Heated chemo during surgery could boost colon cancer survival

NCT ID NCT06783491

Recruiting now Disease control Sponsor: Maimónides Biomedical Research Institute of Córdoba Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 3 trial is testing whether giving chemotherapy before surgery, with or without a heated chemotherapy wash inside the abdomen during surgery, can help people with locally advanced colon cancer live longer without the cancer returning. About 1,083 participants will be randomly assigned to standard treatment or one of two experimental groups. The study aims to see if these proactive approaches improve disease-free survival at 3 years compared to current care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FOLFOX (combination chemotherapy) and mitomycin C (given as heated intraperitoneal chemotherapy during surgery)
What this could lead to: If successful, this could offer a more effective treatment strategy for locally advanced colon cancer, potentially reducing the chance of cancer coming back after surgery.
What could go wrong: This is a large phase 3 trial, but results are not yet known. The added treatments may cause more side effects, and it's unclear if the benefits will outweigh the risks for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED COLORECTAL CANCER

Contacts and locations

Locations

Hospital Universitario Reina Sofia
RECRUITING

Córdoba, Córdoba, 14004, Spain

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