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New drug combo aims to shrink Hard-to-Treat colorectal tumors

NCT ID NCT06820463

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study tests an experimental drug called telisotuzumab adizutecan combined with standard chemotherapy in people whose colorectal cancer has spread. The goal is to see if the combination shrinks tumors and is safe. About 390 adults will take part at hospitals worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

telisotuzumab adizutecan (an investigational antibody-drug conjugate) combined with standard chemotherapy drugs (FOLFOX, 5FU, leucovorin, bevacizumab, or panitumumab)

What this could lead to

If successful, this could offer a new treatment option for people with metastatic colorectal cancer that has spread and is hard to treat.

What could go wrong

This is an early Phase 2 trial, so the drug may not work better than current treatments. Side effects from the combination could be significant, and the study will take about 6 years to complete.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Aichi Cancer Center /ID# 270113

    RECRUITING

    Nagoya, Aichi-ken, 464-8681, Japan

  • Austin Health /ID# 270692

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • Centre Hospitalier Universitaire de Poitiers /ID# 270225

    RECRUITING

    Poitiers, New Aquitaine, 86021, France

  • Chu De Lille - Hopital Claude Huriez /ID# 270222

    RECRUITING

    Lille, Hauts-de-France, 59037, France

  • City of Hope National Medical Center /ID# 270255

    RECRUITING

    Duarte, California, 91010, United States

  • Dana-Farber Cancer Institute /ID# 270624

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Fakultni Thomayerova nemocnice /ID# 269632

    RECRUITING

    Prague, Praha, Hlavni Mesto, 140 59, Czechia

  • Fakultni nemocnice Hradec Kralove - Sokolska /ID# 268773

    RECRUITING

    Hradec Králové, 500 05, Czechia

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 271651

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hadassah Medical Center-Hebrew University /ID# 268007

    RECRUITING

    Jerusalem, 91120, Israel

  • Hope And Healing Cancer Services /ID# 271562

    RECRUITING

    Hinsdale, Illinois, 60521, United States

  • Hospital De Amor /ID# 271874

    RECRUITING

    Barretos, São Paulo, 14784-400, Brazil

  • Hospital Sao Rafael /ID# 271681

    RECRUITING

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Hospital Universitario Marques de Valdecilla /ID# 269732

    RECRUITING

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Vall de Hebron /ID# 270191

    RECRUITING

    Barcelona, 08035, Spain

  • Hôpital Européen Georges Pompidou /ID# 270224

    RECRUITING

    Paris, 75015, France

  • Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 270546

    RECRUITING

    São Paulo, 01401-002, Brazil

  • Kaohsiung Chang Gung Memorial Hospital /ID# 269726

    RECRUITING

    Kaohsiung City, 833, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 269724

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Linkou Chang Gung Memorial Hospital /ID# 269725

    RECRUITING

    Taoyuan City, 333, Taiwan

  • Macquarie University /ID# 271514

    RECRUITING

    Sydney, New South Wales, 2109, Australia

  • Mater Hospital Brisbane /ID# 270694

    RECRUITING

    South Brisbane, Queensland, 4101, Australia

    Contact Phone: •••-•••-••••

  • Medizinische Universitaet Wien /ID# 268872

    RECRUITING

    Vienna, 1090, Austria

  • National Cancer Center Hospital /ID# 270112

    RECRUITING

    Chuo-Ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East /ID# 270114

    RECRUITING

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital /ID# 270835

    RECRUITING

    Tainan, 704, Taiwan

  • National Taiwan University Hospital /ID# 269717

    RECRUITING

    Taipei, 100, Taiwan

  • Nebraska Cancer Specialists - Omaha - Wright Street /ID# 271646

    RECRUITING

    Omaha, Nebraska, 68130, United States

  • Nucleo De Pesquisa Clinica Da Rede Sao Camilo /ID# 272311

    RECRUITING

    São Paulo, 04014-002, Brazil

  • Oncology Hematology Care - Eastgate /ID# 271493

    RECRUITING

    Cincinnati, Ohio, 45245, United States

  • Oncosite - Centro de Pesquisa Clinica em Oncologia /ID# 270147

    RECRUITING

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • One Clinical Research /ID# 270695

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Pan American Center for Oncology Trials - Rio Piedras /ID# 268809

    RECRUITING

    Rio Piedras, 00935, Puerto Rico

  • Puerto Rico Medical Research Center /ID# 268825

    RECRUITING

    San Juan, 00917-5022, Puerto Rico

  • Rabin Medical Center. /ID# 268008

    RECRUITING

    Petah Tikva, Central District, 4941492, Israel

  • Rambam Health Care Campus- Haifa /ID# 268006

    RECRUITING

    Haifa, 3109601, Israel

  • Saint Lukes Hospital of Kansas City /ID# 270633

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • Shaare Zedek Medical Center /ID# 268009

    RECRUITING

    Jerusalem, 9103102, Israel

  • St Marianna University School Of Medicine /ID# 270111

    RECRUITING

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • St. Luke's Hospital /ID# 269963

    RECRUITING

    Panórama, Thessaloniki, 55236, Greece

  • Taipei Veterans General Hospital /ID# 269718

    RECRUITING

    Taipei, 112, Taiwan

  • Tel Aviv Sourasky Medical Center /ID# 268010

    RECRUITING

    Tel Aviv, Tel Aviv, 6423906, Israel

  • Texas Oncology - Austin Midtown /ID# 271354

    RECRUITING

    Austin, Texas, 78705, United States

  • Texas Oncology - Deke Slayton Cancer Center /ID# 271355

    RECRUITING

    Webster, Texas, 77598, United States

  • The Queen Elizabeth Hospital /ID# 270693

    RECRUITING

    Woodville South, South Australia, 5011, Australia

  • Theagenio Cancer Hospital /ID# 269640

    RECRUITING

    Thessaloniki, 54639, Greece

  • Tohoku University Hospital /ID# 270966

    RECRUITING

    Sendai, Miyagi, 980-8574, Japan

  • UCLA - Santa Monica /ID# 270621

    RECRUITING

    Santa Monica, California, 90404, United States

  • University Of Washington-Fred Hutchinson Cancer Center - Seattle /ID# 271298

    RECRUITING

    Seattle, Washington, 98109, United States

  • University of Chicago Medical Center /ID# 271688

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of North Carolina Medical Center /ID# 267786

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

  • Virginia Cancer Specialists - Fairfax /ID# 271351

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Yale New Haven Hospital /ID# 270565

    RECRUITING

    New Haven, Connecticut, 06510, United States