New hope for toddlers with aggressive brain cancer: experimental spinal-fluid chemo

NCT ID NCT06942039

Recruiting now Disease control Sponsor: C17 Council Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This early-phase study tests whether adding chemotherapy directly into the spinal fluid (intrathecal topotecan) followed by maintenance pills is feasible for children under 6 with high-risk embryonal brain tumors. About 15 children will receive this treatment after standard high-dose chemo. The goal is to see if the approach is safe enough to study further, not to cure the disease.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor central nervous system primitive neuroectodermal neoplasm cerebral neuroblastoma childhood central nervous system primitive neuroectodermal neoplasm childhood medulloblastoma embryonal tumor with multilayered rosettes ependymoblastoma hypertrophic pyloric stenosis medulloblastoma medulloblastoma non-WNT/non-SHH group 3 medulloblastoma non-WNT/non-SHH group 4 medulloepithelioma neuroblastoma Neuroectodermal Tumors, Primitive Pinealoma pineoblastoma rhabdoid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL TERATOID/RHABDOID TUMOR CNS EMBRYONAL TUMOR CNS EMBRYONAL TUMOR WITH RHABDOID FEATURES CNS EMBRYONAL TUMOR, NOS CNS, MEDULLOBLASTOMA EMBRYONAL TUMOR WITH ABUNDANT NEUROPIL AND TRUE ROSETTES EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES EPENDYMOBLASTOMA MEDULLOBLASTOMA, CHILDHOOD MEDULLOBLASTOMA, GROUP 3 MEDULLOBLASTOMA, GROUP 4 MEDULLOEPITHELIOMA NEUROBLASTOMA PINEOBLASTOMA

Contacts and locations

Locations

Alberta Children's Hospital
RECRUITING

Calgary, Alberta, Canada
BC Children's Hospital
RECRUITING

Vancouver, British Columbia, Canada
CHU Sainte-Justine
RECRUITING

Montreal, Quebec, Canada
CHU de Québec-Université Laval
RECRUITING

Québec, Quebec, Canada
CancerCare Manitoba (CCMB)
RECRUITING

Winnipeg, Manitoba, Canada
Centre hospitalier universitaire de Sherbrooke (CHUS)
RECRUITING

Sherbrooke, Quebec, Canada
IWK Health Centre
NOT_YET_RECRUITING

Halifax, Nova Scotia, Canada
London Health Sciences Centre
RECRUITING

London, Ontario, Canada
McMaster Children's Hospital
RECRUITING

Hamilton, Ontario, Canada
Montreal Children's Hospital (McGill)
NOT_YET_RECRUITING

Montreal, Quebec, Canada
Stollery Children's Hospital
RECRUITING

Edmonton, Canada
The Hospital for Sick Children
RECRUITING

Toronto, Canada

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