spain
Hosp. Gral. Univ. Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hosp. Univ. Marques de Valdecilla
RECRUITING

Santander, 39008, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Umum Sarawak
RECRUITING

Kuching, 93586, Malaysia
Hubei province tumor hospital
RECRUITING

Wuhan, 430079, China
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan, 33305, Taiwan
Ludwig-Maximilians-Universitaet Muenchen
RECRUITING

Munich, 81377, Germany
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
NYU Langone Long Island Clinical Research Associates
RECRUITING

New York, New York, 10016, United States
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
O Neal Comprehensive Cancer Center at UAB
RECRUITING

Birmingham, Alabama, 35233, United States
Pan American Center for Oncology Trials LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Princess Margaret Cancer Centre University Health Network
RECRUITING

Toronto, Ontario, M5G 1X6, Canada
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Start Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
Stephenson Cancer Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Sun Yat-sen University - The Sixth Affiliated Hospital Guangdong Gastrointestinal Hospital
RECRUITING

Guangzhou, 510655, China
The Catholic University of Korea Seoul St Mary s Hospital
RECRUITING

Seoul, 06591, South Korea
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Second Affiliated Hospital of Zhejiang University College of Medicine
RECRUITING

Hangzhou, 310003, China
The Second Hospital To Dalian Medical University
COMPLETED

Dalian, 116023, China
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
Universitair Ziekenhuis Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
University of California, Los Angeles UCLA
RECRUITING

Los Angeles, California, 90404, United States
University of Maryland School of Medicine
COMPLETED

Baltimore, Maryland, 21201, United States
University of Michigan Health System
RECRUITING

Ann Arbor, Michigan, 48103, United States
University of Southern California
COMPLETED

Los Angeles, California, 90033, United States
Vanderbilt Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED OR METASTATIC COLORECTAL CANCER