New drug combo aims to shrink Hard-to-Treat colorectal tumors

NCT ID NCT06820463

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 13 times

Summary

This study tests an experimental drug called telisotuzumab adizutecan combined with standard chemotherapy in people whose colorectal cancer has spread. The goal is to see if the combination shrinks tumors and is safe. About 390 adults will take part at hospitals worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: telisotuzumab adizutecan (an investigational antibody-drug conjugate) combined with standard chemotherapy drugs (FOLFOX, 5FU, leucovorin, bevacizumab, or panitumumab)
What this could lead to: If successful, this could offer a new treatment option for people with metastatic colorectal cancer that has spread and is hard to treat.
What could go wrong: This is an early Phase 2 trial, so the drug may not work better than current treatments. Side effects from the combination could be significant, and the study will take about 6 years to complete.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER

Contacts and locations

Locations

Aichi Cancer Center /ID# 270113
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Arthur J.E Child Comprehensive Cancer Centre /ID# 269809
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Austin Health /ID# 270692
RECRUITING

Heidelberg, Victoria, 3084, Australia
Centre Hospitalier Universitaire de Poitiers /ID# 270225
RECRUITING

Poitiers, New Aquitaine, 86021, France
Chu De Lille - Hopital Claude Huriez /ID# 270222
RECRUITING

Lille, Hauts-de-France, 59037, France
City of Hope National Medical Center /ID# 270255
RECRUITING

Duarte, California, 91010, United States
Dana-Farber Cancer Institute /ID# 270624
RECRUITING

Boston, Massachusetts, 02215, United States
Fakultni Thomayerova nemocnice /ID# 269632
RECRUITING

Prague, Praha, Hlavni Mesto, 140 59, Czechia
Fakultni nemocnice Hradec Kralove - Sokolska /ID# 268773
RECRUITING

Hradec Králové, 500 05, Czechia
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 271651
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Hadassah Medical Center-Hebrew University /ID# 268007
RECRUITING

Jerusalem, 91120, Israel
Hope And Healing Cancer Services /ID# 271562
RECRUITING

Hinsdale, Illinois, 60521, United States
Hopital Europeen Georges Pompidou /ID# 270224
RECRUITING

Paris, 75015, France
Hospital De Amor /ID# 271874
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Hospital Sao Rafael /ID# 271681
RECRUITING

Salvador, Estado de Bahia, 41253-190, Brazil
Hospital Universitario Marques de Valdecilla /ID# 269732
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Vall de Hebron /ID# 270191
RECRUITING

Barcelona, 08035, Spain
Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 270546
RECRUITING

São Paulo, 01401-002, Brazil
Kaohsiung Chang Gung Memorial Hospital /ID# 269726
RECRUITING

Kaohsiung City, 833, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 269724
RECRUITING

Kaohsiung City, 807, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 269725
RECRUITING

Taoyuan City, 333, Taiwan
London Health Sciences Centre - Victoria Hospital & Children's Hospital /ID# 270680
RECRUITING

London, Ontario, N6A 5W9, Canada
Macquarie University /ID# 271514
RECRUITING

Sydney, New South Wales, 2109, Australia
Mater Hospital Brisbane /ID# 270694
RECRUITING

South Brisbane, Queensland, 4101, Australia
Medizinische Universitaet Wien /ID# 268872
RECRUITING

Vienna, 1090, Austria
National Cancer Center Hospital /ID# 270112
RECRUITING

Chuo-Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East /ID# 270114
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital /ID# 270835
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital /ID# 269717
RECRUITING

Taipei, 100, Taiwan
Nebraska Cancer Specialists - Omaha - Wright Street /ID# 271646
RECRUITING

Omaha, Nebraska, 68130, United States
Northwest Georgia Oncology Centers /ID# 270245
RECRUITING

Marietta, Georgia, 30060, United States
Nucleo De Pesquisa Clinica Da Rede Sao Camilo /ID# 272311
RECRUITING

São Paulo, 04014-002, Brazil
Oncology Hematology Care - Eastgate /ID# 271493
RECRUITING

Cincinnati, Ohio, 45245, United States
Oncosite - Centro de Pesquisa Clinica em Oncologia /ID# 270147
RECRUITING

Ijuí, Rio Grande do Sul, 98700-000, Brazil
One Clinical Research /ID# 270695
RECRUITING

Nedlands, Western Australia, 6009, Australia
Pan American Center for Oncology Trials - Rio Piedras /ID# 268809
RECRUITING

Rio Piedras, 00935, Puerto Rico
Princess Margaret Cancer Centre /ID# 268715
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Puerto Rico Medical Research Center /ID# 268825
RECRUITING

San Juan, 00917-5022, Puerto Rico
Rabin Medical Center. /ID# 268008
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Rambam Health Care Campus- Haifa /ID# 268006
RECRUITING

Haifa, 3109601, Israel
Saint Lukes Hospital of Kansas City /ID# 270633
RECRUITING

Kansas City, Missouri, 64111, United States
Shaare Zedek Medical Center /ID# 268009
RECRUITING

Jerusalem, 9103102, Israel
St Marianna University School Of Medicine /ID# 270111
RECRUITING

Kawasaki-shi, Kanagawa, 216-8511, Japan
St. Luke's Hospital /ID# 269963
RECRUITING

Panórama, Thessaloniki, 55236, Greece
Taipei Veterans General Hospital /ID# 269718
RECRUITING

Taipei, 112, Taiwan
Tel Aviv Sourasky Medical Center /ID# 268010
RECRUITING

Tel Aviv, Tel Aviv, 6423906, Israel
Texas Oncology - Austin Midtown /ID# 271354
RECRUITING

Austin, Texas, 78705, United States
Texas Oncology - Deke Slayton Cancer Center /ID# 271355
RECRUITING

Webster, Texas, 77598, United States
The Christie NHS Foundation Trust - Christie Hospital /ID# 271561
RECRUITING

Manchester, M20 4BX, United Kingdom
The Queen Elizabeth Hospital /ID# 270693
RECRUITING

Woodville South, South Australia, 5011, Australia
The Royal Marsden - Sutton /ID# 271172
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
Theagenio Cancer Hospital /ID# 269640
RECRUITING

Thessaloniki, 54639, Greece
Tohoku University Hospital /ID# 270966
RECRUITING

Sendai, Miyagi, 980-8574, Japan
UCLA - Santa Monica /ID# 270621
RECRUITING

Santa Monica, California, 90404, United States
University Of Michigan /ID# 270790
RECRUITING

Ann Arbor, Michigan, 48109-5000, United States
University Of Washington-Fred Hutchinson Cancer Center - Seattle /ID# 271298
RECRUITING

Seattle, Washington, 98109, United States
University of Chicago Medical Center /ID# 271688
RECRUITING

Chicago, Illinois, 60637, United States
University of North Carolina Medical Center /ID# 267786
RECRUITING

Chapel Hill, North Carolina, 27514, United States
Virginia Cancer Specialists - Fairfax /ID# 271351
RECRUITING

Fairfax, Virginia, 22031, United States
Yale New Haven Hospital /ID# 270565
RECRUITING

New Haven, Connecticut, 06510, United States

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