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New hope for toddlers with aggressive brain cancer: experimental spinal-fluid chemo

NCT ID NCT06942039

Recruiting now Disease control Sponsor: C17 Council Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests whether adding chemotherapy directly into the spinal fluid (intrathecal topotecan) followed by maintenance pills is feasible for children under 6 with high-risk embryonal brain tumors. About 15 children will receive this treatment after standard high-dose chemo. The goal is to see if the approach is safe enough to study further, not to cure the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor central nervous system primitive neuroectodermal neoplasm cerebral neuroblastoma childhood central nervous system primitive neuroectodermal neoplasm childhood medulloblastoma embryonal tumor with multilayered rosettes ependymoblastoma hypertrophic pyloric stenosis medulloblastoma medulloblastoma non-WNT/non-SHH group 3 medulloblastoma non-WNT/non-SHH group 4 medulloepithelioma neuroblastoma Neuroectodermal Tumors, Primitive Pinealoma pineoblastoma rhabdoid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL TERATOID/RHABDOID TUMOR CNS EMBRYONAL TUMOR CNS EMBRYONAL TUMOR WITH RHABDOID FEATURES CNS EMBRYONAL TUMOR, NOS CNS, MEDULLOBLASTOMA EMBRYONAL TUMOR WITH ABUNDANT NEUROPIL AND TRUE ROSETTES EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES EPENDYMOBLASTOMA MEDULLOBLASTOMA, CHILDHOOD MEDULLOBLASTOMA, GROUP 3 MEDULLOBLASTOMA, GROUP 4 MEDULLOEPITHELIOMA NEUROBLASTOMA PINEOBLASTOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Alberta Children's Hospital

    RECRUITING

    Calgary, Alberta, Canada

    Contact Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

  • BC Children's Hospital

    RECRUITING

    Vancouver, British Columbia, Canada

    Contact

    Contact Email: •••••@•••••

  • CHU Sainte-Justine

    RECRUITING

    Montreal, Quebec, Canada

    Contact Email: •••••@•••••

    Contact

  • CHU de Québec-Université Laval

    RECRUITING

    Québec, Quebec, Canada

    Contact Email: •••••@•••••

    Contact

  • CancerCare Manitoba (CCMB)

    RECRUITING

    Winnipeg, Manitoba, Canada

    Contact

    Contact Email: •••••@•••••

  • Centre hospitalier universitaire de Sherbrooke (CHUS)

    RECRUITING

    Sherbrooke, Quebec, Canada

    Contact Email: •••••@•••••

    Contact

  • IWK Health Centre

    NOT_YET_RECRUITING

    Halifax, Nova Scotia, Canada

    Contact

    Contact Email: •••••@•••••

  • London Health Sciences Centre

    RECRUITING

    London, Ontario, Canada

    Contact Email: •••••@•••••

    Contact

  • McMaster Children's Hospital

    RECRUITING

    Hamilton, Ontario, Canada

    Contact

    Contact Email: •••••@•••••

  • Montreal Children's Hospital (McGill)

    NOT_YET_RECRUITING

    Montreal, Quebec, Canada

    Contact

    Contact Email: •••••@•••••

  • Stollery Children's Hospital

    RECRUITING

    Edmonton, Canada

    Contact Email: •••••@•••••

    Contact

  • The Hospital for Sick Children

    RECRUITING

    Toronto, Canada

    Contact

    Contact Email: •••••@•••••